Clinical trials: Intestinal Anastomosis
Open/ Laparoscopic/ Robotic Resection of the Colon
Collection of Electrophysiological Data During Colon Resection
The study is conducted to record continuous electrophysiological signals from intact and ischemic bowel tissue during colonic resection surgery, in order to train the Exero Medical Leak Detection System classification algorithm…
- Trial name
- NCT04854473
- Testing
- Exero Medical Leak Detection System
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Exero Medical Ltd.
Pouchitis
GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative IPAA Surgery
This study will examine whether the application of GM-CSF, fosfomycin and metronidazole locally in the pouch is safe and effective in the treatment of pouchitis for patients with ulcerative colitis, and whether treatment changes…
- Trial name
- NCT04979832
- Testing
- GM-CSF, fosfomycin and metronidazole
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Zealand University Hospital
Colorectal Cancer, Gastrointestinal Complications
J-Pouch Colorectal Anastomosis or Straight Colorectal Anastomosis in Treating Patients With Rectal Cancer Who Have Undergone Surgery to Remove the Tumor
RATIONALE: It is not yet known whether a J-pouch colorectal anastomosis is more effective than a straight colorectal anastomosis in treating patients with rectal cancer who have undergone surgery to remove the tumor.
- Conditions
- Colorectal Cancer, Gastrointestinal Complications, Perioperative/Postoperative Complications
- Trial name
- NCT01110798
- Testing
- intraoperative complication management/prevention, assessment of therapy complications, gastrointestinal complications management/prevention
- Where
- 4 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Ospedaliera di Padova
Diverticulitis, Surgical Site Infection
Surgical Site Infection Outcomes in Natural Orifice Intracorporeal Anastomosis and Extraction (NICE) Procedure - The NICE Trial
The goal of this observational study is to learn if a new surgical technique, called the NICE procedure, is as safe as standard methods for treating benign left-sided colon and rectal diseases in adults.
- Conditions
- Diverticulitis, Surgical Site Infection, Surgical Site Infections, Colorectal Surgery
- Trial name
- NCT06957236
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Methodist Hospital Research Institute
Colorectal Cancer
INtracorporeal Versus EXTracorpoREal anastoMOsis After Laparoscopic Right Colectomy for Cancer
The aim of this systematic review is to compare intracorporeal (IA) versus extracorporeal anastomosis (EA) after laparoscopic right hemicolectomy for cancer.
- Trial name
- INEXTREMO (NCT01679756)
- Testing
- Laparoscopic right hemicolectomy for cancer
- Where
- Italy
- Volunteers
- 384 people
- Sponsor
- Ospedale Misericordia e Dolce
Rectum Cancer, Faecal Incontinence
Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer.
The occurrence of colorectal cancer has increased from the third most common cancer in 2018 to the second most common cancer in 2023.
- Conditions
- Rectum Cancer, Faecal Incontinence, Faecal Incontinence with Faecal Urgency, Low Anterior Resection Syndrome
- Trial name
- NCT06601985
- Testing
- J-pouch anastomosis, direct anastomosis
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Shanghai 10th People's Hospital
Pouchitis, Pouches, Ileoanal
Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch
The goal of this clinical trial is to learn if mirikizumab works to treat pouch disorders in adults. The main questions it aims to answer are: Does mirikizumab reduce symptoms of pouch disorders Participants will: Take…
- Conditions
- Pouchitis, Pouches, Ileoanal, Pouch, Ileal
- Trial name
- NCT06864403
- Testing
- Mirikizumab - Intravenous (IV), Mirikizumab - Subcutaneous (SC)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Rectal Cancer
Transanual Tube Placement in Low Anterior Resection (LAR) for Rectal Cancer
The purpose of this study is to evaluate the effectiveness of transanual tube placement in low anterior resection (LAR) for rectal cancer in preventing anastomotic leakage.
- Trial name
- NCT02905968
- Testing
- transanual tube placement
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Fudan University
Crohn's Disease, Fistula
Mesenchymal Stem Cells for the Treatment of Pouch Fistulas in Crohn's
The purpose of this study is to determine the safety and feasibility of using allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat people with an ileal pouch anal anastomosis (IPAA) who develop a fistula in the…
- Conditions
- Crohn's Disease, Fistula, Anal Fistula, Pouch, Ileal
- Trial name
- IPAAF (NCT04073472)
- Testing
- mesenchymal stem cells (MSCs)
- Sponsor
- The Cleveland Clinic
Cholangitis, Ascending Cholangitis
Rifaximin for Prevention of Recurrent Mild-to-moderate Ascending Cholangitis After Biliary-enteric Anastomosis
This single-center prospective randomized controlled trial plans to recruit 60 adult patients with recurrent ascending cholangitis after biliary-enteric anastomosis.
