Clinical trials: Intervention Effectiveness
Knee Osteoarthritis, Joint Diseases
Feasibility of a Wearable-enabled Intervention for Promoting Physical Activity in People Knee OA
Physical activity is an essential first-line treatment for patients with knee osteoarthritis (OA). However, a 2013 systematic review found only 13% met the activity recommendation of 150 minutes or more per week.
- Trial name
- TRACK-OA (NCT02313506)
- Testing
- Education session, Fitbit Flex, and remote coaching by a PT, Same intervention with a 1 month delay
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of British Columbia
Psychological Well Being, Mental Health Promotion
PERMA-Based Mobile Psychological Intervention With and Without Telephone Support for University Students
University students face increasing academic and psychosocial demands that place them at risk of reduced psychological well-being.
- Trial name
- NCT07466004
- Testing
- App Based PERMA intervention, App Based PERMA intervention plus telephone multiconference
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Pain, Postoperative, Anxiety Preoperative
The Efficacy of a Mindfulness-Based Virtual Reality Intervention to Reduce Pain in Postoperative Patients
The goal of this randomized clinical trial is to evaluate whether a virtual reality (VR) mindfulness intervention can reduce anxiety and postoperative pain in adults undergoing surgery, primarily hernia and varicose vein…
- Trial name
- VR-MindPain (NCT06961695)
- Testing
- VR Mindfulness-Based Relaxation
- Volunteers
- 64 people
- Sponsor
- Babes-Bolyai University
Malocclusion, Angle Class III
Evaluation of Different Anchorage-supported Appliances and Expansion Procedures for Face Mask Treatment
The purpose of this study is to assess and compare the effect of two appliances (Hybrid-Hyrax expander/ Bonded rapid maxillary expander (RME)) supported by different anchorage units and two different expansion procedures (routine…
- Trial name
- NCT06244563
- Testing
- Face mask with Hybrid-Hyrax, Face mask with Bonded RME, Alternative Rapid Maxillary Expansion and Contraction Protocol (Alt-RAMEC)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Prostate Cancer
Efficacy of Cancer Support Programs: A Social Comparison Theory Analysis
The goal of this research study is to learn if a support group program is acceptable for patients with prostate cancer or patients with breast cancer.
- Trial name
- NCT00798187
- Testing
- Group Meetings, Questionnaire
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- M.D. Anderson Cancer Center
Spasticity
Effectiveness of an Interprofessional Approach to the Treatment of Spasticity With Botulinum Toxin & Non-pharmacological Therapies
Many people with neurological conditions will experience spasticity, a nonvolitional and uncontrollable tightening and/or spasm of muscles.
- Trial name
- NCT07160699
- Testing
- Botulinum Neurotoxin Type A, Non-pharmacological therapies
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Technical University of Bern
Staphylococcal Vaccine
Safety and Efficacy of SA4Ag Vaccine in Adults Having Elective Open Posterior Spinal Fusion Procedures With Multilevel Instrumentation
The purposes of the clinical trial are to determine whether the SA4Ag vaccine can prevent postoperative Staphylococcus aureus infections in patients who are undergoing elective spinal fusion surgery, and to evaluate the safety of…
- Trial name
- STRIVE (NCT02388165)
- Testing
- Staphylococcus aureus 4-Antigen (SA4Ag) Vaccine
- Where
- 301 sites in United States, Austria and 9 more
- Volunteers
- 3,450 people
- Sponsor
- Pfizer
Death Anxiety
The Effectiveness of an Online Self-Delivered Death Anxiety Intervention
The goal of this clinical trial is to examine the effectiveness of the online self-delivered death anxiety intervention developed by our team in the general population with a randomized controlled trial.
- Trial name
- NCT06801132
- Testing
- Online self-delivered death anxiety intervention, Waiting-List (WL) condition
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Peking University
Mental Health Wellness, Professional Burnout
Efficacy of Internet-delivered Strengths Use Intervention
The aim of the study will be to test the efficacy of a novel online-delivered gamification-based intervention for the identification, development, and use of strengths in the workplace.
- Trial name
- NCT05779501
- Testing
- Internet-delivered strengths use intervention, Waiting-list
- Where
- Romania
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- West University of Timisoara
Myopia
Effectiveness of Myopia Control Interventions : A Comparison of Myopia Control in European Children, Adolescents and Young Adults With Defocus Incorporated Multiple Segments (DIMS) and Highly Aspherical Lenslets (HAL) Spectacles, Atropine, Lenses and Combined Treatments
The prevalence of myopia and its complications has risen considerably in recent decades, particularly among children and teenagers.
