Clinical trials: Interventional Study
Anesthesia, Dental
Study of NV-101 for Efficacy, Pharmacodynamics, and Safety in Dental Patients Undergoing Maxillary Procedures
This Phase 3 clinical study is designed as a multicenter, randomized, blinded, controlled study to evaluate the efficacy, pharmacodynamics, and safety of NV-101 administered as a submucosal injection following completion of a…
- Trial name
- NCT00309335
- Testing
- Phentolamine Mesylate (NV-101)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Novalar Pharmaceuticals, Inc.
Cerebral Stroke, Thrombosis, Deep Vein
A Study of Adverse Events and Suspected Adverse Drug Reactions in Patients Under Apixaban for Prevention of Stroke and Systemic Embolism With Non-Valvular Atrial Fibrillation and Venous Thromboembolic Events in Patients Who Have Undergone Elective Hip or Knee Replacement Surgery
To characterize and analyze the number, type and incidence of adverse events/suspected adverse drug reactions in patients treated with Apixaban, according to therapeutic indications approved in Mexico.
- Conditions
- Cerebral Stroke, Thrombosis, Deep Vein, Pulmonary Embolism
- Trial name
- NCT03804125
- Sponsor
- Pfizer
Diabetes Mellitus, Diabetes Mellitus, Type 2
The PACT (Patient Activation Through Conversations) Study
The PACT Study is a cluster randomised trial of a health coach-led patient activation program in type 2 diabetes. The goal of this clinical trial is to evaluate the effectiveness of a health coaching intervention (PACT program)…
- Trial name
- PACT (NCT06444074)
- Testing
- Patient Activation through Conversations (PACT) Program, Usual Care
- Where
- 3 sites in Singapore
- Volunteers
- 432 people
- Sponsor
- National Healthcare Group Polyclinics
Cholangiopancreatography
Exalt D Single-use Duodenoscope in ERCP Procedures in China
Study Objective(s)：This study is to evaluate the feasibility, preliminary safety and performance of Exalt D Single-use Duodenoscope in ERCP procedures in China, to generate local real world data from a Chinese ERCP population.
- Trial name
- ExaltDScope (NCT04687774)
- Testing
- ExaltTM Model D Single-Use Duodenoscope
- Sponsor
- Boston Scientific Corporation
Lumbar Spine Disease, Lumbar Spondylolisthesis
OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study
The objective of this clinical study is to compare OSTEOAMP SELECT Fibers to Infuse Bone Graft, in terms of effectiveness and safety, when used as a bone graft substitute in in skeletally mature patients qualified for 2-lumbar…
- Conditions
- Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis
- Trial name
- SELECT (NCT05405374)
- Testing
- OSTEOAMP, Infuse
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- Bioventus LLC
Esophageal Squamous Cell Carcinoma, Enteral Nutrition Therapy
Chemoradiotherapy With or Without Enteral Nutrition for Locally Advanced Thoracic Esophageal Carcinoma
This is a randomized, prospective, multicenter study.
- Conditions
- Esophageal Squamous Cell Carcinoma, Enteral Nutrition Therapy, Chemoradiotherapy
- Trial name
- NCT02399306
- Testing
- Enteral nutrition, radiotherapy
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Sepsis, Nutrition
Personalized Nutritional Formula for ICU Patients: A Study on Prognosis and Multidimensional Health Markers
This study aims to evaluate the effects of an individualized enteral nutrition formula on clinical outcomes in critically ill adult patients in the intensive care unit (ICU).
- Conditions
- Sepsis, Nutrition, Gut -Microbiota
- Trial name
- NCT07755033
- Testing
- Individualized Enteral Nutrition Formula, Standard Enteral Nutrition Formula
- Volunteers
- 1,200 people
- Sponsor
- Chinese Medical Association
Self Harm
Occupational Therapy for Children and Young People Who Self-harm: A Qualitative Study
The goal of this qualitative observational study is to explore the experiences of children and their carers, receiving occupational therapy for self-harm and the experiences of health professionals delivering these interventions.
- Trial name
- NCT06317155
- Testing
- Occupational therapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Pulmonary Hypertension
Non-interventional Multi-center Study on Patients Under Routine Treatment of Pulmonary Arterial Hypertension (PAH) With Inhaled Iloprost Using I-Neb as a Device for Inhalation
This pilot, non-interventional, company-sponsored, multi-center study documents observational data on patients under routine treatment of Pulmonary Arterial Hypertension (PAH) with inhaled iloprost (using I-Neb device for the…
- Trial name
- COMPHI (NCT01894035)
- Testing
- Iloprost (Ventavis, BAYQ 6256)
- Where
- Portugal
- Volunteers
- 13 people
- Sponsor
- Bayer
Uncomplicated Plasmodium Falciparum Malaria
Efficacy, Safety and Tolerability of KAF156 in Combination With Lumefantrine Solid Dispersion Formulation (LUM-SDF) in Pediatric Population With Uncomplicated Plasmodium Falciparum Malaria
This study aimed to determine the efficacy, safety and tolerability of the investigational drug KAF156 in combination with a solid dispersion formulation of lumefantrine (LUM-SDF) in pediatric patients (6 months to < 18 years of…
- Trial name
- KALUMI (NCT04546633)
- Testing
- KAF156, LUM-SDF, Coartem
- Where
- 9 sites in Burkina Faso, Côte d’Ivoire and 3 more
- Volunteers
- 295 people
- Sponsor
- Novartis Pharmaceuticals
Lung Neoplasms, Mixed Reality
Apple Vision Pro-Assisted Vascular Identification in Lung Surgery
This study is testing whether a new mixed-reality head-mounted display (Apple Vision Pro) can help surgeons see blood vessels more clearly during lung surgery.
- Trial name
- AVP-Lung (NCT07573748)
- Testing
- Apple Vision Pro
- Volunteers
- 20 people
- Sponsor
- The Second People's Hospital of Huai'an
Anxiety, Parents
Limited-English Proficiency (LEP) Virtual Reality (VR) Study
The purpose of this study is to determine if non-invasive distracting devices (Virtual Reality headset) are more effective than the standard of care (i.e., no technology based distraction) for preventing anxiety in parental and…
- Conditions
- Anxiety, Parents, Language
- Trial name
- NCT03689868
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Stanford University
Inflammatory Bowel Diseases
Survey Study About Endoscopy During COVID-19 Pandemic for IBD Doctors
Performance of diagnostic or therapeutic endoscopic procedures in inflammatory bowel disease (IBD) patients can be challenging during a viral pandemic; the main concerns being the safety and protection of patients and health care…
- Trial name
- NCT04970849
- Testing
- observation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Infectious Disease
Contribution of a Video Support to Inform the Patient Before a Complementary Examination in Infectious Diseases
The purpose of this study is that a video tool coupled with standardized information can increase the patient's understanding of the information and thus optimize their medical care
- Trial name
- AVIEMI (NCT06168448)
- Testing
- Oral and written information, Video information
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psychological Resilience, Peer Bullying
School Program for Resilience and Bullying Prevention
This study evaluated whether a school-based psychoeducational program could improve psychological resilience and reduce bullying victimization among high school students in Hatay, Türkiye, following the 2023 earthquake.
- Conditions
- Psychological Resilience, Peer Bullying, Bullying Victimization
- Trial name
- NCT07683858
- Testing
- Psychological Resilience Program, Peer Bullying Awareness Program
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
End Stage Renal Disease, Catheter Infection
AUSTrian Randomized Interventional Study on Dialysis Accesses
Patients with diagnosed end stage renal disease and indication for chronic dialysis rely on a well-functioning access for dialysis.
- Conditions
- End Stage Renal Disease, Catheter Infection, Shunt Malfunction
- Trial name
- AUSTRIA (NCT03764358)
- Testing
- Arteriovenous Fistula, Tunneled Cuffed Catheter
- Where
- Austria
- Volunteers
- 220 people
- Sponsor
- Medical University of Vienna
Schizophrenia; Psychosis, Cognitive Impairment
Hjernegym - Effects of Exergaming in Psychosis: a Clinical Intervention Study
The goal of this clinical intervention study is to investigate the effects of exergaming on cognition and other clinical symptoms in outpatient individuals with schizophrenia.
- Trial name
- NCT05858255
- Testing
- Exergaming
- Where
- Norway
- Volunteers
- 48 people
- Sponsor
- Sykehuset i Vestfold HF
Prediabetes
Preventing Diabetes in Those at Risk by Having a Facilitator and Family Doctor Encourage Healthy Activity and Eating Habits
Nearly six million Canadians are living with an increased risk of diabetes (prediabetes) and approximately 50% of these will develop type 2 diabetes within five years.
- Trial name
- FLIP (NCT01589835)
- Testing
- Lifestyle changes
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- University of British Columbia
Aortic Stenosis, Coronary Artery Disease
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis.
- Conditions
- Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis
- Trial name
- COMPLETE TAVR (NCT04634240)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- 72 sites in United States, Canada
- Volunteers
- 4,000 people
- Sponsor
- University of British Columbia
Chronic Lymphocytic Leukemia
An Observational Study Examining the Effect of Added MabThera Therapy in Patients With Untreated Chronic Lymphocytic Leukemia
This study will examine the effectiveness of MabThera therapy added to a standard chemotherapy regimen for the treatment of previously untreated chronic lymphocytic leukemia (CLL).
- Trial name
- NCT02080884
- Where
- 15 sites in Hungary
- Volunteers
- 150 people
- Sponsor
- Hoffmann-La Roche