Clinical trials: Intensity-modulated Radiotherapy
Locally Advanced Cervical Cancer
Dose Escalation Study of Simultaneous Boost Intensity-Modulated Radiotherapy for Locally Advanced Cervical Cancer
This will be the first study to assess the clinical feasibility of dose escalation with simultaneous integrated boost intensity-modulated radiotherapy for patients with locally advanced cervical cancer.
- Trial name
- DEPICT (NCT01230996)
- Testing
- Cisplatin, Intensity-modulated radiation therapy, Intracavitary brachytherapy
- Where
- 4 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- Barts & The London NHS Trust
Breast Cancer
Intensity Modulated Radiotherapy (IMRT) vs. 3D-conformal Accelerated Partial Breast Irradiation (APBI) for Early Stage Breast Cancer After Lumpectomy
In the setting of radiotherapy as part of breast-conservation therapy for patients with early stage breast cancer, the novel planning and delivery method of intensity modulated radiotherapy is an effective and safe alternative to…
- Trial name
- 2009-APBI (NCT01185132)
- Testing
- accelerated partial breast irradiation - 3D-conformal planning, accelerated partial breast irradiation - IMRT planning
- Where
- 5 sites in United States
- Volunteers
- 660 people
- Sponsor
- Rocky Mountain Cancer Centers
High Risk Prostate Cancer
Hypofractionated Intensity Modulated Radiation Therapy Plus Hormonal Therapy in Patients With High Risk Prostate Cancer
Considering the promising results with hypofractionated in low and intermediate risk prostate cancer, our proposal is to translate this experience to patients with high risk prostate cancer.
- Trial name
- NCT02107287
- Testing
- IMRT Technique
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Sergio Faria
Salivary Gland Squamous Cell Carcinoma, Stage II Salivary Gland Cancer
Phase I Study of IMRT and Molecular-Image Guided Adaptive Radiation Therapy for Advanced HNSCC
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Conditions
- Salivary Gland Squamous Cell Carcinoma, Stage II Salivary Gland Cancer, Stage II Squamous Cell Carcinoma of the Hypopharynx, Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity
- Trial name
- NCT01283178
- Testing
- intensity-modulated radiation therapy, cisplatin, image-guided adaptive radiation therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Head and Neck Cancer
Amifostine With IMRT for Submandibular and Sublingual Salivary Sparing During Head and Neck Cancer Treatment
Primary Objective: To determine if amifostine in combination with IMRT can mitigate the decrease in production of saliva by the submandibular and sublingual salivary glands in patients with HNSCC. Secondary Objectives: 1.
- Trial name
- NCT00409331
- Testing
- Amifostine, Intensity- Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Carcinoma, Squamous Cell
Simultaneous Integrated Boost (SIB)- IMRT
The objective of the study is to assess the feasibility of increasing dose of irradiation with IMRT using a SIB approach over 6 weeks.
- Trial name
- NCT00389727
- Testing
- Radiotherapy
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Retroperitoneal Sarcoma
Proton or Photon RT for Retroperitoneal Sarcomas
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigational therapy to use for…
- Trial name
- NCT01659203
- Testing
- IG-IMPT, IG IMRT
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Head and Neck Cancer
Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX)
The purpose of this study is to evaluate the tolerability and safety of Xevinapant when added to weekly cisplatin-based concurrent chemoradiotherapy (CRT) in the treatment of participants with unresectable locally advanced…
- Trial name
- NCT06056310
- Testing
- Xevinapant, Cisplatin, intensity-modulated radiation therapy (IMRT)
- Where
- 23 sites in United States, Belgium and 4 more
- Volunteers
- 18 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Esophageal Neoplasms
Radiotherapy With or Without Concurrent Chemotherapy for Limited Lymphatic Metastasis of Esophageal Cancer - 3JECROG P-02
This phase III trial is designed to explore a higher radiation dose by using IMRT simultaneous integrated boost technique with or without concurrent chemotherapy for esophageal carcinoma with limited lymph node metastasis.
- Trial name
- NCT03308552
- Testing
- SIB-IMRT, Paclitaxel, Platinum-Based Drug
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Chinese Academy of Medical Sciences
Bone Metastases, Radiotherapy
Single frActIoN eighT Gray Palliative Radiotherapy With Modulated Intensity for Pain Reduction
Non-randomized, monocentric, observational study to evaluate the response in terms of reduction of painful symptoms from bone metastases to radiotherapy with high personalization of treatment: performed with modern technology…
- Conditions
- Bone Metastases, Radiotherapy, Technology
- Trial name
- SAINT (NCT03554135)
- Testing
- Personalization of palliative radiotherapy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cancer: Head or Neck
A Study of the Effect on Oro-dental Complications of Intensity Modulated Radiotherapy (IMRT) Versus Conventional Radiotherapy in Patients With Cancer of the Head or Neck
Study to investigate the effect of two types of radiotherapy on saliva: IMRT versus conventional radiotherapy. In each group, one part will receive normal dental preventive treatment.
