Clinical trials: Intensive Care (ICU)
Epilepsy, Status Epilepticus
Training Program to Improve EEG Competence
The goal of this clinical trial is to investigate the extent to which a practice-oriented training program for intensive care nursing staff and non-physician treatment teams can contribute to the earlier detection of epileptic…
- Conditions
- Epilepsy, Status Epilepticus, Status Epilepticus, Electrographic, Status Epilepticus, Non-Convulsive
- Trial name
- EPI-Train (NCT07689084)
- Testing
- Training Program
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital Marburg
Sepsis, Sepsis and Septic Shock
Role of Transposable Elements in Septic Immune Aging
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1.
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction
- Trial name
- SITE (NCT06809868)
- Testing
- RNA and DNA Sequencing
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sepsis - to Reduce Mortality in the Intensive Care Unit
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis
Sepsis is a severe, life-threatening condition caused by an abnormal host response to infection, which includes systemic inflammation, oxidative stress, and increasing organ dysfunction.
- Trial name
- NCT07655791
- Testing
- Nicotinamide 1000 mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Intensive Care Unit Delirium
PRE-DELIRIC Prediction Model Plus SMART Care to Reduce the Incidence of Delirium in ICU Patients
Delirium is a severe acute brain dysfunction characterised by sudden confusion, inattention and fluctuating level of consciousness, which mainly affects intubated intensive care patients.
- Trial name
- NCT06279390
- Where
- Taiwan
- Volunteers
- 381 people
- Sponsor
- National Taiwan University Hospital
Infant, Newborn, Disease, Genetic Disease
Genome Sequencing in the Intensive Care Unit Population
The purpose of this study is to understand how the use of whole genome sequencing (WGS) may be able to increase the speed with which a diagnosis is made for patients in an intensive care unit population.
- Trial name
- PISCES (NCT04848090)
- Testing
- Neonate WGS Testing
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Jerry Vockley, MD, PhD
Nurse's Role
Patient-related Effects of Primary Nursing
After a one-year phase of development, primary nursing (process-responsible nursing; PP) has been practically implemented on a pilot ICU since January 2022 at the Heart and Diabetes Center NRW.
- Trial name
- ENGAGE (NCT05569317)
- Testing
- primary nursing
- Where
- Germany
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Critical Illness, ICU Patients
Intensive Care Unit Rehabilitation Protocols
The aim of this study was to investigate the effects of NMES combination applied in addition to bicycle ergometry on mobility, functional status, muscle strength and hemodynamic responses in ICU patients.
- Trial name
- ICU-Rehab (NCT07179718)
- Testing
- neuromuscular electrical stimulation, bicycle ergometer
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Hacettepe University
Systemic Inflammatory Response Syndrome, Sepsis
Vitamin D and Critically Ill Patients
The higher rate of vitamin D deficiency is spotted among patients being hospitalized or in critical condition. Especially, vitamin D level below normal prolongs hospital stay and increases incidence of adverse prognosis and…
- Trial name
- NCT01636232
- Where
- China
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Respiratory Failure, Tracheostomy Complication
Ventilation Weaning Strategies and Correlation to Outcomes in Tracheostomized Patients in the Lausanne ICU
This retrospective study aims to study characteristics of patients tracheotomized in the Lausanne ICU, both overall and by primary reasons of intubation.
- Trial name
- NCT04987398
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Piquilloud Imboden Lise
Mechanical Ventilation, Fluid Overload
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients
Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients.
