Clinical trials: Internal Medicine
Insomnia
An Investigational Drug Study in Healthy Adult Volunteers in a Model of Insomnia (0928-007)
A study to evaluate the safety and effectiveness of an investigational drug for insomnia (a sleep disorder).
- Trial name
- NCT00102154
- Testing
- MK0928, gaboxadol / Duration of Treatment: 10 months
- Volunteers
- healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Cardiovascular Diseases, Endothelial Dysfunction
Anti-Inflammatory Drug and Endothelial Function
In this randomized double-blinded clinical trial, 400mg of hydroxychloroquine will be given daily to people over the age of 65 years with moderate-severe obstructive sleep apnea for 8 weeks.
- Conditions
- Cardiovascular Diseases, Endothelial Dysfunction, Sleep Apnea, Atherosclerosis
- Trial name
- HOLD (NCT04161339)
- Testing
- Hydroxychloroquine
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Oncolytic Virus, Diffuse Intrinsic Pontine Glioma
Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma
This is a drug safety assessment clinical trial with a 3+3 dose escalation design, to observe the safety, tolerability and toxicity of a novel oncolytic virus Ad-TD-nsIL12 intratumoral injection in primary DIPG patients…
- Conditions
- Oncolytic Virus, Diffuse Intrinsic Pontine Glioma, Adverse Drug Event
- Trial name
- NCT05717712
- Testing
- Ad-TD-nsIL12
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Capital Medical University
Traditional Chinese Medicine, Insomnia
Insomnia Treated by Traditional Chinese Medicine and Its Circadian Rhythm
Insomnia and sleep disorders are prominent health problems in modern society. High working pressure, fast pace of life, the use of electronic products and other reasons lead to the high incidence of insomnia and sleep disorders…
- Conditions
- Traditional Chinese Medicine, Insomnia, Circadian Rhythm
- Trial name
- NCT04448197
- Testing
- Chinese Medicine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Obstructive Sleep Apnoea, Sleep-Disordered Breathing
Drug-Induced Sleep Endoscopy for the Optimisation of Treatment of Patients With Obstruction Sleep Apnoea
The main diagnostic challenge in patients with OSA (obstructive sleep apnea) is to determine the location of obstruction of the upper airway during sleep.
- Trial name
- NCT02855515
- Testing
- Short-time diagnostic anaesthesia
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Fatigue Symptom, Fatigue
Chronic Fatigue in the Internal Medicine Outpatient Clinic: a Mixed-methods Quantitative and Qualitative Study
With this study, the investigators aim to answer the following research questions: 1. In what percentage of cases does the diagnostic process conducted during a fatigue consultation at the internal medicine outpatient clinic…
- Conditions
- Fatigue Symptom, Fatigue, Fatigue Syndrome, Chronic
- Trial name
- NCT06775262
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Flevoziekenhuis
Pneumology, Hematology
Determination of Voriconazole Levels in Saliva - Validation in Specific Subsets of Patients
The purpose of this study is to investigate the intra-saliva penetration of voriconazole in different subpopulations. The goal is to develop, optimize and validate an easy, non-invasive and painless procedure for Therapeutic Drud…
- Conditions
- Pneumology, Hematology, Internal Medicine, Pediatrics
- Trial name
- NCT01418846
- Where
- 3 sites in Belgium
- Volunteers
- 11 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Poor Quality Sleep, Opiate Addiction
Insomnia and Drug Relapse Risk
The purposes of this study are: 1. to evaluate the relationship between subjective complaints of sleep and objective measures of sleep quality, as measured through polysomnography, and 2.
- Trial name
- NCT00253890
- Testing
- Trazodone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Butler Hospital
Sleep Problems, Haemodialysis
Melatonin and Quality of Life in Dialysis Patients
Sleep problems can lead to a bad quality of life and a raise of morbidity, also in dialysis patients. Sleep problems can be caused by a disturbance of circadian rhythms in our body.
- Trial name
- NCT00388661
- Testing
- Melatonin tablet 3 mg once daily
- Where
- 2 sites in Netherlands
- Volunteers
- 68 people
- Sponsor
- Meander Medical Center
The Focus is to Test a Survey Predicting Readmissions, Inpatient Internal Medicine Patients
A Study Evaluating the Use of Potential Predictors of Readmission in Hospitalized Medicine Patients
The primary objective of this study is the development and implementation of a survey administered to hospitalized patients on Internal Medicine that can be used in conjunction with previously validated predictive indices to…
- Trial name
- NCT03791541
- Testing
- Pharmacist services
- Where
- United States
- Sponsor
- University of Illinois at Chicago
Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs)
Impact of Pharmacotherapy Optimization in Polymedicated Lebanese Older Adults in Primary Health Care Centers
Why are the researchers doing this study? Many older adults take five or more medicines every day. Some of these medicines may no longer help them. Some may even cause harm, such as falls, confusion or tiredness.
- Conditions
- Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs), Primary Health Care, Social Determinants of Health (SDOH)
- Trial name
- PHARMACT-PHC (NCT07866677)
- Testing
- Structured pharmacotherapy optimization, Usual Care
- Where
- Lebanon
- Volunteers
- 452 people
- Sponsor
- National Institute of Public Health, Clinical Epidemiology, and Toxicology-Lebanon (INSPECT-LB)
Patient Hospitalized in Internal Medicine Unit
SCORE of Medication Error in Internal Medecin Unit
Transfers between interfaces of care are recognized as a source of medication discrepancies, medication errors (MEs) and potentially adverse drug events.
- Trial name
- SCOREME (NCT03422484)
- Testing
- Detection and correction of medication error at hospital admission
- Where
- France
- Volunteers
- 1,957 people
- Sponsor
- University Hospital, Montpellier
Diffuse Intrinsic Pontine Glioma
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
Diffuse Intrinsic Pontine Gliomas (DIPG) appear almost exclusively in children and adolescents, representing 15 to 20% of posterior fossa tumours.
- Trial name
- BIOMEDE (NCT02233049)
- Testing
- Erlotinib, Everolimus, Dasatinib
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Wireless Vital Signs Monitoring System, Acutely Ill Complex and Poly-pathological Patients
Role of Wireless Monitoring in Internal Medicine Unit for Ongoing Assessment of Acute Instable Patients
The present study was planned to provide clinical data on the impact of acute and critically ill patients in Internal Medicine Unit activity and economic data enabling to quantify the relative cost of acute patients management…
- Conditions
- Wireless Vital Signs Monitoring System, Acutely Ill Complex and Poly-pathological Patients, Internal Medicine Unit Mission
- Trial name
- LiMS (NCT03050034)
- Testing
- WIN @ Hospital system, Traditional monitoring
- Where
- Italy
- Volunteers
- 296 people
- Sponsor
- Azienda Socio Sanitaria Territoriale del Garda
Sleep Apnea
Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea
The purpose of this research study is to determine the effect of chronic nighttime low oxygen saturations on selected body systems (liver) that break down drugs in children with obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT00310323
- Testing
- Dextromethorphan, Caffeine
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Virginia Commonwealth University
Venous Thromboembolism, Deep Venous Thrombosis
Rate of Venous Thrombosis in Acutely Ill Patients Hospitalized in Internal Medicine Wards
After reports from observational studies suggesting an association between acutely ill medical patients and venous thromboembolism (VTE), interventional trials with anticoagulants drugs have demonstrated a significant reduction…
- Trial name
- AURELIO (NCT03157843)
- Testing
- low-molecular-weight heparin
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Roma La Sapienza
Addiction, Substance Abuse Drug Chronic
Stage III Community-based Efficacy Trial for Mothering From the Inside Out
This is a Stage III community-based randomized clinical efficacy trial testing Mothering from the Inside Out (MIO), the first evidence-based parenting intervention designed to be delivered by addiction counselors in addiction…
- Conditions
- Addiction, Substance Abuse Drug Chronic, Child Neglect, Child Neglect Emotional
- Trial name
- NCT02955199
- Testing
- Mothering From the Inside Out (MIO), Parent Education
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Yale University
Insomnia
Reducing Use of Sleep Medications Assisted by a Digital Insomnia Intervention
Chronic insomnia is one of the most common health problems among Veterans and significantly impacts their health, function, and quality of life.
- Trial name
- SEDATIVE (NCT05027438)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Deprescribing
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development