Clinical trials: Intervention Phase
Pain
Evaluation of DEX-IN During Outpatient Procedures
The primary objective of this study is to evaluate the analgesic efficacy of DEX-IN compared with placebo and active control (fentanyl), in subjects undergoing painful outpatient and office based procedures.
- Trial name
- NCT03348423
- Testing
- DEX-IN, Fentanyl
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baudax Bio
Breast Cancer Survivor, Breast Cancer
Move Together Boston Feasibility Pilot (Sit Less, Move More App for Black Breast Cancer Survivors & At-Risk Relatives)
The purpose of this study is to develop and test a mobile app for Black/African American breast cancer survivors and their relatives, called Move Together, that promotes sitting less and moving more for better health.
- Conditions
- Breast Cancer Survivor, Breast Cancer, Fitness Trackers
- Trial name
- NCT05011279
- Testing
- Move Together app/Garmin Activity Tracker
- Where
- 3 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension
Assessment of Compliance With Antihypertensive Telmisartan Therapy
The purpose of this study is to asses the efficacy and safety of Telmisartan depending on the use of an electronic therapy monitoring device (HelpingHand) in a real life setting and to asses patients compliance to the therapy…
- Trial name
- COAST (NCT00470886)
- Testing
- Telmisartan (Kinzal/Pritor, BAY68-9291)
- Where
- 2 sites in Poland, Slovakia
- Volunteers
- 3,400 people
- Sponsor
- Bayer
Contraceptive Usage
Testing a Modified Family Planning Intervention for Postpartum Women in Uganda
The purpose of this study is to test whether offering incentives to encourage women to attend one-on-one family planning education sessions and offering free, onsite prescription contraceptive methods increases use and…
- Trial name
- NCT04068870
- Testing
- Contraceptive management program
- Where
- Uganda
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Non Small Cell Lung Cancer, Epidermal Growth Factor Receptor Gene Mutation
Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients
The goal of the study is to collect data on patients treated outside of a clinical trial (in routine clinical practice) with standard of care osimertinib with or without chemotherapy in Epidermal Growth Factor Receptor…
- Conditions
- Non Small Cell Lung Cancer, Epidermal Growth Factor Receptor Gene Mutation, Stage III Lung Cancer, Stage IV Lung Cancer
- Trial name
- NCT06538038
- Testing
- Osimertinib, Osimertinib + Chemotherapy
- Where
- 146 sites in United States
- Volunteers
- 200 people
- Sponsor
- PrECOG, LLC.
Prostate Cancer
Early Staged Consent Before Prostate Biopsy
This is a study and a novel approach to clinical trials, testing the feasibility and acceptability of two-stage consent in the context of a trial integrated into routine clinical practice.
- Trial name
- NCT03507725
- Testing
- Meditation, Prostate Biopsy, Questionnaires
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Stroke Intervention, Rehabilitation Exercise
Virtual Reality-Enhanced Rehabilitation for Upper Limb Recovery in Acute Post-Stroke Patients
Post-stroke rehabilitation is essential for maximising motor recovery. Virtual reality (VR) is emerging as a promising adjunct to conventional therapy (CRT), potentially enhancing upper limb motor outcomes.
- Trial name
- VR (NCT07254676)
- Testing
- Virtual Reality-enhanced rehabilitation, Conventional rehabilitation therapy (CRT)
- Where
- Slovenia
- Volunteers
- 52 people
- Sponsor
- University Medical Centre Maribor
Anxiety, Depression
HINCAB-study. Home Based Intervention in Nursing for Coronary Artery Bypass Patients
HINCAB-study is a single senter, prospective, randomised controlled trial. The aim of the study is to test the effect of a home based intervention program.
- Trial name
- NCT00245817
- Testing
- HINCAB
- Where
- Norway
- Volunteers
- 203 people
- Sponsor
- Ullevaal University Hospital
Mental Disorder in Adolescence, Insomnia
Promoting Sleep and Physical Activity Among Adolescent Psychiatric Patients
Mental health disorders pose a significant burden on adolescent populations globally, often accompanied by sleep disturbances. Emerging evidence suggests that addressing sleep issues can improve mental health outcomes, while…
- Conditions
- Mental Disorder in Adolescence, Insomnia, Delayed Sleep-Wake Phase Disorder
- Trial name
- SLEEPAC (NCT06407258)
- Testing
- SLEEPAC
- Where
- 2 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- Christin Lang
Pulmonary Complications, Cardiovascular Complications
The Incidence of Pulmonary, Cardiovascular and Renal System Non-communicable Complications Associated With the Post-acute Phase of the Infection by Covid-19
More than 660 million cases of COVID-19 have been reported worldwide, with 183 million cases in the EU alone. In several people, after recovery, the effects of the first waves of COVID-19 persisted beyond the acute phase and…
- Conditions
- Pulmonary Complications, Cardiovascular Complications, Renal Complications, COVID-19
- Trial name
- POINT (NCT06608849)
- Testing
- Blood samples, Six-minute walk test, Spirometry, HRCT, Heart ultrasound, Completion of questionnaires of symptoms
- Where
- 6 sites in Greece
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Hellenic Institute for the Study of Sepsis
Intraductal Papillary Mucinous Neoplasm of the Pancreas, Recurrent Pancreatic Cancer
Erlotinib Hydrochloride in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery
Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving erlotinib hydrochloride before surgery may make the tumor smaller and reduce the amount of normal tissue…
- Conditions
- Intraductal Papillary Mucinous Neoplasm of the Pancreas, Recurrent Pancreatic Cancer, Stage IA Pancreatic Cancer, Stage IB Pancreatic Cancer
- Trial name
- NCT00482625
- Testing
- erlotinib hydrochloride, conventional surgery, immunohistochemistry staining method
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Kidney Disease
Study Comparing Effects of Lanthanum Carbonate Versus Calcium Acetate Versus Dietary Phosphorus Restriction
Objective: To examine the effects of three commonly applied treatments of disordered phosphorus homeostasis on biochemical markers and vascular characteristics in patients with moderate and advanced non-dialysis dependent chronic…
- Trial name
- NCT01357317
- Testing
- Diet counseling, Phosphorus binder
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Salem Veterans Affairs Medical Center
Atopic Dermatitis, Atopic Hand Eczema
A 32-week Trial to Evaluate the Efficacy and Safety of Tralokinumab in Subjects With Moderate-to-severe Atopic Hand Eczema Who Are Candidates for Systemic Therapy
The purpose of this study is to test if treatment with tralokinumab is safe and efficacious in treating moderate-to-severe atopic hand eczema.
- Trial name
- ADHAND (NCT05958407)
- Testing
- Tralokinumab
- Where
- 69 sites in United States, Belgium and 8 more
- Volunteers
- 235 people
- Sponsor
- LEO Pharma
Post Surgical Neuropathic Pain
Comparison of Qutenza (8% Capsaicin) With a Low-dose Capsaicin for Treatment of Nerve Pain After Surgery
This is an interventional, Phase III, double-blind, randomized, controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of repeated topical application of Qutenza (capsaicin 8% topical system)…
- Trial name
- RISE (NCT04967664)
- Testing
- Qutenza (capsaicin) 8% topical system, capsaicin 0.04% topical system
- Where
- 64 sites in United States, France and 4 more
- Volunteers
- 412 people
- Sponsor
- Averitas Pharma, Inc.
Bariatric Surgery Candidate, Covid19
Obesity Surgery During 2020 Italian Pandemic
The first person-to-person Coronavirus disease (COVID-19) transmission in Italy was reported on Feb 21st, 2020, causing one of the most massive outbreak in Europe so far that stopped immediately all elective surgical procedures.
- Conditions
- Bariatric Surgery Candidate, Covid19, Complication of Surgical Procedure, Pneumonia, Viral
- Trial name
- NCT04480034
- Testing
- Bariatric procedures
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- University of Roma La Sapienza
Chronic Liver Disease, Thrombocytopenia
Safety and Efficacy Study of Lusutrombopag for Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Elective Invasive Procedures
The primary purpose of this study is to compare the efficacy of lusutrombopag with placebo for the treatment of thrombocytopenia in patients with chronic liver disease who are undergoing elective invasive procedures.
- Trial name
- L-PLUS 2 (NCT02389621)
- Testing
- Lusutrombopag
- Volunteers
- 215 people
- Sponsor
- Shionogi
Any Ear Nose or Throat Conditions, With Identified Need for a Diagnostic Procedure or Surgery on or Through the Mucous Membranes of the Nasal Cavities
Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia
Randomized, prospective, multi-center, double blind placebo-controlled parallel group study of a Placebo Topical Solution versus Cocaine HCl 4% Topical Solution for safety and efficacy, and Cocaine HCl 4% and 10% Topical Solution…
- Trial name
- NCT02500836
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- United States
- Volunteers
- 646 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Skin Ulcer Venous Stasis Chronic
Allogeneic ABCB5-positive Stem Cells for Treatment of CVU
The aim of this clinical trial is to investigate the efficacy (by monitoring the wound size reduction of Chronic Venous Ulcers) and safety (by monitoring adverse events) of the medicinal product to be studied after two…
- Trial name
- NCT03257098
- Testing
- allo-APZ2-CVU
- Where
- 9 sites in Germany
- Volunteers
- 31 people
- Sponsor
- RHEACELL GmbH & Co. KG
Covid-19, Nosocomial Infection
COG-UK Project Hospital-Onset COVID-19 Infections Study
Hospitals are recognised to be a major risk for the spread of infections despite the availability of protective measures. Under normal circumstances, staff may acquire and transmit infections, but the health impact of within…
- Conditions
- Covid-19, Nosocomial Infection, Coronavirus, Coronavirus Infection
- Trial name
- COG-UK HOCI (NCT04405934)
- Testing
- Use of virus (Covid-19) genome sequence report to inform infection prevention control procedures
- Where
- United Kingdom
- Volunteers
- 2,170 people
- Sponsor
- University College, London
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