Clinical trials: Intensive Care Patients
Intensive Care Unit Acquired Weakness, Sepsis, Severe
Is NMES Treatment in Sepsis/ Septic Shock Patients Protective in Development of ICU-AW?
Background: Sarcopenia (muscle weakness) characterized by a decrease in muscle mass, strength and performance is a condition that increases with old age.
- Trial name
- NCT04833621
- Testing
- NMES GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Ondokuz Mayıs University
Postoperative Respiratory Failure, Extubation Failure
Assessment of Reintubation Risk Using Multiple Parameters in Postoperative Intensive Care Unit Patients
This prospective, non-interventional observational study will evaluate the risk of reintubation in adult postoperative patients admitted to the intensive care unit after major surgery.
- Conditions
- Postoperative Respiratory Failure, Extubation Failure, Lung Ultrasonography Score, Diaphragm Thickness
- Trial name
- NCT07672106
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Hypomagnesemia, Critical Illness
Hypomagnesemia and Its Clinical Outcome
Magnesium is an essential electrolyte involved in numerous physiological processes, including maintaining cellular integrity, regulating muscle tone, supporting cardiovascular function, and modulating immune responses.
- Conditions
- Hypomagnesemia, Critical Illness, Intensive Care Unit (ICU) Patients, Scoring Systems
- Trial name
- Hypogamnesamia (NCT07089004)
- Testing
- No intervention (observational study)
- Where
- Bangladesh
- Volunteers
- 112 people
- Sponsor
- Bangladesh Bioscience Research Group
Sepsis, Septic Shock
Effect of Statin Therapy on Sepsis-related Mortality in Intensive Care Unit Patients
The average age of patients with sepsis has increased in recent years in parallel with the incidence of sepsis. Many of these patients are frail and require various medications for the treatment of their chronic diseases.
- Trial name
- HGG_UCI1 (NCT06354452)
- Testing
- Person-level linkage of the database looking for relationship with sepsis survival and previous intake of certain drug families and previous dependence on health services.
- Where
- Spain
- Volunteers
- 59,578 people
- Sponsor
- Hospital de Granollers
Contact Lens and Punctal Plug in Preventing Corneal Injuries
A Comparison Between Bandage Contact Lens, Punctal Plugs and Standard Measures in Preventing Corneal Injuries
Study Rationale: The insertion of a bandage contact lens or punctal plug in a defined group of patients admitted to the ICU may be more effective than standard care in decreasing the incidence of corneal injuries.
- Trial name
- COMLENPLSTAN (NCT01961193)
- Testing
- contact lens, punctal plug
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Rabin Medical Center
Fungal Infection
Systemic Fungal Infections in ICU Patients
This study aims to : 1. Diagnosis of Systemic fungal infections in ICU patients. 2. Detection the most common fungal species in ICU. 3. Detection of in vitro antifungal sensitivity pattern
- Trial name
- NCT03292224
- Testing
- - Microscopic examination and culture of collected specimens
- Volunteers
- 100 people
- Sponsor
- Assiut University
Behavior, Health, Pre Diabetes
Developing a Lifestyle Intervention for South Asians
This study aims to test the hypothesis that a culturally tailored lifestyle intervention can improve health behaviors among South Asians with prediabetes and diabetes
- Conditions
- Behavior, Health, Pre Diabetes, Diabetes
- Trial name
- NCT03861546
- Testing
- Healthy lifestyle Shared Medical Appointment (SMA) program
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Emory University
Community-acquired Pneumonia
Amoxicillin Alone Versus Amoxicillin/Clavulanate for Community-acquired Pneumonia in Patients Aged 65 Years or Older, and Hospitalized in a Non-intensive Care Unit Ward
Reduce inappropriate antibiotic use is a priority of public health agencies. Community-acquired pneumonia (CAP) is one of the most important indications for antibiotic prescriptions.
- Trial name
- CAPTAIN (NCT06229288)
- Testing
- Amoxicillin, Amoxicillin/clavulanate
- Where
- 19 sites in France
- Volunteers
- 326 people
- Sponsor
- Nantes University Hospital
Delirium, Critical Illness
Pharmacokinetics and Clinical Effects of Escalating Doses of Clonidine in ICU Patients
This study is developed for assessing the pharmacodynamic and pharmacokinetic properties of intravenous (IV) clonidine in critically ill patients on the ICU, and to estimate the optimal dosing strategy for IV clonidine.
