Clinical trials: Interventional Cardiology
Cardiac Arrest, Acute Coronary Syndrome
Mild Therapeutic Hypothermia for Patients With Acute Coronary Syndrome and Cardiac Arrest Treated With PCI
Mild Therapeutic Hypothermia for Patients with Acute Coronary Syndrome and Cardiac Arrest Treated with Percutaneous Coronary Intervention (UNICORN) study is designed to determine whether mild therapeutic hypothermia (MTH) applied…
- Trial name
- UNICORN (NCT02611934)
- Testing
- Mild Therapeutic Hypothermia (MHT)
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jacek Kubica
Carcinoid Heart Disease, Neuroendocrine Tumors
CardioNETPOL National Registry of Carcinoid Heart Disease
Carcinoid tumors are neuroendocrine tumors (NETs), most commonly originating from the gastrointestinal tract, that may secrete bioactive substances such as serotonin.
- Conditions
- Carcinoid Heart Disease, Neuroendocrine Tumors, Carcinoid Syndrome, Valvular Heart Disease Patients
- Trial name
- CardioNETPOL (NCT07450287)
- Testing
- Observational Registry of Carcinoid Heart Disease
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Cardiovascular Disease
Dietary Intervention and Vascular Function
It is well established that diet plays an important role in both the development and progression of heart disease. Different types of dietary fat have varying effects on heart disease risk factors.
- Trial name
- DIVAS (NCT01478958)
- Testing
- SFA diet, MUFA diet, n-6 PUFA diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 202 people
- Sponsor
- University of Reading
Arteriovenous Fistula, Hemodialysis
Effectiveness of a Structured Intervention on the Development of Self-Care Behaviors With AVF in HD Patients
End stage renal disease patients (ESRD) should be educated to take care of their arteriovenous fistula (AVF). Educational programs should have clear objectives and the interventions should be well defined.
- Trial name
- SISC-AVF (NCT03830658)
- Testing
- Structured Intervention on Self-care with AVF (SISC-AVF)
- Where
- Portugal
- Volunteers
- 89 people
- Sponsor
- Instituto Portugues de Oncologia, Francisco Gentil, Porto
Portal Hypertension, Liver Diseases
Achieving Portal Access With Scorpion Post-Approval Study 2
Creation of the parenchymal tract between the portal vein and the hepatic vein is the most difficult and time consuming step in a TIPS procedure.
- Conditions
- Portal Hypertension, Liver Diseases, Ascites Hepatic, Hydrothorax
- Trial name
- APASS2 (NCT06856655)
- Testing
- Scorpion Portal Vein Access Kit
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Argon Medical Devices
Left Ventricular Dysfunction
Bone Marrow Derived Mononuclear Cells For Myocardial Regeneration
Evaluative pilot study for safety and feasibility with administration of autologous bone bone marrow derived mononuclear cells by endoventricular catheter into the normal border zone fo the ischemic lesion.
- Trial name
- NCT00938847
- Testing
- PCI
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Asklepios proresearch
Aortic Valve Stenosis
Randomized Comparison of Catheter-based Strategies for Interventional Access Site Closure During Transfemoral Transcatheter Aortic Valve Implantation
The aim of the study is to evaluate the clinical efficacy of 2 different vascular closure device (VCD) strategies during transfemoral transcatheter aortic valve implantation (TAVI).
- Trial name
- CHOICE-CLOSURE (NCT04459208)
- Testing
- Manta, ProGlide
- Where
- Germany
- Volunteers
- 516 people
- Sponsor
- Helios Health Institute GmbH
Hypertension
Salt Loading and Thiazide Intervention Study
The investigators of this study propose to examine the relationships between STK39 (Serine Threonine Kinase 39) genotypes and responses to salt loading and to thiazide diuretics, hydrochlorothiazide.
- Trial name
- SALTI (NCT00896389)
- Testing
- Salt loading, Hydrochlorothiazide (HCTZ)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Growth Hormone Deficiency, Idiopathic Short Stature
Long-term Safety and Effectiveness of Growtropin®-II Treatment in Children With Short Stature
This study evaluates long-term safety and effectiveness of Growtropin®-II treatment in children with short stature.
- Conditions
- Growth Hormone Deficiency, Idiopathic Short Stature, Turner Syndrome, Small for Gestational Age
- Trial name
- NCT04798690
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Dong-A ST Co., Ltd.
Coronary Artery Disease
Deutsches Dual Therapy Stent Register
The DTS.DE registry is an initiative for the collection of high quality process and historical data of implantations with the COMBO Dual Therapy Stent in Germany.
