Clinical trials: Intervention Effectiveness
Advanced/Metastatic Gastroesophageal Adenocarcinoma
Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)
The purpose of this study is to assess the efficacy and safety of lenvatinib (E7080/MK-7902) plus pembrolizumab (MK-3475) plus chemotherapy compared with chemotherapy alone in participants with advanced/metastatic…
- Trial name
- NCT04662710
- Testing
- Pembrolizumab, Lenvatinib, Oxaliplatin
- Where
- 177 sites in United States, Argentina and 22 more
- Volunteers
- 895 people
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer Disease
A Study on the Effectiveness of Multidomain Intervention Program for Reducing Risks of Dementia
Investigators aimed to examine the feasibility and effectiveness of a multidomain intervention strategy involving intensive and maintenance programs aimed at reducing the risk of Alzheimer's disease (AD) in at-risk older adults.
- Trial name
- NCT03786510
- Testing
- Active control, Intensive + Maintenance program, Intensive program only
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Neurodevelopmental Disorders (NDD), Preschool Child Development
Efficacy of a Group-based and Digital Parent Sleep Intervention in HK Preschoolers With NDDs
Neurodevelopmental disorders (NDDs) in preschoolers are frequently accompanied by persistent sleep disturbances, such as delayed sleep onset and reduced sleep duration, which exacerbate behavioral problems, impair cognitive…
- Conditions
- Neurodevelopmental Disorders (NDD), Preschool Child Development, Sleep
- Trial name
- NCT07822490
- Testing
- Parent-based Group Face-to-face Intervention, Digital Self-help Intervention
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Cancer-related Problem/Condition, Exercise
Combined Technology Enhanced Home Exercise Program and Other Non-pharmacological Intervention for Cancer Survivors
A 12 weeks technology enhanced home exercise (TEHE) program using mobile technologies that provide immediate feedback and send reminder messages to improve exercise motivation is developed.
- Conditions
- Cancer-related Problem/Condition, Exercise, Acupressure
- Trial name
- TEHEplus (NCT03576274)
- Testing
- Technology Enhanced Home Exercise (TEHE), Auricular Point Acupressure (APA), Mindfulness body scan (MBI)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Coronary Artery Disease, Acute Coronary Syndromes
Aspirin 50mg vs 100mg Combined With P2Y12 Inhibitor After PCI
This is a randomized, open-label, active-controlled, non-inferiority clinical trial (the ASPIRE-LD trial) conducted in China. It aims to compare the efficacy and safety of low-dose aspirin (50 mg once daily) versus standard-dose…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Chronic Coronary Syndrome, Percutaneous Coronary Intervention
- Trial name
- ASPIRE-LD (NCT07846462)
- Testing
- Aspirin, P2Y12 inhibitor
- Where
- China
- Volunteers
- 2,640 people
- Sponsor
- Jilin University
Sleep Disorder (Disorder), Mood Disorders
Exploring the Efficacy of a Breathing Training Intervention in Patients With Emotionally Regulated Sleep Disorders
In recent years, the incidence of sleep disorders, especially insomnia, has been rising. Insomnia can directly lead to damage to patients' daytime functions, such as daytime sleepiness, inattention, etc., affecting people's…
- Trial name
- NCT07495423
- Testing
- respiratory training intervention
- Where
- China
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Preterm, Motor
Investigation of the Effectiveness of Environmental Enrichment-Based Intervention in Preterm Infants
The aim of this study is to investigate the effectiveness the HEP (Homeostasis-Enrichment-Plasticity) approach, which based upon the principles of enriched environment (EE) and ecological theories of development on preterm…
- Conditions
- Preterm, Motor, Development, Infant, Therapy
- Trial name
- NCT05261503
- Testing
- HEP, Traditional Phsical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Istanbul University - Cerrahpasa
Ulcerative Colitis (UC)
Efficacy of Upadacitinib Re-induction Therapy in Patients With Ulcerative Colitis Who Lost Response to 30 mg Maintenance Dose
ReCOUP is a multicenter clinical study designed to evaluate the efficacy of upadacitinib (Rinvoq®) in patients with ulcerative colitis whose disease has become active again despite maintenance treatment with upadacitinib 30 mg.
- Trial name
- ReCOUP (NCT07700446)
- Testing
- Upadacitinib
- Volunteers
- 100 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Tobacco Smoking, Cancer
Effectiveness of Intensive Smoking Cessation Interventions in Patients With Cancer
Smoking accounts for approximately 30% of total cancer deaths each year. Even though former studies show that persons with a cancer diagnosis are less likely to smoke than the general population up to 50% of people who smoke and…
- Conditions
- Tobacco Smoking, Cancer, Tobacco Cessation
- Trial name
- NCT04198688
- Testing
- Intensive Smoking Cessation Intervention
- Volunteers
- 77,380 people
- Sponsor
- Bispebjerg Hospital
Pulmonary Nodules, Lung Cancer (Diagnosis)
The Percutaneous Interventional Surgery Control System for Pulmonary Nodule Biopsy
This prospective, single-center, non-inferiority, randomized controlled clinical trial aims to evaluate the efficacy and safety of a percutaneous interventional surgical control system in performing percutaneous needle biopsy of…
- Conditions
- Pulmonary Nodules, Lung Cancer (Diagnosis), Percutaneous Needle Biopsy, Transthoracic Needle Biopsy
- Trial name
- NCT07277088
- Testing
- Percutaneous Needle Biopsy with Interventional Surgical Control System, Conventional Manual Percutaneous Needle Biopsy
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Jiayuan Sun
Lupus Erythematosus, Systemic
NIS to Examine Disease Activity in SLE Patients Treated With Subcutaneous Anifrolumab in Routine Care
VIOLET is a prospective, single-arm, multi-centre, non-interventional study (NIS) evaluating real-world clinical and patient-reported outcome (PRO) data in adult patients who are initiated on subcutaneous anifrolumab treatment of…
- Trial name
- VIOLET (NCT07424261)
- Where
- 21 sites in Germany
- Volunteers
- 125 people
- Sponsor
- AstraZeneca
Neck Pain, Posterior
Dry Needling, Manual Therapy and Exercise for Neck Pain Management
Since neck pain is the fourth highest disabling condition (with an estimated point prevalence of 20%, lifetime prevalence up to 70% and high recurrence rates), dry needling targeting myofascial trigger points in neck muscles has…
- Trial name
- NCT05607459
- Testing
- Dry Needling, Therapeutic Exercise, Manual Therapy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Camilo Jose Cela University
Intervention, Waitlist Control
Coach-Led Body Image Intervention for Girls in Sport - RCT
According to the World Health Organization, only 15% of 11-17-year-old girls meet the recommended daily physical movement guidelines (e.g., 60 minutes per day).
- Trial name
- NCT05594524
- Testing
- Body Confident Athletes
- Where
- United Kingdom
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- University of the West of England
Emotion Regulation
Process Evaluation of the Effectiveness of Two Transdiagnostic Interventions on Emotion Regulation
Emotional regulation (ER) appears today as a fundamental skill for the adaptation of an individual to his environment. Indeed, functional and efficient ER is crucial for mental well-being, but also for physical health, for the…
- Trial name
- INTREC (NCT05113680)
- Testing
- compassion focused group, emotional competencies
- Where
- France
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University Grenoble Alps
Premature Newborns
Pain Relief in Premature Newborns Through Maternal Intervention During Venipuncture
Extremely premature newborn infants (ELNs) admitted to hospital are exposed to stressful and painful stimuli, and often to maternal separation, which can affect their long-term neurological development.
- Trial name
- PREMAMANDOL (NCT06200662)
- Testing
- Analgesic strategies during the S visit:, Analgesic strategies at visit M
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Strasbourg, France
Treatment Adherence and Compliance, Effectiveness
Educational Intervention and Adherence
quasi-experimental, parallel study, with the objective of evaluating the effectiveness of an educational nursing intervention supported by ICTs, for the improvement of therapeutic adherence in people undergoing hemodialysis…
- Conditions
- Treatment Adherence and Compliance, Effectiveness, Renal Dialysis, Nurse's Role
- Trial name
- Hemodialysis (NCT06742827)
- Testing
- educational intervention based on information and communication technologies.
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Universidad de Antioquia
Parkinson Disease, Occupational Therapy
Effectiveness of Online Program and Task-related Training for Parkinson's Disease
The goal of this clinical trial is to compare the effectiveness of online self-management program and on-site task-related training for people with early stage Parkinson's disease.
- Conditions
- Parkinson Disease, Occupational Therapy, Telerehabilitation, Activities of Daily Living
- Trial name
- NCT06248073
- Testing
- on-line self-management training, onsite task-related training
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung University
Child Development, Social Protection
Strong Families, Thriving Children "Sugira Muryango"_Activity C
The proposed study will test the effectiveness of the Strong Families, Thriving Children "Sugira Muryango" program as delivered by community based workers and aligned with the Rwandan social protection system.
- Trial name
- NCT02510313
- Testing
- Sugira Muryango
- Where
- Rwanda
- Volunteers
- 2,911 people
- Sponsor
- Boston College
Postoperative Pain
Efficacy and Safety of a Collagen Bupivacaine Implant in Women Following Abdominal Hysterectomy
The purpose of this study is to determine whether the CollaRx Bupivacaine implant is safe and effective in reducing the amount of narcotic pain medication needed to control pain during the first 24 hours after abdominal…
- Trial name
- NCT00624910
- Testing
- Bupivacaine Collagen Sponge (CollaRx®)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Innocoll
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI)
Efficacy and Safety of Shortening Dual Antiplatelet Therapy Duration with IVUS Guidance in PCI Patients
This study is designed to assess the efficacy and safety of de-escalating dual antiplatelet therapy (DAPT) at 1 month compared to the standard 12 months of therapy in patients undergoing percutaneous coronary intervention (PCI)…
- Conditions
- Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI), Intravascular Ultrasound, Dual Antiplatelet Therapy
- Trial name
- SHORTDAPT (NCT06648720)
- Testing
- DAPT de-escalation
- Where
- Vietnam
- Volunteers
- 3,566 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
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