Clinical trials: Intensive Care Unit
Critical Illness
Comparing Clinical Outcomes Between Ketamine-midazolam and Morphine-midazolam for Continous Sedation in ICU Patients.
A prospective, double-blinded, multicenter randomized control trial. All critically ill patients above 12 years of age requiring continuous sedation for >24hrs in the ICU will be screened and those meeting selection criteria (and…
- Trial name
- KeMiMof (NCT03407404)
- Testing
- Ketamine-Midazolam, Morphine -Midazolam
- Where
- Uganda
- Volunteers
- 124 people
- Sponsor
- Makerere University
Solid Tumor, Adult
Impact of ICU on the Quality of Life in Cancer Patients
This is an observational, prospective, monocentric, case-control study. Investigators aim to compare the quality of life and oncological treatment strategy in cancer patients admitted or not in ICU.
- Trial name
- QdV-ONCOREA (NCT04310033)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Death, Brain
Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP)
Brain death (BD) is characterized by a severe brain injury resulting in irreversible loss of all brain and brainstem functions, while other organs may remain viable.
- Trial name
- APNEAFLO2W (NCT07640009)
- Testing
- Apnea test under HHFO followed by an apnea test under CPAP., Apnea test under CPAP followed by an apnea test under HHFO.
- Where
- 4 sites in France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Critical Illness
Taiwan Center of Outcome and Resource Evaluation
The main purpose of this proposal is to build a multicenter de-identification adult intensive care units database in Taiwan. In future, the Joint Data Management Committee and investigators can use the data for evaluation of…
- Trial name
- NCT04875260
- Testing
- Critical Care
- Where
- 10 sites in Taiwan
- Volunteers
- 600,000 people
- Sponsor
- National Taiwan University Hospital
COPD Exacerbation
Effect of Cough Assist Device in COPD Patients Admitted to Respiratory Intensive Care Unit at Assiut University Hospital
1. To evaluate the effecacy of cough assist device (CAD) in COPD patients admitted in RICU either on invasive or Non-invasive ventilation. 2. To detect any possible complications associated with the use of cough assist device.
- Trial name
- NCT05491408
- Testing
- Cough assist device
- Volunteers
- 100 people
- Sponsor
- Assiut University
Older Patients, Postoperative Care
Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients
Patients in the intensive care unit (ICU) often develop anxiety and agitation, sleep disturbances, and delirium. Delirium occurrence is associated with worse early and long-term outcomes.
- Conditions
- Older Patients, Postoperative Care, Intensive Care Unit, Dexmedetomidine
- Trial name
- NCT07151716
- Testing
- Dexmedetomidine, Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Delirium in the Intensive Care Unit
Ceribell Delirium Monitor Outcomes Pilot Study
This pilot study is designed as a pre- and post-delirium monitor cohort study, with a prospective intervention cohort and a retrospective control cohort.
- Trial name
- DOM (NCT07449416)
- Testing
- Ceribell Delirium Monitoring System
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Ceribell Inc.
Sepsis
Pro-adrenomedullin as a Prognostic Marker in Neonatal Sepsis
The aim of this study was to clarify the prognostic value of serum pro-Adrenomedullin level in neonatal sepsis. Eighty term and preterm neonates with sepsis were enrolled in this study.
- Trial name
- NCT01362504
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Procedural Pain, Preterm Infants
Effectiveness of Gentle Touch Technique on Pain Level During Painful Procedures in Preterm Infants
Preterm infants in neonatal intensive care units frequently undergo painful procedures that may affect their physiological stability, including pain level and respiratory parameters.
- Trial name
- NCT07470398
- Testing
- Gentle Touch Technique
- Where
- 3 sites in Iraq
- Volunteers
- 60 people
- Sponsor
- Karbala University
Dyspnea
Impact of Dyspnea on Patients in the Intensive Care Unit
Although pain has been extensively studied in ICU patients, only a few studies have focused on dyspnea, which is experienced by 50% of mechanically ventilated patients.
