Clinical trials: Intensive Care
Insomnia, Sleep Fragmentation
Suvorexant and Sleep/Delirium in ICU Patients
Investigators will evaluate the efficacy of postoperative oral suvorexant treatment on nighttime wakefulness after persistent sleep onset (WASO) among adult cardiac surgical patients recovering in the cardiac intensive care unit…
- Conditions
- Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
- Trial name
- NCT04092894
- Testing
- Suvorexant 20 mg
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Critical Illness, Family Members
Addressing Palliative Care Needs Among Intensive Care Unit Family Members
The quality of palliative care is highly variable for many patients treated in intensive care units (ICUs) and their family members.
- Conditions
- Critical Illness, Family Members, Psychological Distress, Informal Caregivers
- Trial name
- ICUconnect (NCT03506438)
- Testing
- Needs-focused mobile app, Usual care
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Duke University
Primary Health Care, Health Care Costs
Evaluation of Intensive Management Patient Aligned Care Team
This evaluation will examine the feasibility, implementation, and effectiveness of a quality improvement intervention-Intensive Management Patient Aligned Care Team (ImPACT)-for high-risk patients.
- Trial name
- ImPACT (NCT02932228)
- Testing
- ImPACT
- Volunteers
- 583 people
- Sponsor
- VA Office of Research and Development
Acute Respiratory Failure
Novel Arm Restraint in the Intensive Care Unit
The goal of this pilot is to evaluate a novel restraint device in 8 older mechanically ventilated patients to demonstrate that 1) the revised novel restraint prototype is safe and 2) a future randomized controlled trial (RCT) is…
- Trial name
- NCT03621475
- Testing
- Novel restraint
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Vermont
Intra-Abdominal Hypertension
Intra-Abdominal Hypertension in Neonatal Intensive Care Patients
The observational study is designed to determine the feasibility of performing Intra-Abdominal Pressure (IAP) via bladder pressure measurements and of tracking IAP in neonates who require bladder catheterization.
- Trial name
- NCT00747552
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Critical Illness
European Mortality & Length Of Intensive Care Unit (ICU) Stay Evaluation (ELOISE)
The starting point of ELOISE is the significant number of Intensive Care Unit (ICU) survivors who die after the transfer to ward.
- Trial name
- ELOISE (NCT01422070)
- Where
- Italy
- Volunteers
- 6,433 people
- Sponsor
- Università degli Studi di Ferrara
Anesthesia
Anesthesia and Lymphocytes Apoptosis
Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for…
- Trial name
- OPCAB (NCT01461551)
- Testing
- Sevoflurane, Propofol, combine of sevoflurane and propofol
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Ruijin Hospital
Analgesia
Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)
This study will be a multicentre randomized, open-label, phase IIIb study. This study will evaluate two different techniques of sedation: an analgesia based regimen with remifentanil versus a conventional sedation based regimen…
- Trial name
- NCT00436345
- Testing
- Remifentanil, Propofol
- Where
- 6 sites in Italy
- Volunteers
- 39 people
- Sponsor
- GlaxoSmithKline
High Flow Nasal Cannula
HFNC Flow Titration and Effort of Breathing in the PICU
High-flow nasal cannula (HFNC) is a method of non-invasive respiratory support used to decrease the effort of breathing (EOB) in patients with a wide variety of respiratory diseases in the pediatric intensive care unit.
- Trial name
- HFNCandEOB (NCT02793674)
- Testing
- Fisher & Paykel high flow nasal cannula, Vapotherm high flow nasal cannula
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital Los Angeles
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Vancomycin-Resistant Enterococcus
Effect of Bed Bathing Methods on VRE Colonization in ICU Patients
This randomized controlled trial aims to compare the effects of two different bed bathing methods on vancomycin-resistant Enterococcus (VRE) colonization in adult intensive care unit patients.
- Trial name
- NCT07364435
- Testing
- Bed Bath, Disposable antibacterial bed bath wipes, Chlorhexidine gluconate 4%
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people
- Sponsor
- Özkan Kasap
Critically Ill, Post Intensive Care Syndrome
Testing of a New Therapeutic Vibration Device to Reduce Neuromuscular Weakness in Hospitalized Patients
Objective: Test the ability of vibration to produce physiologic, biochemical, and anatomic changes consistent with exercise that would help prevent the development of muscle weakness that occurs when patients are immobile for…
- Trial name
- NCT03479008
- Testing
- Therapeutic Vibration Device
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pediatric Congenital Heart Surgery
Predictive Value of the FORE-SIGHT™ Monitor for Hemodynamic Deterioration
The postoperative period after congenital heart surgery in children can be a very critical episode, where it is of utmost importance to closely monitor the circulation in these patients.
- Trial name
- NCT01706497
- Testing
- Cerebral tissue oxygen saturation monitoring, blinded
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- KU Leuven
Critically Ill
Is There Any Correlation Between Respiratory Variation Ratios of Internal Jugular Vein and Inferior Vena Cava?
Intravascular volume assesment is important for the management of the patients in the intensive care unit. Respiratory variation ratio of the inferior vena cava (IVC) can be determined by ultrasonography (USG) and is a useful…
- Trial name
- NCT04173741
- Testing
- USG measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Hacettepe University
Neonatal Neuroimaging
Development of a MR Scanner Capable of Being Sited in a Neonatal Intensive Care Unit (Firefly Sheffield)
This study investigates a novel magnetic resonance imaging (MRI) system designed by GEHC for imaging viable neonate and infant populations.
- Trial name
- NCT02785588
- Testing
- 3.0 T Neonatal MRI scanner
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Stress
Bundle Consent and Expectation Setting in Pediatric Intensive Care Unit
The purpose of this research study is to find out about how obtaining consent for procedures in the PICU affects parental/caregiver stress.
- Trial name
- NCT04697173
- Testing
- Single consent
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- Virginia Commonwealth University
Hypotension
Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial
The use of peri-arrest bolus epinephrine (PBE) has emerged as a rescue strategy for life-threatening hypotension in pediatric intensive care units (ICU) despite scant published data supporting its use in this setting.
- Trial name
- EPIDose (NCT05327556)
- Testing
- Epinephrine 0.5 mcg/kg, Epinephrine 1 mcg/kg
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Children's Hospital
Intubation
Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
Emergency intubation of patients in intensive care is a high-risk endeavour. For many decades, succinylcholine has been the neuromuscular blocking agent of choice.
- Trial name
- NCT00355368
- Testing
- Succinylcholine, Rocuronium
- Where
- Switzerland
- Volunteers
- 420 people
- Sponsor
- University Hospital, Basel, Switzerland
Bacterial Infections
French Study In ICU Patients Treated With Tigecycline
This study will describe clinical outcome and safety data collected prospectively in subjects hospitalized in an intensive care unit (ICU) presenting with an infection for which treatment with tigecycline, alone or in…
- Trial name
- NCT00799591
- Testing
- Observational study so no intervention in the patient.
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Delirium
ORIC-I: Optimizing Recovery From Intensive Care: Mechanical Ventilation and Delirium
The purpose of this study is to determine if treating delirious intensive care unit patients with haloperidol improves mortality.
- Trial name
- NCT00300391
- Testing
- haloperidol
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh