Clinical trials: Internal Fixation
Ankle Fractures, Pilon Fracture
FRAME Study (Frailty-Related Ankle Fracture Management and Evaluation)
This will be a multi-centre randomized controlled trial, with London Health Sciences Centre (LHSC) as the lead site. Elderly patients with complex ankle fractures who meet the inclusion criteria and provide consent will be…
- Trial name
- FRAME (NCT05131321)
- Testing
- Primary ankle arthrodesis (fusion), ORIF (open reduction and internal fixation), Intramedullary Fibular Nailing (IMFN)
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Humeral Fracture
Treatment of Humeral Fractures With Long PHILOS Plates Using a Modified Technique and Approach Avoids Radial Nerve Palsy
Radial paralysis is a well-known complication of plate osteosynthesis on the humeral shaft. At the University Hospital Basel, these fractures have been treated in an adapted procedure with long PHILOS plates using a modified…
- Trial name
- NCT05256849
- Where
- Switzerland
- Volunteers
- 61 people
- Sponsor
- University Hospital, Basel, Switzerland
Ankle Fractures
Diabetic Fibular Nail Study
Our null hypothesis is that fibular intramedullary fixation (IMFN) does not impact complication rates when compared to standard of care treatment with open reduction and internal fixation (ORIF).
- Trial name
- NCT05204485
- Testing
- Fibular intramedullary nail, Open reduction and internal fixation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Chicago
Metacarpal Shaft Fractures
metaCARpal Bone Osteosynthesis Trail
Background Metacarpal shaft fractures account for 30-50% of hand fractures (Karl et al., 2015; Kollitz et al., 2014; van Onselen et al., 2003), with diaphyseal spiral and oblique fractures of the second to fifth ray posing unique…
- Trial name
- CARBO (NCT07357493)
- Testing
- Non-operative treatment with early mobilization, Operative treatment
- Where
- Sweden
- Volunteers
- 552 people
- Sponsor
- Karolinska Institutet
Elbow Fracture, Elbow Arthropathy
Can Secondary Total Elbow Arthroplasty After Failed Internal Fixation or Non-operative Treatment of Distal Humeral Fractures Achieve Equal Results as Primary Arthroplasty?
Total elbow arthroplasty (TEA) results in immediate pain release with good functional results after distal humerus fractures. But still open reduction and internal fixation is recommended as treatment of choise due to a lifelong…
- Trial name
- NCT03302533
- Testing
- Total elbow arthroplasty
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Diakoniekrankenhaus Friederikenstift
Fracture Fixation, Internal
A Clinical Study to Evaluate the Safety and Efficacy of Biologic Hollow Bone Screws
Traditional fracture fixation devices can cause corrosion, allergies, and stress shielding effects. They often require removal after healing, risking secondary damage.
- Trial name
- NCT06942247
- Testing
- Active Comparator: Fracture Fixation (Inion Freedom Screws), Experimental: Fracture Fixation (Biological Hollow Bone Screws)
- Where
- China
- Volunteers
- 160 people
- Sponsor
- FengYafei
Ankle Fractures, Fracture
Outcome of Rehabilitation Following Internally Fixed Ankle Fractures
The purpose of this study is to examine the effect of variations in practice, ranging from early functional rehabilitation to complete immobilsation in post operative patients with ankle fixation following fractures.
- Trial name
- NCT02160197
- Testing
- Aircast XP Walker boot, Plaster Immobilisation
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- Countess of Chester NHS Foundation Trust
Fractures, Comminuted, Fracture Fixation, Internal
Comparative Study of Fixation or Fusion of Calcaneal Fractures
A multicentre randomized controlled trial that will be conducted at Level 1 trauma centres across Canada. It will compare patients who receive open reduction, internal fixation for Sanders IV calcaneal fractures to patients who…
- Trial name
- Sanders IV (NCT00679393)
- Testing
- Open reduction internal fixation, Fusion
- Where
- 4 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Distal Radius Fracture
Minimally Invasive Closed Reduction and Internal Fixation With Screws for Distal Radius Fracture
The purpose of this study is to confirm that minimally invasive closed reduction and internal fixation with fully threaded headless cannulated compression screws for distal radius fracture repair has advantages over conventional…
- Trial name
- NCT02784678
- Testing
- closed reduction group, open reduction group
- Volunteers
- 60 people
- Sponsor
- Shenyang Medical College
Tibia Distal Fracture, Nonunion of Fracture of Tibia
Is Far Cortical Locking More Effective Than Bicortical Locking in Treating AO 43A1-3 Fractures?
Delayed union or nonunion, which is a common complication of periarticular fractures repaired with angled locking plate systems, may be due to the unintentionally rigid formation of this system.
- Trial name
- NCT06005090
- Testing
- Far Cortical Locking Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Saglik Bilimleri Universitesi
Distal Radius Fracture
Early Mobilization After Volar Plate Osteosynthesis of Distal Radius Fractures
The aim of this study is to investigate the post operational mobilization after volar locking plate osteosynthesis of distal radius fractures.
- Trial name
- E-MOB (NCT01576224)
- Testing
- Removable splint "omni med", Fischer Medical Aps, DK-2800 Lyngby, Denmark
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Breast Ptosis
Hybrid Autologous Breast Augmentation in Mastopexy With Internal BRA Fixation; Using Local Breast Tissues and Fat Grafting
The breast is a very important organ for women's self-esteem and is regarded as a symbol of femininity. Deviations from normal size, shape, and symmetry are interpreted as unattractive and a sign of aging.
- Trial name
- NCT07197190
- Testing
- Autologous augmentation mastopexy with subpectoral lipofilling and upper and medial pole fat grafting.
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Assiut University
Humeral Shaft Fractures
Open Reduction and Internal Fixation of Humeral Midshaft Fracture: Anterior Versus Posterior Plate Fixation
About 13 out of 10,000 patients get a humeral shaft fracture each year, accounting for 1.0-3.0% of all fractures. The central part of the humerus is where 60% of all humeral fractures occur.
- Trial name
- NCT07775690
- Testing
- Open Reduction Internal Fixation (ORIF) using Anterior approach for plate fixation, Open Reduction Internal Fixation (ORIF) using Posterior approach for plate fixation
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Dr Jahanzaib Ramay
Unstable Ankle Fractures With Syndesmotic Disruption
Early vs Delayed Weightbearing After Surgical Fixation of Unstable Ankle Fractures With Syndesmosis Disruption
No study has prospectively compared a traditional post-operative non-weightbearing protocol versus early post-operative weightbearing as tolerated for unstable ankle injuries after surgical fixation of the syndesmosis.
- Trial name
- NCT05587842
- Testing
- Early Weightbearing management post operation, Delayed Weightbearing management post operation (Traditional)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Arizona