Clinical trials: Intervertebral Disc, Degenerative
Lumbar Disc Disease, Lumbar Spine Degeneration
The Six-Minute Walking Test (6WT) and Timed-Up-and-Go (TUG) Test as Measures of Objective Functional Impairment in Patients Undergoing Interlaminar or Transforaminal Epidural Steroid Injection for Lumbar Degenerative Disc Disease (DDD)
The primary objective is to determine the validity of the Six-Minute-Walking Test (6WT) and Timed-Up and Go (TUG) test to measure objective functional impairment (OFI) in patients undergoing either interlaminar epidural steroid…
- Conditions
- Lumbar Disc Disease, Lumbar Spine Degeneration, Lumbar Spinal Stenosis
- Trial name
- NCT04062942
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
Radiculopathy, Cervical, Myelopathy Cervical
Pilot Study of ZetaFuse™ Bone Graft for the Treatment of Cervical Degenerative Disc Disease
The goal of this pilot clinical trial is to test the safety and preliminary performance of the ZetaFuse Bone Graft in patient requiring fusion of the C3-C7 vertebral bones due to pain or loss of neurological function.
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Neurological Abnormality, Disc Disease
- Trial name
- NCT05971329
- Testing
- Cervical Fusion (ZetaFuse™ Bone Graft)
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Zetagen Therapeutics, Inc
Degenerative Disc Disease (DDD)
Retro Comparison of Subsidence Following Interbody Devices in Lumbar Spine
The objective of this retrospective study is an investigational clinical follow-up, of patients treated with interbody fusion devices (IBFD), both expandable (EXP) and static (STC), according to their intended use and cleared…
- Trial name
- NCT05536453
- Testing
- Lumbar Interbody Fusion Devices
- Where
- 4 sites in United States
- Volunteers
- 465 people
- Sponsor
- Spine and Scoliosis Research Associates
Spinal Disease, Degenerative Disc Disease
OssiMend BA in Posterolateral Instrumented Lumbar Fusion
The primary objective of this study is to measure the success rate of lumbar fusion in subjects at 12 months when instrumented lumbar arthrodesis is performed using OssiMend Bioactive Moldable as the bone grafting material
- Trial name
- NCT04775537
- Testing
- OssiMend™ Bioactive Moldable
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Collagen Matrix
Low Back Pain, Disc Disease
Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs
Intradiscal delivery of bone marrow concentrate (BMC) into discs, facet, epidural space, and sacroiliac joints
- Conditions
- Low Back Pain, Disc Disease, Disc Degeneration, Arthropathy Vertebrae
- Trial name
- NCT04559295
- Testing
- Bone Marrow Concentrate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stem Cures
Degenerative Disc Disease, Degenerative Spondylolisthesis
Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion
The purpose of this study is to evaluate safety and preliminary efficacy of Neofusetm in subjects with a diagnosis of degenerative disc disease (DDD) in 1 or 2 adjacent vertebral levels between L1 and S1 and undergoing…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT00810212
- Testing
- PLF with autograft, PLF with NeoFuse
- Where
- United States
- Sponsor
- Mesoblast, Ltd.
Intervertebral Disc Degeneration
Smoking Effect on Lumbar Intervertebral Disc Degeneration
Besides normal aging, genetic and environmental factors are important potential determinants of lumbar disc degeneration. Smoking causes serious health problems, particularly lung and other cancers, heart disease and respiratory…
- Trial name
- NCT04702126
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 360 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Degenerative Disc Disease
Enhanced Metal Reduction Techniques for Definitive CT Scanning to Assess Spinal Fusion With TM-Ardis
To determine if the subject metal reduction software helps to better visualize bone interphase and fusion reliability. Assess whether the appropriate procedural modification facilitates clearer images when implanted with a…
- Trial name
- NCT02170558
- Testing
- TM- Ardis implant and Metal Reduction CT software
- Where
- United States
- Sponsor
- Zimmer Biomet
Degenerative Disc Disease
XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD)
The purpose of this study is to evaluate the safety and effectiveness of XL TDR in patients with single-level degenerative disc disease compared to other devices approved by the FDA for the same or similar indications.
- Trial name
- XL TDR (NCT00927238)
- Testing
- XL TDR, Lumbar fusion surgery
- Where
- 17 sites in United States
- Volunteers
- 246 people
- Sponsor
- NuVasive
Degenerative Disc Disease, Trauma Injury
A Safety Study on Posterior Pedicle Screw System
The goal of this study is to assess the MUST MINI system safety in patient who will undergo a posterior cervical spine fusion intervention.
- Conditions
- Degenerative Disc Disease, Trauma Injury, Tumor
- Trial name
- MUST MINI PMS (NCT05821920)
- Testing
- MUST MINI system
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Medacta International SA
Lumbar Degenerative Disc Disease
Percutaneous Dynamic Stabilization (PDS) System Versus Fusion for Treating Degenerative Disc Disease
The objective of this study is to evaluate the safety and effectiveness of the PDS System compared to the surgical control of posterolateral fusion with autograft and pedicle screw fixation for the treatment of one or two levels…
- Trial name
- NCT00878579
- Testing
- PDS System, Fusion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Interventional Spine, Inc.
Degenerative Disc Disease
Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease
This study is looking at a new machine called the Accu-Spina which administers internal disc decompression by following a computer program.
- Trial name
- NCT00165893
- Testing
- Accu-Spina Device/IDD therapy, Physical Therapy
- Volunteers
- 50 people
- Sponsor
- Emory University
Degenerative Disc Disease, Lumbar Region
Orthokine Therapy in Lumbar Degenerative Disease
The aim of the trial is the comparison of the effectiveness of two methods of Orthokine administration (periradicular or epidural) in lumbar degenerative disc disease.
- Trial name
- OLDDD (NCT04734327)
- Testing
- Orthokine periradicular injection, Orthokine epidural injection
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Sutherland Medical Center
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Degenerative Disc Disease
Interbody Systems: Post Market Clinical Follow-up Study
This is a prospective, multi-center study of subjects who will undergo spinal fusion surgery utilizing Stryker Interbody Systems that require post market clinical follow up (PMCF).
- Trial name
- NCT04911257
- Testing
- Cervical or Lumbar Spinal fusion
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- K2M, Inc.
Degenerative Disc Disease
Long-term Assessment of BDyn Dynamic Stabilization Device in Patients With Lumbar Degenerative Disc Disease
The goal of this clinical trial is to estimate the cumulative reoperation rate at upper adjacent segment level in patients treated with BDyn dynamix stabilization for lumbar degenerative disc diseases over long-term follow-up.
- Trial name
- MOBIDYN (NCT07580664)
- Testing
- Dynamic Lumbar Stabilization Device
- Volunteers
- 150 people
- Sponsor
- Cousin Biotech
Degenerative Disc Disease
Study of the ReGelTec HYDRAFIL System
A study designed to treat patients with back pain associated with degenerative lumbar disc disease.
- Trial name
- NCT04984629
- Testing
- HYDRAFIL
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- ReGelTec, Inc.
Degenerative Disc Disease
Patient Outcomes Using an Expandable Spacer
This study is a post-market clinical follow-up study. The data collected from this study will serve the purpose of confirming safety and performance of the ALTERA™ Expandable implant.
- Trial name
- NCT03162666
- Testing
- ALTERA
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Globus Medical Inc
Intervertebral Disc Degeneration
Adjacent Segment Mechanics in Cervical Arthrodesis Patients
This study aims to determine to what extent patient-specific factors, iatrogenic factors, and biomechanical factors influence cervical spine mechanics after single-level and two-level arthrodesis.
- Trial name
- NCT03028402
- Testing
- C5-C6 arthrodesis
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Lumbar Disc Disease
Single Center Study Comparing MOBIS II ST vs MOBIS PEEK
Prospective randomized clinical study comparing SIGNUS MOBIS PEEK vs SIGNUS MOBIS II ST in patients with Degenerative Disc Disease at one or two contiguous levels from L2-S1
- Trial name
- MOBIS_US (NCT02852187)
- Testing
- SIGNUS MOBIS PEEK Cage, SIGNUS MOBIS II ST Cage
- Where
- United States
- Sponsor
- Signus Medizintechnik GmbH