- Conditions
- Mechanical Ventilation, Fluid Overload, Deresuscitation, Ventilator-free Days
- Trial name
- CONFIDENCE (NCT05188092)
- Testing
- Lung ultrasound guided deresuscitation
- Where
- 3 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Respiratory Distress Syndrome, Newborn
Feasibility Study of Placement and Surfactant Administration Through a Preterm Size Laryngeal Mask Airway in Very Low Birth Weight Neonates With Respiratory Distress Syndrome
Surfactant administration via a supraglottic airway device or laryngeal mask airway (SALSA) is a minimally invasive method of instilling surfactant in the trachea during spontaneous breathing and after applying nasal continuous…
- Trial name
- NCT06606444
- Testing
- Surfactant Administration Through Laryngeal or Supraglottic Airways
- Where
- Vietnam
- Volunteers
- 45 people
- Sponsor
- Karolinska Institutet
Sepsis - to Reduce Mortality in the Intensive Care Unit, Trauma Coagulopathy
ROTEM in Sepsis Trauma Outcome in Intensive Care
This prospective observational study aims to investigate the ability of advanced ROTEM analysis using Principal Component Analysis (PCA) to detect early signs of disseminated intravascular coagulation (DIC) and trauma-induced…
- Trial name
- ROSTIC (NCT06891599)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Stockholm
COVID-19
Therapeutic Plasmapheresis in Critically Ill Adult Patients With COVID-19 Confirmed Diagnosis
Introduction: The SARS-CoV-2 outbreak has left more than two million infected worldwide in the first four months of COVID-19 epidemic.
- Trial name
- PLASMA (NCT04480632)
- Testing
- Convalescent plasma
- Where
- Colombia
- Volunteers
- 44 people
- Sponsor
- Fundación Cardiovascular de Colombia
Status Epilepticus
Prognosis Factors Associated With Convulsive Status Epilepticus in Adults
The aim of the study is to evaluate, prospectively, prognosis factors associated with convulsive status epilepticus (CSE) in adults hospitalized in intensive care units.
- Trial name
- NCT00318578
- Where
- 34 sites in France
- Volunteers
- 100 people
- Sponsor
- Versailles Hospital
Inpatient Hospitalization, Intensive Care Unit Admission, Inpatient Mortality, Sepsis and Septic Shock
Linking Novel Diagnostics With Data-Driven Clinical Decision Support in the Emergency Department
The primary objective of this study is to validate the use of an electronic clinical decision support (CDS) tool, TriageGO with Monocyte Distribution Width (TriageGO-MDW), in the emergency department (ED).
- Trial name
- NCT05335135
- Testing
- TriageGO-MDW Clinical Decision Support, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Stocastic, LLC
Burnout Syndrome
Burnout Syndrome in the Intensive Care Unit Before and During a Palliative Care Trial
One hundred ICU doctors, nurses and psychologists from 4 / 8 ICUs of the Greek group of the 28 European units participating in the EPIC stepped-wedge trial (ClinicalTrials.gov NCT06605079) will each complete the same four-part…
- Trial name
- BURNOUT-EPIC (NCT07069010)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Alcohol Abuse, Alcoholism
Consequences of At-risk Alcohol Consumption in ICU Patients
At-risk drinking is known to cause a high incidence of alcohol withdrawal syndrome which has a high impact on morbidity and mortality.
- Trial name
- NCT03565016
- Testing
- no interventional study
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Nantes University Hospital
Cardiac Arrest
Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Out of Hospital Cardiac Arrest
Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds…
- Trial name
- AfterROSC1 (NCT04167891)
- Testing
- Calculation of early prognosis score
- Where
- 27 sites in Belgium, France
- Volunteers
- 1,144 people
- Sponsor
- AfterROSC
Palliative Care, Intensive Care Unit
Critical Care and Palliative Care Medicine Together in the ICU
Will earlier palliative care medicine consultation in the ICU result in decreased length of stay in the ICU and hospital, as well as, increased patient and family satisfaction.
- Conditions
- Palliative Care, Intensive Care Unit, Hospice
- Trial name
- NCT03520023
- Testing
- Palliative Care Consult
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Mayo Clinic
Delirium, Cognitive Impairment
Validation of the PreSchool Confusion Assessment Method for the Intensive Care Unit (psCAM-ICU)
The investigators hypothesize that critical care trained registered nurses and physicians can perform measurements of cognitive impairment in critically ill pediatric patients in a reliable and valid manner.
- Trial name
- NCT02481115
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University