Clinical trials: Intensive Care Unit Delirium
Delirium, Sedation
Neurosteer Bedside Monitoring System
The purpose of this study is to evaluate the clinical utility of Neurosteer's brain monitoring platform for monitoring delirium, sedation, and agitation in intubated and sedated ICU patients.
- Conditions
- Delirium, Sedation, Agitation
- Trial name
- NCT06718764
- Testing
- Neurosteer's single-channel EEG monitoring device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Circadian Rhythm, Sleep Quality
Circadian Rhythm and Delirium in ICU
The study aims to investigate the status of circadian rhythm and sleep quality in ICU patients and their influence factors. And explore the pathway of circadian rhythm on ICU delirium.
- Conditions
- Circadian Rhythm, Sleep Quality, Intensive Care Unit Delirium
- Trial name
- NCT05342987
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Shanghai Zhongshan Hospital
Critical Illness, Delirium in the Intensive Care Unit
Digital and Plasma Biomarkers in Delirium
The goal of this observational study is to learn if there are potential digital and plasma-based biomarkers that could help detect, predict, and prognosticate delirium in older adult patients who are admitted to the intensive…
- Conditions
- Critical Illness, Delirium in the Intensive Care Unit, Sleep Quality
- Trial name
- DELTA (NCT07694206)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Scripps Health
Delirium
Agents Intervening Against Delirium in Intensive Care Unit
Delirium is a frequent condition in the Intensive Care Unit (ICU) with no existing evidence-based treatment. The aim of the AID-ICU study is to assess the benefits and harms of haloperidol treatment for the management of ICU…
- Trial name
- AID-ICU (NCT03392376)
- Testing
- Haloperidol Injection, Saline (0,9%)
- Where
- 16 sites in Denmark, Finland and 2 more
- Volunteers
- 1,000 people
- Sponsor
- Zealand University Hospital
Delirium, Critical Illness
Haloperidol for Delirium in Adult Critically Ill Patients
The EuRIDICE trial will study whether haloperidol as a first line treatment for ICU delirium reduces delirium duration (and severity).
- Conditions
- Delirium, Critical Illness, Intensive Care Psychosis, Cognitive Impairment
- Trial name
- EuRIDICE (NCT03628391)
- Testing
- Haloperidol
- Where
- 8 sites in Netherlands
- Volunteers
- 142 people
- Sponsor
- Erasmus Medical Center
Delirium, Intensive Care Unit Delirium
PREdiction of DELIRium in Medical ICU Patients
In intensive care unit (ICU) patients, the ability to predict delirium may help reduce its incidence, duration, and severity. The PREdiction of DELIRium in ICU (PRE-DELIRIC) model was recently developed for this purpose.
- Trial name
- NCT04218461
- Testing
- PRE-DELIRIC model
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Istanbul Demiroglu Bilim University
Delirium
Reducing Delirium in the Surgical Intensive Care Unit
Delirium is an acute disturbance in mental abilities and confusion that affects many patient in the hospital and is caused by multiple factors including and altered sleep/wake cycles and multiple sedating medications.
- Trial name
- NCT02856737
- Testing
- eye masks and earplugs
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Medical Center
Pediatric Delirium, Pediatric Intensive Care
Pediatric Delirium in Swedish Paediatric Intensive Care Units
This observational study aims to determine the incidence of delirium among children in a pediatric intensive care unit (PICU) and to identify associated risk factors.
- Conditions
- Pediatric Delirium, Pediatric Intensive Care, Risk Factors
- Trial name
- PADI (NCT07365215)
- Where
- 3 sites in Sweden
- Volunteers
- 676 people
- Sponsor
- Uppsala University
Adult Disease, Intensive Care Unit Syndrome
Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients
For patients undergoing mechanical ventilation, light sedation is better than deep sedation for the outcomes, which is manifested as shortened length of ICU stay, shortened duration of mechanical ventilation, and decreased…
- Conditions
- Adult Disease, Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Delirium
- Trial name
- NCT03172897
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Peking University First Hospital
Delirium, Intensive Care Unit Syndrome
Risk Factors for Delirium in Critically Ill Surgical Patients
Delirium is characterized by changes in mental status, inattension, disorganized thinking, and altered consciousness. Prevalence of delirium in critically ill patients has varied from 20~80% depending on the severity of illness.
