Clinical trials: Intervention Effectiveness
Uterine Cervical Cancer
Evaluation of Long-term HPV Vaccine Efficacy
Summary For ethical and practical reasons pre-licensure clinical efficacy phase III trials for GSK Biologicals' HPV-16/18 LI VLP AS04 vaccine used cervical intraepithelial grade 2 and above (CIN2+) lesions as surrogate efficacy…
- Trial name
- NCT01393470
- Testing
- Screening for cervical cancer
- Where
- 15 sites in Finland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Tampere University
Subacromial Pain Syndrome
Comparison of SEP Exercises Versus SSMP With Tendon Loading & Resistance Exercise in Shoulder Pain.
Shoulder pain is one of the most prevalent and disabling musculoskeletal condition. A new diagnostic terminology used to describe shoulder pain is rotator cuff-related shoulder pain (RCRSP), as histological findings were similar…
- Trial name
- NCT05408949
- Testing
- Single exercise into pain (SEP) program, Shoulder Symptom Modification Procedure (SSMP), Functional Rehabilitation Program
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 68 people
- Sponsor
- Gulf Medical University
Sexual Arousal Disorder, Sexual Desire Disorder
The Effectiveness of Online Interpersonal Relationships-Based Pyschoeducation in Increasing Sexual Interest and Arousal in Women With Sexual Interest and Arousal Disorder
This study will be conducted to examine the effectiveness of interpersonal relationships-based online psychoeducation developed for women with sexual interest and arousal disorders.
- Trial name
- NCT06445855
- Testing
- Interpersonal relationship-based intervention program
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Marmara University
Substance Dependence, HIV (Human Immunodeficiency Virus)
Pre-exposure Prophylaxis (PrEP) for Health
This randomized controlled trial will test the efficacy of "PrEP for Health," a behavioral intervention to improve the use of antiretroviral pre-exposure prophylaxis (PrEP) among at-risk people who inject drugs (PWID) in two…
- Trial name
- PrEP (NCT04430257)
- Testing
- HIV and PrEP education, Motivational interviewing, Problem-solving and planning
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Brown University
HIV Infections, Smoking
Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV
This project will compare the effectiveness of an HIV-specific comprehensive wellness intervention designed to have broad appeal to smokers living with HIV to the effectiveness of standard care services that include referral to…
- Conditions
- HIV Infections, Smoking, Smoking Cessation
- Trial name
- WISH (NCT04505371)
- Testing
- Wellness Intervention for Smokers with HIV
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Pathological Gambling
Efficacy of an Internet-based Psychological Intervention for Problem Gambling and Gambling Disorder
The aim of this study is to assess the efficacy of an online CBT-based intervention combined with an Ecological Momentary Intervention (EMI) and different complementary tools for the treatment of problem gambling and gambling…
- Trial name
- NCT04074681
- Testing
- Gambling Internet-based Protocol
- Volunteers
- 134 people
- Sponsor
- Universitat Jaume I
Sarcopenia
Nutritional Intervention for Age-related Muscular Function and Strength Losses-Study 2
Men and women lose muscle mass and strength with age. Loss of muscle mass and strength is accompanied by a loss of muscle function which can lead to diminished quality of life and more importantly can lead to serious fall…
- Trial name
- NCT02043171
- Testing
- HMB plus Vitamin D, Non-Exercise, Exercise
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Metabolic Technologies Inc.
Knee Arthropathy
A Pilot Feasibility Study Comparing Smartphone Home-based Rehabilitation Program Against the Usual Hospital and Outpatient Physiotherapy Care on Clinical and Cost Effectiveness for Total Knee Replacement Patients
Knee osteoarthritis (OA) is a common, chronic, and costly condition whilst total knee replacement (TKR) is a common orthopaedic surgical intervention.
- Trial name
- NCT06248034
- Testing
- Smartphone application with tele-monitoring rehabilitation, Hospital-based rehabilitation program
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Primary Prevention
FIT FIRST Teen - School Intervention Study
The goal of this cluster randomised controlled trial is to investigate the effects of the FIT FIRST Teen program on adolescents' physical fitness, motivation, and well-being, as well as the implementation of such a program within…
- Trial name
- NCT06615791
- Testing
- FIT FIRST Teen
- Where
- Denmark
- Volunteers
- 912 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Postmenopause
Effects of Wellnara on Climacteric Symptoms
Aim of this NIS is to obtain further information on efficacy, tolerability, and acceptance of Wellnara in a large user population under the conditions of routine medical practice.
- Trial name
- NCT00913926
- Testing
- E2/LNG oral (Wellnara, BAY86-5029)
- Where
- Germany
- Volunteers
- 749 people
- Sponsor
- Bayer
Obsessive Compulsive Disorder
Exercise and Health Intervention for Patients With Obsessive Compulsive Disorder (OCD)
The purpose of this study is to test the effect of a moderate-intensity aerobic exercise intervention for Obsessive Compulsive Disorder (OCD) patients interested in reducing symptoms.
- Trial name
- NCT01242735
- Testing
- Aerobic exercise, Health and Wellness
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Butler Hospital
Schizophrenia, Schizotypal Disorder
The OPUS YOUNG Trial. Early Intervention Versus Treatment as Usual for Adolescents With First-episode Psychosis
The OPUS YOUNG (OY) study investigates the efficacy of early intervention service versus treatment as usual (TAU) for adolescents aged 12-17 years with a first-episode psychosis.
