Clinical trials: Interleukin
Malignant Melanoma
Intratumoral Application of L19IL2 in Patients With Malignant Melanoma
Phase II, non-randomized, multicenter, prospective study designed to test the efficacy and safety of intratumorally administered L19IL2 in patients suffering from metastatic melanoma.
- Trial name
- NCT01253096
- Testing
- Intratumoral injections of L19IL2
- Where
- 3 sites in Austria, Germany
- Volunteers
- 25 people
- Sponsor
- Philogen S.p.A.
Mouth Diseases, Periodontal Inflammation
Evaluation of Biomarkers Levels in Gingival Crevicular Fluid, Saliva and Serum for Different Periodontal Diseases
The aim of this study is; detection of interleukin(IL)-38, IL-36 gamma(γ) , IL-17 and matrix metalloproteinase(MMP)-9 levels in gingival crevicular fluid (GCF), saliva and serum samples of periodontally healthy, gingivitis and…
- Conditions
- Mouth Diseases, Periodontal Inflammation, Periodontal Diseases
- Trial name
- NCT05435131
- Testing
- GCF obtaining, Saliva Obtaining, Serum obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Whole Body Vibration, Aerobic Training
Whole Body Vibration Versus Aerobic Training on Interleukin 6 and Endurance After Renal Transplantation
This study aimed to compare the effect of whole body vibration versus aerobic training on interleukin 6 and endurance after renal transplantation in patients after renal transplantation.
- Conditions
- Whole Body Vibration, Aerobic Training, Interleukin 6, Endurance
- Trial name
- NCT07333105
- Testing
- whole body vibration, stationary bicycle
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Diabetic Foot Ulcer
Efficacy of LL-37 Cream on Bacteria Colonization, Inflammation Response and Healing Rate of Diabetic Foot Ulcers
Diabetic foot ulcer (DFU) is a common complication of diabetes with global prevalence of 6.3%. Treatment of diabetic foot ulcer (DFU) is challenging with disappointing outcome.
- Trial name
- NCT04098562
- Testing
- LL37, Standard Wound Care
- Where
- 3 sites in Indonesia
- Volunteers
- 40 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Psoriasis
A Study of Safety and Effectiveness of Ustekinumab (CNTO 1275) in Patients With Moderate to Severe Plaque-type Psoriasis
The primary purpose of this study is to evaluate the effectiveness and safety of ustekinumab (CNTO 1275) in the treatment of patients with moderate to severe plaque psoriasis.
- Trial name
- PHOENIX1 (NCT00267969)
- Testing
- ustekinumab
- Where
- 42 sites in United States, Belgium and 1 more
- Volunteers
- 766 people
- Sponsor
- Centocor Research & Development, Inc.
Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma
Genetically Engineered Cells (EGFRt/19-28z/IL-12 CAR T Cells) for the Treatment of Relapsed or Refractory CD19+ Hematologic Malignancies
This phase I trial tests the safety, side effects, and best dose of genetically engineered cells called EGFRt/19-28z/IL-12 CAR T cells, and to see how they work in treating patients with hematologic malignancies that makes a…
- Conditions
- Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Follicular Lymphoma, Recurrent High Grade B-Cell Lymphoma
- Trial name
- NCT06343376
- Testing
- Biopsy, Biospecimen Collection, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Roswell Park Cancer Institute
Refractory Malignant Solid Tumors, mRNA Vaccine
Clinical Trial of IL - 22BP Safety, Tolerability, and Antitumor Activity in Refractory Solid Tumors.
This study aims to investigate the safety and efficacy of the IL-22BP in patients with refractory malignant solid tumors.
