Clinical trials: Internal Limiting Membrane
Macular Holes
Comparative Analysis of Large Macular Hole Surgeries
This study compares the anatomical and visual outcomes in a large series of patients affected by idiopathic macular holes larger than 400 µm treated using pars plana vitrectomy and gas tamponade combined with internal limiting…
- Trial name
- CAOLMHS (NCT04116892)
- Testing
- the Cover group, the Fill group, the peeling group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epiretinal Membrane, Vitreomacular Traction
Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel
Epiretinal membranes (ERM) are cellular membranes on the surface of the retina that result in distortion of the vision (metamorphopsia), and decreased best-corrected visual acuity.
- Trial name
- NCT00892619
- Testing
- using ILM forceps alone, Breaking and peeling with end-grasping forceps
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Michael E. DeBakey VA Medical Center
Macular Hole, Macular Hole Surgery
Minimal Vitrectomy and ILM Flap with Sodium Hyaluronate Gel for MH
The purpose of this clinical trial is to compare the prognostic validity of two different surgical approaches: minimal posterior pole vitrectomy combined with a sodium hyaluronate gel-covered internal limiting membrane(ILM) flap…
- Conditions
- Macular Hole, Macular Hole Surgery, Idiopathic Macular Hole, Macular Hole of Left Eye (Disorder)
- Trial name
- ILM MH (NCT06685328)
- Testing
- minimal posterior pole vitrectomy combined with a sodium hyaluronate gel-covered internal limiting membrane(ILM) flap with balanced saline filling and postoperative supine position, Conventional vitrectomy combined with inner limiting membrane flap flip coverage with sterile air filling and postoperative prone position
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Jie Zhong
Macula Hole, Retinal Detachment
Amniotic Membrane for Recurrent Macular Hole
Macular hole surgery were tried by different surgeons using many techniques with different successes but still there were many recurrences.
- Conditions
- Macula Hole, Retinal Detachment, Myopic Macular Degeneration
- Trial name
- NCT03528122
- Testing
- Recurrent opened macular hole
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Minia University
Patients With Proliferative Diabetic Retinopathy Who Have Active Fibrovascular Proliferation
Pars Plana Vitrectomy for Diabetic Fibrovascular Proliferation With and Without Internal Limiting Membrane Peeling
Internal limiting membrane peeling in diabetic vitrectomy will help prevent postoperative epiretinal membrane formation
- Trial name
- NCT00556244
- Testing
- ILM peeling
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Macular Holes
Clinical Study of Translocated Internal Limiting Membrane Flap Reposition for the Treatment of Idiopathic Macular Hole
The main objective of this study is to evaluate the therapeutic effectiveness of the internal limiting membrane (ILM) peeling and translocation surgery compared to the conventional surgical approach for treating large idiopathic…
- Trial name
- NCT06063005
- Testing
- Translocation ILM Flap, ILM Peeling
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Macular Hole, Myopia
Efficacy and Safety of Myopic Macular Hole Closure Surgery Without Endotamponade Agent
Macular hole (MH) is a common condition that affects approximately 1.6/1000 elderly Chinese population. The prevalence is expected to be even higher in individuals with high myopia (HM), an established risk factor for MH.
- Trial name
- NCT07129798
- Testing
- ILM flap with no endotamponade technique
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Macular Pucker, Macular Cyst
Inner Nuclear Macular Microcyst is a Risk Factor for Macular Cystoid Changes After Phacoemulsification in Eyes With Previous Vitrectomy and Macular Pucker Removal
To evaluate the visual acuity, macular thickness, morphological changes after cataract surgery in eyes with previous vitrectomy for macular pucker. Associated risk factors were also investigated.
- Trial name
- NCT03934190
- Volunteers
- 46 people
- Sponsor
- Changhua Christian Hospital
Efficacy, Safety
Effect of PPV+ILM Peeling +/- Subretinal Injection of Ringer Lactate in Management of Nontractional Refractory DME
To evaluate the efficacy and safety of combined pars plana vitrectomy and planned foveal detachment through subretinal injection of ringer's solution in patients with non-tractional refractory diabetic macular edema.
- Trial name
- NCT06271473
- Testing
- vitrectomy + ILM peeling +/- planned foveal detachment via subretinal injection of ringer's solution.
- Where
- 2 sites in Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Macular Disease
Clinicopathologic Findings for Macular Disease
this study is to analyze and compare the ultrastructure of the retinal and vitreous plane of the epiretinal membrane and internal limiting membrane removed during macular surgery and to evaluate relation between the…
- Trial name
- NCT00994227
- Testing
- vitrectomy for macular disease
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Hallym University Medical Center
Macular Hole, Surgery
Internal Limiting Membrane Peeling-reposition to Treat Idiopathic Macular Holes
To compare the morphologic and functional outcomes of internal limiting membrane peeling-reposition versus peeling in idiopathic macular holes
- Trial name
- NCT03020459
- Testing
- peeling-reposition, peeling, Brilliant Blue G
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Macular Hole Surgery
Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole Surgery
The idiopathic macular hole, age-related disease, is a major cause of vision loss and affects at least two persons in 1000 after 40 years. This hole causes an acute decline linked to a central scotoma.
- Trial name
- MICROCOL (NCT02894424)
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Vitreoretinal Detachment, Vitreo-Retinal Adhesion
Microarchitecture of Vitreoretinal Contact
Investigation of the vitreoretinal contact microarchitecture in the macular and paramacular zones of the human retina.
- Trial name
- NCT04802889
- Testing
- scanning electron microscopy
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Maculopathy, High Myopia
Surgical Outcome of Vitrectomy for Myopic Traction Maculopathy in Highly Myopic Eyes
Surgical outcome of vitrectomy for myopic traction maculopathy in highly myopic eyes was evaluated in each stage. Efficacy of internal limiting membrane was also evaluated whether it may improve visual outcome.
- Conditions
- Maculopathy, High Myopia, Surgery
- Trial name
- NCT01658761
- Testing
- vitrectomy
- Where
- Japan
- Volunteers
- 64 people
- Sponsor
- Kyorin University
Macular Holes
ILM Peeling Versus Inverted Flap Technique for Treatment of Macular Hole: Near Visual Acuity Outcomes
A prospective randomised study comparing the near visual acuity outcomes using Salzburg Reading Desk in pseudophakic patients with idiopathic full-thickness macular hole treated with pars plana vitrectomy with internal limiting…
- Trial name
- NCT04698226
- Testing
- 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling and SF6 tamponade, 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Stage 2 or 3 Full Thickness Macular Hole
Full Thickness Macular Hole and Internal Limiting Membrane Peeling Study
A macular hole is a fairly common problem in the retina and is an important cause of loss of central vision. The aim of this study is to determine whether, in patients with a stage 2 or 3 full thickness macular hole (FTMH)…
- Trial name
- FILMS (NCT00286507)
- Testing
- Vitrectomy, post hyaloid detachment and gas injection with or without ILM peel.
- Where
- 9 sites in Ireland, United Kingdom
- Volunteers
- 141 people
- Sponsor
- University of Aberdeen
Macular Holes, Epiretinal Membrane
Comparison of Efficacy Between ILM Forceps
This study is a Single center, prospective, observational, multi surgeon randomized controlled trial. Subjects will be assessed pre-operatively, operatively and at 1 month postoperatively.
- Trial name
- NCT06536569
- Testing
- Internal limiting membrane (ILM) Peeling with Sharkskin Forceps, Internal limiting membrane (ILM) Peeling with Standard Forceps
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of British Columbia
Epiretinal Membrane, Macular Pucker
EpiRetinal Membrane Peeling and Internal Limiting Membrane
To study and compare visual acuity in patients undergoing removal of the epiretinal membrane with and without the removal of the internal limiting membrane at baseline versus 6 month.
- Conditions
- Epiretinal Membrane, Macular Pucker, Internal Limiting Membrane
- Trial name
- ERMP&ILM (NCT04802265)
- Testing
- Epiretinal membrane surgery
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Clermont-Ferrand
Epiretinal Membrane, Macular Pucker
Perioperative Topical Nepafenac After Epiretinal Membrane Surgery
This prospective comparative study evaluates whether perioperative topical nepafenac improves early anatomical and functional recovery after pars plana vitrectomy with epiretinal membrane and internal limiting membrane peeling.
- Trial name
- NEPERM (NCT07736690)
- Testing
- Nepafenac 0.1% Ophthalmic Suspension, Pars Plana Vitrectomy With Epiretinal Membrane and Internal Limiting Membrane Peeling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
Comparison of 3D Visualization and Microscope for VR Surgery
Damages From Macular Grasping During Vitrectomy Comparing Traditional and 3D Microscope
Randomized, prospective, descriptive and comparative clinical study. The comparison is between a group of patients affected by macular pucker or macular hole, whose macular peeling is performed using a traditional optical…
- Trial name
- NCT05113212
- Testing
- Macular surgery with NGENUITY surgical display system, Macular surgery with standard operating microscope
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Anna Rita Daniele, MD