- Trial name
- Clokin1 (NCT02466373)
- Testing
- Clonidine (Catapresan®) 0,150 mg/ml, ampoule 1 ml
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Deventer Ziekenhuis
Patient Admitted in Reanimation
Hydrocortisone Use After Etomidate in Intensive Care
the objective of the study is to assess the value of substitution with 200mg/24h of hydrocortisone for 48 hours for patients in intensive care who have received a single injection of etomidate
- Trial name
- NCT00862381
- Testing
- Hydrocortisone
- Where
- 2 sites in France
- Volunteers
- 106 people
- Sponsor
- University Hospital, Grenoble
Bacterial Infections
PROcalcitonin Reduce Antibiotic Treatments in Acute-Ill Patients (PRORATA)
The study is a prospective, randomized, controlled intervention trial conducted in 9 centers, comparing a conventional strategy versus a PCT-guided strategy to start or to discontinue antibiotics, in patients with suspected…
- Trial name
- PRORATA (NCT00472667)
- Testing
- Procalcitonin guided strategy
- Where
- France
- Volunteers
- 630 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, ICU Delirium
Validation of the Polish Version of CPOT
Pain experienced by critically ill patients is a major problem affecting nearly 50% of the patients. Assessing pain in critically ill patients is a challenge even in an intensive care unit (ICU) with a minimal opioid-based…
- Trial name
- POL-CPOT (NCT03024528)
- Testing
- CPOT assessment
- Where
- Poland
- Volunteers
- 71 people
- Sponsor
- Pomeranian Medical University Szczecin
Methicillin-Resistant Staphylococcus AureuS
Population Pharmacokinetics of Linezolid
Linezolid is the first of a new class of antibacterial drugs, the oxazolidinones. It has a specific inhibitory activity against Gram positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).
- Trial name
- NCT01200654
- Testing
- Linezolid
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
COVID-19, Respiratory Failure
Photobiomodulation Therapy Combined With Static Magnetic Field in Patients With COVID-19
Coronavirus disease 2019 (COVID-19) is a disease caused by a novel coronavirus called SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).
- Trial name
- NCT04386694
- Testing
- Active PBMT/sMF
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho
Acute Disease
Is a Positive NECPAL in ICU Patients Associated With Higher Mortality
The aim of the present study is to evaluate the usefulness of the NECPAL scale in identifying Intensive Care Unit (ICU)-admitted patients at higher risk of dying within 90 days of ICU admission
- Trial name
- NCT07007156
- Testing
- NECPAL positive
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Covid19, SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere
Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Intensive Care Unit Patients
There is currently no known treatment for COVID19. Active smokers are infrequent among patients with COVID-19 which has led our team to hypothesize that nicotine is responsible for this protective effect via the nicotinic…
- Trial name
- NICOVID-REA (NCT04598594)
- Testing
- Patch, Nicotine
- Where
- 18 sites in France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19
Evaluation of Safety & Efficacy of MIR 19 ® Inhalation Solution in Patients With Moderate COVID-19
This is Phase 2 multi-center controlled randomized study to assess the efficacy and safety of MIR 19® via 14 days of treatment of participants with symptomatic moderate COVID-19.
- Trial name
- NCT05184127
- Testing
- MIR 19 ®, Standard COVID-19 therapy
- Where
- Russia
- Volunteers
- 156 people
- Sponsor
- National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
Adverse Event, Indicator
a Multifaceted Program for Improving Quality of Care in ICU
Medical errors that affect patient safety have generated huge concern since the publication of "To Err Is Human" 6 years ago [1].
- Conditions
- Adverse Event, Indicator, Intensive Care Units
- Trial name
- NCT00461461
- Testing
- meeting nurses / physicians, quality improvement sessions
- Where
- 3 sites in France
- Volunteers
- 2,117 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Family Engagement, Critical Care, Intensive Care
The Family Cares Trial
The goal of this pilot study is to learn if virtual peer support groups and strengths-based skills training can help family caregivers of ICU survivors providing ongoing support to ICU survivors after hospital discharge.
- Conditions
- Family Engagement, Critical Care, Intensive Care, Patient and Family Engagement, Health Care Delivery
- Trial name
- Family Cares (NCT06984770)
- Testing
- Virtual peer support group intervention, Caregiver Support intervention, Resources
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Intensive Care, Airway Extubation
High-flow Nasal Oxygen Therapy to Prevent Extubation Failure in Adult Trauma Intensive Care Patients
A significant proportion of patients who are intubated for trauma-related injuries, will fail the extubation process. This means that, when the decision has been made to remove the endotracheal tube, a certain proportion of these…
- Conditions
- Intensive Care, Airway Extubation, Critical Care, Oxygen Therapy
- Trial name
- NCT06110390
- Testing
- High flow nasal oxygen
- Where
- Qatar
- Volunteers
- 450 people
- Sponsor
- Hamad Medical Corporation