Clinical trials: Interventional；
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention in High-Fidelity Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- LABYR (NCT04253587)
- Testing
- LabyrinthVR, Coherence, Tablet
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Self Injurious Behavior, Adolescent Behavior Problem
IMAGINATOR 2.0: Co-design and Early Evaluation of a Novel Blended Digital Intervention Targeting Self-harm in Young People
This study aims to investigate acceptability and feasibility of a new version of the Imaginator intervention, Imaginator 2.0, targeting self-harm behaviour in young people aged 12-25 under mental health services in the UK.
- Conditions
- Self Injurious Behavior, Adolescent Behavior Problem, Child Behavior Problem, Mental Health Disorder
- Trial name
- IMAG2 (NCT06311084)
- Testing
- Imaginator 2.0
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- Imperial College London
Pain
Pain Perception With Tenaculum Placement
Randomized controlled trial that compares methods of tenaculum placement during intrauterine device insertion and their effect on pain.
- Trial name
- NCT02969421
- Testing
- Cough method for placement of tenaculum, Slow Tenaculum Placement of tenaculum
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
COVID-19
Treatment of COVID-19 Patients With Anti-interleukin Drugs
The purpose of this study is to test the safety and effectiveness of individually or simultaneously blocking IL-6 and IL-1 versus standard of care on blood oxygenation and systemic cytokine release syndrome in patients with…
- Trial name
- COV-AID (NCT04330638)
- Testing
- Usual Care, Anakinra, Siltuximab
- Where
- 15 sites in Belgium
- Volunteers
- 342 people
- Sponsor
- University Hospital, Ghent
Emotional Distress, Burnout, Professional
A Self-directed Mobile Mindfulness Intervention to Address Distress and Burnout in Frontline Healthcare Workers
This is a pilot randomized waitlist control trial assessing if the feasibility of using a mobile mindfulness app to treat emotional distress and burnout amongst nurses taking care of COVID-19 patients.
- Conditions
- Emotional Distress, Burnout, Professional, Stress, Job, Anxiety
- Trial name
- LIFT-HCW (NCT04816708)
- Testing
- LIFT Mindfulness
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Duke University
Sex, Unsafe, Adolescent Behavior
Study Proposal for Web Based Intervention to Promote the Safe Usage of Dating Applications in Young Adults
This study will evaluate the effectiveness of a program in promoting the safe usage of dating applications amongst young adults in Hong Kong.
- Conditions
- Sex, Unsafe, Adolescent Behavior, Behavior, Sex
- Trial name
- NCT03685643
- Testing
- Intervention - Dating application topic, Control - Health and exercise topic
- Where
- 2 sites in Hong Kong
- Volunteers
- 578 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dementia, Alzheimer Disease
Play Intervention for Dementia for Promoting Cognitive Function: A Feasibility Study
This study intends to use Play Intervention for Dementia (PID) to promote cognitive functions of people with early to moderate dementia.
- Trial name
- NCT02846415
- Testing
- Play Intervention for Dementia
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Hypertension, Pulmonary
Piloting Mindfulness Meditation Program for Underserved Racial Minority Adults With Pulmonary Hypertension
The MMPH program will include two Zoom-delivered sessions (Weeks #1 \& #4), six video-recorded sessions (Weeks #2, #3, #5, #6, #7, #8), and daily mindfulness meditation practice using a mobile APP during an eight-week study…
- Trial name
- MMPH (NCT05387889)
- Testing
- Mindfulness Meditation for Pulmonary Hypertension (MMPH)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- State University of New York at Buffalo
Chronic Liver Disease, Thrombocytopenia
Safety and Efficacy Study of Lusutrombopag for Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Elective Invasive Procedures
The primary purpose of this study is to compare the efficacy of lusutrombopag with placebo for the treatment of thrombocytopenia in patients with chronic liver disease who are undergoing elective invasive procedures.
- Trial name
- L-PLUS 2 (NCT02389621)
- Testing
- Lusutrombopag
- Volunteers
- 215 people
- Sponsor
- Shionogi
Diagnostic and/or Interventional Radiology Procedures
Angio-Seal Interventional Radiology (IR) Registry
The purpose of this study is to collect data on the standard of care use of the St. Jude Medical (SJM) Angio Seal™ Evolution™ and V-Twist Integrated Platform (VIP) Devices in diagnostic and/or interventional radiology patient…
- Trial name
- NCT01222104
- Where
- 10 sites in United States
- Volunteers
- 634 people
- Sponsor
- Abbott Medical Devices
Alcoholism
Health Focused Motivational Treatment for Alcohol Dependent Veterans
The purpose of this study is to determine whether a health focused motivational intervention will reduce alcohol use for dependent veterans who are receiving outpatient alcohol and drug treatment.
- Trial name
- NCT00252590
- Testing
- Health Motivational Feedback, Health Education, Control - treatment as usual
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Autism Spectrum Disorder
Daily Living Skills Intervention for 9th and 10th Graders With Autism Spectrum Disorders
The current study seeks to develop the first daily living skills (DLS) intervention package for high functioning adolescents with autism spectrum disorder (ASD) and evaluate its effectiveness.
- Trial name
- NCT03984513
- Testing
- Surviving and Thriving in the Real World, Program for the Education and Enrichment of Relational Skills
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Health Attitude, Knowledge, Attitudes, Practice
Development and Pilot Test of a Postnatal mHealth Intervention - Phase 2
The goal of the study is to assess the feasibility and acceptability of the optimized MeSSSSage intervention which was developed and revised based on the results of our initial pilot testing.
- Conditions
- Health Attitude, Knowledge, Attitudes, Practice, Post Partum Depression, Acceptability of Health Care
- Trial name
- MESSAGE (NCT04693585)
- Testing
- MESSSSAGE - live, MESSSSAGE - asynchronous
- Where
- India
- Volunteers
- 201 people
- Sponsor
- University of California, San Francisco
Hemophilia
LR769 in Congenital Hemophilia Patients With Inhibitors Undergoing Elective Surgery or Invasive Procedures
The purpose of this study, PerSept 3, is to evaluate LR769 for the prevention of excessive bleeding and achievement of hemostasis in congenital hemophilia A or B patients who have inhibitors to Factor VIII or Factor IX , are aged…
- Trial name
- PerSept3 (NCT02548143)
- Testing
- Coagulation Factor VIIa (Recombinant)
- Where
- 9 sites in United States, Mexico and 4 more
- Volunteers
- 12 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Heart Diseases
A Partnership to Translate an Evidence-based Intervention (Take Heart) for Vulnerable Older Adults With Heart Disease
To evaluate the effectiveness of Take Heart, a behavioral/educational program for adults age 50+ with heart disease, or with at least two risk factors for heart disease, that helps them to better manage their health condition(s).
- Trial name
- NCT02950818
- Testing
- Take Heart
- Where
- United States
- Volunteers
- 453 people
- Sponsor
- University of Michigan
Gross Motor Development Delay, Social Skills
SKIPping With PAX: An Integrated Gross Motor and Social-Emotional Skill Intervention
The purpose of this study was to test the effects of an integrated intervention on the gross motor and social-emotional development of rural preschool boys and girls.
- Conditions
- Gross Motor Development Delay, Social Skills, Social Behavior, Sedentary Behavior
- Trial name
- NCT04656990
- Testing
- Integrated Intervention
- Where
- United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Autism Spectrum Disorders
Intranasal Oxytocin and Learning in Autism
The main objective of this study is to determine the safety and therapeutic potential of intranasal oxytocin in children and adolescents with autism spectrum disorder (ASD) when paired with a computer game intervention that is…
- Trial name
- NCT01417026
- Testing
- Intranasal Oxytocin (Trade name: Syntocinon)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Robert Schultz
Stroke
Community Participation Transition After Stroke
Stroke is one of the most serious, disabling health conditions in the United States. Patients who undergo rehabilitation treatment for stroke have a high rate of disability.
- Trial name
- COMPASS (NCT02396589)
- Testing
- Education Group, Home Modifications Group
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Sexual Aggression, Heavy Drinking
Emotion Regulation Interventions for Alcohol-Related Sexual Aggression
Rates of sexual assault are alarmingly high, and alcohol is consistently implicated in the majority of these assaults. Despite well-intentioned prevention efforts, this pandemic continues unabated, warranting the development of…
- Trial name
- NCT03159468
- Testing
- Cognitive Restructuring, Mindfulness, Alcohol consumption
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- University of Washington
Diet Modification
A Home-based Intervention to Improve the Diet Quality of Preschoolers
U.S. children eat too little fruits and vegetables and whole grains, and too many energy dense foods, dietary behaviors associated with increased morbidity from cardiovascular diseases.
- Trial name
- NCT03923491
- Testing
- Healthy Feeding, Healthy Eating, Reading Readiness
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
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