- Trial name
- DTS Register (NCT02102997)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- OrbusNeich
Myocardial Infarction
STREAM-Strategic Reperfusion (With Tenecteplase and Antithrombotic Treatment) Early After Myocardial Infarction
This study aims at evaluating, in a proof of concept approach, the outcome of patients presenting with acute ST-elevation myocardial infarction within 3 hours of symptom onset in either a pre-hospital setting or community…
- Trial name
- NCT00623623
- Testing
- primary PCI, enoxaparin, catheterisation
- Where
- 201 sites in Austria, Belgium and 14 more
- Volunteers
- 1,899 people
- Sponsor
- Boehringer Ingelheim
Descending Aortic Dissection, Postoperative Pain
Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI
The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving…
- Conditions
- Descending Aortic Dissection, Postoperative Pain, Thoracoabdominal Aortic Aneurysm
- Trial name
- 2020Ketamine (NCT04600089)
- Testing
- Saline, Ketamine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Eric Johnson
Stroke, Osteoporosis
Sarcopenia and Risk of Falls in Patients With Major Chronic Diseases
The objective of this study is to investigate the effects of therapeutic exercise and nutrition intervention for sarcopenia and risk of falls in patients with major chronic diseases.
- Conditions
- Stroke, Osteoporosis, Chronic Kidney Diseases, Cancer
- Trial name
- NCT03798418
- Testing
- elastic band strengthening exercise, diet counseling
- Where
- Taiwan
- Volunteers
- 186 people
- Sponsor
- Changhua Christian Hospital
Cardiovascular Diseases, Health Behavior
Evaluation of a Socio-ecological Cardiovascular Disease Prevention Intervention for Ultra-Orthodox Jewish Hasidic Women
The purpose of this research study is to design, implement, and evaluate a community level, socio-ecological based CVD prevention intervention using a participatory approach for women in a homogeneous ultra-Orthodox Jewish…
- Trial name
- NCT03201523
- Testing
- Socio-ecologial, community-based intervention
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Atrial Fibrillation
Decentralized Trial in Atrial Fibrillation Patients
The purpose of this study is to validate an approach to decentralize, or virtualize, the clinical trial experience for enrolled subjects, through the coordinated use of multiple digital health and telehealth technologies.
- Trial name
- DeTAP (NCT04471623)
- Testing
- Use of DeTAP App and Home Devices
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Stanford University
Acute ST-segment Elevation Myocardial Infarction
Effect of Low-dose Intracoronary Reteplase on Myocardial Infarct Size During Primary Percutaneous Coronary Intervention
OBJECTIVE: To determine whether a therapeutic strategy involving low-dose intracoronary fibrinolytic therapy with reteplase infused after coronary reperfusion will reduce the myocardial infarction size.
- Trial name
- RECOVERII (NCT04571580)
- Testing
- Normal Saline, Reteplase Injection 9mg, Reteplase Injection 18mg
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Ge Junbo
Hypertension, Cardiovascular Risk Factor
Intervention Study on Hypertension Management Combined With Health Promotion at Commune Level
A quasi-experimental study design was chosen to compare the model of hypertension management at commune-level with conventional management for people with high blood pressure in two communes (one for intervention versus one for…
- Conditions
- Hypertension, Cardiovascular Risk Factor, Lifestyle
- Trial name
- NCT01560806
- Testing
- Commune Hypertension Management
- Where
- Vietnam
- Volunteers
- 2,400 people
- Sponsor
- Vietnam National Heart Institute
Persistent Atrial Fibrillation
Effect of Empirical Left Atrial Appendage Isolation on Long-term Procedure Outcome in Patients With Persistent or Long-standing Persistent Atrial Fibrillation Undergoing Catheter Ablation
The purpose of this prospective randomized study is to assess whether empirical Left Atrial Appendage (LAA) isolation along with the standard approach of pulmonary vein isolation (PVI) and ablation of extra-pulmonary triggers is…
- Trial name
- BELIEF (NCT01362738)
- Testing
- RFCA of PV and extra-PV triggers, LAA isolation along with the conventional ablation strategy
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Cardiac Disease, Anesthesia
The Use of Remimazolam for TEE
This is a prospective randomized study. The purpose of this study is to compare the use of remimazolam vs propofol (standard practice) for transesophageal echocardiogram (TEE).
- Trial name
- NCT07829458
- Testing
- Remimazolam, Propofol
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypertension, Medication Adherence
Effectiveness and Adoption of the TelTex4BP Intervention Among Adults With Hypertension in Nepal
Despite evidence of preventing cardiovascular disease (CVD) risk through lifestyle changes, many patients with hypertension (HTN) do not comply with this and suffer from CVD and other complications.
- Conditions
- Hypertension, Medication Adherence, Blood Pressure, Cardiovascular Diseases
- Trial name
- TelTex4BP (NCT05979168)
- Testing
- Phone call and text Messages
- Where
- 2 sites in Nepal
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Central Department of Public Health