- Trial name
- NCT00323466
- Testing
- IMRT versus conventional radiotherapy
- Where
- Belgium
- Volunteers
- 43 people
- Sponsor
- University Hospital, Ghent
Malignant Neoplasms of Lip Oral Cavity and Pharynx, Oropharyngeal Cancer
Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer
The goal of this clinical research study is to compare the use of MRI simulations to plan different doses of intensity modulated radiotherapy (IMRT) to the standard IMRT dose in patients with low risk human papilloma virus…
- Trial name
- NCT03224000
- Testing
- Modified Barium Swallow (MBS), Swallowing Questionnaire, Symptom Questionnaire
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- M.D. Anderson Cancer Center
Small-cell Lung Cancer
Simultaneous Integrated Boost vs. Routine IMRT in Limited-stage Small-cell Lung Cancer
Thoracic radiotherapy concurrent with chemotherapy stands for the standard regime for limited staged small cell lung cancer. Involved node radiation（INF） replaced elective node irradiation（ENI） as the more popular since several…
- Trial name
- NCT04500145
- Testing
- SIB-IMRT, routine IMRT
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Cervix Cancer, Radiotherapy, Adjuvant
Postoperative Hypofractionated Intensity-modulated Radiation Therapy in Cervical Cancer
To investigate the acute toxicities, late toxicities, and treatment results when the early cervical cancer patients are treated by hypofractionated intensity-modulated radiotherapy (2.5 Gy X 16 fractions, once a day) after…
- Conditions
- Cervix Cancer, Radiotherapy, Adjuvant, Radiotherapy, Intensity-Modulated, Hypofractionated Dose
- Trial name
- NCT03239626
- Testing
- POHIM-RT
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Ovarian Cancer, Tubal Carcinoma
Consolidation Whole Abdominal Intensity-Modulated Radiation Therapy (IMRT) in Advanced Ovarian Cancer
The primary objective of this phase-II study is to assess the toxicity of consolidation intensity-modulated whole-abdominal radiotherapy using tomotherapy in patients with advanced optimally debulked stage International…
- Conditions
- Ovarian Cancer, Tubal Carcinoma, Primary Peritoneal Carcinoma
- Trial name
- OVAR-IMRT-02 (NCT01180504)
- Testing
- intensity-modulated whole-abdominal radiotherapy
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University Hospital Heidelberg
Head and Neck Cancer
Parotid-gland Stem-cell Sparing Intensity-modulated Radiotherapy
Rationale: Radiation-induced parotid gland dysfunction, often leading to xerostomia is the most-frequently occurring side-effect with a major impact on patient-reported quality of life after radiotherapy for head and neck cancer…
- Trial name
- SCS-IMRT (NCT01955239)
- Testing
- Intensity-modulated Radiotherapy
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- University Medical Center Groningen
Breast Cancer
Partial Breast Irradiation Using Accelerated Intensity Modulated Radiotherapy
This is a phase I- II feasibility study for delivering partial breast irradiation (PBI) in selected patients with early stage, lymph node negative, breast cancer after breast-conserving surgery using accelerated Intensity…
- Trial name
- NCT00581529
- Testing
- IMRT
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan Rogel Cancer Center
Prostate Cancer
Safety Study of Pelvic and Prostatic SIB-IMRT With Long-term Androgen Deprivation for High Risk Localized Prostate Cancer
The purpose of this study is to evaluate the incidence of urinary and rectal acute side effects of a pelvic and prostatic intensity-modulated arctherapy with simultaneous integrated boost (SIB-IMRT)combined with long-term…
- Trial name
- NCT01704027
- Testing
- Simultaneous integrated boost intensity-modulated arctherapy, Androgen deprivation
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Georges Francois Leclerc
Acute Toxic Effects, Tumor Responses
Dose Escalation of Lobaplatin Concurrent With IMRT for the Treatment of NPC: A Phase I Clinical Trial
Nasopharyngeal carcinoma (NPC) is a common malignant tumor in Southern China area, which is characterized by obvious regional characteristics and "Guangdong cancer".
- Trial name
- NCT03188497
- Testing
- Lobaplatin, linear accelerator
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Nasopharyngeal Carcinoma
The Role of Concurrent Chemotherapy for Lower Risk Locally Advanced Nasopharyngeal Carcinoma(NPC) in the Era of IMRT
The purpose of this study is to verify that simultaneous integrated boost IMRT (SIB-IMRT) alone is non-inferior to SIB-IMRT combined with concurrent chemotherapy for low-risk locally advanced nasopharyngeal carcinoma.
- Trial name
- NCT01817023
- Testing
- SIB-IMRT, Cisplatin
- Where
- 6 sites in China
- Volunteers
- 590 people
- Sponsor
- Chinese Academy of Medical Sciences