Clinical trials: Insulin-dependent Diabetes Mellitus
Type 1 Diabetes, Hypoglycemia
Pen-Administered Low-Dose Dasiglucagon for Prevention and Treatment of Hypoglycemia in People With Type 1 Diabetes
The aim of the study is to evaluate the efficacy, safety and feasibility of outpatient-utilization of low-dose dasiglucagon administered via a multi-dose reusable pen injector in preventing and treating mild hypoglycemia in…
- Trial name
- NCT04764968
- Testing
- Dasiglucagon
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, Type 1
REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL)
The trial is conducted in the United Kingdom (UK), Australia, Canada, Denmark and the Netherlands. The aim is to test whether 3 years treatment with metformin added to titrated insulin therapy (towards target HbA1c 7.0%/53…
- Trial name
- REMOVAL (NCT01483560)
- Testing
- Metformin
- Where
- 24 sites in Australia, Canada and 3 more
- Volunteers
- 493 people
- Sponsor
- University of Glasgow
Type 1 Diabetes Mellitus
Single Hormone Closed Loop Study With PDT Sensor
The study described within this protocol is designed to test a single hormone closed-loop algorithm for managing blood glucose in type 1 diabetes using insulin only and a new device for measuring glucose continuously in the…
- Trial name
- NCT03528174
- Testing
- Artificial Pancreas Control system (APC), Pacific Diabetes Technologies CGM Insulin Infusion system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Diabetes Mellitus, Type 1
Cardiovascular Autonomic Neuropathy in Patients With Type 1 Diabetes Mellitus.
testing of autonomic function and relationship with exercise and Qol in diabetic patients and controls
- Trial name
- NCT03481374
- Testing
- autonomic function testing
- Where
- Belgium
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Clinical Evaluation of BD NEXT Pen Needle
This prospective, multi-center, 2 period cross-over study is designed to determine if people who use injection pens for subcutaneous medication delivery prefer the BD NEXT pen needle (PN) in comparison with currently marketed pen…
- Trial name
- NCT01852136
- Testing
- BD NEXT 31G x 5 mm pen needle, BD NEXT 31G x 8mm pen needle, BD NEXT 32G x 4mm pen needle
- Where
- 5 sites in United States, Canada
- Volunteers
- 217 people
- Sponsor
- Becton, Dickinson and Company
Hypoglycemia, Inflammatory Response
Consequences of Hypoglycaemia on Cardiovascular and Inflammatory Responses
People with Type 1 diabetes (T1DM), type 2 diabetes (T2DM) and healthy volunteers will undergo a hypoglycaemic clamp to to investigate the effect of hypoglycaemia on cardiovascular and inflammatory responses.
- Conditions
- Hypoglycemia, Inflammatory Response, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- HCIR (NCT03976271)
- Testing
- hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus (T1DM)
Pediatric Insulin Plan Calculator for T1DM Management
This is a multi-centre, prospective, randomized, open-label controlled trial designed to evaluate the effectiveness of a flexible digital insulin dose calculator in children under 12 years of age with Type 1 Diabetes Mellitus…
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus (T1DM), T1DM, T1DM - Type 1 Diabetes Mellitus
- Trial name
- FLEXI-T1D (NCT07427134)
- Testing
- Flexible Digital Insulin Dose Calculator
- Where
- 2 sites in Iraq, Pakistan
- Volunteers
- 440 people
- Sponsor
- Sultan Qaboos University
Diabetes Mellitus, Type 1, Eating Disorders
Safe Management of People With Type 1 Diabetes and EAting Disorders studY
There is currently no effective intervention for type 1 diabetes and eating disorders. The main objective of STEADY Stage 2 is to test the feasibility of the newly developed STEADY intervention.
- Trial name
- STEADY-II (NCT05140564)
- Testing
- STEADY intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Type 1 Diabetes (T1D), Sleep Health
Type 1 Diabetes REst for Metabolic Health
Research has shown a link between poor sleep health and late circadian timing with cardiometabolic health in adolescents with type 1 diabetes (T1D).
- Trial name
- T1DREaM (NCT06627504)
- Testing
- Sleep Health and Circadian Timing Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Impact of Eccentric Training in Hypoxia With Creatine on Metabolic Control and VO2max in Patients With Type 1 Diabetes
Exercise plays an important role in treatment of diabetes. In recent years exercise training in normobaric hypoxia is used in training programs for athletes and in rehabilitation and also commercially.
