Clinical trials: Intensive Care Medicine
Intensive Care Medicine, Mechanical Ventilation
The Classification of Difficult Weaning and the Predictive Value of Relative Factors for Difficult Weaning
To evaluate the distribution of different types of difficult weaning and the predictive value of weaning relative factors.
- Conditions
- Intensive Care Medicine, Mechanical Ventilation, Weaning
- Trial name
- NCT02487927
- Testing
- weaning
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Jianfeng Xie
Intensive Care
Impact of the Save the Shame! Game on Advanced Life Support Knowledge
Gamification, listed by the European Resuscitation Council (ERC) as a learning process in its 2021 guidelines, is a new digital innovation tool that brings added value towards motivation that seems to reuse time in a creative…
- Trial name
- NCT05692375
- Where
- Portugal
- Volunteers
- 24 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Serum Concentrations, Intoxication
Blood Serum Concentrations of Routine Drugs in Patients Treated in the Intensive Care Unit.
To follow up the result of a quality measurement based on the results of a new routine for drug analysis introduced during a period of time in the intensive care unit.
- Conditions
- Serum Concentrations, Intoxication, Post Mortem Concentrations
- Trial name
- INTOx (NCT02305004)
- Where
- Sweden
- Volunteers
- 359 people
- Sponsor
- Uppsala University
Anemia, Critical Illness
Oxygen Extraction-guided Transfusion in Critically Ill Patients
Anemia is common in intensive care unit (ICU) patients and often appears early in the ICU course. The optimal management red blood cells RBC transfusion in critically ill patients remains controversial and clinical studies in…
- Trial name
- NCT03767127
- Where
- Italy
- Volunteers
- 177 people
- Sponsor
- Università degli Studi di Ferrara
Neonatal Seizures
Levetiracetam Versus Phenobarbitone for the Treatment of Neonatal Seizures in a Tertiary Care Hospital.
Neonatal seizures are a common neurological emergency in newborn babies and can lead to serious brain injury if not treated promptly.
- Trial name
- LEV-NEO (NCT07401433)
- Testing
- Levetiracetam, Phenobarbital Sodium Injection
- Where
- Pakistan
- Volunteers
- 260 people
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Shock
Vasoactive Drugs in Intensive Care Unit
The investigators hypothesis is that for ICU patients with shock, the use of the vasoactive drugs phenylephrine and vasopressin will reduce tachydysrhythmias when compared to norepinephrine and epinephrine.
- Trial name
- NCT02118467
- Testing
- Norepinephrine, Epinephrine, Phenylephrine
- Where
- United States
- Volunteers
- 836 people
- Sponsor
- University of Chicago
Antifungal Agents
Screening Anti-Fungal Exposure in Intensive Care Units
Adequate antifungal therapy is a critical determinant of survival in patients admitted to an Intensive Care Unit (ICU) with suspected or proven fungal infections.
- Trial name
- SAFE-ICU (NCT03136926)
- Where
- 47 sites in United States, Australia and 11 more
- Volunteers
- 150 people
- Sponsor
- The University of Queensland
Seizure Recurrence
Mobile Video Education and Machine Learning-Based Risk Prediction in Neonatal Seizure Management
This mixed-methods study will develop a machine learning-based model to identify infants at high risk of seizure recurrence after discharge from the neonatal intensive care unit.
- Trial name
- NCT07695623
- Testing
- Mobile Video-Supported Education
- Volunteers
- 60 people
- Sponsor
- Istanbul Saglik Bilimleri University
Critical Illness, Intensive Care Medicine
VoiceLove: An App-Based COMMunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE)
VoiceLove is a phone application allowing family and patients to share information in a secure platform. This project will compare the VoiceLove app to usual care to learn about whether VoiceLove improves patient-family…
- Trial name
- COMMUNICATE (NCT06923462)
- Testing
- Communication Application
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Distress Syndrome (ARDS), Proning
A Trial of Staff Time With Proned Patients in the ICU Using the 'BathMat'
Proning is a way of helping people who are very sick and have trouble breathing. It involves lying patients on their front to get more oxygen into their body.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Proning, Intensive Care Medicine
- Trial name
- NCT06844617
- Testing
- BathMat
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
COVID-19
Study to Evaluate the Safety and Efficacy of High Dose Intravenous Immune Globulin (IVIG) Plus Standard Medical Treatment (SMT) Versus SMT Alone in Participants in Intensive Care Unit (ICU) With Coronavirus Disease (COVID-19)
The purpose of the study is to determine if a high dose of Intravenous Immune Globulin (IVIG) plus Standard Medical Treatment (SMT) can reduce all-cause mortality versus SMT alone in hospitalized participants with COVID-19…
- Trial name
- NCT04480424
- Testing
- GAMUNEX-C, Standard Medical Treatment
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- Grifols Therapeutics LLC
Intensive Care Unit Syndrome
Hemodynamic Impact of the Administration of PAracetamol in Patients Hospitalized in the Intensive Resuscitation Medicine Department [PAREA]
Paracetamol is commonly used in case of pain or fever. Few previously clinical studies has highlighted an arterial hypotension linked to intravenous administration of paracetamol.
