Clinical trials: Interleukin-6
Gastric Cancer
Association and Mechanism Between Cyclooxygenase-2 and Interleukin-6 in Gastric Cancer
Evidence is rapidly accumulating that chronic inflammation may contribute to carcinogenesis through multiple mechanisms in a number of malignancies, including gastric carcinoma (GC).
- Trial name
- NCT00172627
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Periodontitis, Polymorphism, Restriction Fragment Length
Analysis of Pregnancy-Associated Plasma Protein-A and Interleukin-6 Gene Polymorphisms in Patients With Periodontitis
The aim of this study is to evaluate the relationship between pregnancy associated plasma protein-A (PAPP-A) and interleukin-6 (IL-6) gene polymorphisms and stage 3 grade B and C (S3GBC) periodontitis, and to compare…
- Trial name
- NCT06540755
- Testing
- genetic polymorphism analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Marmara University
Arthritis, Juvenile Rheumatoid, Still's Disease, Juvenile Onset
Single Patient Use of Tocilizumab in Systemic Onset Juvenile Idiopathic Arthritis
The purpose of this study is to see if tocilizumab is safe and effective for treating systemic onset Juvenile Idiopathic Arthritis (soJIA).
- Trial name
- NCT00868751
- Testing
- tocilizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Tufts Medical Center
Pain, Pain, Postoperative
Effect of Quranic Recitation and Classical Music on Pain Intensity and Interleukin-6 Levels After Lower Limb Orthopedic Surgery With Intrathecal Anesthesia
The goal of this study is to determine the effect of murottal and classical music on postoperative pain intensity and interleukin 6 levels in patients undergoing lower extremity orthopedic surgery with spinal anesthesia.
- Conditions
- Pain, Pain, Postoperative, Inflammation, Orthopedic Surgical Procedures
- Trial name
- QRCM (NCT06713044)
- Testing
- Murottal Therapy Intervention Name: Murottal (Islamic verse recitation), Classical Music Therapy Intervention Name: Classical Music Listening, Standard Care (in control arm)
- Where
- Indonesia
- Volunteers
- 33 people
- Sponsor
- Universitas Jenderal Soedirman
Primary Hypertension, Grade 2
Aerobic Exercise vs Physiological Ischemic Training in Stage 2 Hypertension
This study aims to compare the effects of aerobic exercise (AE) and physiological ischemic training (PIT) on inflammatory and angiogenesis biomarkers (VEGF, IL-6, IL-10), cardiorespiratory fitness, muscle strength, and quality of…
- Trial name
- NCT07375407
- Testing
- Aerobic Exercise (AE), Physiological Ischemic Training (PIT)
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran
Magnesium Deficiency
One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running
This study investigated the effect of magnesium supplementation on exercise performance and functional recovery in recreational endurance athletes in conjunction with measures of blood glucose, lactate, IL-6 and sIL-6R.
- Trial name
- NCT04216836
- Testing
- Magnesium oxide
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Worcester
Hemiarthroplasty, Arthroplasty, Replacement, Hip
Effects of Surgery Start Time on Postoperative Interleukin-6, Interleukin-8, and Cortisol
Cortisol is a hormone that increases after trauma or surgery and has circadian rhythm. It has a form that is increased in the morning and decreased in the evening.
- Trial name
- NCT03076827
- Testing
- Total hip replacement, Hemi-arthroplasty
- Volunteers
- 44 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Corona Virus Disease
Anti-il6 Treatment of Serious COVID-19 Disease With Threatening Respiratory Failure
Coronavirus disease 2019 (COVID-19) is caused by the newly discovered coronavirus, SARS-CoV-2. The median time from onset of symptoms of COVID-19 to development of acute respiratory distress syndrome (ARDS) has been reported as…
- Trial name
- TOCIVID (NCT04322773)
- Testing
- RoActemra iv, RoActemra sc, Kevzara sc
- Where
- 2 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Marius Henriksen
Rheumatoid Arthritis
Acute Response to Exercise in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the joints, causing pain, edema, physical disability and poor quality of life.
- Trial name
- NCT04927546
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Juvenile Open Angle Glaucoma, Dry Eye Disease (DED)
Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye
The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients.
- Conditions
- Juvenile Open Angle Glaucoma, Dry Eye Disease (DED), Interleukin 6, Retinal Nerve Fiber Layer Thickness
- Trial name
- HONEY-JOAG (NCT07396441)
- Testing
- Stingless bee honey (Kelulut)
- Where
- 4 sites in Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Sains Malaysia
Ureteral Stone, Kidney Stones
THE EFFECTS OF MIRABEGRON AND TAMSULOSIN FOR PATIENTS WITH URETERAL STENTS
Double J stent (ureteral stent) can cause discomfort to patients, generally due to irritation of the bladder mucosa, especially in the trigone area, smooth muscle spasm, and reflux of urine into the ureter.
- Conditions
- Ureteral Stone, Kidney Stones, Ureteral Stenosis
- Trial name
- NCT06124066
- Testing
- Mirabegron 50 MG
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Hasanuddin University
Acute Myeloid Leukemia, Vitamin D Deficiency
Vitamin D Effect on A Disintegrin-like And Metalloprotease Thrombospondin1 Motif 13& Interleukin 6 in Leukemia
A Disintegrin-like And Metalloprotease with Thrombospondin type 1 motif 13 (ADAMTS13) deficiency was incriminated in poor prognosis, high probability of serious complications and mortality in acute myeloid leukemia (AML)…
- Conditions
- Acute Myeloid Leukemia, Vitamin D Deficiency, ADAMTS13, Interleukin 6
- Trial name
- NCT05149339
- Testing
- Cholecalciferol 2800 I.U. ml oral drops
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Endometriosis
Evaluation of New Biomarkers in Stage 3 and 4 Endometriosis
The diagnostic value of Annexin V, sVCAM-1, sICAM-1, vascular endothelial growth factor and Proinflammatory cytokines (TNF-a and interleukin-6) in ovarian endometriosis and deep infiltrating endometriosis, their levels in…
- Trial name
- NCT05312528
- Testing
- endometriosis surgery, other benign condition surgeries
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Asthma
A Phase 2a Study to Evaluate the Effects of Sirukumab in Subjects With Severe Poorly Controlled Asthma
Sirukumab is a fully human anti interleukin (IL)-6 immunoglobulin G1-kappa monoclonal antibody (MAb) which is in development for the treatment of rheumatoid arthritis (RA).
- Trial name
- NCT02794519
- Testing
- Sirukumab, Rescue medication
- Where
- 8 sites in United States, Spain
- Sponsor
- GlaxoSmithKline
Burns, Sepsis
Comparison Between Interleukin 6 and Procalcitonin in Detecting Sepsis and Incidence of Mortality in Burn ICU Patients
The investigators will compare the efficacy of Interleukin-6 (IL-6) as a better indicator than procalcitonin in burn patients with sepsis or septic shock regarding success of treatment and early ICU discharge.
- Conditions
- Burns, Sepsis, Septic Shock, Death
- Trial name
- NCT06915974
- Testing
- Interleukin 6
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Cerebral Venous Thrombosis
Anticoagulation Combined With Tocilizumab for Interleukin-6 Receptor Inhibition in Acute Cerebral Venous Thrombosis
This study aims to evaluate the efficacy and safety of tocilizumab, an interleukin-6 (IL-6) receptor antagonist, combined with standard anticoagulant therapy compared with standard anticoagulant therapy alone in patients with…
- Trial name
- NCT07801638
- Testing
- Tocilizumab, Standard Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Capital Medical University
Interleukin-6 Inhibition, Physical Stress
Acute Exercise and NK Cell Regulation in Tissue and Circulation After IL-6R Blockade
The study is a randomized controlled trial studying the acute effect of intense aerobic exercise upon NK (Natural Killer) cell activation and appetite-regulation in human participants with or without concommitant IL-6R receptor…
- Conditions
- Interleukin-6 Inhibition, Physical Stress, Appetitive Behavior
- Trial name
- NCT04616235
- Testing
- Tocilizumab Injectable Product, Saline 0.9% 100 ml NaCl 0.9% will be infused over 1 hour
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
COVID, SARS Pneumonia
Safety and Efficacy of Tocilizumab in Moderate to Severe COVID-19 With Inflammatory Markers
The trial evaluates the efficacy and safety of Tocilizumab, which rapidly reduces the inflammation process through inhibition of IL-6 in patients with moderate to severe COVID-19 with increased inflammatory markers.
- Conditions
- COVID, SARS Pneumonia, Cytokine Release Syndrome
- Trial name
- TOCIBRAS (NCT04403685)
- Testing
- Tocilizumab
- Where
- 7 sites in Brazil
- Volunteers
- 129 people
- Sponsor
- Beneficência Portuguesa de São Paulo
Whole Body Vibration, Aerobic Training
Whole Body Vibration Versus Aerobic Training on Interleukin 6 and Endurance After Renal Transplantation
This study aimed to compare the effect of whole body vibration versus aerobic training on interleukin 6 and endurance after renal transplantation in patients after renal transplantation.
- Conditions
- Whole Body Vibration, Aerobic Training, Interleukin 6, Endurance
- Trial name
- NCT07333105
- Testing
- whole body vibration, stationary bicycle
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital