Clinical trials: Intensive Care Unit ICU
Critical Illness, Family Members
Addressing Palliative Care Needs Among Intensive Care Unit Family Members
The quality of palliative care is highly variable for many patients treated in intensive care units (ICUs) and their family members.
- Conditions
- Critical Illness, Family Members, Psychological Distress, Informal Caregivers
- Trial name
- ICUconnect (NCT03506438)
- Testing
- Needs-focused mobile app, Usual care
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Duke University
Acute Respiratory Failure
Novel Arm Restraint in the Intensive Care Unit
The goal of this pilot is to evaluate a novel restraint device in 8 older mechanically ventilated patients to demonstrate that 1) the revised novel restraint prototype is safe and 2) a future randomized controlled trial (RCT) is…
- Trial name
- NCT03621475
- Testing
- Novel restraint
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Vermont
Critical Illness
European Mortality & Length Of Intensive Care Unit (ICU) Stay Evaluation (ELOISE)
The starting point of ELOISE is the significant number of Intensive Care Unit (ICU) survivors who die after the transfer to ward.
- Trial name
- ELOISE (NCT01422070)
- Where
- Italy
- Volunteers
- 6,433 people
- Sponsor
- Università degli Studi di Ferrara
Anesthesia
Anesthesia and Lymphocytes Apoptosis
Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for…
- Trial name
- OPCAB (NCT01461551)
- Testing
- Sevoflurane, Propofol, combine of sevoflurane and propofol
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Ruijin Hospital
Analgesia
Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)
This study will be a multicentre randomized, open-label, phase IIIb study. This study will evaluate two different techniques of sedation: an analgesia based regimen with remifentanil versus a conventional sedation based regimen…
- Trial name
- NCT00436345
- Testing
- Remifentanil, Propofol
- Where
- 6 sites in Italy
- Volunteers
- 39 people
- Sponsor
- GlaxoSmithKline
High Flow Nasal Cannula
HFNC Flow Titration and Effort of Breathing in the PICU
High-flow nasal cannula (HFNC) is a method of non-invasive respiratory support used to decrease the effort of breathing (EOB) in patients with a wide variety of respiratory diseases in the pediatric intensive care unit.
- Trial name
- HFNCandEOB (NCT02793674)
- Testing
- Fisher & Paykel high flow nasal cannula, Vapotherm high flow nasal cannula
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital Los Angeles
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Pediatric Congenital Heart Surgery
Predictive Value of the FORE-SIGHT™ Monitor for Hemodynamic Deterioration
The postoperative period after congenital heart surgery in children can be a very critical episode, where it is of utmost importance to closely monitor the circulation in these patients.
- Trial name
- NCT01706497
- Testing
- Cerebral tissue oxygen saturation monitoring, blinded
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- KU Leuven
Critically Ill
Is There Any Correlation Between Respiratory Variation Ratios of Internal Jugular Vein and Inferior Vena Cava?
Intravascular volume assesment is important for the management of the patients in the intensive care unit. Respiratory variation ratio of the inferior vena cava (IVC) can be determined by ultrasonography (USG) and is a useful…
- Trial name
- NCT04173741
- Testing
- USG measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Hacettepe University
Neonatal Neuroimaging
Development of a MR Scanner Capable of Being Sited in a Neonatal Intensive Care Unit (Firefly Sheffield)
This study investigates a novel magnetic resonance imaging (MRI) system designed by GEHC for imaging viable neonate and infant populations.
- Trial name
- NCT02785588
- Testing
- 3.0 T Neonatal MRI scanner
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Stress
Bundle Consent and Expectation Setting in Pediatric Intensive Care Unit
The purpose of this research study is to find out about how obtaining consent for procedures in the PICU affects parental/caregiver stress.
- Trial name
- NCT04697173
- Testing
- Single consent
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- Virginia Commonwealth University
Hypotension
Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial
The use of peri-arrest bolus epinephrine (PBE) has emerged as a rescue strategy for life-threatening hypotension in pediatric intensive care units (ICU) despite scant published data supporting its use in this setting.