- Trial name
- PAREA (NCT06430697)
- Testing
- paracetamol administration
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Metabolic Acidosis
ADVOS® Versus CVVHD in Metabolic or Mixed Acidosis
The aim of the study is to investigate the effects of ADVOS® therapy in critically ill patients with acute kidney injury, necessity of renal replacement therapy and acidosis.
- Trial name
- NCT05842369
- Testing
- ADVOS, CVVHD
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Artifical Intelligence
ChatGPT-5 vs. CDSS for Drug-Drug Interactions in ICU
Evaluating ChatGPT-5 for Detecting Potential Drug-Drug Interactions in Intensive Care: A Comparative Analysis with a Clinical Decision Support System Background: Polypharmacy is a frequent challenge in intensive care units…
- Trial name
- NCT07314125
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Waiting-time in the Anaesthesia Admissions Ambulance
Optimizing of Waiting - Time in the Anesthesia Admissions Ambulance of the Charité - University Medicine Berlin by Support of a Mobile Application - a Pilot Study
In this study the investigators measure and optimize the patients waiting time in the preanesthetic assessment by integrating an interactive mobile device.
- Trial name
- NCT02457767
- Sponsor
- Charite University, Berlin, Germany
Critical Care Medicine, Transportation of Patients
Pediatric Intensive Care Transport Registry
The aim is to establish a nationwide registry for pediatric intensive care transports in Germany. The project aims to describe and analyse the need for, and current practice of, specialised transports.
- Conditions
- Critical Care Medicine, Transportation of Patients, Pediatrics
- Trial name
- PIT Registry (NCT07070258)
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Philipps University Marburg
Life Quality, Hospital Mortality
Effect of Nutritional Support and Early Rehabilitation on Sepsis
Sepsis is a syndrome of life-threatening organ dysfunction caused by a dysregulated host response to infection.Acute catabolic response in critically ill patients struck by sepsis, manifested by massive protein breakdown in a…
- Trial name
- NUSPOTER (NCT05781971)
- Testing
- high protein, rehabilitation, standard protein
- Volunteers
- 1,600 people
- Sponsor
- Jinling Hospital, China
Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care
SEPREVEN: a Stepped-wedge Randomised Controlled Trial
Adverse events are frequent in Neonatal Intensive Care Units' (NICU) patients and account for a high morbidity and mortality. Possible severe adverse events are central line associated bloodstream infections (CLABSI), ventilator…
- Conditions
- Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care, Catheter-related Bloodstream Infection (CRBSI) Nos, Quality of Healthcare
- Trial name
- SEPREVEN (NCT02598609)
- Testing
- Education program for NICU caregivers
- Where
- 12 sites in France
- Volunteers
- 8,000 people
- Sponsor
- Dr Caeymaex Laurence
Anesthesia, Intensive Care Medicine
Optimization of Morphinomimetic Administration Intraoperatively: Evaluation of the Impact of the NOL Index on the Occurrence of Postoperative Adverse Events Related to Morphinomimetics
Reducing the quantity of morphinomimetics during the operative period reduces the prevalence and intensity of adverse effects. However, morphinomimetics are indispensable during surgery, as they limit the autonomic nervous…
- Trial name
- NOL-Impact (NCT06861634)
- Testing
- Nol index
- Where
- 6 sites in France
- Volunteers
- 332 people
- Sponsor
- University Hospital, Tours
Education, Training
Simulation-based Training in the Anaesthesia Residency Curriculum
This study aims to describe the current implementation and structure of simulation-based education and training in anaesthesiology and intensive care residency programmes across countries affiliated with the World Federation of…
- Conditions
- Education, Training, Simulation Based Medical Education, Anesthesia
- Trial name
- NCT07771569
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Brno University Hospital