- Trial name
- NCT03050021
- Where
- South Korea
- Volunteers
- 251 people
- Sponsor
- Suk-Kyung
Agitated Delirium, Delirium Confusional State
Phenobarbital for Agitated Delirium
The goal of this clinical trial is to test whether the medication phenobarbital is as effective for treating agitated delirium among adult patients admitted to the intensive care unit.
- Conditions
- Agitated Delirium, Delirium Confusional State, Delirium in the Intensive Care Unit, Hyperactive Delirium
- Trial name
- NCT07548489
- Testing
- Phenobarbital, Conventional therapy group
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Pain, Sedation
Assessment of Analgesia, Sedation, Physical Restraints and Delirium in Spanish Intensive Care Units
This study assess which Spanish intensive care units evaluate and record, in a standardized way, levels of pain, sedation / agitation, use of physical restraints and prevalence of delirium.
- Conditions
- Pain, Sedation, Agitation, Delirium
- Trial name
- ASCyD (NCT03773874)
- Testing
- Assessment
- Where
- Spain
- Volunteers
- 1,574 people
- Sponsor
- Hospital Universitario Getafe
Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD)
Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO)
Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis. Despite improved procedural outcomes, neurocognitive complications such as postoperative delirium (POD) and postoperative…
- Conditions
- Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD), Delirium - Postoperative, Neurocognitive Disorders
- Trial name
- HVU-NEURO (NCT07626567)
- Volunteers
- 500 people
- Sponsor
- Heart and Brain Research Group, Germany
Mechanically Ventilated Patients
Prevention of Delirium in Intensive Care by Melatonin
This is a double-blind, randomized, placebo-controlled, Phase 2b/3 two-part adaptive clinical trial. The trial is designed to investigate the pharmacokinetics and the efficacy of multiple dosing regimens of melatonin and to…
- Trial name
- DEMEL (NCT03524937)
- Testing
- MELATONIN (HIGH DOSE), MELATONIN (LOW DOSE)
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium, Sleep Fragmentation
Direct Noise Reduction in the Intensive Care Units (ICU) Using Earplugs and Noise Canceling Headphones
This study seeks to examine the effects of overnight noise reduction in critically ill patients who are receiving mechanical ventilation.
- Trial name
- NCT01343095
- Testing
- Foam Earplugs, Noise Canceling Headphones
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University
Myocardial Infarction (MI), Delirium, Intensive Care Unit, Randomised Controlled Trial
Mannitol Administration for Delerium Prevention
The aim of the study is to evaluate the efficacy of adjuvant administration of mannitol for the prevention of delirium in patients with myocardial infarction.
- Trial name
- MAD (NCT06759259)
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Intensive Care Unit Syndrome, Mechanical Ventilation Complication
Ketamine Infusion as Sedative Analgesic in Severe ARDS
To evaluate whether ketamine is a safe sedative-analgesic agent to be used in an intensive care unit (ICU) setting as compared to traditionally used agents such as propofol, opioids, and midazolam
- Conditions
- Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
- Trial name
- KISS (NCT04818827)
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Interfaith Medical Center
Delirium, AAA
Abdominal Aortic Aneurysm Patients Remain at Risk for Delirium on the Surgical Ward After Intensive Care Unit Dismissal
The incidence of delirium following open abdominal aortic aneurysm (AAA) surgery is significant, with incidence rates ranging from 12 to 33%.
- Conditions
- Delirium, AAA, Intensive Care Unit Delirium, Surgery--Complications
- Trial name
- NCT04080557
- Testing
- Surgery
- Where
- Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Amphia Hospital
Critical Illness, Delirium
Electroencephalography and Sleep Quality With Lormetazepam in the Intensive Care Unit
The goal of this clinical trial is to test the effect of continuous lormetazepam infusion on EEG patterns in critically ill patients who are given continuous infusion of lormetazepam in an intensive care unit setting.
- Conditions
- Critical Illness, Delirium, Sleep Disorders, Circadian Rhythm
- Trial name
- CLIO-ICU (NCT06473415)
- Testing
- Electroencephalography
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University