Clinical trials: Intensive Care Units, Pediatric
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
Critically Ill Severe Bronchiolitis
Helmet Continuous Positive Airway Pressure Support for Severe Bronchiolitis in PICUs
Binary randomized peep level of Helmet CPAP (1-0). The first patient enrolled will be assign to treatment 1 (10 cmH2O peep level), independently from its BSS.
- Trial name
- NCT02977585
- Testing
- 10 cmH2O peep
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Mechanical Ventilation
Retrospective Study on Prolonged Sedation Effects With Inhaled Agents in PICU
The objective of the study is to evaluate the effects of halogenated gases on sedation and analgesia, to describe the tolerance and to determine the risk factors for failure, in pediatric intensive care patients during prolonged…
- Trial name
- RESPIRE (NCT05064592)
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pediatric Patient (1m-21y), ICU Admission
Pediatric Intensive Care Units (ICUs) at Emory-Children's Center Glycemic Control: The PedETrol Trial
The primary goal of this project is to determine whether normalizing hyperglycemia is a safe approach to improve multisystem organ function in critically ill children requiring intensive care.
- Conditions
- Pediatric Patient (1m-21y), ICU Admission, Hyperglycemia
- Trial name
- PedETrol (NCT01116752)
- Testing
- Active Glycemic Control Strict (80-140mg/dL) vs. Conservative (190-220mg/dL) (with or without Continuous Glucose Monitoring)
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Indiana University
Peripheral Venous Cannulation
Ultrasound Guided Peripheral Intravenous Catheterization in the Pediatric Intensive Care Unit.
This is a randomized controlled prospective study. The purpose of this study is to compare a recently described technique of ultrasound (US) guided, dynamic needle tip positioning (DNTP), to the traditional technique of vein…
- Trial name
- NCT04268225
- Testing
- US guided dynamic needle tip positioning peripheral intravenous cannulation, Traditional peripheral intravenous cannulation
- Volunteers
- 90 people
- Sponsor
- Rabin Medical Center
Pediatric ALL, Critical Illness
Singapore's Health Outcomes After Critical Illness in Kids
What is the problem? Every year about 2.5 million children are affected by critical illness and require admission to the pediatric intensive care unit (PICU).
- Conditions
- Pediatric ALL, Critical Illness, Post Intensive Care Unit Syndrome
- Trial name
- SHACK (NCT04637113)
- Testing
- This is a non-interventional study
- Where
- Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Asthma Childhood
Ideal Steroids for Asthma Treatment in the PICU
Determine if differences in (1) pediatric intensive care unit length of stay, (2) continuous nebulized albuterol duration, and (3) a composite outcome of advanced asthma therapy incidence including use of non-invasive ventilation…
- Trial name
- iSTAT PICU (NCT03900624)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Johns Hopkins All Children's Hospital
Acute Respiratory Distress Syndrome, Pediatric Intensive Care Unit
Pediatric Acute Respiratory Distress Syndrome Asia Study
Mortality rates in children with pediatric acute respiratory distress syndrome (PARDS) are higher in Asia compared to other regions.
- Conditions
- Acute Respiratory Distress Syndrome, Pediatric Intensive Care Unit, Mechanical Ventilation
- Trial name
- PARDS Asia (NCT04068038)
- Testing
- Ventilation protocol
- Where
- 19 sites in China, Hong Kong and 8 more
- Volunteers
- 738 people
- Sponsor
- KK Women's and Children's Hospital
Posttraumatic Stress Disorder, Parents
Posttraumatic Stress Disorder in Parents and Children After Discharge From the Pediatric Intensive Care Unit
Background: If disorders that occur immediately after a trauma are not treated, they may become chronic and turn into severe health problems.
- Conditions
- Posttraumatic Stress Disorder, Parents, Children, Only
- Trial name
- PTSD (NCT05186844)
- Testing
- survey application
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Noise Exposure, Sedative Withdrawal Delirium
Sound Levels in the Pediatric Cardiac Critical Care Unit and Their Correlation With Sedation Administration, Delirium Scores and Patient Heart Rate
There is limited data regarding sound levels and burden in the pediatric cardiac critical care unit and how this compares with WHO standards.
- Conditions
- Noise Exposure, Sedative Withdrawal Delirium, Sedative Toxicity
- Trial name
- NCT04777695
- Testing
- Decibel Monitor
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's National Research Institute
Acute Respiratory Failure
Study on Ventilation Distribution With Electrical Impedance Tomography for Paediatric Respiratory Failure
Electrical impedance tomography (EIT) is a non-invasive, bedside monitoring technique that provides continuous, real-time information about the regional distribution of the ventilation.
- Trial name
- PELUCHE1 (NCT05347563)
- Testing
- Electrical impedance tomography
- Where
- 4 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Post Intensive Care Syndrome, Narrative Medicine
Effect of Pediatric Intensive Care Unit Diaries on PICS-p
When children become very sick and need to stay in a Pediatric Intensive Care Unit (PICU), it can have a big impact on their recovery and their family's well-being.
- Conditions
- Post Intensive Care Syndrome, Narrative Medicine, Post Traumatic Stress Disorder, Anxiety
- Trial name
- PICS-p (NCT06310109)
- Testing
- PICU diary
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Bambino Gesù Children's Hospital IRCCS
Acute Kidney Injury, Congenital Heart Disease
Acute Kidney Injury After Cardiac Surgery on CPB
The purpose of this retrospective study is to determine the incidence and severity of acute kidney injuries (AKI) after heart surgery on cardiopulmonary bypass (CPB) in the pediatric intensive care unit (PICU) in Lausanne…
- Conditions
- Acute Kidney Injury, Congenital Heart Disease, Surgery, CBP
- Trial name
- NCT03513718
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sepsis
Pharmacokinetics and Pharmacodynamics of Ceftazidime in Pediatric ICU Patients
Mortality benefit has been proven with early antibiotic administration in sepsis. Antimicrobial therapy should be based on early achievement of effective drug concentrations by optimizing the pharmacokinetic/pharmacodynamics of…
- Trial name
- NCT03133910
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Central Venous Catheters
Evaluation of the Occurrence of Early Thrombosis on Central Venous Catheter by Ultrasound in Pediatric Intensive Care Unit
The objective of this study is to prospectively describe the incidence of early venous thrombosis secondary to the placement of a percutaneous central venous catheter, in a pediatric intensive care unit, by systematic ultrasound…
- Trial name
- Thromb-US (NCT04194736)
- Testing
- Ultrasound scan
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intensive Care Psychosis
Follow-up in Pediatric Intensive Care Unit
Background In developed countries, mortality rates in pediatric intensive care units (PICUs) are around 4% and thus, most children admitted to these units survive.
- Trial name
- APRELAREA (NCT06363344)
- Testing
- Questionnaires : PHQ-9 (Kroenke, 2001), the PSC (Sheldrick, 2012), the ASQ-SE (Squires, 2015), the PedsQL (Varni, 1999)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Circadian Dysrhythmia, Sleep Disturbance
PICU-related Sleep and Circadian Dysregulation Pilot Study
A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old.
- Conditions
- Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
- Trial name
- NCT06505447
- Testing
- Daytime light exposure, Daytime restricted feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Sepsis
Using Biomarkers to Optimize Antibiotic Strategies in Sepsis
The proposed work will provide critical insights into the potential impact of a biomarker-based algorithm on reducing unnecessary antibiotic use in different adult and pediatric/neonatal ICU's.
- Trial name
- NCT02207114
- Testing
- Biomarker Algorithm Intervention
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- University of Pennsylvania
Hypoxemia, Arrhythmias
Differences in Morbidity Between a Necessity Endotracheal Suctioning Protocol Versus a Routine Endotracheal Suctioning
Morbidity frequency associated to a endotracheal suctioning is different between a necessity endotracheal suctioning protocol versus a routine endotracheal protocol.
- Conditions
- Hypoxemia, Arrhythmias, Cardiac Arrest, Ventilator Associated Pneumonia
- Trial name
- NCT01069185
- Testing
- Necessity endotracheal suctioning, Routine endotracheal suctioning
- Where
- Colombia
- Volunteers
- 92 people
- Sponsor
- Hospital Pablo Tobón Uribe
Ventilator Associated Pneumonia (VAP)
Pulmonary Infections and Barotrauma Associated With MV IN PICU
This study aims to determine the incidence, risk factors and outcome of ventilation associated common complication in the PICUs at Assiut University Children Hospital in Egypt.
- Trial name
- NCT05792501
- Testing
- Mechanical ventilation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University