- Conditions
- Refractory Malignant Solid Tumors, mRNA Vaccine, Interleukin
- Trial name
- NCT07040943
- Testing
- IL-22BP
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- West China Hospital
Bullous Pemphigoid, Pemphigoid
Ixekizumab in the Treatment of Bullous Pemphigoid
Recently, Interleukin (IL)-17 has been identified as a key driver of chronic inflammation in Bullous Pemphigoid (BP). Ixekizumab is a recombinant high-affinity fully human monoclonal antibody that targets IL-17A Immunoglobulin…
- Trial name
- NCT03099538
- Testing
- Ixekizumab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Hepatitis C
Outcomes in Hepatitis C After Living Donor Liver Transplantation in Association With Interleukin 28 B
Hepatitis C is the leading cause of liver transplants in the USA. Given that there is a national organ shortage, living donor liver transplantation has became a viable option for patients with end stage liver disease who are not…
- Trial name
- NCT01429155
- Testing
- Interleukin 28B genotype
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Henry Ford Health System
Infertility Assisted Reproductive Technology
The Impact of Uterine Immunity and Its Alterations on the Embryo Implantation Process
Evaluation of uterine immunity, histological picture, and endometrial microbiome for embryo implantation
- Trial name
- UTIMEE (NCT07120958)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Momo Fertilife
Still's Disease, Adult-Onset, Still's Disease, Juvenile-Onset
A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD)
The aim of this study is to demonstrate the efficacy and to evaluate the safety, pharmacokinetics (PK) and immunogenicity of anakinra in patients with newly diagnosed Still's disease, including SJIA (Systemic juvenile idiopathic…
- Trial name
- anaSTILLs (NCT03265132)
- Testing
- anakinra
- Where
- 39 sites in United States, Canada
- Volunteers
- 13 people
- Sponsor
- Swedish Orphan Biovitrum
Psoriasis
Immune Infiltrate Analysis of Psoriasis Skin During Therapy With Anti-interleukin 23 (IL-23)
Psoriasis is an immune-mediated inflammatory skin disease characterized by the presence of erythematous and itchy plaques. Psoriasis has a multifactorial pathogenesis, environmental and genetic factors contribute to its…
- Trial name
- NCT06792487
- Testing
- skin biopsy
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pancreatic Cancer
Role of the Cystic Fluid Interleukins and Tumor Necrosis Factor (TNF) Levels in Characterizing Pancreatic Cysts Detected by Endoscopic Ultrasound (EUS)
This study aims to find a correlation between cytokines levels and malignancy potential of different cystic types.
- Trial name
- NCT03178812
- Testing
- EUS with fine-needle aspiration of pancreatic cyst, Laboratory Blood test
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Rhinitis; Allergic, With Asthma
Efficacy Study of Homeopathic Medicines in Treatment of Allergic Rhinitis and/or Induced Bronchial Asthma
The purpose of this study is to test whether individualized homeopathic medicines can produce any significant effect beyond placebo in treatment of allergic rhinitis and/or induced bronchial asthma
- Trial name
- SBRCTHILARBA (NCT02255136)
- Testing
- Individualized homeopathic medicines
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Mahesh Bhattacharyya Homoeopathic Medical College and Hospital
Basal Cell Carcinoma
Intratumoral phIL12 GET
Electroporation provides non-viral gene delivery method for plasmid DNA. Its clinical application was already proven in preclinical and in clinical trial in treatment of melanoma skin metastases with plasmid coding IL-12, in USA.
- Trial name
- SmartGeneH&N (NCT05077033)
- Testing
- phIL12 GET
- Where
- 2 sites in Slovenia
- Volunteers
- 9 people
- Sponsor
- Institute of Oncology Ljubljana
Acute Respiratory Failure, Acute Respiratory Infection
Airway Inflammatory Response During Illness in Children With Respiratory Failure
The purpose of this study has two major goals: 1) to measure the amount of two specific hormones interleukin (IL)-10 and interleukin (IL)-12p70 in mucous and blood; and 2) compare the hormone levels in two specific areas of the…
- Conditions
- Acute Respiratory Failure, Acute Respiratory Infection, Acute Respiratory Distress Syndrome
- Trial name
- NCT02047877
- Where
- United States
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder, Bipolar Disorder
Naturalistic Study of Ketamine in the Treatment of Depression
This study aims to examine the effect of ketamine in decreasing the risk of suicide in patients with depression and its effectiveness as an antidepressant agent.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Bipolar I Disorder
- Trial name
- NCT05249309
- Testing
- Ketamine
- Where
- 2 sites in Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Leukemia, Pediatric Cancer
Haploidentical Natural Killer (NK) Cells With Epratuzumab for Relapsed Acute Lymphoblastic Leukemia (ALL)
The goal of this clinical research study is to learn if transferring the donor's NK cells, in combination with an antibody called epratuzumab and low-dose interleukin (IL-2), into your body can be done safely.
- Trial name
- NCT00941928
- Testing
- Epratuzumab, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Delirium
Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia
Postoperative delirium after total knee replacement surgery has been related to significant morbidity and mortality among high risk patients. Anesthetic care might play a role in the development of postoperative delirium.
- Trial name
- NCT03120442
- Testing
- Propofol, Dexmedetomidine, Fentanyl
- Where
- Thailand
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Analgesia, Surgical Procedure, Unspecified
TLIP Block Versus Modified TLIP Block for Posterior Decompression and Stabilization Surgery
This study aimed to compare the analgesia effectivity of TLIP and modified TLIP block in Posterior Lumbar Decompression and Stabilization Surgery Perioperatively.
- Trial name
- NCT05104203
- Testing
- Thoracolumbar Interfascial Plane block, Modified Thorcolumbar Interfascial Plane block
- Where
- Indonesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia