Clinical trials: Intervention Phase
Life-threatening Illness, Palliative
Initiating ACP in General Practice. A Phase II Study
End-of-life care often fails in providing optimal patient-centred care and quality of life. Patients frequently suffer from inadequate control of pain, from a lack of communication about their illness and options for treatment…
- Trial name
- NCT02775032
- Testing
- Advance care planning conversations between patients and their GP
- Sponsor
- Vrije Universiteit Brussel
Parkinson Disease, Prodromal Stage
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
α-Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are the second most common neurodegenerative diseases.
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
- Trial name
- ALPHA-FIT (NCT07324330)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Financial Burden, Health Behavior
Economic Empowerment and Health Promotion of Uganda Grandmother-caregivers.
Background: There are an estimated 163 million children worldwide who are under the care of their grandparents or other relatives.
- Conditions
- Financial Burden, Health Behavior, Social Support
- Trial name
- BAJJAJJA (NCT07011264)
- Testing
- The BAJJAJJA intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Utah
Stroke, Stroke, Ischemic
Behavioral Activation for Post-Stroke Sedentary Behavior Using Telehealth
Adults with stroke-related disability spend more time sedentary than adults without stroke-related disability, which places them at risk for poor cardiovascular health outcomes.
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- teleABLE (NCT05029284)
- Testing
- teleABLE
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Minnesota
Chronic Thromboembolic Pulmonary Hypertension
A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery and/or Interventional Treatment
Selexipag is available in many countries for the treatment of pulmonary arterial hypertension (PAH). Due to the similarities between PAH and chronic thromboembolic pulmonary hypertension (CTEPH) and the observed efficacy of other…
- Trial name
- SELECT (NCT03689244)
- Testing
- Selexipag
- Where
- 162 sites in United States, Argentina and 29 more
- Volunteers
- 128 people
- Sponsor
- Actelion
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Culturally Based Brief Expressive Writing Intervention for the Improvement of Health in Chinese Immigrant Stage 0-III Breast Cancer Survivors, Writing to Heal Study
This clinical trial studies the effect of a culturally based brief expressive writing intervention in improving the health of Chinese immigrant stage 0-III breast cancer survivors.
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT04754412
- Testing
- Behavioral, Psychological or Informational Intervention, Best Practice, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- M.D. Anderson Cancer Center
Schizophrenia
Safety and Efficacy of Switching to Quetiapine in Outpatients With Schizophrenia
This is a single-arm, phase IV, open-label, prospective, non interventional study in approximately 600 patients that will be followed for 6 months in order to evaluate the safety and efficacy of quetiapine.
- Trial name
- Q-chase (NCT00690365)
- Volunteers
- 576 people
- Sponsor
- AstraZeneca
Sedentary Lifestyle, Stage III Prostate Cancer AJCC v7
Fatigue Interventions in Cancer (Exercise Intervention)
This randomized pilot phase II trial studies how well exercise intervention with or without internet-based cognitive behavior therapy works in reducing fatigue in participants with prostate cancer that has spread to other places…
- Conditions
- Sedentary Lifestyle, Stage III Prostate Cancer AJCC v7, Stage IV Prostate Cancer AJCC v7
- Trial name
- NCT03421782
- Testing
- Cognitive Behavior Therapy, Exercise Intervention
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Utah
Huntington's Disease
Feasibility and Acceptability of Implementing a Clinic-based Physical Activity Coaching Intervention in People With Premanifest and Early Stage HD
This study will evaluate the feasibility and acceptability of a clinic-based physical activity coaching intervention in people with pre-manifest and early stage Huntington's Disease (HD).
- Trial name
- NCT03306888
- Testing
- Physical Activity Coaching
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Teachers College, Columbia University
Multiple Primary Lung Cancers
The Efficacy of PD-1 Antibody Sintilimab on Early-stage Multiple Primary Lung Cancer With Ground Glass Density.
A single-center,prospective interventional study to explore the efficacy of PD-1 antibody Sintilimab on early-stage multiple primary lung cancer patients with ground-glass nodules in CT scan.
- Trial name
- NCT04026841
- Testing
- PD-1 antibody Sintilimab
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Oligo-metastatic Stage IV Non-small Cell Lung Cancer
The Optimal Intervention Time of Radiotherapy for Oligometastatic Stage IV Non-small Cell Lung Cancer（NSCLC）
This study evaluates the optimal intervention time of radiotherapy for oligometastatic stage iv lung cancer.
