Clinical trials: Intensive Care Patients
Tracheostomy Patients, Tracheostomy Decannulation
Tracheostomy Practice in Adult Intensive Care Units
ON TRACH is an international, multicentre, observational study with the aim of characterising the timing and practice of tracheostomy insertion, management, weaning and longer-term outcomes of these patients, in intensive care…
- Conditions
- Tracheostomy Patients, Tracheostomy Decannulation, Intensive Care (ICU)
- Trial name
- ON TRACH (NCT07769021)
- Where
- 13 sites in United States, Brazil and 6 more
- Volunteers
- 2,500 people
- Sponsor
- Royal College of Surgeons, Ireland
Critical Illness, Energy Supply; Deficiency, Severe
GLUCOSAFE 2 - A New Tool for Nutritional Management and Insulin-therapy in the Intensive Care Unit (ICU)
The survival and the outcomes of critically ill patients are strongly influenced by insulin-therapy and nutritional support. The GLUCOSAFE 2 pilot study, aims to test the performance and the security of the new GLUCOSAFE 2…
- Conditions
- Critical Illness, Energy Supply; Deficiency, Severe, Protein Deficiency, Hypoglycemia
- Trial name
- NCT03890432
- Testing
- GLUCOSAFE 2, Local protocol control group with routine care, Historical control group with routine care
- Where
- 2 sites in Switzerland
- Volunteers
- 213 people
- Sponsor
- HEIDEGGER CP
Ventilator Weaning, Mechanical Ventilation
Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients
The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in…
- Conditions
- Ventilator Weaning, Mechanical Ventilation, Respiratory Insufficiency Requiring Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07120438
- Volunteers
- 55 people
- Sponsor
- Gadjah Mada University
Shock
Evaluation of the Pharmacokinetics of Caspofungin in ICU Patients
Although the pharmacokinetics of Caspofungin has been studied in healthy subjects and patients, only a few studies have been performed in critically-ill patients.
- Trial name
- CaspoKin (NCT02596984)
- Testing
- Caspofungin
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Gram-Negative Bacterial Infections
An Observational Pharmacokinetic Sudy of Ceftolozane-Tazobactam in Intensive Care Unit in Patients With and Without CRRT
The purpose of this study is to try to find out how critically ill patients receiving the antibiotic, ceftolozane-tazobactam, process it in their body.
- Trial name
- CT-PK (NCT02962934)
- Testing
- Non CRRT group, CRRT group
- Where
- Australia
- Volunteers
- 18 people
- Sponsor
- Royal Brisbane and Women's Hospital
Postoperative Pain, Delirium - Postoperative
Analgesia Methods and Early Mobilization in Geriatric ICU Patients After Major Surgery
This study looks at how different pain-control methods affect how quickly older adults get out of bed and start moving again after major surgery.
- Conditions
- Postoperative Pain, Delirium - Postoperative, Frailty, Postoperative Care in Geriatric Intensive Care Patients
- Trial name
- NCT07709975
- Testing
- Systemic Opioid Analgesia (± Multimodal), Epidural Analgesia, Peripheral Nerve Block (± Multimodal)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Acute Respiratory Distress Syndrome (ARDS)
Surviving ARDS: The Influence of Quality of Care and Individual Patient Characteristics on Quality of Life
The purpose of the DACAPO study ("Surviving ARDS: the influence of quality of care and individual patient characteristics on quality of life") is to investigate the role of quality of care and individual patient characteristics…
- Trial name
- DACAPO (NCT02637011)
- Where
- 3 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Regensburg
Opiate Withdrawal Syndrome
Neurostimulation for Opiate Withdrawal in the PICU
This is a prospective pilot study to investigate the effects of Percutaneous Electrical Nerve Field Stimulation (PENFS) on symptoms of opioid withdrawal in pediatric patients in the intensive care unit.
- Trial name
- NOW (NCT03975192)
- Testing
- Percutaneous Electrical Nerve Field Stimulation
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Thromboprophylaxis, Critical Illness
Pharmacokinetic Profiles of Subcutaneous Enoxaparin for Thromboprophylaxis in Critically Ill Patients With Renal Failure Treated or Not With Continuous Veno-veinous Hemofiltration.
Thromboprophylaxis is recommended for critically ill patients without contraindications and is usually achieved by the subcutaneous daily administration of a low dose of low molecular weight heparin (LMWH).
- Conditions
- Thromboprophylaxis, Critical Illness, Intensive Care (ICU)
- Trial name
- AKI-ENOXA (NCT07384598)
- Testing
- Anti-Xa profiles after the subcutaneous administration of a prophylactic dose of enoxaparin
- Volunteers
- 60 people
- Sponsor
- Clinique Saint Pierre Ottignies
Intensive Care Unit, Life Stress
Evaluating Effectiveness of a Communication Facilitator : A Randomized Trial
This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their…
- Conditions
- Intensive Care Unit, Life Stress, Family Members, Facilitation, Social
- Trial name
- Famirea - FCS (NCT04133753)
- Testing
- Facilitator-Based Intervention
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amikacin Treatment
Prescription Strategies of Amikacin in Intensive Care Patients on Renal Replacement Therapy: an Observational Prospective Multicenter Study
Amikacin is the aminoglycoside of choice for treatment of severe infections in intensive care. An achievement of its objectives in pharmacokinetics and pharmacodynamics is difficult in intensive care patients because of…
- Trial name
- AMIDIAL-ICU (NCT04322019)
- Testing
- Data record
- Where
- France
- Volunteers
- 112 people
- Sponsor
- CHU de Reims
Sepsis, Severe Sepsis
Pharmacokinetic of Ceftriaxone in Septic ICU Patients
Ceftriaxone pharmacokinetics variability in intensive care unit septic patients In intensive care units, drug dosage is often based on study made on healthy volunteers or on less severe patients.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PORTHOS (NCT00449800)
- Testing
- ceftriaxone
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Association Pour La Promotion A Tours De La Reanimation Medicale
Sleep Wake Disorders, Critical Illness
Multimodal Sleep Promotion in Surgical ICU Patients
Sleep disturbances are highly prevalent among patients admitted to intensive care units (ICUs). Critical illness, environmental factors, and routine clinical care frequently result in fragmented sleep, reduced sleep quality, and…
- Trial name
- MULTISLEEP (NCT07672509)
- Testing
- Multimodal Sleep Promotion Intervention
- Volunteers
- 50 people
- Sponsor
- Fundación de investigación HM
Acute Coronary Syndrome
Patients Returning to Work After Acute Coronary Syndrome
The literature is quite rich concerning the factors which influence the return to work after acute coronary syndrome. They can be divided into three categories: factors linked to the patient, those linked to the workstation and…
- Trial name
- ACS (NCT05145777)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Hope, Comfort
The Effect of Book Reading on Comfort, Hope, Anxiety and Vital Signs of Intensive Care Unit Patients
This study was planned to investigate the effect of reading aloud books on comfort, hope, anxiety and vital signs in patients hospitalized in intensive care unit. This study was designed as a randomized controlled clinical trial.
- Conditions
- Hope, Comfort, Anxiety, Vital Signs
- Trial name
- NCT06465875
- Testing
- Reading a book
- Volunteers
- 70 people
- Sponsor
- TC Erciyes University
Subarachnoid Haemorrhagic Stroke
A Biopsychosocial-Based Multimodal Approach to Reducing the Risk of Delirium in ICU
As part of this study, an intervention program aimed at preventing delirium in patients with subarachnoid hemorrhage treated in the intensive care unit will be implemented.
- Trial name
- NCT07249619
- Testing
- Routine Therapy (Medical, environmental accodamation, face-to-face commucation), Biopsychosocial-Based Multimodal Approach
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Emre Şenocak
Post-extubation Dysphagia
Post-extubation Dysphagia
Mechanical ventilation is a widely used treatment on the Intensive Care Unit (ICU). Swallowing dysfunction (dysphagia) after extubation may cause aspiration, and is associated with poor outcomes: pneumonia, reintubation, a…
- Trial name
- NCT03761823
- Where
- Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diarrhea Caused by Drug, Clostridium Difficile Infections
Faecal Bacteriotherapy for Postantibiotic Diarrhoea in Critically Ill Patients
Rationale: Postantibiotic diarrhoea in critically ill patients is common, often prolonged and currently there is no effective treatment of it.
- Trial name
- FEBATRICE (NCT05430269)
- Testing
- Faecal bacteriotherapy (FBT), standard-of-care protocolised treatment of postantibiotic diarhea
- Where
- 2 sites in Czechia
- Volunteers
- 36 people
- Sponsor
- Charles University, Czech Republic
Critical Illness
Economics of Diarrhoea in Intensive Care Unit
Enteral nutrition (EN) is the first choice route for nutritional support in ICU patients with a functioning digestive tract. Nevertheless, EN alone is often associated with digestive intolerance, including diarrhoea.
- Trial name
- NCT01922570
- Testing
- nutrition
- Where
- Switzerland
- Volunteers
- 305 people
- Sponsor
- University Hospital, Geneva
Immersive Virtual Reality, Discomfort
Effect of a Virtual Reality Program on Patient Comfort in the Surgical Intensive Care Unit
Admission to a surgical intensive care unit (ICU) following major surgery is associated with a number of discomforts, not only related to the disease itself, but also to the care provided or the ICU environment itself (lights…
- Conditions
- Immersive Virtual Reality, Discomfort, IPREA, Intensive Care Unit
- Trial name
- ZION (NCT06830369)
- Testing
- HypnoVR, usual health care
- Where
- France
- Volunteers
- 194 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens