Clinical trials: Intestinal Anastomosis
Ulcerative Colitis
Amino Acids in Ileal Pouch-anal Anastomosis for Ulcerative Colitis
The detrimental effects of catabolism, insuline resistance and muscle wasting on surgical outcome is wellknown. This catabolism is especially pronounced in patients with acute or chronic inflammation (IBD, cancer) and for those…
- Trial name
- AMINOPOUCH (NCT02084550)
- Testing
- Vaminolac, Saline
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Aarhus University Hospital
Anastomotic Leak, Anastomotic Leak Large Intestine
Low Tie Versus High Tie of the Inferior Mesenteric Vein During Colorectal Cancer Surgery: A Randomized Clinical Trial
This study aim to determine if a different surgical technique could result in a lower anastomotic leak rate. The two techniques are equally used around the world and well described by the international literature but this is the…
- Conditions
- Anastomotic Leak, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum, Colon Cancer
- Trial name
- LOTHVEIN (NCT05411783)
- Testing
- Low tie of IMV
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- San Carlo di Nancy Hospital
Colo-rectal Cancer, Colonic Neoplasms Malignant
The Use of Indocyanine Green Near-infrared Fluorescence for Bowel Perfusion Quantitative Assessment in Order to Prevent Anastomotic Leakage in Colorectal Surgery
Anastomotic leakage (AL) is a serious complication after surgery for colon cancer, leading to a significant increase in mortality.Intraoperative fluorescence imaging using indocyanine green has proven to be a feasible and…
- Trial name
- ICG-NIRF (NCT06845306)
- Testing
- ICG-guided bowel perfusion assessment, Conventional Bowel Anastomosis group
- Where
- Russia
- Volunteers
- 1,268 people
- Sponsor
- Vadim Kuznetsov
Rectal Cancer, Colon Cancer
Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior to Colorectal Anastomosis During Left-Sided or Rectal Resections for Colorectal or Ovarian Cancer. (Revascularisation Colique)
Colorectal cancers and ovarian cancers are respectively the 2nd and 5th cause of cancer mortality in France. Surgical resection is a crucial step in the therapeutic management of colorectal cancers.
- Conditions
- Rectal Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT07098182
- Testing
- Clamping and restauration of arterial blood of the inferior mesenteric artery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Colorectal Neoplasms, Crohn Disease
Early Alimentation Following Colorectal Surgery
This study wants to address the question of whether or not oral alimentation should be begun early in patients following colorectal surgery compared to the classical diet which depends on reappearance of functional intestinal…
- Trial name
- NCT00290524
- Testing
- Oral alimentation started 12 hours after colorectal surgery
- Where
- 4 sites in Canada
- Volunteers
- 800 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Rectal Cancer
Quality of Life of Patients After Rectal Cancer Resection .
Surgical treatment of cancer of the lower rectum by resection and coloanal anastomosis or abdominoperineal resection in both cases exposes the patient to significant functional digestive sequelae (anal incontinence or permanent…
- Trial name
- QRAAP (NCT07764120)
- Volunteers
- 22 people
- Sponsor
- University Hospital, Grenoble
Pouchitis, Irritable Pouch Syndrome
Efficacy of Liraglutide Therapy in Patients With IPAA
Patients with an ileal pouch-anal anastomosis(IPAA; pouch) due to refractory inflammatory bowel disease and increased bowel frequency in the absence of significant pouch inflammation will be randomized to liraglutide or placebo…
- Trial name
- NCT04763564
- Testing
- Liraglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Crohn's Disease of Large Intestine, Malignant Neoplasm of Colon
Evaluation of Ability to Detect Bowel Gas During Laparoscopic Right Colectomy With Intracorporeal Anastomosis
Undetected bowel perforation is a rare but dangerous complication of laparoscopic surgery. If the injury is not detected and treated at the time of the surgical procedure, the patient can suffer severe complications, including…
- Trial name
- NCT04964297
- Testing
- Obtaining bowel gas samples
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Weill Medical College of Cornell University
Crohn Disease, IBD
Comparing Manual Versus Stapled Side to Side Ileocolic Anastomosis in Crohn's Disease
RESEARCH QUESTION Are handsewn (end to end and Kono S side to side) anastomoses superior to side to side stapled anastomosis after ileocolic resection for Crohn's disease with respect to endoscopic recurrence, gastrointestinal…
- Conditions
- Crohn Disease, IBD, Ileocolitis, Crohn's Ileocolitis
- Trial name
- HAND2END (NCT05246917)
- Testing
- Handsewn anastomosis
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- IRCCS San Raffaele
Enhanced Recovery After Surgery, Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge
Resumption of Enteral Feeding After Bowel Anastomosis
Resumption of oral feeding after small intestine surgery is a matter of controversy .Some surgeons advocate early resumption while others don't.early feeding is initiated as soon as the patient recovers from effects of…
- Conditions
- Enhanced Recovery After Surgery, Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge, Defecation, Vomiting, Postoperative
- Trial name
- NCT06906289
- Testing
- resumption of enteral feeding within 24 hours of surgery, resumption of enteral feeding after 24-48 hours
- Where
- Pakistan
- Volunteers
- 204 people
- Sponsor
- Khyber Teaching Hospital
Colon Cancer
Intracorporeal Versus Extracorporeal Anastomotic After Laparoscopic Right Colectomy
Background: Laparoscopic assisted right hemicolectomy is recommended for right colon cancer. As a more minimally invasive procedure, intracorporeal ileocolic anastomosis has potential advantages: reducing torsion and traction on…
- Trial name
- NCT05493033
- Testing
- Intracorporeal anastomotic after LRC, Extracorporeal anastomotic after LRC
- Volunteers
- 1,158 people
- Sponsor
- Beijing Friendship Hospital
Colorectal Cancer
Indicators of Anastomotic Leak After Colorectal Surgery
We reviewed the patient underwent colorectal surgery with anastomosis and identified patients with anastomotic leak. Then we started to figure out what blood investigation could be related to anastomotic leak.