- Trial name
- OITROLC (NCT02076477)
- Testing
- concurrent chemoradiotherapy, Docetaxel, pemetrexed
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Aging, Adaptation
Psycho-educational Intervention Programme for Comprehensive Preparation for Retirement: Study Protocol
Background: The transition to retirement can be a challenging event, necessitating the adjustment of new routines, roles and expectations.
- Conditions
- Aging, Adaptation, Psychosocial Factors, Psychology
- Trial name
- NCT06533202
- Testing
- Psychoeducational Programme, Education Programme
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Advanced Lung Carcinoma, Malignant Female Reproductive System Neoplasm
Conquer Fear SUPPORT Intervention in Supporting Patients With Stage III-IV Lung or Gynecologic Cancer
This trial will pilot a psychosocial intervention called Conquer Fear Support (CFS) in patients with stage III-IV lung or gynecologic cancer who are experiencing fear of cancer progression.
- Conditions
- Advanced Lung Carcinoma, Malignant Female Reproductive System Neoplasm, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8
- Trial name
- NCT03776253
- Testing
- Psychosocial Care Conquer Fear Support intervention (psychoeducation, attention training, worry management, and detached mindfulness components), Questionnaire Administration
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- City of Hope Medical Center
Engaging in Regular Physical Exercise
Non-Stage-Matched Intervention to Enhance High School Female Students' Readiness to Engage in Regular Physical Exercise
A non-stage-matched intervention based on the Transtheoretical Model of Change
- Trial name
- NCT05938777
- Testing
- Non-Stage-Matched Intervention
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Non-Small Cell Carcinoma of Lung, TNM Stage 4
A Real World Study Based on NGS (TRUMPRWS)
This is a descriptive observational study, in which data are collected in an epidemiological fashion. This study does not intend to alter or intervene the current medical practice of the recruited patients.
- Trial name
- TRUMPRWS (NCT03605602)
- Testing
- No treatment is included in this protocol.
- Where
- China
- Volunteers
- 2,700 people
- Sponsor
- Guangdong Association of Clinical Trials
Depression
Harnessing Network Science to Personalize Scalable Interventions for Adolescent Depression (TRACK to TREAT Phase 2)
We will recruit 216 subjects meeting the eligibility criteria. After completing a baseline battery session via secure video conferencing and 3-week phone survey period, adolescents will be randomly assigned to receive 1 of 3…
- Trial name
- NCT04607902
- Testing
- Supportive Therapy SSI, Behavioral Activation SSI, Growth Mindset SSI
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Stony Brook University
Colitis, Ulcerative
An Open Label Phase 4 Study to Evaluate Efficacy of Early Versus Late Use of Vedolizumab in Ulcerative Colitis
This multi-centre open label study will involve a minimum of 120 patients in 2 cohorts: 60 patients with 'early UC' defined as disease duration < 4 years and no other treatments than aminosalicylates and/or corticosteroids and 60…
- Trial name
- LOVE-UC (NCT02646657)
- Testing
- Vedolizumab 300 mg
- Where
- 20 sites in Belgium, Hungary and 1 more
- Volunteers
- 120 people
- Sponsor
- Geert D'Haens
Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 5
The Agenda-Setting for Kidney Disease Trial
The goal of this clinical trial is to learn if a tool with a list of discussion topics, called a structured clinical visit agenda-setting intervention (SAS), works for people with advanced chronic kidney disease (CKD) who receive…
- Trial name
- ASK (NCT07024953)
- Testing
- Chronic Kidney Disease Structured Agenda-Setting Tool
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Head and Neck Squamous Cell Carcinoma
A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010/LEAP-010)-China Extension
This is a study of pembrolizumab (MK-3475) with or without lenvatinib (E7080/MK-7902) as a first line intervention in a PD-L1 selected population with participants with recurrent or metastatic head and neck squamous cell…
- Trial name
- NCT05523323
- Testing
- Lenvatinib, Pembrolizumab
- Where
- 28 sites in China
- Volunteers
- 112 people
- Sponsor
- Merck Sharp & Dohme LLC
Non-Small Cell Lung Carcinoma
Study of Capmatinib in Indian Patients With MET Exon 14 Skipping Mutation Positive Advanced NSCLC.
The Drugs Controller General of India (DCGI) granted approval for Rahika® (capmatinib) film-coated tablets (150 mg and 200 mg) for the treatment of adult patients with advanced or metastatic non-small cell lung cancer (NSCLC)…
- Trial name
- NCT05110196
- Testing
- Capmatinib 150 mg, Capmatinib 200 mg
- Where
- 15 sites in India
- Volunteers
- 50 people
- Sponsor
- Novartis Pharmaceuticals
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.