- Trial name
- NCT07895433
- Testing
- Rifaximin combined with standard care, Standard Care (in control arm)
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Ulcerative Colitis, Pouchitis
Intestinal Ultrasound for the Evaluation of Pouchitis and Other Outcomes After Ileal Pouch-Anal Anastomosis
Intestinal ultrasound (IUS) has been studied in the evaluation of inflammatory bowel disease (IBD) and is increasingly used as a non-invasive, easy to use, cost-effective tool for point-of-care to assess disease activity and more…
- Trial name
- NCT06316999
- Testing
- Intestinal Ultrasound
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Rectal Cancer, Retention, Urinary
Incidence of Acute Urine Retention: Randomized Clinical Trial Comparing Early, Mid or Late Urinary Catheter Removal in Patients With Rectal Resection
DESIGN: Randomized, open-label and parallel clinical trial, assigned to early, mid, or late withdrawal of urinary catheter with a 1: 1: 1 allocation ratio.
- Conditions
- Rectal Cancer, Retention, Urinary, Urinary Tract Infections, Surgical Site Infection
- Trial name
- RAOREC (NCT04751149)
- Testing
- Removal of Urinary Catheter
- Where
- Spain
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Hospital Donostia
Colorectal Surgery
COMPRES - COMpression Anastomosis Ring (CAR™ 27/ColonRing™) Post maRketing Evaluation Study
The performance of the ColonRing™ will be comparable to or better than the reported performance of staplers.
- Trial name
- COMPRES (NCT01091155)
- Testing
- ColonRing (Colorectal anastomosis)
- Where
- 13 sites in United States, Austria and 4 more
- Volunteers
- 288 people
- Sponsor
- novoGI
Rectal Cancer
Rectal Cancer Trial On Defunctioning Stoma
The hypothesis of the present trial was that the use of a defunctioning loop stoma reduces the rate of symptomatic anastomotic leakage from 15% to 7.5% after low anterior resection of the rectum for cancer.
- Trial name
- RECTODES (NCT00636948)
- Where
- Sweden
- Volunteers
- 234 people
- Sponsor
- Rectal Cancer Trial on Defunctioning Stoma Study Group
Anastomotic Complication, Anastomotic Leak Small Intestine
Open Abdomen and Delayed Anastomosis After Anastomotic Dehiscences to Avoid Stomas
Phase III clinical trial to evaluate the efficacy of the open abdomen as bridging therapy to perform transit reconstruction in patients with anastomotic dehiscence.
- Conditions
- Anastomotic Complication, Anastomotic Leak Small Intestine, Anastomotic Leak Large Intestine
- Trial name
- STOP-STOMA (NCT05233995)
- Testing
- Damage Control Surgery
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP)
Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare)
RIPAF (Rete Italiana Poliposi Adenomatosa Familiare) is a national, multicenter observational registry designed to establish a coordinated Italian network for the management of Familial Adenomatous Polyposis (FAP) and related…
- Conditions
- Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP), MUTYH-Associated Polyposis (MAP), Non-APC/MUTYH Associated Polyposis (NAMP)
- Trial name
- RIPAF (NCT07461246)
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Rectum Cancer
End to End Versus Side to End Anastomosis After Anterior Resection of Cancer Rectum
Comparison between end to end and side to end anastomosis after anterior resection of cancer rectum and compare the outcomes of both surgical techniques. The main outcomes were bowel functional outcomes and QoL.
- Trial name
- NCT06311279
- Testing
- Anterior resection of Rectal cancer
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Surgical Site Infection, Anastomotic Leak
Oral Antibiotic Prophylaxis in Colorectal Surgery
The investigators perform a case-control study to compare preparation before elective colorectal surgery. The first group is a prospective patient - registry in all patients with mechanical bowel preparation (MBP) and oral…
- Trial name
- ABCR (NCT03759886)
- Testing
- Paromomycin Sulfate Powder
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Postoperative Complications, Psychosomatic Disorder
Development of Machine Learning Models for the Prediction of Complications After Colonic, Colorectal and Small Intestine Anastomosis in Psychiatric and Non-psychiatric Patient Collectives (P-Study)
Our study aims to lay the basis for a predictive modeling service for postoperative complications and prolonged hospital stay in patients suffering from psychiatric diseases undergoing colorectal surgery.
- Conditions
- Postoperative Complications, Psychosomatic Disorder, Psychiatric Disorder, Cancer
- Trial name
- NCT05257863
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- Dr. Med Anas Taha
Colo-rectal Cancer, Anastomosis, Leaking
The Factors Influencing the Success of Redo Surgery and Anal Function for Anastomosis Failure or Local Tumor Recurrence
To analyze the influencing factors of the success of redo surgery due to anastomotic fistula or anastomotic recurrence after rectal cancer surgery and to evaluate the anal function of patients
- Trial name
- NCT07440888
- Testing
- redo surgery
- Volunteers
- 143 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences