Clinical trials: Intervention Effectiveness
Segment Elevation Myocardial Infarction (STEMI)
NATURE (EnVast as an Adjunct PPCI in Subjects Presenting With STEMI)
This study is designed to compare the safety and effectiveness of blood clot (thrombus) removal in subjects presenting with ST-segment elevation myocardial infarction (STEMI) with the enVast coronary system versus conventional…
- Trial name
- NATURE (NCT04969471)
- Testing
- enVast stent, conventional treatment
- Where
- 11 sites in Italy, Netherlands and 1 more
- Volunteers
- 148 people
- Sponsor
- Vesalio
Cancer, Pain
Study of the Efficacy of Kalinox® 170 Bar in Adult Oncology
In the oncology practice, The National Union of the Centres of Fight Against the Cancer recently published the Standards, Options and Recommendations for the coverage of the pains provoked during the invasive gestures of a short…
- Trial name
- NCT00646945
- Testing
- 50% Oxygen/50% Nitrous oxide premix (Kalinox 170 bar), 50% Oxygen/50% Nitrogen premix
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Air Liquide Santé International
Arthritis, Psoriatic
Study to Evaluate the Real-World Effectiveness, Safety and Tolerability of Treatment With Apremilast in Psoriatic Arthritis Patients Followed in Canadian Routine Care (APPRAISE)
This will be a Canadian observational study utilizing a prospective cohort design. Patients with active psoriatic arthritis (PsA) for whom the treating physician has decided, prior to and independently of enrollment in the study…
- Trial name
- APPRAISE (NCT03608657)
- Testing
- Apremilast
- Where
- 19 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Amgen
Factor VIII Deficiency
A Phase 3 Open-label Interventional Study of Intravenous Recombinant Coagulation Factor VIII Fc-von Willebrand Factor-XTEN Fusion Protein, Efanesoctocog Alfa (BIVV001), in Patients With Severe Hemophilia A
Primary Objective: To evaluate the efficacy of BIVV001 as a prophylaxis treatment in prophylaxis treatment arm. Secondary Objectives: To evaluate the efficacy of BIVV001 as a prophylaxis treatment.
- Trial name
- XTEND-1 (NCT04161495)
- Testing
- efanesoctocog alfa (BIVV001)
- Where
- 47 sites in United States, Argentina and 17 more
- Volunteers
- 159 people
- Sponsor
- Bioverativ, a Sanofi company
Coronary Artery Disease (CAD), Percutaneous Coronary Intervention (PCI)
Clinical Study of Coronary Extension Catheter
This prospective, multicenter, single-arm study plans to enroll 69 subjects. Subjects meeting the protocol criteria will receive treatment with coronary extension catheters.
- Trial name
- NCT07742345
- Testing
- Coronary Extension Catheter
- Where
- China
- Volunteers
- 69 people
- Sponsor
- BrosMed Medical Co., Ltd
Diabetes
Safety, Acceptability and Efficacy of a Long-term Intervention With a Diabetes-specific Low-carbohydrate, High-mono-unsaturated Fatty Acid Containing Oral Nutritional Supplement on Glycaemic Control in Type 2 Diabetic Patients
The purpose of the study is to determine the safety, acceptability and the efficacy of a 12-week intervention with a diabetes-specific oral nutritional supplement on glycaemic control in type 2 diabetic patients with or at risk…
- Trial name
- NCT01241695
- Testing
- Oral nutritional supplement, food for special medical purposes
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Fresenius Kabi
Attention Deficit Hyperactivity Disorder
Software Treatment for Actively Reducing Severity of ADHD in Adults (STARS ADHD Adult)
The purpose of this study is to evaluate the effects of the videogame-like digital therapy on attentional functioning and symptoms in Adults diagnosed with ADHD.
- Trial name
- NCT05183919
- Testing
- Digital Treatment
- Where
- 14 sites in United States
- Volunteers
- 223 people
- Sponsor
- Akili Interactive Labs, Inc.
Human Papillomavirus, High-Grade Squamous Intraepithelial Lesions
Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL
The purpose of this research study is to test the safety and effectiveness of the investigational study vaccine, called TVGV-1. The study will test the vaccine in women with high grade HPV cervical infection.
- Trial name
- NCT02576561
- Testing
- TVGV-1, GPI-0100
- Where
- 11 sites in United States
- Volunteers
- 10 people
- Sponsor
- THEVAX Genetics Vaccine
Aesthetics Procedure
Post-market Study on BtHCROSS® for Restoring Facial Volume After a Single Injection
This clinical study investigated the safety and effectiveness of BtHCROSS, a hyaluronic acid-based injectable used to restore facial volume and reduce wrinkles.
- Trial name
- NCT07301619
- Testing
- BtHCROSS®
- Where
- Spain
- Volunteers
- 203 people
- Sponsor
- i+Med S.Coop.
Migraine Disorders
Treximet (Sumatriptan/Naproxen Sodium), Formerly Known as TREXIMA, for Menstrual Migraine in Women With Dysmenorrhea
This study was designed to determine efficacy of TREXIMA compared to placebo for the treatment of a menstrual migraine.
- Trial name
- NCT00329459
- Testing
- sumatriptan succinate/naproxen sodium
- Where
- 34 sites in United States
- Volunteers
- 320 people
- Sponsor
- GlaxoSmithKline
Coronary Artery Disease
PRECISION GRX Post-Market Study - Japan
To collect data on the routine patterns of use, safety and effectiveness, including the clinical and technical performance of the CorPath GRX System, in the delivery and manipulation of coronary guidewires and stent/balloon…
- Trial name
- NCT03870087
- Testing
- Robotic-assisted PCI
- Where
- 8 sites in Japan
- Volunteers
- 242 people
- Sponsor
- Siemens Healthineers Endovascular Robotics, Inc.
Smoking Cessation
Escape Smoke Project: Non-Intervention Non-Drug Multicenter Study on the Real-life Effectiveness of Smoking Cessation in General Practice in Denmark
Real life smoking cessation rates after 24 weeks non-intervention design. Approximately 40 General Practice (GP) centers with 800 smokers will participate.
- Trial name
- ESCAPE SMOKE (NCT01544621)
- Testing
- Smoking cessation
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- Pfizer
Infertility
Prospective, Multi-centre, Non-Interventional Study to Investigate the Effectiveness of REKOVELLE® for Ovarian Stimulation for Asian Women in Real World Settings
Primary objective is to investigate the effectiveness of REKOVELLE® in women undergoing their first REKOVELLE® ovarian stimulation treatment in real world practice in Asian countries.
- Trial name
- PROFOUND (NCT06561958)
- Testing
- REKOVELLE
- Where
- 31 sites in Japan, South Korea and 3 more
- Volunteers
- 1,526 people
- Sponsor
- Ferring Pharmaceuticals
Heart Failure, Chronic Obstructive Pulmonary Disease
Coventry Outcomes Study of Seniors (COSS): A Comparative Effectiveness Study to Evaluate the Effect of a Multidisciplinary Team's Intervention on the Incidence of Nonelective Hospitalizations in a Medicare Population
The investigators are studying the impact of the interventions of a multidisciplinary team (MDT) - consisting of a Coventry case manager, social worker, and medical director, alongside a Medco specialist pharmacist - on the…
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease, Cardiovascular Disease, Diabetes
- Trial name
- COSS (NCT01014884)
- Testing
- Multidisciplinary team interventions, Multidisciplinary team bimonthly visits either in person or via telephone., Usual case management and pharmacy management as provided by the health Plan and the pharmacy benefit manager
- Where
- 2 sites in United States
- Volunteers
- 2,150 people
- Sponsor
- Medco Health Solutions, Inc.
Drug Coated Balloon, Bioresorbable Scaffold
Leave Nothing Behind Study Which Compares DCB With Bail Out BRS Versus BRS Strategy Alone
The goal of this study is to investigate the equivalence in early and long-term efficacy between the two "Leave nothing behind strategies" (Drug-Coated Baloon [DCB] strategy with bail-out BioResorbable Scaffold [BRS] versus BRS…
- Conditions
- Drug Coated Balloon, Bioresorbable Scaffold, Percutaneous Coronary Intervention (PCI), Acute Coronary Syndrome (ACS)
- Trial name
- LNB (NCT07038408)
- Testing
- Angioplasty with DCB (bail-out BRS), Angioplasty with BRS
- Where
- Estonia
- Volunteers
- 2,256 people
- Sponsor
- Ceric Sàrl
Peripheral Arterial Disease, Peripheral Vascular Diseases
ACHIEVE GRX Registry
This study will evaluate real-world performance of the CorPath GRX System in peripheral vascular interventions.
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Diseases, Renal Artery Disease, Carotid Artery Diseases
- Trial name
- NCT04513613
- Testing
- Procedure/Surgery: Robotic-PVI
- Sponsor
- Siemens Healthineers Endovascular Robotics, Inc.
Postoperative Pain
Efficacy and Safety of a Collagen Bupivacaine Implant in Women Following Abdominal Hysterectomy
The purpose of this study is to determine whether the CollaRx Bupivacaine implant is safe and effective in reducing the amount of narcotic pain medication needed to control pain during the first 24 hours after abdominal…
- Trial name
- NCT00624910
- Testing
- Bupivacaine Collagen Sponge (CollaRx®)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Innocoll
Diabetes, Diabetes Mellitus, Type 1
Observational Study on Efficacy and Safety in Patients Using NovoMix® 30 for the Treatment of Diabetes
This study is conducted in Asia. The aim of this observational study is to evaluate the efficacy on blood glucose control while using NovoMix® 30 FlexPen® under normal clinical practice conditions in Korea.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- UPGRADE (NCT00737776)
- Testing
- biphasic insulin aspart 30
- Where
- South Korea
- Volunteers
- 1,068 people
- Sponsor
- Novo Nordisk A/S
Advanced/Metastatic Gastroesophageal Adenocarcinoma
Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)
The purpose of this study is to assess the efficacy and safety of lenvatinib (E7080/MK-7902) plus pembrolizumab (MK-3475) plus chemotherapy compared with chemotherapy alone in participants with advanced/metastatic…
- Trial name
- NCT04662710
- Testing
- Pembrolizumab, Lenvatinib, Oxaliplatin
- Where
- 177 sites in United States, Argentina and 22 more
- Volunteers
- 895 people
- Sponsor
- Merck Sharp & Dohme LLC
Benign Prostatic Hyperplasia (BPH)
A Multi-center, International Prospective Follow up Study
The study objective is to assess the safety and efficacy of iTind three to five years following treatment.
- Trial name
- NCT04579913
- Testing
- Review of medical history, administration of questionnaires, uroflowmetry and PVR as measured by ultrasound
- Where
- 5 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- Medi-Tate Ltd.
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