Clinical trials: Interstitial Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF), Progressive Pulmonary Fibrosis
A Pilot Study to Assess Body Mass Composition Measurement Using BIA and Muscle Ultrasound in IPF and PPF Patients on Anti-fibrotic Medications
To assess the impact on body mass composition from anti-fibrotic medications used in fibrotic lung disease by using BIA and muscle ultrasound
- Trial name
- AF-BMC (NCT07332117)
- Testing
- No Interventions, No intervention
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Interstitial Lung Disease (ILD)
Better Tests- Improving Diagnostic Accuracy and Prognostication in Interstitial Lung Diseases
Patients with interstitial lung diseases (ILD) suffer significant delays in obtaining a diagnosis, and objective evidence of support for immunosuppressive therapies, due to weaknesses in the diagnostic tests available in ILD…
- Trial name
- Better Tests (NCT07615504)
- Where
- 3 sites in United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Cough, ILD
A Non-pharmacological Cough Control Therapy
Coughing affects almost all individuals with ILD leading to physical, psychological and social distress and prevents individuals from performing their activities of daily living, working or socialising in public places.
- Conditions
- Cough, ILD, Pulmonary Disease, Pulmonary Fibrosis
- Trial name
- NCT04767074
- Testing
- Non-pharmacological Cough control Therapy
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- West Park Healthcare Centre
Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis
129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study
This research is a study to test the reliability of Hyperpolarized Xenon MRI (HXe MRI) as a biomarker in interstitial lung disease.
- Trial name
- NCT04677426
- Testing
- Hyperpolarized Xe129
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Idiopathic Pulmonary Fibrosis
A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of SM04646 Inhalation Solution in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
SM04646-IPF-03 is a Phase 2a, multi-center, open-label study evaluating the safety and efficacy of a single inhaled, nebulized dose of SM04646 solution over a 12-week treatment regimen in subjects with mild to moderate IPF.
- Trial name
- NCT03591926
- Testing
- SM04646
- Where
- 6 sites in Australia, New Zealand
- Sponsor
- Biosplice Therapeutics, Inc.
Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
The Role of Rheumatological Evaluation in the Management of Patients With Interstitial Lung Disease
We hypothesized that the multi-disciplinary assessment of interstitial lung disease patients would lead to a more accurate diagnosis and consequently alterations in treatment regimens that may lead to improved outcomes.
- Conditions
- Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Connective Tissue Disease
- Trial name
- NCT01809574
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Meir Medical Center
Lung; Disease, Interstitial, With Fibrosis, Dermatomyositis
Basiliximab Treating Interstitial Pneumonia of CADM
This is a 52-week, randomized, open and routine treatment controlled study. This study will assess the safety and efficacy of basiliximab as an add-on treatment for interstitial pneumonia in clinical amyopathic dermatomyositis…
- Trial name
- NCT03192657
- Testing
- Basiliximab, Calcineurin Inhibitors, Steroids
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Idiopathic Pulmonary Fibrosis (IPF)
Downhill Walking in IPF
In this study; will examine the effects of downhill walking (eccentric exercise training) on exercise capacity, quality of life, and blood lactate levels in individuals with IPF.
- Trial name
- NCT06756230
- Testing
- Pulmonary Rehabilitation, Downhill Walking, Treadmill Walking without incline
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Saglik Bilimleri Universitesi
Pulmonary Fibrosis, COVID-19
Pulmonary Fibrosis After Severe COVID-19 Pneumonia
Patients discharged after hospitalization for COVID-19 pneumonia were retrospectively selected by radiologically established criteria that at admission presented at chest computed tomography (CT) (i) normal lung parenchyma <50%…
- Trial name
- SPIFFERO (NCT06423560)
- Testing
- Computed tomography
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- IRCCS San Raffaele
Idiopathic Pulmonary Fibrosis, Gastroesophageal Reflux
Treatment of IPF With Laparoscopic Anti-Reflux Surgery
This study will test the hypothesis that treatment with laparoscopic anti-reflux surgery in subjects with idiopathic pulmonary fibrosis (IPF) and abnormal gastroesophageal reflux (GER) will slow the decline of forced vital…
- Trial name
- WRAP-IPF (NCT01982968)
- Testing
- Surgery
- Where
- 5 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of California, San Francisco
Pulmonary Fibrosis
Evaluating the Effectiveness of Prednisone, Azathioprine, and N-acetylcysteine in Patients With IPF
Idiopathic pulmonary fibrosis (IPF) is a long-term lung disease that affects an individual's ability to breathe. In this randomized, double-blind, placebo-controlled trial, we assigned patients with idiopathic pulmonary fibrosis…
- Trial name
- PANTHER-IPF (NCT00650091)
- Testing
- N-acetylcysteine (NAC)
- Where
- 26 sites in United States
- Volunteers
- 264 people
- Sponsor
- Duke University
Pulmonary Fibrosis
Oxygen Nanobubble Drink Impact on Exercise in Pulmonary Fibrosis
Approximately 1 in 5 (or 12.7 million adults) in the UK have longstanding respiratory illnesses, and 6.5 million patients report taking prescription medication to ease the burden.
- Trial name
- NCT05711290
- Testing
- Oxygen Nanobubble
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Oxford
Fibrotic Interstitial Lungs Diseases, Idiopathic Pulmonary Fibrosis (IPF)
Study on the Efficacy of Quercetin Intake in Patients With Fibrotic Interstitial Lung Diseases.
Fibrotic interstitial lung diseases (F-ILDs), including both idiopathic pulmonary fibrosis (IPF) and non-IPF, are chronic and progressive lung diseases characterized by excessive scarring of lung tissue, leading to declining lung…
- Conditions
- Fibrotic Interstitial Lungs Diseases, Idiopathic Pulmonary Fibrosis (IPF), Progressive Pulmonary Fibrosis
- Trial name
- NCT07466420
- Testing
- Quercetin (dietary supplement), Usual treatment
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Katerina M. Antoniou
Idiopathic Pulmonary Fibrosis
Respiratory Muscle Strength in Patients With Idiopathic Pulmonary Fibrosis
Respiratory muscle strength, dyspnea perception, physical activity and quality of life measurements will be performed and groups will be compared in two groups consisting of patients with idiopathic pulmonary fibrosis referred to…
- Trial name
- NCT03588260
- Testing
- no intervention - cross-sectional observational only
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Pulmonary Fibrosis, Hypertension, Pulmonary
Sildenafil to Increase Exercise Capacity in Individuals With Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects an individual's ability to breathe. Currently, no medications can reverse the damage to the lungs caused by IPF, but individuals are encouraged to engage…
- Trial name
- NCT00352482
- Testing
- Sildenafil (50 mg)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Idiopathic Pulmonary Fibrosis
Jin-shui Huan-xian Granule in the Treatment of IPF
This study is to evaluate the efficacy and safety of Jin-shui Huan-xian granule for idiopathic pulmonary fibrosis (IPF), establish the treatment scheme, and obtain the high quality clinical evidences.
- Trial name
- NCT04187690
- Testing
- Jin-shui Huan-xian granule
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Henan University of Traditional Chinese Medicine
HIV Infections
The Safety and Effectiveness of Zidovudine in the Treatment of HIV-Infected Children With Mild to Moderate Symptoms
To determine the safety and usefulness of zidovudine (AZT) for the treatment of children 3 months to 12 years of age. This study is designed to determine if children who are infected with HIV and who have a special type of lung…
- Trial name
- NCT00000990
- Testing
- Zidovudine
- Where
- 33 sites in United States
- Volunteers
- 224 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Idiopathic Pulmonary Fibrosis
Pulmonary Rehabilitation for Idiopathic Pulmonary Fibrosis
The purpose of this study is to determine the effects of Pulmonary Rehabilitation (PR) on shortness of breath, exercise capacity, symptom control, mental health, cognitive function, and quality of life in patients with Idiopathic…
- Trial name
- NCT00692796
- Testing
- Pulmonary rehabilitation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Jewish Health
Idiopathic Pulmonary Fibrosis
(ARTEMIS-IPF) Randomized, Placebo-Controlled Study to Evaluate Safety and Effectiveness of Ambrisentan in IPF
The ARTEMIS-IPF study was conducted to determine if ambrisentan was effective in delaying disease progression and death in participants with idiopathic pulmonary fibrosis (IPF), to evaluate its safety, and to evaluate its effect…
- Trial name
- ARTEMIS-IPF (NCT00768300)
- Testing
- Ambrisentan
- Where
- 185 sites in United States, Argentina and 20 more
- Volunteers
- 494 people
- Sponsor
- Gilead Sciences
Idiopathic Pulmonary Fibrosis
Evolution of Lung 18FDG Uptake in Patients With Idiopathic Pulmonary Fibrosis and Receiving Pirfenidone
Idiopathic pulmonary fibrosis (IPF) is a rare and fatal lung disease characterized by unpredictable changes with variable kinetics of progression.
- Trial name
- PET-Fibrosis (NCT03692481)
- Testing
- 18FDG-PET scan
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris