Clinical trials: Intervertebral Disc, Degenerative
Degenerative Disc Disease
Trinity Elite in Lumbar Fusion
This prospective, post-market, open label clinical study is designed to examine the lumbar fusion rate at 24 months post operative in subjects who have undergone a lumbar fusion surgery using Trinity Elite with or without local…
- Trial name
- NCT02969616
- Testing
- Trinity Elite
- Volunteers
- 300 people
- Sponsor
- Orthofix Inc.
Degenerative Disc Disease, Degenerative Spondylolisthesis
Lumbar Interbody Implant Study
The objective of this study is to evaluate the safety and performance of NuVasive interbody implants when used during thoracic and/or lumbar spine surgery as measured by reported complications, radiographic outcomes, and…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis, Spinal Stenosis
- Trial name
- NCT04418830
- Where
- 16 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- NuVasive
Degenerative Disc Disease
Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degeneration
The purpose of this study is to compare the safety and preliminary efficacy of intradiscal injections of two doses of IDCT (Discogenic Cells + Sodium Hyaluronate vehicle) and one sham control in subjects with chronic low back…
- Trial name
- NCT03955315
- Testing
- IDCT
- Where
- 6 sites in Japan
- Volunteers
- 38 people
- Sponsor
- DiscGenics, Inc.
Discogenic Pain
Bone Marrow Concentrate Intradiscal Injection for Chronic Discogenic Low Back Pain
A double-blind, placebo-controlled study to determine the efficacy of intradiscal injection of bone marrow concentrate on discogenic low back pain.
- Trial name
- NCT03340818
- Testing
- Bone Marrow Concentrate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- APM Spine and Sports Physicians
Intervertebral Disc Degeneration, Spinal Fusion
A Post Market Surveillance on INFUSE Bone Graft
This study aims to evaluate the safety and effectiveness of INFUSE™ Bone Graft in the real-world setting in Korea.
- Conditions
- Intervertebral Disc Degeneration, Spinal Fusion, Lumbar Disc Disease
- Trial name
- NCT05299762
- Testing
- INFUSE™ Bone Graft
- Where
- South Korea
- Volunteers
- 600 people
- Sponsor
- Medtronic Spinal and Biologics
Intervertebral Disc Degeneration
EvaluatIon of Autologous Nucleus Pulposus Cells (aNPC) in Degenerative Disc Disease
This is an open-label, single-center Phase I/II clinical trial investigating the safety and efficacy of autologous nucleus pulposus cells (aNPC) in patients with disc degeneration.
- Trial name
- NCT07168603
- Testing
- aNPC
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- ASTEROGENE Biomedical Co. Ltd.
Lumbar Degenerative Disc Disease
A Prospective Non-concurrent Controlled Evaluation of Open and MAS® PLIF
The study is a prospective non-concurrent controlled observational evaluation of short-term operative results. As such, study sites will capture perioperative (through 6-week postoperative follow-up) case data associated with 10…
- Trial name
- NCT01640977
- Testing
- Open PLIF (posterior lumbar interbody fusion), MAS PLIF
- Where
- 4 sites in United States
- Volunteers
- 67 people
- Sponsor
- NuVasive
Degenerative Disc Disease
Clinical Study of rhBMP-2/BCP With the TSRH® Spinal System for Posterolateral Lumbar Fusion in Patients With Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP/BCP/TRSH Spinal System in treatment of the patients with degenerative disc disease.
- Trial name
- NCT01494454
- Testing
- rhBMP-2/BCP/TSRH® or rhBMP-2/BCP/CD HORIZON® Spinal System, Autograft/TSRH® or autograft/CD HORIZON® Spinal System.
- Volunteers
- 197 people
- Sponsor
- Medtronic Spinal and Biologics
Intervertebral Disc Disease
Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease
The purpose of this trial is to test the effectiveness of the use of a new therapeutic strategy in treating patients with degenerative disc disease lumbar intervertebral fusion with instrumented posterolateral autologous…
- Trial name
- NCT01513694
- Testing
- Instrumented posterolateral arthrodesis
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Red de Terapia Celular
Degenerative Disc Disease
Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease
The objective of this study is to assess the safety and tolerability of YH14618 during 24 weeks of follow-up period after single administration in patients with degenerative disc disease.
