Clinical trials: Intervention Phase
Asthma, Respiratory Tract Disease
Houston "Breathe Easy" Healthy Homes-Based Model for Multifamily Rental Communities
The primary purpose of this pragmatic randomized clinical trial is to examine whether the addition of a phone-based multicomponent environmental intervention customized for Houston public housing residents with asthma will result…
- Conditions
- Asthma, Respiratory Tract Disease, Lung Diseases, Sinusitis, Chronic
- Trial name
- NCT05345080
- Testing
- Exposure-Reduction Intervention
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Baylor College of Medicine
Overactive Bladder (OAB)
A Study Measuring and Tracking Changes in Overactive Bladder (OAB) Medication
The purpose of this study is to track changes in overactive bladder (OAB) medical regimen and/or OAB medication dosage requirements.
- Trial name
- NCT01317810
- Sponsor
- Astellas Pharma Inc
Cancer Survivor, Stage I Rectosigmoid Cancer
Personalized Dietary Intervention in Managing Bowel Dysfunction and Improving Quality of Life in Stage I-III Rectosigmoid Cancer Survivors
This pilot clinical trial studies how well personalized dietary intervention works in managing bowel dysfunction and improving quality of life in stage I-III rectosigmoid cancer survivors.
- Conditions
- Cancer Survivor, Stage I Rectosigmoid Cancer, Stage II Rectosigmoid Cancer, Stage III Rectosigmoid Cancer
- Trial name
- NCT03063918
- Testing
- Informational Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- City of Hope Medical Center
Prostate Cancer, Psychosocial Effects of Cancer and Its Treatment
Communication and Intimacy-Enhancing Therapy for Men With Early Stage Prostate Cancer and Their Partners
RATIONALE: Participating in a therapy program may enhance communication and intimacy between men with prostate cancer and their partners.
- Conditions
- Prostate Cancer, Psychosocial Effects of Cancer and Its Treatment, Sexual Dysfunction and Infertility, Sexuality and Reproductive Issues
- Trial name
- NCT00503646
- Testing
- communication intervention, counseling intervention, questionnaire administration
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Parkinson's Disease (PD)
Parkinson's Research In Metagenomic Early Stage Biomarkers
This 2x2 factorial, randomized, controlled pilot study aims to identify a specific microbiota pattern, which could constitute a biomarker of Parkinson's disease, and to evaluate whether specific pathotypes can be associated with…
- Trial name
- PRIME_2025 (NCT07097103)
- Testing
- Mediterranean Diet Intervention, Intensive Physical Activity Intervention, Control
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS San Raffaele Roma
Hypertension
The Real-Life Efficacy and Safety of Telmisartan in Patients With Arterial Hypertension
The main purpose of this study is to asses the efficacy and safety of telmisartan, with the special attention on the influence of telmisartan on selected metabolic parameters of patients.
- Trial name
- METABOLIC (NCT00471003)
- Testing
- Pritor (Telmisartan , BAY68-9291)
- Where
- 4 sites in Croatia, Poland and 2 more
- Volunteers
- 5,448 people
- Sponsor
- Bayer
Diabetic Kidney Disease, Diabetic Nephropathy
Effect of LIXIsenatide on the Renal System
Based on preclinical and small-sized studies in non-diabetic individuals, incretin-based therapies, i.e. glucagon-like peptide (GLP)-1 receptor agonists and dipeptidyl peptidase-4 inhibitors, may hold promise in preventing the…
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathy, Diabetes Mellitus, Glucagon-Like Peptide 1
- Trial name
- ELIXIRS (NCT02276196)
- Testing
- Lixisenatide, Insulin glulisine
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Lung Cancer (NSCLC)
Exercise and Nutrition on Early-stage NSCLC Outcomes: the STARLighT Study
The general goal of the STARLighT study is to test whether a structured physical exercise and nutritional intervention significantly impacts clinical outcomes in patients with early-stage lung cancer.
- Trial name
- STARLighT (NCT07042724)
- Testing
- Physical exercise and nutrition intervention for the neoadjuvant setting, Physical exercise and nutrition for the adjuvant setting, Health educational material
- Where
- Italy
- Volunteers
- 324 people
- Sponsor
- Universita di Verona
Cervical Dysplasia
A Phase II Single-arm Intervention Trial of Nelfinavir in Patients With Grade 2/3 or 3 Cervical Intraepithelial Neoplasia
Preliminary data showed that Nelfinavir has selective apoptotic effects on HPV+ cervical tumor cell lines. Furthermore, in a Phase I clinical trial, the combination of NFV and chemoradiotherapy showed acceptable toxicity and…
- Trial name
- NCT01925378
- Testing
- Nelfinavir
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Musculoskeletal Cancers
Trial Evaluating Hypnosis Using Virtural Reality vs Standard Pain Management During Musculoskelettal Biopsy
The primary objective of this trial is to evaluate the benefit of the virtual reality technology in the pain management for patients having a radio-guided musculoskeletal biopsy indication
- Trial name
- REVENRI (NCT03418597)
- Testing
- Deep local anesthesia + Virtual reality, Deep local anesthesia alone
- Where
- France
- Volunteers
- 99 people
- Sponsor
- Centre Leon Berard
Environmental Enteric Dysfunction (EED)
Maternal Probiotic Intervention to Improve Gut Health - Trial II - Burkina Faso (MPIGH-II)
Burden: Environmental Enteric Dysfunction (EED) is an enteropathic condition characterized by altered gut permeability, infiltration of immune cells and changes in villous architecture and cell differentiation.
