Clinical trials: Intestinal Anastomosis
Fracture of Hip, Ileus
Peripheral Perfusion Index in Acute Surgical Patients
Introduction Perioperative haemodynamic instability is associated with postoperative morbidity and mortality. Macrocirculatory parameters, such as the conventionally obtained mean arterial blood pressure and cardiac output, may…
- Conditions
- Fracture of Hip, Ileus, Perforated Viscus, Anastomotic Leak
- Trial name
- NCT03757442
- Where
- Denmark
- Volunteers
- 1,338 people
- Sponsor
- Hvidovre University Hospital
Rectal Cancer
Reinforcement of Rectal Anastomosis-RORA
The anastomotic leaks are multivariable in its origin. The incidence varies among different centers between 4% and as high as 25%.
- Trial name
- NCT02589483
- Testing
- The rectal anastomosis will be reinforced with HemoPatch., Hemopatch
- Where
- 2 sites in Sweden
- Volunteers
- 10 people
- Sponsor
- St Goran's Hospital
Anastomotic Leakage
Anastomotic Leakage Following Laparoscopic Resection for Rectal Cancer
Anastomotic leak (AL) is a breakdown of a suture line in a surgical anastomosis with a subsequent leakage of the luminal content.
- Trial name
- NCT02718729
- Testing
- Laparoscopic resection for rectal cancer
- Where
- 2 sites in Egypt, Italy
- Volunteers
- 59 people
- Sponsor
- Mansoura University
Treatment, Anastomotic Leakage
TreatmENT of AnastomotiC LeakagE After COLON Cancer Resection
This international multicentre retrospective cohort study aims to research anastomotic leakage after colon cancer resection and has two main objectives: 1.
- Conditions
- Treatment, Anastomotic Leakage, Resection, Colon Cancer
- Trial name
- TENTACLE-Colon (NCT06528054)
- Testing
- Development of a model for predicting 90-day mortality and to compare various treatment strategies for anastomotic leakage
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Colorectal Cancer
Gut Microbiota, Anastomotic Leak and Colorectal Cancer
This is a prospective study evaluating the relation between the gut microbiota composition, intestinal healing after colorectal surgery and colorectal cancer behavior.
- Trial name
- NCT04071964
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Anastomotic Leak, Rectal Cancer
Comparative Study of Circular Stapling Instruments
After removing the rectum at surgery, bowel continuity can sometimes be restored by an anastomosis between the anus and the bowel. This anastomosis is most commonly created by the use of surgical circular stapling instruments.
- Trial name
- NCT00399009
- Testing
- AutoSuture Premium Plus CEEA/Ethicon Proximate ILS
- Where
- Sweden
- Volunteers
- 880 people
- Sponsor
- Uppsala University Hospital
Intestinal Diseases, Intestinal Resection
Implementation of a Pediatric ERAS-based Protocol in Intestinal Resection With Primary Anastomosis
Enhanced Recovery After Surgery (ERAS) is a multimodal perioperative care strategy designed to reduce surgical stress, decrease postoperative complications, and accelerate recovery after surgery.
- Trial name
- PeERAS (NCT07504549)
- Testing
- Standardized Pediatric ERAS-Based Perioperative Protocol
- Where
- 9 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Michał Pasierbek
Ileal Pouch, Crohn Disease
Study of Mesenchymal Stem Cells for the Treatment of Ileal Pouch Fistula's in Participants With Crohn's Disease
Restorative proctocolectomy with ileal pouch anal anastomosis (IPAA) is the procedure of choice for patients with ulcerative colitis, familial adenomatous polyposis, and select patients with Crohn's disease due to overall low…
- Trial name
- IPAAF (NCT04519684)
- Testing
- Mesenchymal stem cells
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Anthony Lembo
Anastomotic Leak, Rectal Cancer
Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Healing
Rationale: The surgical complication of intestinal anastomotic leak remains a clear and present danger to patients despite advances in surgical technique and ever more powerful antibiotics.
- Trial name
- SES-DTA (NCT02682485)
- Testing
- Cipro, metronidazole, neomycin combo, Serial Endoscopic Surveillance, Saline
- Sponsor
- University of Chicago
Anastomotic Leak Small Intestine, Anastomotic Leak Large Intestine
Enhanced Perioperative Care for the Prevention of Colorectal Anastomotic Leakage
This multicenter open-label trial is designed to evaluate if the implementation of an enhanced peri-operative care protocol results in an optimal intraoperative condition of the patient and in a decrease in incidence of…
- Conditions
- Anastomotic Leak Small Intestine, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum, Intraoperative Awareness
- Trial name
- DOUBLE CHECK (NCT05250882)
- Testing
- Enhanced perioperative care protocol
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 1,600 people
- Sponsor
- Amsterdam UMC, location VUmc
Esophageal Neoplasms, Stomach Neoplasms
Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer
Improvements to treatment strategies for patients upper gastrointestinal cancers have produced an increasing population of people who remain free from disease recurrence in the long term.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385617
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Intraoperative Fluid Volume, Hemodynamics
Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis
pulse pressure variation based intraoperative fluid therapy versus traditional fluid therapy for colonic cancer patients undergoing mass resection and anastomosis for maintaining adequate hydration without complications.
- Conditions
- Intraoperative Fluid Volume, Hemodynamics, Serum Lactate, Intestinal Edema
- Trial name
- NCT05502835
- Testing
- pulse pressure variation, conventional fluid management
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Rectal Cancer
SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter RCT on Anastomotic Leak
The goal of this clinical trial is to learn whether using a reinforcing material called SIS (small intestinal submucosa) during bowel connection after rectal cancer surgery can help prevent anastomotic leakage-a serious…
- Trial name
- NCT07209787
- Testing
- SIS-reinforced anastomosis
- Where
- China
- Volunteers
- 966 people
- Sponsor
- Beijing Chao Yang Hospital
Intestinal Anastomosis Complication
Magnamosis First-in-human Study of Feasibility and Safety
Anastomosis of intestine or other viscera currently requires open or laparoscopic surgery and is often the most difficult, time-consuming, and expensive part of many operations.
- Trial name
- Magnamosis (NCT02043392)
- Testing
- Magnamosis
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Michael Harrison
Colon Cancer
Colonic Resection or Stoma, or Self-expandable Metallic Stent for obstruCtive Left cOlon Cancer
CROSCO-1 study is a national, multi-center, prospective observational study presenting patients to the emergency departments of the participating centers with obstructive left colon cancer (in the absence of metastases and…
- Trial name
- CROSCO-1 (NCT05801211)
- Testing
- primary tumor resection
- Volunteers
- 434 people
- Sponsor
- Azienda Sanitaria di Firenze
Anastomosis; Complications, Colon Disease
Computed Tomography vs. Endoscopy Study
Patients undergoing elective surgery for left-sided colon resection are asked to participate in this study: Every patient undergoes two types of examinations (endoscopy, CT scan) on day 3, 4 or 5 postoperatively.
- Conditions
- Anastomosis; Complications, Colon Disease, Leak, Anastomotic
- Trial name
- NCT03148054
- Testing
- Computer Tomography and Endoscopy
- Where
- Switzerland
- Volunteers
- 416 people
- Sponsor
- Spital Limmattal Schlieren
Anastomotic Leak Large Intestine, Anastomotic Leak Rectum
"Colorectal Leakage App" for Early Detection of Anastomotic Leakage After Colorectal Surgeries
The aim of this prospective observational study is to evaluate the effectiveness of the mobile application "Colorectal Leakage App" in the early diagnosis of anastomotic leakage after colorectal surgeries at the National Research…
- Trial name
- NCT06273826
- Testing
- "Colorectal Leakage App"
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- National Research Oncology and Transplantology Center, Kazakhstan
Early Feeding, Bowel Anastomosis
Early Feeding vs 5-day Fasting After Distal Elective Bowel Anastomoses in Children. A Randomized Controlled Trial
Purpose: To determine the safety and efficacy of early enteral feeding after distal (ileum-colon) elective bowel anastomoses in children.
- Trial name
- NCT01028807
- Testing
- Early feeding, 5 day fasting
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Tracheo-Esophageal Fistula with Atresia of Esophagus
Use of Indocyanine Green During Primary Repair of Oesophageal Atresia and Distal Tracheo-oesophageal Fistula
This study aims to look at babies having a primary or delayed primary oesophageal repair for OA with dTOF to evaluate if using Indocyanine green (ICG) and near infrared fluorescence (NIRF) can decrease the rates of anastomotic…
- Trial name
- iTOF (NCT05735964)
- Testing
- Indocyanine green
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust