Clinical trials: Intervention Phase
Healthy
Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects
Explore the detoxifying potential of hydroxytyrosol and its effects on Phase II enzyme expression (leading to xenobiotics detoxification in the liver).
- Trial name
- NCT02273622
- Testing
- hydroxytyrosol
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Traumatic Articular Cartilage Defects in the Knee Joint
Phase III Study to Evaluate Safety and Effectiveness of NOVOCART 3D Plus vs. Microfracture in Knee Cartilage Defects
In this phase 3 clinical trial, a second generation ACI (autologous chondrocyte implantation technique) is compared to standard of care therapy (microfracture) to treat traumatic cartilage defects of the knee for efficacy and…
- Trial name
- N3D (NCT01656902)
- Testing
- NOVOCART® 3D plus, Microfracture
- Where
- 35 sites in Austria, Czechia and 8 more
- Volunteers
- 263 people
- Sponsor
- Tetec AG
Symptom Managemen, Late Stage Lung Cancer
The Impact of Symptom Management Nursing Intervention on the QoL of Patients With Advanced Lung Cancer: Mediation of Self-management Efficacy and Regulation of Psychological Resilience
Symptom management nursing intervention can improve the self-management efficacy, psychological resilience, and QoL of patients with advanced lung cancer.
- Conditions
- Symptom Managemen, Late Stage Lung Cancer, QoL, Self Management Efficacy
- Trial name
- NCT07679165
- Testing
- routine nursing group, standardized systematic SM nursing group
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Jie Zeng
Sleep Disorders, Circadian Rhythm
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers
EuRhythDia II is a multicenter, randomized, double-blind controlled study. The rationale of EuRhythdia is to explore the effects of 12 weeks of timed melatonin treatment on circadian rhythm, metabolic control and cardiovascular…
- Trial name
- NCT02108353
- Testing
- Melatonin 2mg
- Where
- 3 sites in Germany, Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Dietary and Exercise Interventions in Reducing Side Effects in Patients With Stage I-IIIa Breast Cancer Receiving Aromatase Inhibitors
This phase I/II trial studies how well dietary and exercise interventions work in reducing side effects in patients with stage I-IIIa breast cancer taking aromatase inhibitors.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT03953157
- Testing
- Dietary Intervention, Exercise Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Menstrual Cycle
Menstrual Phase and Smoking Cessation at a State Quitline
Quitlines are efficient and cost-effective treatments for smoking cessation, yet little research has explored how to personalize and optimize quitline services for women.
- Trial name
- Project Phase (NCT03908320)
- Testing
- Menstrual Cycle Timing, NRT Patch, Cessation Counseling
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Alzheimer's Disease
A Phase III Trial of Nilvadipine to Treat Alzheimer's Disease
Alzheimer's disease (AD) is an ever-increasing public health concern among the aging population and is the most common form of dementia affecting more than 15 million individuals worldwide and around 5 million Europeans.
- Trial name
- NILVAD (NCT02017340)
- Testing
- Nilvadipine
- Where
- 23 sites in France, Germany and 7 more
- Volunteers
- 511 people
- Sponsor
- Prof Brian Lawlor
Ulcerative Colitis
A Study to Evaluate the Efficacy and Safety of ZYIL1 Oral Capsules for the Treatment of Patients With Mild to Moderately Active Ulcerative Colitis Resistant or Intolerant to Oral Aminosalicylates
The purpose of this study is to evaluate efficacy and safety of ZYIL1 oral capsule twice a day for 12 weeks for treatment of mild to moderate active ulcerative colitis resistant or intolerant to oral aminosalicylates.
- Trial name
- NCT06398808
- Testing
- Arm1, Arm 2
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Zydus Lifesciences Limited
HIV
MHealth HIV Prevention for Transgender Women
This study aims to inform the development of an acceptable and usable smartphone app for transgender women (TGW) in Malaysia to deliver an integrated HIV prevention intervention that incorporates screening and guidance for HIV…
- Trial name
- NCT05271097
- Testing
- MyLink2Care app full functionality, MyLink2Care app major intervention features inactivated
- Where
- Malaysia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
End-Stage Renal Disease, Hemodialysis
Hemocontrol and Blood Pressure Control in Dialysis Patients
Volume overload contributes significantly to the pathogenesis of hypertension in hemodialysis patients. The Hemocontrol(HC)system (Gambro), which automatically adjusts ultrafiltration rate and dialysate conductivity according to…
- Trial name
- NCT00319774
- Testing
- Hemocontrol Biofeedback System
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Montréal
Advanced Solid Tumors
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With Advanced Solid Tumors.
The therapeutic approach taken by trial SAKK 66/17 is different from those already used in clinical practice and possibly offers patients a therapeutic benefit after failure of standard chemotherapy and immunotherapy.
- Trial name
- NCT03993678
- Testing
- IP-001, Thermal Ablation
- Where
- 3 sites in Switzerland
- Volunteers
- 28 people
- Sponsor
- Swiss Cancer Institute
Antibiotic Stewardship in Community Hospitals
Antimicrobial Stewardship in Community Hospitals
The Infectious Diseases Society of America (IDSA) guidelines recommend two "core" strategies for Antibiotic Stewardship (AS): 1) antimicrobial restriction and preauthorization and 2) prospective audit with intervention and…
- Trial name
- NCT02212808
- Testing
- Antimicrobial restriction, Post-antimicrobial prescription review
- Volunteers
- 3,972 people
- Sponsor
- Duke University
Stroke, Acute Ischemic, Albumin
Intra-arterial Albumin Infusion After Endovascular Therapy for Stroke Patients
The purpose of this study is to investigate the safety and feasibility of intra-arterial albumin infusion for patients with acute ischemic stroke after successful thrombectomy and to further explore the optimal dose of albumin…
- Conditions
- Stroke, Acute Ischemic, Albumin, Endovascular Procedures, Large Vessel Occlusion
- Trial name
- NCT05953623
- Testing
- Albumin
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Tianjin Huanhu Hospital
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Web-based Lifestyle Program, mHealth and EMA Intervention, to Improve Weight Loss in Rural Stage I-III Postmenopausal Breast and Endometrial Cancer Survivors, HERO-C Trial
This clinical trial identifies the needs and preferences of rural stage I-III postmenopausal breast and endometrial cancer survivors and evaluates the impact of an adaptive, online program, mobile (m)Health + ecological momentary…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Endometrial Carcinoma
- Trial name
- NCT07723235
- Testing
- Aerobic Exercise, Biospecimen Collection, Dietary Intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Immunocytoma/Morbus Waldenström, B-Cell Non-Hodgkin's Lymphoma
Interventional Study on Pentostatin, Cyclophosphamide and Rituximab in Indolent B-Cell Non-Hodgkin-Lymphoma (B-NHL)
The combination of Fludarabine and Cyclophosphamide have yielded overall response rates of over 80% in previously untreated patients with indolent Non-Hodgkin-Lymphoma.
- Conditions
- Immunocytoma/Morbus Waldenström, B-Cell Non-Hodgkin's Lymphoma, B-Cell Chronic Lymphocytic Leukemia
- Trial name
- PERLL (NCT00927797)
- Testing
- Cyclophosphamide, Pentostatin, Rituximab
- Volunteers
- 185 people
- Sponsor
- Heidelberg University
Anxiety Disorders
Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders
The purpose of the study is to develop a personalized, user-friendly computerized treatment for anxiety disorders linked to primary care.
- Trial name
- AIM-PC (NCT02266446)
- Testing
- Attention & Interpretation Modification
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brown University
Assessment, Lipedema
Physical Therapy in Lipedema Surgery
The goal of this observational study or clinical trial is to know evaluate the effects of a modified Complete Decongestive Therapy protocol using the Godoy Method in the postoperative period following lipedema surgery.
- Conditions
- Assessment, Lipedema, Vascular Diseases, Dermatologic Complication
- Trial name
- NCT05966779
- Testing
- modified CDT physical therapy protocol, based on Godoy's Method
- Where
- Spain
- Volunteers
- 293 people
- Sponsor
- University of Alcala
Obstructive Sleep Apnea, Overhydration
Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx)
The purpose of this study is to investigate the effect of renal transplantation on fluid overload and its consequence on the severity of obstructive sleep apnea, in patients with end stage chronic kidney disease.
- Conditions
- Obstructive Sleep Apnea, Overhydration, End Stage Renal Disease, Renal Transplantation
- Trial name
- SASinTx (NCT02020642)
- Testing
- Renal transplantation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Contraception, Empowerment
Strengthening Contraceptive Counseling Services: Research Protocol for a Multi-phase Complex Intervention in Pakistan and Nigeria
High-quality contraceptive counseling can strengthen global efforts to reduce the unmet need for and suboptimal use of modern contraceptives.
- Conditions
- Contraception, Empowerment, Decision Making
- Trial name
- NCT06081842
- Testing
- Contraceptive counseling strengthening intervention package
- Volunteers
- 7,920 people, healthy volunteers welcome
- Sponsor
- World Health Organization
HIV Infection
Connect to Protect Partnerships for Youth Prevention Interventions: Phase II
This is Phase II of a three stage project whose overall goals are to develop viable community-based HIV prevention interventions and to form and maintain the necessary community collaborations to support such Adolescent Trials…
- Trial name
- NCT00103896
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 16,706 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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