- Trial name
- NCT06345612
- Testing
- hypoxia, normoxia, creatine supplementation
- Where
- Poland
- Volunteers
- 28 people
- Sponsor
- Silesian Centre for Heart Diseases
Type 1 Diabetes Mellitus, Adolescent Behavior
Using an mHealth App to Transition Care of Type-1 Diabetes From Parents to Teens
Type 1 diabetes (T1D) afflicts approximately 154,000 people under the age of 20. Most people with T1D are diagnosed at a young age; their parents have to manage their child's condition.
- Conditions
- Type 1 Diabetes Mellitus, Adolescent Behavior, Parent-Child Relations, Communication
- Trial name
- NCT03436628
- Testing
- MyT1DHero
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Diabetes Mellitus, Type 1
Islet Cell Transplants for Diabetes
The purpose of this study is to test the safety and efficacy of islet cell transplants for the treatment of type 1 diabetes mellitus.
- Trial name
- NCT00303134
- Testing
- Islet Cell Transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Weill Medical College of Cornell University
Type 1 Diabetes
Hybrid Closed-Loop Hotel Studies With Medtronic PID Controller
The primary objective of this study is to evaluate the safety and efficacy of the Medtronic hybrid closed-loop (HCL) system utilizing the proportional-integral-derivative algorithm with insulin feedback (PID-IFB) optimized to…
- Trial name
- NCT02280863
- Testing
- Medtronic Hybrid Closed-loop System - Android Platform, Medtronic Hybrid Closed-loop Integrated System
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes Mellitus, Type 1
To Examine the Lung When People With Diabetes Take an Inhaled Form of Insulin, Compared to Subcutaneous Insulin.
To examine the lung when people with diabetes take an inhaled form of insulin, compared to subcutaneous insulin.
- Trial name
- NCT00143104
- Testing
- Inhaled insulin
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pfizer
Diabetes Mellitus, Diabetes Mellitus, Type 1
An Open-Label, FIH Study Evaluating the Safety and Tolerability of VCTX210A Combination Product in Subjects With T1D
This is an open-label, multicenter, Phase 1 study evaluating the safety and tolerability of VCTX210A combination product in patients with T1D
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT05210530
- Testing
- VCTX210A unit
- Where
- 3 sites in Canada
- Volunteers
- 7 people
- Sponsor
- CRISPR Therapeutics AG
Hypo-unawareness, Type 1 Diabetes Mellitus
Effect of a Medium Chain Triglyceride Supplemented Diet on Cognitive Function and Brain Activation in Type 1 Diabetes.
Insulin treatment often causes the blood glucose levels to fall too low (hypoglycemia). Hypoglycemia can be associated with confusion and disorientation as well as other symptoms such as palpitations, sweating and tremors.
- Trial name
- NCT01315171
- Testing
- Medium chain triglycerides
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Type 1 Diabetes
Study of A Cell-Phone System to Improve Health of Youth With Diabetes
FL3X is an integrated diabetes self-management system that incorporates modern cell phone technology with behavioral modification approaches to improve diabetes self-management in high-risk youth.
- Trial name
- FL3X (NCT02280564)
- Testing
- health coaching with technology support
- Where
- 3 sites in United States
- Volunteers
- 74 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Type 1, Monogenic Diabetes
Monogenic Diabetes Misdiagnosed as Type 1
The study has two aims: 1. To (1a) determine the frequency of monogenic diabetes misdiagnosed as type 1 diabetes (T1D) and (2) to define an algorithm for case selection. 2.
- Conditions
- Diabetes Mellitus, Type 1, Monogenic Diabetes, Neonatal Diabetes, Maturity-onset Diabetes in the Young (MODY)
- Trial name
- ADDAM (NCT03988764)
- Testing
- None AHT
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Pharmacokinetic Properties of FIAsp in Children, Adolescents and Adults With Type 1 Diabetes
This trial is conducted in Europe. The aim of the trial is to investigate the pharmacokinetic (the exposure of the trial drug in the body) properties of FIAsp (faster-acting insulin aspart) in children, adolescents and adults…
- Trial name
- NCT02035371
- Testing
- Faster-acting insulin aspart, insulin aspart
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes, Diabetes in Children
The T1D Parent Check-In: A Preventative Intervention
The goal of this clinical trial is to learn how to best support families during the first year of a child or teen's Type 1 diabetes (T1D) diagnosis.
- Trial name
- NCT06160934
- Testing
- T1D Parent Check-in
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
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