Clinical trials: Interleukin-6
Juvenile Idiopathic Arthritis
Pharmacokinetics, Efficacy and Safety of Olokizumab In Patients With Juvenile Idiopathic Arthritis
The primary objective of this study is to evaluate the pharmacokinetics (PK) of olokizumab (OKZ) in patients with polyarticular juvenile idiopathic arthritis aged >2 and <18 years in two doses (64 mg or 48 mg every 4 weeks)…
- Trial name
- NCT07517575
- Testing
- OKZ q4w
- Where
- 14 sites in Russia
- Volunteers
- 71 people
- Sponsor
- R-Pharm International, LLC
Rheumatoid Arthritis
The Long-term Safety and Efficacy of CDP6038 (Olokizumab) With Active Rheumatoid Arthritis
The purpose of this study is to evaluate the long-term safety and tolerability of CDP6038 (olokizumab) treatment in adult subjects with active rheumatoid arthritis (RA) who completed study RA0083 [NCT01463059].
- Trial name
- NCT01533714
- Testing
- CDP6038 (olokizumab)
- Where
- 32 sites in Japan, South Korea and 1 more
- Volunteers
- 103 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Healthy Participants, Diabetes Mellitus (Type 2)
Effect of Type 2 Diabetes on Biomarker Levels in Albumin Platelet-Rich Fibrin
Diabetes mellitus is a metabolic disease that can negatively affect wound healing and tissue repair. Albumin platelet-rich fibrin (Alb-PRF) is a blood-derived biomaterial used in periodontal and regenerative treatments.
- Trial name
- NCT07672652
- Testing
- Venous blood sampling and Alb-PRF preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Trauma, Stress Induced Hyperglycemia
Stress Induced Hyperglycemia In Trauma
The clinical relevance of the observed stress induced hyperglycemia in trauma patients remains unclear. The earlier studies suggested the implications of cytokines in stress induced hyperglycemia and the outcomes after trauma.
- Conditions
- Trauma, Stress Induced Hyperglycemia, Diabetes Mellitus
- Trial name
- SIHG (NCT02999386)
- Where
- Qatar
- Volunteers
- 300 people
- Sponsor
- Hamad Medical Corporation
Preeclampsia, Periodontal Diseases
Maternal Periodontal Status and Cytokines in Preeclampsia
Background: The purpose of this study is to examine the relationship between maternal preeclampsia and periodontal parameters and the correlation of these two disorders with maternal gingival crevicular fluid levels (GCF) of…
- Trial name
- NCT03088228
- Testing
- gingival crevicular fluid collection
- Volunteers
- 80 people
- Sponsor
- Hacer Sahin Aydinyurt
Post-COVID19 Condition
Effect of Vitamin D Supplementation on Glutathione Peroxidase (GPx) Activity, Interleukin-6 (IL-6) Levels and Clinical Outcomes in Post-COVID-19 Patients
The goal of this clinical trial is to evaluate the effectiveness of vitamin D supplementation in treating neuropsychiatric symptoms and improving antioxidant levels in individuals diagnosed with post-COVID-19 condition, a state…
- Trial name
- VITDPOSTCOVID (NCT06419712)
- Testing
- vitamin D (cholecalciferol) supplementation
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Escuela Militar de Graduados de Sanidad, SEDENA
Inflammation on Dialysis, Bacteriuria in Hemodialysis Patients
Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients
When considering occult infections during the diagnostic workup of inflammation in Hemodialysis (HD) patients, the urine-deprived bladder is frequently dismissed as potential site of infection.
- Trial name
- NCT01570556
- Testing
- Antibiotic treatment
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Assaf-Harofeh Medical Center
Covid19, Corona Virus Infection
Effect of Pentoxifylline on Prognosis of Coronavirus Disease 2019 (COVID- 19) Infection
Coronavirus disease 2019 (COVID-19) remains a threatening pandemic, due to its rapid transmission, uncertain risk factors for progression that lead to its lethality and yet unsatisfactory antiviral therapy or prophylaxis.
- Conditions
- Covid19, Corona Virus Infection, Cytokine Storm
- Trial name
- NCT04739345
- Testing
- Pentoxifylline
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Ain Shams University
Weight, Body Weight
Addressing Weight Bias Internalization to Improve Adolescent Weight Management Outcomes: Randomized Pilot Trial
Weight stigma and weight bias internalization (WBI) are common among adolescents at higher weight statuses. WBI is associated with negative physical and mental health outcomes.
- Conditions
- Weight, Body Weight, Weight Bias, Weight Stigma
- Trial name
- SWIFT (NCT06864208)
- Testing
- Behavioral Weight Management, Weight Bias Internalization
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The Miriam Hospital
Pain
Pregabalin on Interleukin-6 Levels in Living Donor Kidney
Pregabalin, a ligand for alfa2delta subunits of voltage-gated calcium channels, has been shown to be an effective adjuvant therapy for acute postoperative pain, by inhibiting central sensitization.
- Trial name
- NCT01529190
- Testing
- Pregabalin
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Early Childhood Caries
Salivary Interleukin-32, Interleukin-10, Interleukin-6 and Tumor Necrosis Factor-alpha Levels in Children
This study aimed to evaluate the levels of interleukin 10, interleukin 6, interleukin 32 and tumor necrosis factor-alpha (TNF-α) in saliva of children with early childhood caries.
- Trial name
- NCT04958005
- Testing
- ELISA
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Aydin Adnan Menderes University
Prostate Cancer
S0354, Anti-IL-6 Chimeric Monoclonal Antibody in Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy
RATIONALE: Monoclonal antibodies, such as anti-IL-6 chimeric monoclonal antibody, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00433446
- Testing
- CNTO 328
- Where
- 123 sites in United States
- Volunteers
- 62 people
- Sponsor
- SWOG Cancer Research Network
Chronic Obstructive Pulmonary Disease, COPD
Interleukin 6-guided Antibiotic Prescriptions in AECOPD Inpatients
In this multicenter, prospective, randomized controlled study, we aimed to figure out, compared with the global chronic obstructive pulmonary disease initiative (GOLD) guideline -guided antibiotic therapy, whether Interleukin 6…
- Trial name
- NCT06612476
- Testing
- Interleukin 6-guided antibiotic therapy, GOLD-guided antibiotic therapy
- Volunteers
- 440 people
- Sponsor
- Ningbo No. 1 Hospital
Pre-frail Elderly
The Effect of Cholecalciferol in Pre-frail Elderly
Vitamin D plays important role in musculoskeletal health and has been known to influence immune system. Inflammaging is one of risk factors that may contribute to development of frailty in elderly.
- Trial name
- NCT04847947
- Testing
- Cholecalciferol
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Indonesia
Healthy, Glucagon Resistance
Interplay Between Interleukin-6 and Glucagon in the Regulation of Human Amino Acid and Protein Homeostasis
The goal of this proof-of-concept study is to learn if interleukin-6 changes the effect of glucagon in healthy volunteers. The main question it aims to answer is: Does IL-6 influence how effectively glucagon lowers the…
- Conditions
- Healthy, Glucagon Resistance, Amino Acid Change
- Trial name
- IGLU (NCT06721910)
- Testing
- Tocilizumab
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Irritable Bowel Syndrome With Constipation
An Evaluation of Cultured Milk Drink on Immune Status of Patients With Irritable Bowel Syndrome: Constipation Predominant
Our previous work on the use of probiotics improved the clinical symptoms in irritable bowel syndrome with constipation-predominant.
- Trial name
- NCT04647045
- Testing
- Cultured milk drink
- Where
- Malaysia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Obesity, Insulin Resistance
Impact of FTO Gene Variation on Body Composition, Lipid Profile, Insulin Resistance, Advanced Glycation End-Products and Ghrelin Levels in Response to Hypocaloric, Protein Rich-Diet
Obesity is a widespread disease that basically develops from unhealthy lifestyle and genetics. The Fat-mass and obesity associated (FTO) gene affects appetite and energy intake of the body, thus elevating fat mass and body…
- Conditions
- Obesity, Insulin Resistance, Dyslipidemias, Advance Glycation
- Trial name
- NCT06426017
- Testing
- High Protein Low Calorie Dietary Intervention
- Where
- 2 sites in Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Cardiac Arrest
Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
Acute myocardial infarction complicated with cardiogenic shock trigger IL-6, the strong inflammatory response, result in multiple organ failure, even death.
- Trial name
- NCT02633358
- Testing
- Therapeutic hypothermia group
- Where
- Taiwan
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Polycystic Ovary Syndrome, Gingivitis
Evaluation of the Effect of Non-Surgical Periodontal Treatment in Women With Polycystic Ovary Syndrome
The goal of this clinical trial is to compare women with polycystic ovary syndrome and systemically healthy woman in relation to their gums and gum treatment outcomes as well as to investigate the role of a new biomarker in gum…
- Trial name
- NCT06567132
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Rheumatoid Arthritis, Idiopathic Juvenile Arthritis
Pharmacogenetic Studies on Anti-IL-6 Receptor Monoclonal Antibodies on the Treatment of Rheumatic Diseases
Tocilizumab and Sarilumab are first-line biological disease-modifying anti-rheumatic drug (bDMARD) which inhibits Interleukin 6 (IL-6) pathway through blockade of its receptor on the treatment of Rheumatoid Arthritis and other…
- Conditions
- Rheumatoid Arthritis, Idiopathic Juvenile Arthritis, Giant Cell Arteritis, Still Disease
- Trial name
- NCT05045001
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau