Clinical trials: Interstitial Lung Diseases
Sarcoidosis, Pulmonary, Sarcoidosis Skin
the PHENOSAR Trial: Use of Antibiotics in Treatment of Sarcoidosis
In this study it is investigated whether treatment with azithromycin in combination with doxycycline reduces the bacterial load of C.
- Trial name
- NCT05291468
- Testing
- FDG-PET/CT
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- St. Antonius Hospital
Granulomatosis With Polyangiitis
A Phase IIa Study of Intravenous Rituximab in Pediatric Participants With Severe Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis
This Phase IIa international multicenter, open-label, uncontrolled study will evaluate the safety and pharmacokinetics of rituximab (MabThera/Rituxan) in pediatric participants with severe granulomatosis with polyangiitis (GPA)…
- Trial name
- NCT01750697
- Testing
- Rituximab
- Where
- 23 sites in United States, Canada and 6 more
- Volunteers
- 25 people
- Sponsor
- Hoffmann-La Roche
Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
It's Not JUST Idiopathic Pulmonary Fibrosis Study
Study of progression of fibrosis in ILD
- Trial name
- INJUSTIS (NCT03670576)
- Testing
- Optional Bronchoscopy, Quality of Life Questionnaires, Blood Samples for Biomarkers
- Where
- 24 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Nottingham
Diffuse Parenchymal Lung Disease, Frailty
Evaluation of Patients With Diffuse Parenchymal Lung Diseases Regarding Frailty
There are very few studies in the literature examining the frailty levels of diffuse parenchymal lung disease (DPLD) patients and its effect on their functional status despite the high prevalance of frailty in patients with DPLD…
- Conditions
- Diffuse Parenchymal Lung Disease, Frailty, Physical Inactivity
- Trial name
- NCT06171425
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Progressive Pulmonary Fibrosis, Interstitial Lung Disease
SUPPORT-T in Patients With Progressive Pulmonary Fibrosis and Their Caregivers
This pilot randomized controlled trial evaluates the feasibility, acceptability, and accessibility of SUPPORT-T, a digitally delivered palliative care intervention for patients with Progressive Pulmonary Fibrosis (PPF) and their…
- Trial name
- NCT07269262
- Testing
- SUPPORT-T Educational Intervention
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Medical University of South Carolina
Idiopathic Pulmonary Fibrosis (IPF)
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MNKD-201 in Patients With Idiopathic Pulmonary Fibrosis
MKC-NI-002 is a Phase 1b, randomized, double-blind, placebo-controlled study of nintedanib inhalation powder (MNKD-201) in patients with Idiopathic Pulmonary Fibrosis (IPF).
- Trial name
- NCT07344558
- Testing
- MNKD-201(Nintedanib DPI)
- Where
- 9 sites in United States
- Volunteers
- 27 people
- Sponsor
- Mannkind Corporation
Interstitial Lung Disease
Pursed Lip Breathing in Interstitial Lung Disease
This randomized, cross-over study aims at describing the effect of pursed lip breathing on exercise-induced dyspnea and exercise capacity in patients with interstitial lung disease.
- Trial name
- NCT02934750
- Testing
- Pursed lip breathing
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Lung; Disease, Interstitial, With Fibrosis, Dermatomyositis
Basiliximab Treating Interstitial Pneumonia of CADM
This is a 52-week, randomized, open and routine treatment controlled study. This study will assess the safety and efficacy of basiliximab as an add-on treatment for interstitial pneumonia in clinical amyopathic dermatomyositis…
- Trial name
- NCT03192657
- Testing
- Basiliximab, Calcineurin Inhibitors, Steroids
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Interstitial Lung Disease
Hyperpolarized 129Xe MRI for Imaging Pulmonary Function
The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function.
- Trial name
- NCT01280994
- Testing
- Hyperpolarized 129Xenon Gas
- Where
- United States
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Interstitial Lung Disease, Pulmonary Hypertension
Biomarkers in Pulmonary Hypertension Associated to Interstitial Lung Disease
The presence of an abnormally increased pulmonary blood pressure worsens the prognosis of patients with interstitial pulmonary disease.
- Conditions
- Interstitial Lung Disease, Pulmonary Hypertension, Biomarkers
- Trial name
- NCT00820729
- Where
- 2 sites in Denmark
- Volunteers
- 212 people
- Sponsor
- University of Aarhus
Idiopathic Pulmonary Fibrosis
Prospective Study of Fibrosis In the Lung Endpoints (PROFILE - Central England)
The overall aim of this study is to develop a test that predicts the prognosis of IPF (Idiopathic Pulmonary Fibrosis) and which could be used to determine whether new treatments for IPF are likely to work.
- Trial name
- PROFILE (NCT01134822)
- Where
- United Kingdom
- Volunteers
- 330 people
- Sponsor
- University of Nottingham
Idiopathic Pulmonary Fibrosis
Feasibility & Effect of a Tele-rehabilitation Program in Idiopathic Pulmonary Fibrosis (IPF)
Introduction Idiopathic Pulmonary Fibrosis (IPF) is a progressive fibrotic lung disease of unknown cause with a median survival of 3-5 years.
- Trial name
- 3-IPF (NCT03548181)
- Testing
- Virtual Autonomous Physiotherapist Agent (VAPA)
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Hypertension, Pulmonary, Lung Diseases, Interstitial
Study of TX000045 in Participants With Pulmonary Hypertension Due to Interstitial Lung Disease
The primary purpose of this study is to assess the effect of TX000045 on pulmonary vascular resistance (PVR) in participants with pulmonary hypertension secondary to interstitial lung disease (PH-ILD) and to assess the safety and…
- Trial name
- NCT07473700
- Testing
- TX000045
- Where
- 16 sites in United States, Poland and 4 more
- Volunteers
- 25 people
- Sponsor
- Tectonic Operating Company, Inc.
COVID-19, Critical Illness
Immune Modulation by Exosomes in COVID-19
Following whole blood stimulation with mesenchymal stem cell derived exosomes, immune phenotype, cytokine release and mRNA expression patterns from critically ill patients with COVID-19 will be determined.
- Conditions
- COVID-19, Critical Illness, Hypercytokinemia, Lung Fibrosis
- Trial name
- IMECOV19 (NCT05191381)
- Testing
- Application of exosomes in a whole blood assay
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease in Patients With Rheumatoid Arthritis
Teleconsultation Approach to CTD-ILD Care Delivery in Rural UnderServed CommuniTies (TRUST Initiative)
Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a rare and complex condition that affects some individuals with autoimmune disorders such as rheumatoid arthritis (RA).
- Conditions
- Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease in Patients With Rheumatoid Arthritis, Interstitial Lung Disease Due to Systemic Disease
- Trial name
- NCT07217093
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St. Lawrence Health System
Interstitial Lung Disease, Scleroderma
CompRehensive Phenotypic Characterization of Patients With Scleroderma-Associated ILD and PH
Patients with interstitial lung disease (ILD) and scleroderma who develop pulmonary hypertension (PH) do not fit well into the current classification system and treatments for pulmonary hypertension.
- Conditions
- Interstitial Lung Disease, Scleroderma, Pulmonary Hypertension
- Trial name
- CRUSADE (NCT03726398)
- Testing
- Opsumit 10 Mg Tablet
- Where
- United States
- Sponsor
- Franz Rischard, DO
Idiopathic Pulmonary Fibrosis
A Study to Evaluate the Efficacy and Safety of AK3280 in Patients With Idiopathic Pulmonary Fibrosis
This study is a randomized, double-blind, placebo-controlled, multi-center phase II clinical study conducted in China to compare the efficacy and safety of two different dose groups of AK3280 in IPF patients compared to the…
- Trial name
- NCT05424887
- Testing
- AK3280
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Shanghai Ark Biopharmaceutical Co., Ltd.
Mediastinal Lymphadenopathy, Mediastinal Lesions
Safety and Performance Profile of Cryobiopsy in Bronchial Endoscopy
Transbronchial cryobiopsy is a relatively recent technique, increasingly used for the diagnosis of various respiratory diseases, including neoplasms, diffuse interstitial lung diseases (ILDs), and rejection after lung…
- Conditions
- Mediastinal Lymphadenopathy, Mediastinal Lesions, Diffuse Interstitial Lung Diseases
- Trial name
- SeReCryo (NCT07301697)
- Testing
- performance of a transbronchial cryobiopsy or EBUS-cryobiopsy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Idiopathic Pulmonary Fibrosis, IPF
Biomarker Modulation and the Inhibition of NKT1 Cells by Oral GRI-0621 in Patients With IPF
This is a Phase 2a, randomized, double-blind, multi-center, placebo-controlled, parallel-design, 2-arm study. Approximately 36 subjects with IPF will be randomized in a 2:1 ratio for GRI-0621 4.5mg or Placebo.
- Trial name
- NCT06331624
- Testing
- Tazarotene (GRI-0621)
- Where
- 16 sites in United States, Australia and 1 more
- Volunteers
- 35 people
- Sponsor
- GRI Bio Operations, Inc.
Interstitial Lung Disease, Surfactant Dysfunction
Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes
The aim of this proposed study is to evaluate the efficacy and safety of hydroxychloroquine (HCQ) in children's interstitial lung diseases(chILD) with genetic causes. This study is a randomized controlled clinical trial.
- Trial name
- NCT04532346
- Testing
- Hydroxychloroquine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University