- Trial name
- NCT01526330
- Testing
- YH14618
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yuhan Corporation
Degenerative Disc Disease
Percutaneous Minimal Invasive Pedicular Screw and Rod Insertion in Circumferential Lumbar Fusion
Convalescence after lumbar surgery is dependent on the extensiveness of the surgical procedure. Minimal invasive techniques in lumbar spine surgery are reported to achieve excellent clinical results with less pain, morbidity and…
- Trial name
- NCT01513577
- Testing
- Pedicle screws, Percutaneous stab incisions
- Volunteers
- 16 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Cervical Disc Herniation
Muscular Endurance And Its Association With Neck Pain, Disability, Neck Awareness, And Kinesiophobia
The aim of this study was to investigate the relationship of muscular endurance of the trunk, upper extremities, and scapular region as well as cervical region, with pain, neck awareness, and kinesiophobia in patients with…
- Trial name
- NCT05121467
- Testing
- Pain Assessment, Assessment of Muscular Endurance, Assessment of Neck Awareness
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Hacettepe University
Low Back Pain, Disc Disease
Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs
Intradiscal delivery of bone marrow concentrate (BMC) into discs, facet, epidural space, and sacroiliac joints
- Conditions
- Low Back Pain, Disc Disease, Disc Degeneration, Arthropathy Vertebrae
- Trial name
- NCT04559295
- Testing
- Bone Marrow Concentrate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stem Cures
Lumbar Disc Degenerative Disease
Drug Use Survey (DUS) of Triple Therapy (Methycobal (MBL)+ Myonal (MYO)+ Non-steroidal Anti-inflammatory Drags (NSAID)) on the Symptom Relief of Lumbar DDD in China
The purpose of this study is to observe the overall satisfaction of patients with degenerative disc disease after receiving triple therapy.
- Trial name
- NCT01299077
- Where
- 10 sites in China
- Volunteers
- 478 people
- Sponsor
- Eisai China Inc.
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Degenerative Disc Disease, Spine Fusion
Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion
This is a phase IV post-marketing study for MagnetOs Easypack Putty. MagnetOs Easypack Putty is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with degenerative disc disease…
- Conditions
- Degenerative Disc Disease, Spine Fusion, Back Pain
- Trial name
- PROOF (NCT04679844)
- Testing
- MagnetOs Easypack Putty, Demineralized Bone Matrix or Fibers mixed with local autograft bone
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kuros Biosurgery AG
Cervical Intervertebral Disc Degeneration
Cervical I/F Cage for Anterior Cervical Fusion
The purpose of this study is to determine the clinical success of the Cervical I/F Cage in treatment of one or two adjacent levels of degenerative disc disease of the cervical spine compared with standard of care treatment using…
- Trial name
- NCT00215293
- Testing
- Cervical I/F Cage, Autograft or allograft with a plate, or autograft alone.
- Volunteers
- 240 people
- Sponsor
- DePuy Spine
Low Back Pain, Physical Therapy
Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings
Low back pain is a common musculoskeletal disorder associated with substantial disability and reduced quality of life. Although magnetic resonance imaging (MRI) is frequently used to identify structural spinal abnormalities, the…
- Conditions
- Low Back Pain, Physical Therapy, Lumbar Degenerative Disc Disease, Lumbar Disc Herniation
- Trial name
- NCT07648927
- Testing
- Standard Physical Therapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bahçeşehir University
Degenerative Disc Disease
Carbofix Pedicle Screw System: Evaluation of the Clinical and Radiographic Outcomes of the Use of a Carbon Fiber Device Compared to Titanium Devices in Patients Undergoing Spinal Arthrodesis for Degenerative Spinal Diseases
Previous clinical study carried out on cancer patients at IOR Spine Surgery (approved in October 2014). The carbon device is indicated in patients suffering from vertebral tumors who need stabilization and will then carry out…
- Trial name
- NCT06209684
- Testing
- Titanium, Carbofix
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Istituto Ortopedico Rizzoli
Intervertebral Disc Degeneration, Intervertebral Disc Displacement
Proprio Spine Measurement Tool
This study will prospectively collect data to evaluate the effectiveness of a novel intraoperative spinal measurement system to assist the surgeon with intraoperatively achieving pre-planned alignment-related parameters to the…
- Conditions
- Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Osteochondrosis
- Trial name
- NCT07023393
- Testing
- Intraoperative spinal measurement system
- Where
- United States
- Sponsor
- Duke University