- Trial name
- DYSTRESS (NCT02336464)
- Where
- France
- Volunteers
- 624 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pneumonia
An Observational Clinical Study on the Construction of an Artificial Neural Network Model for ICU Pneumonia
To achieve rapid, intelligent and accurate microbiological diagnosis and treatment for ICU pneumonia, an artificial neural network model for microbiological diagnosis is established, which depends on many clinical cases and…
- Trial name
- NCT06661499
- Testing
- establish an artificial neural network model
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Chinese Medical Association
Respiratory Distress Syndrome
Ventilatory Monitoring in Children With Respiratory Distress Syndrome With Electrical Impedance Tomography
INTRODUCTION: Electrical impedance tomography is a tool for noninvasive monitoring of pulmonary ventilation in real time, which is used during alveolar recruitment maneuvers in patients with acute respiratory distress syndrome.
- Trial name
- NCT03768921
- Testing
- PEEP Titriation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Metodista de Piracicaba
Lung Transplant; Complications
Readmissions of Lung Transplant Patients in ICU.
A multi-centre, prospective and observational study was carried out from August 2012 to June 2016 in five Spanish tertiary-care university hospitals with well-established lung transplant programs: Vall d'Hebron (Barcelona)…
- Trial name
- NCT03767049
- Testing
- Colection of clinical data
- Volunteers
- 153 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Respiratory Insufficiency, Weaning, Ventilator
Parasternal Intercostal Ultrasound vs RSBI for Weaning Prediction
Mechanical ventilation is essential in the management of critically ill patients, but deciding the proper time to wean and extubate remains a significant challenge.
- Conditions
- Respiratory Insufficiency, Weaning, Ventilator, Respiration, Artificial, Intensive Care Units
- Trial name
- NCT07144878
- Testing
- Parasternal Intercostal Ultrasound and RSBI Assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Intensive Care Unit, SARS-CoV2
Assessment of SARS-CoV-2 Effect on Post-traumatic Stress of Patients Hospitalized in Intensive Care Unit
Patients admitted to the intensive care unit develop psychiatric disorders, such as anxiety, depression or post-traumatic stress disorder, which can be prolonged.
- Trial name
- FAMILY-COVID (NCT04872049)
- Where
- France
- Volunteers
- 264 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Central Nervous System Diseases, Acute Respiratory Failure
Clinical Evaluation of Swallowing Disorders as a Predictor of Extubation Failure
Patients with failed extubation stay significantly longer in an intensive care unit (ICU) and have a higher mortality rate, than those intubated successfully.
- Conditions
- Central Nervous System Diseases, Acute Respiratory Failure, Shock, Heart Failure
- Trial name
- EVAKIN (NCT00780078)
- Testing
- extubation
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Patients Admitted to the ICU
Empiric Antibiotic Treatment for Septic Patients in the Intensive Care Unit
Sepsis is one of the most common causes of ICU admission. About 5-15% of patients admitted to the hospital with an infection will have sepsis, and about 30-40% of them will have septic shock.
- Trial name
- NCT05924126
- Testing
- empiric antibiotic therapy
- Where
- Israel
- Volunteers
- 155 people
- Sponsor
- Meir Medical Center
Neonatal Infection
Antibiotic Use in a Neonatal Intensive Care Unit Practicing Integrative Medicine
The goal of this study is to describe the antibiotic use in a neonatal intensive care unit (NICU) in Germany that is practising integrative medicine.
- Trial name
- NCT04893343
- Testing
- Antibiotic treatment, No antibiotic treatment
- Where
- Germany
- Volunteers
- 246 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Covid19, SARS-CoV Infection
Infection Control for Severe Acute Respiratory Syndrome Coronavirus 2
The investigators aim to develop expert consensus statements on infection control management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in intensive care units (ICU).
- Conditions
- Covid19, SARS-CoV Infection, SARS Pneumonia, Coronavirus Infection
- Trial name
- IC-COVID-19 (NCT04665960)
- Where
- United Arab Emirates
- Volunteers
- 35 people
- Sponsor
- NMC Specialty Hospital