- Trial name
- NCT06156358
- Testing
- No intervention
- Volunteers
- 441 people
- Sponsor
- King Abdulaziz University
Rectal Cancer Patients, Rectal Cancer Surgery
FLuorescent Angiography in REduction of Anastomotic Leak in Rectal Cancer Surgery
The goal of this clinical trial is to find out whether using a special green dye called indocyanine green (ICG) during minimally invasive rectal cancer surgery can help surgeons assess blood flow to the bowel and reduce leakage…
- Conditions
- Rectal Cancer Patients, Rectal Cancer Surgery, Colorectal Cancer, Anastomotic Leak Rectum
- Trial name
- FLARE (NCT07899125)
- Testing
- Indocyanine Green Fluorescence Angiography, Standard Surgical Perfusion Assessment
- Where
- India
- Volunteers
- 610 people
- Sponsor
- Basavatarakam Indo American Cancer Hospital & Research Institute
Gastric Ulcer, Duodenal Ulcer, Anastomotic Ulcer, Reflux Oesophagitis,"Non-erosive Reflux Disease, Zollinger-Ellison Syndrome
Nexium Capsules Clinical Experience Investigation
The purpose of this study is to confirm the safety profile / factors which impact safety and efficacy of Nexium capsules in daily clinical usage for the patients who have been prescribed Nexium for "gastric ulcer", "duodenal…
- Trial name
- NCT01434485
- Where
- 47 sites in Japan
- Volunteers
- 3,691 people
- Sponsor
- AstraZeneca
Rectal Cancer
Selective sPlenic flExure Mobilization for Low colorEctal Anastomosis After D3 lYmph Node Dissection (Speedy Trial)
In the Low Anterior Resection of rectum for cancer, the section level of IMA and the need of SFM is still debated. The aim of this study is to explore the different impacts of high and low ligation with peeling off vascular…
- Trial name
- SpeeDy (NCT03895255)
- Testing
- Paraaortic lymph node dissection, IMA high ligation, TME, routine splenic flexure mobilization, Paraaortic lymph node dissection, IMA low ligation, TME, selective splenic flexure mobilization
- Where
- Russia
- Volunteers
- 142 people
- Sponsor
- Russian Society of Colorectal Surgeons
Rectum Cancer
The Role of Pelvic Peritonization in Laparoscopic or Robotic Low Anterior Resection
A randomized controlled clinical trial to compare the short and long outcomes of low anterior resection for middle-low rectal cancer with or without pelvic peritonization.
- Trial name
- NCT03699761
- Testing
- Closure of the pelvic peritoneum, Nonclosure of the pelvic peritoneum
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Southwest Hospital, China
Colorectal Cancer
Robotic Top-down Intersphincteric Resection
The present study is to develop the novel robotic surgical technique and enhance the surgery quality for the treatment of distal rectal cancer.
- Trial name
- NCT05961969
- Testing
- Robotic surgery
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Ulcerative Colitis, Familial Adenomatous Polyposis
Ten Versus Fifteen Centimeter Pouch in IPAA Surgery
The aim of this randomized controlled trial is to compare outcome after construction of an ileal (J-shaped) reservoir of 10 versus 15 centimeters in primary ileal pouch-anal anastomosis surgery.
- Trial name
- TESTIMONY (NCT06538402)
- Testing
- 10 cm pouch, 15 cm pouch
- Where
- 2 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Odense University Hospital
TME, Rectal Cancer Surgery
REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department
The purpose of this multicenter randomized non-inferiority trial is to evaluate the safety of low anterior resection for rectal cancer performed with versus without a diverting stoma in patients with a low predicted risk of…
- Conditions
- TME, Rectal Cancer Surgery, Low Rectal Cancer, Middle Rectal Cancer
- Trial name
- RELOAD (NCT07463261)
- Testing
- Without a preventive stoma, With a preventive stoma
- Where
- 7 sites in Russia
- Volunteers
- 442 people
- Sponsor
- ANO Scientific and Practical Club for the Development of Modern Medical Technologies
Low Anterior Resection Syndrome, Malignant Anal Neoplasm
Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study
This phase II trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to…
- Conditions
- Low Anterior Resection Syndrome, Malignant Anal Neoplasm, Malignant Bladder Neoplasm, Malignant Cervical Neoplasm
- Trial name
- NCT04066894
- Testing
- Explantation, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center