Clinical trials: Interleukin
Idiopathic Subglottic Stenosis
Effects of Interleukin (IL)-17A Inhibition on Idiopathic Subglottic Stenosis
The purpose of this phase 2 study is to examine if inhibiting IL-17A activation using the biologic drug Taltz, in idiopathic subglottic stenosis patients will decrease scar fibroblast proliferation therefore reducing or…
- Trial name
- NCT05309616
- Testing
- Taltz
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Asthma
Non-Eosinophilic Biological Effects of IL-5
This study aims to investigate the role of IL-5 in suppressing anti-viral immune responses in bronchial epithelial cells (BECs) and in peripheral blood mononuclear cells (PBMCs) from 5 people with asthma.
- Trial name
- NCT06026202
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Imperial College London
Ulcerative Colitis, Inflammatory Bowel Disease
Study Evaluating rhIL-11 in Left-Sided Ulcerative Colitis
To explore the safety of orally delivered rhIL-11 in patients with mild to moderate left-sided ulcerative colitis. To explore the effects of orally administered rhIL-11 on pharmacogenomics in blood samples and in colonic biopsy…
- Trial name
- NCT00038922
- Testing
- rhIL-11
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
INTERLEUKIN 6
Cytokine Hemadsorption in Covid 19 Patients With Bacterial Sepsis
In this retrospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in COVID-19 ICU patients with or without sepsis.
- Trial name
- NCT04920851
- Testing
- cytokine hemadsorption
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Derince Training and Research Hospital
Melanoma (Skin)
Vaccine Therapy in Treating Patients With Melanoma
Phase I trial to study the effectiveness of vaccine therapy in treating patients with melanoma that cannot be treated with surgery. Vaccines may make the body build an immune response that may kill tumor cells.
- Trial name
- NCT00003556
- Testing
- ALVAC-hB7.1, canarypox-hIL-12 melanoma vaccine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Interleukin 12, Interleukin 23
Role of IL 12 and IL 23 as Potential Biomarkers in Diagnosis of Early Crohn's Disease
This study aims to evaluate the role of Interleukin (IL)-12 and IL-23 as potential biomarkers in the diagnosis of early Crohn's disease.
- Conditions
- Interleukin 12, Interleukin 23, Biomarker, Diagnosis
- Trial name
- NCT06844565
- Testing
- Immunohistochemistry procedure
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Tanta University
Osteo Arthritis Knee
Cartilage Adaptation and Response to Interleukins and Exercise
This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.
- Trial name
- CARTILEX (NCT03410745)
- Testing
- Exercise.
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Bispebjerg Hospital
Advanced or Metastatic Solid Tumors
A Dose Escalation/Expansion Study of MDK-703 in Patients With Advanced or Metastatic Solid Tumors
This is an open-label, dose escalation and dose expansion study of MDK-703 as a monotherapy and in combination with other cancer therapies in adult study participants with advanced or metastatic solid tumors.
- Trial name
- ORCHID-1 (NCT05716295)
- Testing
- MDK-703, Checkpoint Inhibitor, Immune
- Where
- 6 sites in United States
- Volunteers
- 26 people
- Sponsor
- Medikine, Inc.
Stress Related Mucosal Disease
Study on Correlated Factors of Barrier and Immune Function in Stress Related Mucosal Disease (SRMD)
To study the changes of barrier and immune function in Stress Related Mucosal Disease (SRMD).
- Trial name
- NCT03200158
- Testing
- Endoscopy biopsy and blood
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Xiuli Zuo
Asthma, Hypersensitivity
Phase II Efficacy Study of Aerosolized Recombinant Human IL-4 Receptor in Asthma
Asthma is a chronic inflammatory disorder of the airways characterized by reversible airflow obstruction. Fourteen million persons (6.4%) in the United States report having asthma, and from 1980 to 1994 the prevalence of…
- Trial name
- NCT00001909
- Testing
- Soluble recombinantly produced IL-4R
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
B-cell Non-Hodgkin Lymphoma
A Study of De-immunized DI-Leu16-IL2 Administered Subcutaneously in Participants With B-cell NHL
This dose-escalation study is designed for determining the safety, tolerability, pharmacokinetics (PK), biological, and clinical activity of DI-Leu16-IL2 administered to participants with cluster of differentiation 20 (CD20)…
- Trial name
- DI-Leu16-IL2 (NCT01874288)
- Testing
- DI-Leu16-IL2
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- Alopexx Oncology, LLC
HIV Infections
Safety of and Immune Response to an HIV Vaccine (VRC-HIVDNA009-00-VP) Administered With Interleukin-2/Immunoglobulin (IL-2/Ig) DNA Adjuvant in Uninfected Adults
This study will test the safety of and immune system response to a new HIV vaccine. The vaccine in this study is made from HIV DNA produced in a laboratory.
- Trial name
- NCT00069030
- Testing
- VRC-HIVDNA009-00-VP (Gag-Pol-Nef-multiclade-Env) with adjuvant VRC-ADJDNA004-IL2-VP
- Where
- 7 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intrahepatic Cholestasis of Pregnancy
Il-17 Levels in Intrahepatic Cholestasis of Pregnancy
The aim of this study is to investigate maternal and fetal serum IL-17 levels in pregnant women with intrahepatic cholestasis of pregnancy and to find out if Th-17 cells have a role in progress of intrahepatic cholestasis of…
- Trial name
- NCT01898832
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Breast Cancer
A Study to Prevent Rash in People Starting Alpelisib for the Treatment of Breast Cancer
The researcher are doing this study to find out whether benralizumab is effective at preventing skin rashes caused by alpelisib in people who have metastatic breast cancer. Skin rash is a common side effect of alpelisib.
- Trial name
- NCT05966584
- Testing
- Benralizumab, fulvestrant or AIs) and PI3K inhibition (alpelisib)
- Where
- 7 sites in United States
- Volunteers
- 1 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Clear Cell Renal Cell Carcinoma, Metastatic Kidney Carcinoma
Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer
This phase I/II trial studies the side effects and best dose of entinostat when given together with aldesleukin and to see how well this works in treating patients with kidney cancer that has spread to other places in the body.
- Conditions
- Clear Cell Renal Cell Carcinoma, Metastatic Kidney Carcinoma, Stage III Renal Cell Cancer AJCC v7, Stage IV Renal Cell Cancer AJCC v7
- Trial name
- NCT01038778
- Testing
- Aldesleukin, Computed Tomography, Entinostat
- Where
- 4 sites in United States
- Volunteers
- 47 people
- Sponsor
- National Cancer Institute (NCI)
Acne Vulgaris
Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome
The goal of this clinical trial is to investigate the effectivity and safety of mild to moderate acne vulgaris therapy using Zingiber officinale 5 % transdermal patch.
- Trial name
- NCT06787222
- Testing
- tretinoin 0.025% + Z. officinale patch, tretinoin 0.025% cream
- Where
- Indonesia
- Volunteers
- 26 people
- Sponsor
- Hasanuddin University
Melanoma
IL2 Imaging in Metastatic Melanoma
T cell infiltration of tumor lesions is a known prognostic factor in several tumor types and is used as treatment mechanism in some of these tumor types.
- Trial name
- NCT02922283
- Testing
- IL2-PET scan, Tumor biopsy, CT scan
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- University Medical Center Groningen
Systemic-Onset Juvenile Idiopathic Arthritis
Interleukin-1 Receptor Antagonist (IL-1RA) (ANAKINRA) IN SEVERE SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS
1. Main objective: To test the efficacy of anakinra treatment in children or young adults with corticosteroid-resistant or -dependent Systemic-Onset Juvenile Idiopathic Arthritis (SO-JIA) 2.
- Trial name
- NCT00339157
- Testing
- Anakinra, Pneumo23
- Where
- 6 sites in France
- Volunteers
- 24 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Inflammation on Dialysis, Bacteriuria in Hemodialysis Patients
Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients
When considering occult infections during the diagnostic workup of inflammation in Hemodialysis (HD) patients, the urine-deprived bladder is frequently dismissed as potential site of infection.
- Trial name
- NCT01570556
- Testing
- Antibiotic treatment
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Assaf-Harofeh Medical Center
Discolored Teeth
Effect on Periodontal Markers by Bleaching Intracoronal Technique
OBJECTIVES: The aim of this clinical randomized, double-blind clinical study was to assess the markers levels of RANKL IL-1B and OPGL, involved in the external cervical resorption as a primary outcome, and change color…
- Trial name
- BLEIC (NCT02718183)
- Testing
- Hydrogen Peroxide 35% (Opalescence Endo - Ultradent, USA), carbamide peroxide 37% (Whiteness Superendo, FGM, Brazil).
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chile