- Trial name
- MPIGH-II (NCT07134790)
- Testing
- VE818, Oral Vancomycin
- Where
- Burkina Faso
- Volunteers
- 144 people
- Sponsor
- University Ghent
Tobacco Smoking Cessation, Motivation
Pro-Change Smoking Cessation Intervention
The purpose of this study is to determine whether a behavioral economics solution impacts smoking cessation program engagement and quit rates.
- Trial name
- NCT02299076
- Testing
- Behavioral economics incentives, Minimal incentives
- Where
- United States
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- VAL Health, LLC
Metastatic Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8
Occupational Therapy Fatigue Management-Based Intervention for Metastatic Renal Cell Carcinoma
This clinical trial studies the effects of occupational therapy fatigue management in patients with renal cell cancer that has spread to other places in the body (metastatic).
- Trial name
- NCT04961320
- Testing
- Occupational Therapy, Questionnaire Administration
- Sponsor
- City of Hope Medical Center
Dementia, Alzheimer Disease
Learning and Coping With Early Stage Dementia
The overall aim of this study is to investigate how home dwelling people with early-stage dementia cope with their disease, explored through their participation in a 12-week health promotion course, through 3 sub-studies; 1) The…
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- NCT03741543
- Testing
- A 12-week health promotion course
- Volunteers
- 108 people
- Sponsor
- Helse Stavanger HF
Sleep, Psychological Stress
Sleeping Healthy/Living Healthy Development
This pilot study will: (1) develop Sleeping Healthy/Living Healthy, a school-based health center (SBHC) intervention that combines MBIH and sleep hygiene strategies to improve sleep quality in urban adolescents with poor sleep…
- Trial name
- NCT04484649
- Testing
- Sleeping Healthy/Living Healthy, Attention Control
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cardiovascular Diseases, Cardiac Rehabilitation
SMART to Optimize an Intervention to Maintain Health Improvements After Cardiac Rehabilitation
The study is sponsored by the National Heart, Lung, and Blood Institute, which is part of the National Institutes of Health. The study expects to enroll 400 subjects.
- Trial name
- EMPOWER ME (NCT06886789)
- Testing
- Text Messaging, Fully Automated Online Program, Low-Intensity Cardiac Rehabilitation Maintenance Program
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The Miriam Hospital
Smokers, Former Smokers
A Study of Exercise and Pharmacologic Intervention on Systemic Inflammation
This is a study assessing the feasibility of performing an anti-aging intervention which is a combination of an exercise regimen, spermidine supplementation, and either rapamycin or lamivudine.
- Trial name
- NCT07058974
- Testing
- lamivudine, rapamycin, Exercise Regimen
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Myeloproliferative Disorders, Leukemia
A Standardized Nursing Intervention Protocol for HCT Patients
RATIONALE: Visiting patients at home to teach them about self care after a stem cell transplant may be more effective than standard therapy in improving quality of life.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00951626
- Testing
- exercise intervention, telephone-based intervention, dietary intervention
- Where
- United States
- Volunteers
- 282 people
- Sponsor
- City of Hope Medical Center
Fatigue, Nausea and Vomiting
Supportive Intervention Programs Study
This randomized clinical trial studies the preliminary efficacy of a yoga skills training (YST) compared to counseling and education (CE) for reducing treatment-related symptoms in patients with colorectal cancer who are…
- Conditions
- Fatigue, Nausea and Vomiting, Pain, Recurrent Colon Cancer
- Trial name
- SIPS (NCT01590147)
- Testing
- Yoga therapy, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Wake Forest University
Lung Cancer, Surgery
Neoadjuvant Intra-tumor Double Immunotherapy for Lung Cancer.
This phase II trial studies how well intra-tumor injection of double checkpoint inhibitors work when given alone and in combination with chemotherapy or/and bevacizumab in treating patients with previously untreated stage I-IIIA…
- Conditions
- Lung Cancer, Surgery, Non-small Cell Lung Cancer
- Trial name
- NCT06492421
- Testing
- ipilimumab, pembrolizumab, durvalumab, idarubicin, bevacizumab
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
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