Clinical trials: Internal Limiting Membrane
Macular Holes
The Use of Amniotic Membrane or Internal Limiting Membrane for Large or Refractory Macular Holes: A Prospective Study
Prospective, randomized, unmasked interventional study. To evaluate anatomical and functional results through microperimetry in cases of refractory or large macular holes (MH), using amniotic membrane (AM) or internal limiting…
- Trial name
- NCT04904679
- Testing
- Pars plana Vitrectomy with internal limiting membrane peeling
- Where
- 2 sites in Brazil
- Volunteers
- 23 people
- Sponsor
- Hospital Oftalmologico de Sorocaba
Epiretinal Membrane, Macular Pucker
Intraoperative Analysis of the Central Retina in ERF
Changes in the retinal anatomy that occur in epiretinal fibrosis have not been sufficiently studied. It is possible that epiretinal fibrosis leads not only to traction dislocation of the macula, but also to ILM anatomical…
- Trial name
- NCT04802915
- Testing
- Intraoperative ERM and ILM staining with their assessment and removal
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Myopic Traction Maculopathy
Predictors of Vitrectomy Outcomes in Myopic Foveoschisis
This prospective pilot study evaluates factors that predict outcomes after vitrectomy for myopic foveoschisis (MFS), a sight-threatening complication of high myopia that can lead to progressive visual loss, foveal detachment…
- Trial name
- NCT07774637
- Testing
- pars plana vitrectomy
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore National Eye Centre
Myopic Traction Maculopathy, Pars Plana Vitrectomy
Vitrectomy With Internal Limiting Membrane Peeling for Myopic Traction Maculopathy
Investigate the effectiveness and safety of pars plans vitrectomy, with internal limiting membrane peeling for cases of myopic traction maculopathy
- Conditions
- Myopic Traction Maculopathy, Pars Plana Vitrectomy, Internal Limiting Membrane Peeling
- Trial name
- NCT04278079
- Testing
- Pars Plana Vitrectomy with Internal Limiting Membrane peel
- Volunteers
- 52 people
- Sponsor
- Tanta University
Diabetic Retinopathy, Macular Edema
ILM Peeling in PDR Patients Undergoing PPV for VH
Subjects undergoing ILM peeling during vitrectomy will have better visual acuity and lower rates of DME to control subjects
- Trial name
- NCT03660371
- Testing
- PPV/MP, PPV without MP
- Where
- Mexico
- Volunteers
- 258 people
- Sponsor
- Rush Eye Associates
Macula Hole
Macular Hole Surgery With Temporal Inverted Internal Limiting Membrane Flap (MARTIAL)
Since 1991, idiopathic macular holes (MH) can benefit from an effective treatment initially involving pars plana vitrectomy, stripping of epiretinal membranes and intraocular gas tamponade followed by facedown positioning.
- Trial name
- MARTIAL (NCT03287102)
- Testing
- Macular hole surgery
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Macular Hole Surgery, ILM Peeling
Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study)
The aim of this study is to compare the functional visual outcomes, anatomical closure rate and macular perfusion changes assessed by OCT and OCTA after surgical repair of macular hole using Tenon capsule graft versus ILM flap.
- Conditions
- Macular Hole Surgery, ILM Peeling, Tenon Capsule, ILM Flap
- Trial name
- NCT07633457
- Testing
- vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)]
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Internal Limiting Membrane Peeling
Internal Limiting Membrane Peeling on Retinal Displacement
The purpose of this study is to investigate displacement of the retina after idiopathic macular hole surgery with different internal limiting membrane peeling patterns.
- Trial name
- NCT04655781
- Testing
- idiopathic macular hole (MH) surgery
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hacular Hole Repair
The (Flip and Fix) Internal Limiting Flap Technique Versus the Classic Temporal Flap for Macular Hole Repair
Purpose To describe a novel technique of MH repair and compare it to the perfluorocarbon liquid (PFCL) assisted temporal ILM flap technique.
- Trial name
- Flip and Fix (NCT06441656)
- Testing
- Vitrectomy with ILM flap
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Alexandria University
Macular Hole
Internal Limiting Membrane Peeling for Large Macular Holes
Rational of the study: for macular holes larger than 400 µm the rate of failure is of more than 20%. It is for these eyes that it is necessary to show the benefit of internal limiting membrane (ILM) peeling in term of vision and…
- Trial name
- NCT00190190
- Testing
- With Peeling of Limiting the Intern of the Retina, Internal limiting membrane peeling
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epiretinal Membrane
Change in Foveal Avascular Zone After Removal of Epiretinal Membrane and Internal Limiting Membrane
Fovea is characterized by its vessel-free zone, called foveal avascular zone and it can be visualized by fluorescein angiography.
- Trial name
- NCT01985490
- Testing
- epiretinal membrane and internal limiting membrane removal
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Idiopathic Epiretinal Membrane
Macular Resurfacing Using Autologous ILM Patch Transposition for Idiopathic Epiretinal Membrane
Idiopathic epiretinal membrane is a condition in which abnormal tissue grows on the surface of the retina and can cause blurred vision and distortion.
- Trial name
- NCT07767539
- Testing
- Non-Inverted Autologous Internal Limiting Membrane (ILM) Patch Transposition, Conventional Epiretinal Membrane and Internal Limiting Membrane Peeling
- Volunteers
- 90 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Retinal Disease, Epiretinal Membrane
Effects of Internal Limiting Membrane Peeling on Visual Function in Epiretinal Membrane Surgery
The patients who are diagnosed with idiopathic epiretinal membrane and scheduled to undergo epiretinal membrane removal will be treated with conventional vitrectomy and the epiretinal membrane will be removed.
- Trial name
- NCT04130841
- Testing
- Internal Limiting Membrane Peeling
- Where
- South Korea
- Volunteers
- 135 people
- Sponsor
- Seoul National University Hospital
Retinal Detachment
Evaluation of Visual Functions After Pars Plana Vitrectomy With and Without Internal Limiting Membrane Peeling in RRD
Internal limiting membrane peeling is performed during vitrectomy for macular diseases such as macular holes, macular edema due to diabetic retinopathy and retinal vein occlusion.
- Trial name
- NCT04139811
- Testing
- Pars Plana Vitrectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Macular Edema
Mechanical Properties of the Internal Limiting Membrane and Intraoperative Utility of Brilliant Blue g (Bbg) and Indocyanine Green (Icg) Assisted Chromovitrectomy
Intravitreal dyes are intended to make the surgical extraction of the Internal limiting membrane (ILM) safer and more complete. However, the search for an adequate vitaly dye is ongoing.
- Trial name
- NCT01485575
- Testing
- Use of intraoperative filters in vitrectomy
- Where
- 3 sites in Austria, Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Retinal Sensitivity
Foveal Sparing of the ILM
To compare the retinal sensitivity of complete internal limiting membrane (ILM) peeling versus foveal sparing ILM peeling during vitrectomy for epiretinal membrane or macular hole.
- Trial name
- NCT03488576
- Testing
- Complete Macular Peeling, Macular Peeling with Foveal Sparing
- Volunteers
- 190 people
- Sponsor
- Università degli Studi di Brescia
Epiretinal Membrane
Randomized Trial Comparing Epiretinal Membrane Surgery With and Without Internal Limiting Membrane Removal
Macular epiretinal membrane (ERM) is a semitranslucent, avascular, fibrocellular membrane on the inner surface along the internal limiting membrane (ILM) of the retina.
- Trial name
- NCT01532765
- Testing
- Pars plana vitrectomy and epiretinal membrane peel, ILM peel assisted by ICG, CE-IOL
- Where
- 3 sites in Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Optic Disc Structural Anomaly, Maculopathy
Surgical Management of Optic Disc Pit Maculaopathy
To evaluate the anatomical and functional results of pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) peeling, endolaser photocoagulation and gas tamponade in management of optic disc pit (ODP)…
- Trial name
- NCT03185936
- Testing
- pars plana vitrectomy with internal limiting membrane (ILM) peeling
- Volunteers
- 9 people
- Sponsor
- Minia University
Epiretinal Membrane of Both Eyes
Optical Coherence Tomography Angiography (OCTA) Changes in Patients With Epiretinal Membranes (ERM) With and Without Peeling of the Internal Limiting Membrane (ILM)
Main objective The objective is to compare two surgical options in vitrectomies for epiretinal membranes using parameters of optical coherence tomography angiography.
- Trial name
- NCT05287009
- Testing
- ILM nonpeeling, ILM peeling
- Where
- Austria
- Volunteers
- 51 people
- Sponsor
- Medical University of Graz