- Trial name
- EPIDose (NCT05327556)
- Testing
- Epinephrine 0.5 mcg/kg, Epinephrine 1 mcg/kg
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Children's Hospital
Bacterial Infections
French Study In ICU Patients Treated With Tigecycline
This study will describe clinical outcome and safety data collected prospectively in subjects hospitalized in an intensive care unit (ICU) presenting with an infection for which treatment with tigecycline, alone or in…
- Trial name
- NCT00799591
- Testing
- Observational study so no intervention in the patient.
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Serious Injury, Communication
A Communication Tool to Improve Communication in the ICU
The purpose of this study is to test the effectiveness of the Best Case/Worst Case-ICU communication tool on quality of communication, clinician moral distress, and ICU length of stay for older adults with serious traumatic…
- Trial name
- NCT05780918
- Testing
- Best Case/Worst Case-ICU Communication Tool
- Where
- 8 sites in United States
- Volunteers
- 7,320 people
- Sponsor
- University of Wisconsin, Madison
Acute Respiratory Failure, Post-Intensive Care Syndrome
Mobile Critical Care Recovery Program for Acute Respiratory Failure Survivors
The m-CCRP randomized controlled trial will evaluate the efficacy of a collaborative critical care recovery program from acute respiratory failure (ARF) survivors in accomplishing the Institute of Healthcare Improvement's triple…
- Trial name
- m-CCRP (NCT03053245)
- Testing
- Mobile Critical Care Program, Attention Control
- Where
- 3 sites in United States
- Volunteers
- 503 people
- Sponsor
- Indiana University
Invasive Candidiasis
β-D-Glucan (BDG) Surveillance With Preemptive Anidulafungin vs. Standard Care for Invasive Candidiasis in Surgical Intensive Care Unit (SICU) Patients
This is a single center, prospective, open label assessment of β-D-glucan surveillance with preemptive anidulafungin therapy versus standard care for the prevention of invasive candidiasis in at-risk surgical intensive care unit…
- Trial name
- NCT00672841
- Testing
- Preemptive Therapy with Anidulafungin, Empiric antifungal therapy based on physician discretion.
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Duke University
Diabetes
Continuous Glucose Monitoring in Critically Ill
The goal of this clinical research study is to learn if The Guardian® blood-sugar monitoring device can be used reliably in patients with high blood sugar who are receiving care in the ICU.
- Trial name
- NCT00707434
- Testing
- Guardian® blood-sugar monitoring device
- Where
- 6 sites in United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Delirium, Psychomotor Agitation
Nicotine Replacement Therapy in the Intensive Care Unit
The purpose of this study is to determine whether transdermal nicotine replacement therapy is safe and effective for treating nicotine withdrawal symptoms in the critically ill smoking patient.
- Conditions
- Delirium, Psychomotor Agitation, Substance Withdrawal Syndrome, Nicotine Replacement Therapy
- Trial name
- NicGoWell (NCT01362959)
- Testing
- Transdermal nicotine patch, Cutaneous patch, containing no active substances
- Where
- 2 sites in Netherlands
- Volunteers
- 47 people
- Sponsor
- Gelderse Vallei Hospital
Communication, Critical Illness
Improving Family Meetings in the Pediatric Cardiac Intensive Care Unit
This study aims to improve communication between medical teams, patients, and families in the pediatric cardiac intensive care unit.
- Trial name
- NCT03749330
- Testing
- CICU Team And Loved Ones Communicating (CICU TALC)
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Children's Hospital of Philadelphia
Early Ventilator Associated Pneumonia
Duration of Antibiotic Treatment for Early VAP (DATE) Trial
Hypothesis: 4 days of antibiotic therapy, as compared to 8 days, is equally effective and results in decreased antibiotic exposure among surgical ICU patients with early VAP.
- Trial name
- DATE (NCT01994980)
- Testing
- Default 4 days antibiotic therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Denver Health and Hospital Authority