- Trial name
- NCT07120165
- Testing
- Demographic data collection, Ophthalmological history, Ophthalmological data at each examination
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Rheumatoid Arthritis
An Observational Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis And Inadequate Response Or Intolerance to a First Anti-TNF Alpha Therapy
This prospective, multi-center, observational study will evaluate the efficacy and the safety of MabThera (rituximab) in participants with rheumatoid arthritis who have not responded or have been intolerant to a first anti-TNF…
- Trial name
- NCT01592292
- Testing
- Rituximab, Adalimumab, Etanercept
- Where
- 15 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Hoffmann-La Roche
Cancer
A Dyadic Approach to Cancer Care: a Feasibility and Efficacy Partner-based Exercise Study
The primary goal of this study will be to assess the feasibility and acceptability of a partner-based 12-week exercise intervention for cancer caregivers and their care recipient.
- Trial name
- C4C (NCT05333016)
- Testing
- Multimodal exercise
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Nova Scotia Health Authority
Self Efficacy, Loneliness
New in Town-Internet Intervention for Migrants
New in Town is an internet intervention for migrants that aims at increasing social self-efficacy. The study aim is to evaluate its effectiveness.
- Conditions
- Self Efficacy, Loneliness, Social Skills
- Trial name
- NCT04088487
- Testing
- New in Town-Interner Intervention for Migrants
- Where
- Poland
- Volunteers
- 178 people
- Sponsor
- University of Social Sciences and Humanities, Warsaw
COVID - 19, Renal Transplant
Safety and Effectiveness of a Remdesivir Treatment to Prevent Severe COVID-19 in Kidney Transplant Patients
Since the start of the COVID-19 pandemic, the approach to solid organ transplantation has evolved. Transplants using organs (excluding lungs) from COVID-19-positive donors have shown short-term safety, but there is limited data…
- Conditions
- COVID - 19, Renal Transplant, SARS CoV 2 Infection
- Trial name
- COVIDKIDNEY (NCT07197164)
- Testing
- Remdesivir (RDV)
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Autism Spectrum Disorders
Water Competency Intervention in Autism
AquOTic is an evidence-based, occupational therapy-led intervention designed to enhance water competency and swim safety skills in children on the autism spectrum.
- Trial name
- NCT07076264
- Testing
- AquOTic
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Ohio State University
ST Elevation (STEMI) Myocardial Infarction
High-Dose Rosuvastatin Preloading for Enhanced Outcomes in STEMI Patients Undergoing Primary PCI
To compare the efficacy of high dose rosuvastatin preloading vs placebo before primary PCI in terms of MACE at 30 days
- Trial name
- HEROS-PCI (NCT06924684)
- Testing
- Statin monotherapy (rosuvastatin or atorvastatin)
- Where
- 2 sites in Pakistan
- Volunteers
- 66 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
ESR1 Gene Mutation, Advanced Breast Cancer
Current Status of Treatment for Chinese Patients With ESR1-mutated HR+/HER2-advanced Breast Cancer
This is a prospective, non-interventional real-world study to observe the efficacy and safety of different treatment regimens in patients with ESR1-mutated HR+/HER2-advanced breast cancer after failure of endocrine therapy.
- Trial name
- NCT06548919
- Testing
- Endocrine therapy, Chemotherapy Prednisone
- Where
- China
- Volunteers
- 450 people
- Sponsor
- SciClone Pharmaceuticals
Risk of Coronary Obstruction Following Transcatheter Aortic Valve Replacement (TAVR) Procedure
The ShortCut™ Study Protocol
A Prospective, Multicenter, Non-Randomized, Single-Arm, Open-Label Clinical Study to Demonstrate the Safety and Effectiveness of the ShortCut™ device for splitting bioprosthetic aortic valve leaflets in patients who are presented…
- Trial name
- NCT04952909
- Testing
- ShortCut™
- Where
- 23 sites in United States, France and 3 more
- Volunteers
- 60 people
- Sponsor
- Pi-cardia
Meniscectomy, Osteoarthritis
The VENUS Clinical Study (Verifying the Effectiveness of the NUsurface® System)
The NUsurface® Meniscus Implant Randomized Study is a multi-center, prospective randomized, interventional clinical trial to test the hypothesis that the NUsurface implant is superior to the non-surgical standard of care in…
- Trial name
- VENUS (NCT02136901)
- Testing
- NUsurface® Meniscus Implant, NSAID's and Non-surgical Treatment Options, Intra-Articular Injections with Corticosteroids
- Where
- 7 sites in Belgium, France and 4 more
- Volunteers
- 34 people
- Sponsor
- Phoenix Kinetics
HIV, Non Communicable Diseases
Effects of a Package of Evidence-based Interventions and Implementation Strategies Based on WHO PEN for People Living With HIV and Cardio-metabolic Conditions in Lusaka, Zambia
The purpose of this study is to evaluate the effects of a multi-level intervention known as "TASKPEN," adapted from the World Health Organization (WHO) Package of Essential Noncommunicable Disease Interventions (WHO-PEN) for the…
- Trial name
- TASKPEN UH3 (NCT05950919)
- Testing
- TASKPEN
- Where
- 12 sites in Zambia
- Volunteers
- 5,747 people
- Sponsor
- University of North Carolina, Chapel Hill
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