- Conditions
- Schizophrenia, Schizotypal Disorder, Delusional Disorder, Acute and Transient Psychotic Disorder, Unspecified
- Trial name
- OPUS-YOUNG (NCT04916626)
- Testing
- OPUS YOUNG, Treatment as Usual
- Where
- Denmark
- Volunteers
- 284 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Diabetes, Diabetes Mellitus, Type 1
Investigating the Safety and Effectiveness of Insulin Degludec in a Real World Population With Type 1 and 2 Diabetes Mellitus
This study is conducted in Europe. The aim of this non-interventional study is to investigate the safety and effectiveness of insulin degludec (Tresiba®) in a real world population with type 1 (T1DM) and 2 (T2DM) diabetes…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- ReFLeCT (NCT02392117)
- Testing
- insulin degludec
- Where
- 8 sites in Denmark, Germany and 6 more
- Volunteers
- 1,262 people
- Sponsor
- Novo Nordisk A/S
Diet, Growth
The prEgnanCy and eArly Childhood nutrItion triaL (ECAIL)
The purpose of this study is to conduct a randomized controlled trial among 800 socially disadvantaged pregnant women and their families to test the effectiveness of a multi-component home visitation nutrition program, compared…
- Conditions
- Diet, Growth, Infant, Physical Activity
- Trial name
- ECAIL (NCT03003117)
- Testing
- Experimental: Intervention Program, Active comparator: Usual Care
- Where
- 2 sites in France
- Volunteers
- 607 people, healthy volunteers welcome
- Sponsor
- French Red Cross
Sepsis, Pneumonia
Comparative Effectiveness of Readmission Reduction Interventions for Individuals With Sepsis or Pneumonia
An adaptive platform trial to compare effectiveness of different care models to prevent readmissions for patients hospitalized with sepsis or lower respiratory tract infection.
- Conditions
- Sepsis, Pneumonia, Lower Resp Tract Infection, Covid19
- Trial name
- ACCOMPLISH (NCT04829188)
- Testing
- Structured Telephone Support (STS), Low-intensity Remote Patient Monitoring (RPM-Low), High-intensity Remote Patient Monitoring (RPM-High)
- Where
- United States
- Volunteers
- 1,296 people
- Sponsor
- University of Pittsburgh
Alcohol Use Disorder
Transcranial Temporal Interference Stimulation Targeted of the Amygdala as an Intervention for Alcohol Use Disorder Patients
The purpose of this research is to investigate the efficacy of transcranial temporal interference stimulation (tTIS) targeting the amygdala in patients with alcohol use disorder.
- Trial name
- NCT07472673
- Testing
- tTIS on Amygdala, 10 Hz
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Oral Hygiene in Patients With Fixed Orthodontic Appliances, Dental Plaque
Effectiveness of Personalized Digital Oral Health Intervention in Patients With Fixed Orthodontic Appliances.
This study will evaluate whether personalized digital oral-health education delivered through WhatsApp messages can improve oral hygiene in patients aged 16-25 years who wear fixed orthodontic appliances (braces).
- Conditions
- Oral Hygiene in Patients With Fixed Orthodontic Appliances, Dental Plaque, Gingivitis Infection
- Trial name
- PDHOI (NCT07910851)
- Testing
- Personalized Digital Oral Health Education via WhatsApp, Standard Oral-Hygiene Instructions
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kurdistan Higher Council of Medical Specialties
Substance-related Disorders, Mental Health Literacy
Brave Heart Intervention and Mental Health Outcomes Among Young People in Sierra Leone
Young people in Sierra Leone face a growing crisis of substance use and mental health struggles, but the country has very few mental health professionals to help them, only a handful of psychiatrists and no psychologists for a…
- Conditions
- Substance-related Disorders, Mental Health Literacy, Adolescent Health, Substance Use Disorder (SUD)
- Trial name
- NCT07853092
- Testing
- Brave Heart Intervention
- Where
- Sierra Leone
- Volunteers
- 2,244 people, healthy volunteers welcome
- Sponsor
- Slum and Rural Health Initiative
Infertility, Distress, Emotional
Testing an Evidence-Based Self-Help Program for Infertility-Related Distress in Women
Now affecting one in six couples in Canada, infertility is defined as a lack of conception after 12 or more months of regular, unprotected sexual intercourse.
- Conditions
- Infertility, Distress, Emotional, Mental Health Issue
- Trial name
- NCT06006936
- Testing
- Coping with Infertility Self-Help Program
- Where
- Canada
- Volunteers
- 170 people
- Sponsor
- University of Regina
Career Decision-making Difficulties, Worry
REBT Intervention Program for Career Decision-making Difficulties in High School Pupils
Career decision-making difficulties are frequent problems for adolescents. Regular intervention or prevention programs mainly provide information for the students about themselves, about the world of work, about their interests…
- Conditions
- Career Decision-making Difficulties, Worry, Psychological Distress
- Trial name
- NCT03807895
- Testing
- REBT Career Intervention, Regular Career Intervention
- Where
- Romania
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
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