Clinical trials: Intervention Effectiveness
Obesity
Effectiveness of Primary Care Physicians in Delivering Weight Control Counseling
This randomized clinical trial will determine the efficacy of physicians providing weight control advice to their overweight and obese patients in primary care practice.
- Trial name
- NCT00017706
- Testing
- physician-delivered weight control
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Wrinkles and Rhytides
Efficacy Study for Magnetic Induction to Treat Wrinkles
In this study we propose to test the Biofusionary Bebe in order to reduce skin laxity and improve contour and cosmesis.
- Trial name
- NCT01701440
- Testing
- Biofusionary Bebe
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rocky Mountain Biosystems, Inc.
Type 2 Diabetes Mellitus
Preventive Effectiveness of Primary Care Physician-led CGM-supported Comprehensive Intervention on Cardio-metabolic-immune Diseases in Community Patients With Type 2 Diabetes (Community Diabetes Control Project)
This community-based trial evaluates whether primary care physicians, equipped with continuous glucose monitoring (CGM) and trained under a standardized protocol with specialist backup, can improve diabetes outcomes through…
- Trial name
- CDCP (NCT07885904)
- Testing
- comprehensive intervention
- Where
- China
- Volunteers
- 15,400 people
- Sponsor
- Xiangya Hospital of Central South University
Migraine
Eptinezumab as Preventive Treatment of Migraine in Adults With Migraine
This study evaluates the efficacy of eptinezumab to prevent migraine in participants with chronic migraine.
- Trial name
- Sunrise (NCT04921384)
- Testing
- Eptinezumab
- Where
- 87 sites in China, Georgia and 6 more
- Volunteers
- 981 people
- Sponsor
- H. Lundbeck A/S
Caregivers With Toddler Receiving Early Intervention
The Effect of Self-efficacy and Relationship Through Behavior Modification by Hybrid Mode
The past literature supports the use of digital media as a medium to provide ongoing interventions for families caring for children with difficulties and the opportunity to intervene directly through caregivers, and to combine…
- Trial name
- NCT05827952
- Testing
- behavior modification-Atomic Habit by hybrid
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Vascular Closure Device
The Ladera Suture-Mediated Large Bore Closure Pivotal Study
The study objective is to demonstrate the safety and efficacy of the investigational device to achieve hemostasis of common femoral artery access sites in participants undergoing percutaneous interventional catheterization…
- Trial name
- FASTEN II (NCT07541235)
- Testing
- Ladera LBC System
- Where
- Australia
- Volunteers
- 214 people
- Sponsor
- Ladera Medical
Smoking Cessation, Mouth Diseases
Tobacco Cessation Intervention Study for Oral Diseases
This study is to verify the efficacy of tobacco cessation in patients with oral diseases; periodontitis, dental implant and oral mucosal diseases by a multicenter prospective trial.
- Conditions
- Smoking Cessation, Mouth Diseases, Periodontal Diseases, Leukoplakia
- Trial name
- TISOD (NCT02737176)
- Testing
- Tobacco cessation intervention
- Where
- 2 sites in Japan
- Volunteers
- 812 people
- Sponsor
- Association for the Japanese Academy of Maxillofacial Implants
Colorectal Cancer
A Psychosocial Intervention for Patients With Colorectal Cancer and Their Family Caregivers
This study aims to develop a smartphone-based psychosocial intervention for patients with colorectal cancer and their family caregivers and to improve patients' confidence in self-care, psychological well-being, social support…
- Trial name
- iCanManage (NCT04159363)
- Testing
- An interactive Colorectal Cancer self-Management enhancement smartphone-based psychosocial intervention programme (iCanManage)
- Volunteers
- 200 people
- Sponsor
- Singapore Cancer Society
Depression in Adolescence, Suicidal Ideation
Stratified Care Intervention for Suicidal Ideation, Depression, and Non-Suicidal Self-Injury in Adolescents (Reframe-IT+ & CARIBOU)
The aim of this study is to evaluate the acceptability, feasibility, and fidelity of implementing a stratified care intervention for adolescents with suicidal ideation and depressive symptoms, and to preliminarily explore its…
- Conditions
- Depression in Adolescence, Suicidal Ideation, Non Suicidal Self Injury
- Trial name
- NCT07780084
- Testing
- Reframe-IT and CARIBOU
- Where
- Chile
- Volunteers
- 90 people
- Sponsor
- Universidad de los Andes, Chile
Advanced Medical Directive, a Legal Document Signed in Advance to State Healthcare Preferences
Increasing the Uptake of Advanced Directives in SingHealth Polyclinics
An Advanced Medical Directive (AMD) is a legal document in Singapore that allows one to inform their medical practitioner that they do not want any life-sustaining treatment should they become unconscious and terminally ill where…
- Trial name
- NCT03499847
- Testing
- standardised face-to-face counselling session, advanced medical directive pamphlet
- Where
- 4 sites in Singapore
- Volunteers
- 189 people
- Sponsor
- SingHealth Polyclinics
Healthy
Effectiveness of an Intensive Intervention to Improve Physical Activity in Postmenopausal and Sedentary Women
This is a randomized clinical trial aimed at postmenopausal women aged 45 to 70 years old selected in urban primary care centers of two centers (Spain).
- Trial name
- NCT03872258
- Testing
- Control, Intervention group
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Learning Disorders, Learning Disabilities
Efficacy of the MovinCog Intervention in Children
This study aims to test the efficacy of the MovinCog Intervention to enhance cognitive abilities in children 7-15 yrs. The intervention consists of two parts: a physical exercise regimen, based on high-intensity training, and a…
- Conditions
- Learning Disorders, Learning Disabilities, Cognitive Change
- Trial name
- NCT03255499
- Testing
- Exercise, Cognitive, Active control
- Where
- New Zealand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Anxiety, Social Phobia
Efficacy of an App-based CBT Featuring Virtual Reality for Anxiety Disorders
Primary aim is to evaluate the efficacy of a (minimally) therapist-guided app-based psychotherapy with virtual reality exposure therapy (ALISA) in participants with agoraphobia with or without panic disorder, social anxiety…
- Conditions
- Anxiety, Social Phobia, Panic Disorder, Agoraphobia
- Trial name
- ALISA (NCT05510804)
- Testing
- ALISA
- Where
- 2 sites in Germany
- Volunteers
- 222 people
- Sponsor
- Bartosz of Zurowski
Chronic Migraine in Children
A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine
To find out if eptinezumab is better than placebo (normal saline solution) in lowering the number of days with migraine in young people ages 12 to 17 with chronic migraine.
- Trial name
- PROSPECT-2 (NCT04965675)
- Testing
- Eptinezumab
- Where
- 79 sites in United States, Argentina and 9 more
- Volunteers
- 285 people
- Sponsor
- H. Lundbeck A/S
Depression, Anxiety
Online Wellness Intervention for College Students
We are evaluating the effects of an online single-session mental health intervention (the Common Elements Toolbox; COMET). To evaluate COMET, we are conducting a randomized controlled trial with college students attending…
- Conditions
- Depression, Anxiety, Well-being
- Trial name
- NCT04740411
- Testing
- The Common Elements Toolbox (COMET)
- Where
- United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol-Related Disorders, Substance-Related Disorders
"Effectiveness of a Brief Intervention for Substances Consumption Linked to the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST): A Randomized Control Trial in Chilean Primary Care."
Alcohol and drugs consumption are among the highest risk factor for health in Chile and abroad. In Chile, harmful use of alcohol continues to be a major contributor to the burden of disease while lost years of healthy life are…
- Conditions
- Alcohol-Related Disorders, Substance-Related Disorders, Substance Abuse
- Trial name
- NCT01573416
- Testing
- ASSIST-linked brief intervention for hazardous and harmful substance use., Observation
- Where
- 30 sites in Chile
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Obesity, Overweight
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric…
- Trial name
- ADVANCE (NCT06672549)
- Testing
- Orforglipron
- Where
- 116 sites in United States, Belgium and 11 more
- Volunteers
- 125 people
- Sponsor
- Eli Lilly and Company
COVID-19, Anxiety
Remote Psychological Intervention for COVID-19 Survivors With AKI and Caregivers (REPICOV-AKI)
The frequency of psychological conditions in recovered COVID-19 patients with Acute Kidney Injury (AKI) and their informal primary caregivers (IPC) is unknown; as well as the effects of psychological therapy in this population.
- Conditions
- COVID-19, Anxiety, Depressive Symptoms, Acute Kidney Injury
- Trial name
- REPICOV-AKI (NCT06522776)
- Testing
- Cognitive behavioral therapy
- Where
- Mexico
- Volunteers
- 98 people
- Sponsor
- Jesus Rivero, MD
End Stage Renal Disease
Fluid Overload in Peritoneal Dialysis
The objective of this study is to determine the effectiveness of treating peritoneal dialysis (PD) patients with fluid overload by a structured nurse-lead intervention protocol.
- Trial name
- NCT02557347
- Testing
- Aggressive fluid management
- Where
- Hong Kong
- Volunteers
- 102 people
- Sponsor
- Chinese University of Hong Kong
Chronic Rhinitis, Chronic Pharyngitis
Efficacy and Safety of High-Concentration 35 kDa Hyaluronan Gel for Chronic Nasopharyngitis
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of nasopharyngeal administration of 13.6% high-concentration 35 kDa hyaluronan (HA35) care gel in subjects with chronic…
- Conditions
- Chronic Rhinitis, Chronic Pharyngitis, Nasopharyngitis, Posterior Pharyngeal Inflammation
- Trial name
- HA35 (NCT07568548)
- Testing
- 13.6% High-Concentration 35 kDa Hyaluronan (HA35) Nasopharyngeal Care Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
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