Clinical trials: Intestinal Anastomosis
Pancreatic Cancer, Pancreatic Neoplasms
Monitoring of patIents With Microdialysis Following Pancreaticoduodenectomy
A pancreaticoduodenectomy is performed in patient with pancreatic cancer. The most common and serious complication is leakage between the intestine and the remnant pancreas after this procedure. It occurs in 20-30%.
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Biliary Tract Cancer, Duodenal Cancer
- Trial name
- MINIMUM (NCT03631173)
- Testing
- Surgical og radiological intervention, antibiotics
- Where
- Norway
- Volunteers
- 201 people
- Sponsor
- Oslo University Hospital
Colon Cancer, Splenic Flexure Mobilization
Surgical Outcomes in Splenic Flexure Cancers: A Multicenter Comparison of Segmental vs. Extended Hemicolectomy (SPARROW Study)
SPARROW Study: Surgical Outcomes in Splenic Flexure Cancer Colonic cancers located at the splenic flexure where the transverse colon turns into the descending colon are uncommon and represent less than 10% of all colorectal…
- Conditions
- Colon Cancer, Splenic Flexure Mobilization, Right Hemicolectomy, Left Hemicolectomy
- Trial name
- SPARROW (NCT07289568)
- Testing
- Colectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Acibadem University
Colorectal Cancer, Colorectal Neoplasms
Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage
This is a randomized, controlled, parallel, multicenter trial to determine the difference in post-operative anastomotic leakages in colorectal surgery, where anastomosis perfusion is evaluated using indocyanine green fluorescence…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Gastrointestinal Cancer, Gastrointestinal Neoplasms
- Trial name
- ICG-COLORAL (NCT03602677)
- Testing
- ICG fluorescence imaging
- Where
- 2 sites in Finland
- Volunteers
- 1,062 people
- Sponsor
- Oulu University Hospital
Complications, Quality of Life
Double Tract Anastomosis and Gastric Tube Anastomosis to Proximal Gastrectomy
Gastric cancer as one of the most common gastrointestinal cancers, radical resection of primary lesions combined with dissection of regional lymph-nodes is acknowledged by surgeons all over the world.
- Conditions
- Complications, Quality of Life, Remnant Gastritis, Reflux Esophagitis
- Trial name
- DTA>A (NCT02288728)
- Testing
- Gastric tube anastomosis, Double-track anastomosis
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Jian-Kun Hu
Colon Neoplasms, Crohn Disease (CD)
Feasibility Study of the SEGER Device in Laparoscopic Gastrointestinal Surgery
This is a first-in-human feasibility study designed to evaluate the safety and performance of the SEGER device in patients undergoing elective laparoscopic gastrointestinal surgery requiring intracorporeal anastomosis.
- Conditions
- Colon Neoplasms, Crohn Disease (CD), Obesity & Overweight
- Trial name
- SEGER-FIH (NCT07508592)
- Testing
- SEGER Device
- Where
- El Salvador
- Volunteers
- 10 people
- Sponsor
- Seger Surgical Solutions
Crohn Disease
Surgical Prevention of Anastomotic Recurrence by Excluding Mesentery in Crohn's Disease
Kono and collegues have described a new anastomotic technique to restore bowel contintuity after ileocecal resection for Crohn's disease (CD).
- Trial name
- SuPREMeCD (NCT02631967)
- Testing
- Kono anastomosis, Stapled side-to-side anastomosis
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- Federico II University
Colorectal Anastomosis, Left-sided Colon Resection
Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections
The purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in…
- Conditions
- Colorectal Anastomosis, Left-sided Colon Resection, Anastomotic Leak, Anastomotic Complication
- Trial name
- SECURE (NCT07351071)
- Testing
- Signia™ circular stapler with Tri-Staple™ Technology (Signia™ Circular Stapling system)
- Where
- 10 sites in United States
- Volunteers
- 137 people
- Sponsor
- Medtronic - MITG
Crohn Disease
KONO-S Anastomosis Compared to Conventional Ileocolonic Anastomosis to Reduce Recurrence in Crohn's Disease
Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) currently affecting one person in a thousand in France. It can lead to numerous digestive complications such as fistulas, abscesses or stenosis.
- Trial name
- KOALA (NCT05974358)
- Testing
- Kono-S anastomosis, Conventional anastomosis for ileocolonicresection of Crohn's disease
- Where
- 15 sites in France
- Volunteers
- 226 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Colorectal Cancer (CRC), Surgery, Colorectal
Study of Colorectal Anastomosis Failures With First Sigmoid or Left Colonic Artery Preservation With D3 Lymphadenectomy
This study is a randomized, controlled trial comparing the short- and long-term outcomes of left colonic artery or first sigmoid artery preservation for rectal surgery.
- Conditions
- Colorectal Cancer (CRC), Surgery, Colorectal, Oncology
- Trial name
- COLAP-D3 (NCT06938490)
- Testing
- Anterior rectal resection with D3-lymphatic dissection
- Where
- Russia
- Volunteers
- 778 people
- Sponsor
- the BELOOSTROV Clinic of High Technologies
Colon Cancer
The Laparoscopic Right Colectomy With Intracoroporeal Anastomosis
This is a randomized, controlled, "non-inferiority" trial to determine the non-difference in post-operative complications rate in laparoscopic right colectomy with intracorporeal or extracorporeal anastomosis formation.
- Trial name
- LaRCIa (NCT05026268)
- Testing
- intracorporeal anastomosis
- Where
- Russia
- Volunteers
- 2 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Rectal Cancer
Rectal Cancer Anastomosis 4 Check Study
Anastomotic failure (AF), including anastomotic leakage (AL), increases morbidity and mortality after colorectal cancer (CRC) resection.
- Trial name
- REC4T (NCT04637061)
- Testing
- intraoperative near infrared (NIR) indocyanine green (ICG)-induced fluorescence angiography (FA) and air leak testing to assess the integrity and the perfusion levels of the colorectal anastomosis, Air Leak test, Evaluation of the anastomotic rings
- Volunteers
- 287 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ulcerative Colitis, Postoperative Complications
TAMIS-IPAA vs. Lap-IPAA for Ulcerative Colitiis
The objective of this RCT is to compare the postoperative outcome of transanal versus transabdominal minimally invasive proctectomy with ileal pouch-annal anastomosis in patients with ulcerative colitis.
- Conditions
- Ulcerative Colitis, Postoperative Complications, Ileal Pouch
- Trial name
- NCT03536988
- Testing
- TAMIS-IPAA, Lap-IPAA
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Jinling Hospital, China
Colon Cancer
Intracorporeal Anastomosis Versus Extracorporeal Anastomosis for Left Colon Cancer
This study aims to investigate the effects of intracorporeal anastomosis and extracorporeal anastomosis in laparoscopic-assisted radical left hemicolectomy on surgical site infection.
- Trial name
- NCT04201717
- Testing
- laparoscopic assisted left colectomy (extracorporeal anastomosis group), total laparoscopic left colectomy (intracorporeal anastomosis group)
- Where
- 12 sites in China
- Volunteers
- 350 people
- Sponsor
- Jilin University
Colorectal Cancer
Safety and Feasibility of Laparoscopic Intracorporeal Anastomosis for Colorectal Surgery- A Multiple Center Real World Study
The goal of this observational study is to explore the safety and feasibility of laparoscopic intracorporeal anastomosis in colorectal cancer surgery. The main questions it aims to answer are: 1.
- Trial name
- SELECTED (NCT05911152)
- Testing
- Intracorporeal anastomosis
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Cancer Patients, Rectal Cancer Surgery
Postoperative Outcomes of Single-stapled Anastomosis Combined With Transanal Natural Orifice Specimen Extraction
Natural Orifice Specimen Extraction (NOSE) eliminates the need for additional abdominal incisions in minimally invasive colorectal procedures, potentially reducing the risk of wound complications and postoperative pain.
- Trial name
- NOSE (NCT07358247)
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Istituto Clinico Humanitas
Colorectal Cancer
Does Administration of Antibiotics in Patients Undergoing Surgery for Colorectal Cancer Result in Less Complications and Better Prognosis?
The primary objectives of this randomized clinical trial are to evaluate if perioperative SDD can reduce clinical anastomotic leakage rate and its septic consequences as well as other infectious complications.
- Trial name
- SELECT (NCT01740947)
- Testing
- Selective decontamination of the digestive tract (SDD) (colistin sulfate, tobramycin, amphotericin B)
- Where
- 5 sites in Netherlands
- Volunteers
- 485 people
- Sponsor
- H. Jaap Bonjer, PhD
Crohn Disease, Recurrence
Comparison of Two Stapled Antimesenteric Anastomosis for CD: a Randomized Control Trial Study
The postoperative recurrence of Crohn's diseases (CD) remains high. Stapled anti-mesenteric functional end-to-end anastomosis was safe for CD patients. Its impact on the postoperative recurrence of CD was unknown.
- Trial name
- NCT05658081
- Testing
- Kono-S group, Side-to-side group
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Jinling Hospital, China
Ulcerative Colitis, Inflammatory Bowel Diseases
Complications and Outcomes of Pouch Excision
Procedure is offered today to most patients with chronic ulcerative colitis (CUC) or familial adenomatous polyposis (FAP) who are candidates for total proctocolectomy.
- Trial name
- NCT03952195
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Rectal Neoplasms
Perfusion Outcomes With Near Infrared-Indocyanine Green Imaging System in Laparoscopic Total Mesorectal Excision for Mid- or Low-rectal CanceR
It is a multicenter, prospective, and randomized controlled clinical study of patients with mid- or low- rectal cancer who received laparoscopic TME surgery aims to explore whether the application of near infrared-indocyanine…
- Trial name
- POSTER (NCT04012645)
- Testing
- application of near infrared-indocyanine green imaging system, Non-application of near infrared-indocyanine green imaging system
- Where
- 2 sites in China
- Volunteers
- 547 people
- Sponsor
- Zhongtao Zhang
Gastric Ulcer (GU), Duodenal Ulcer (DU)
A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases
The objective of this study is to assess the safety, pharmacokinetics, pharmacodynamics and efficacy of repeated once daily oral administration of D961H 10 mg and D961H 20 mg in Japanese paediatric patients aged 1 to 14 years old…
- Conditions
- Gastric Ulcer (GU), Duodenal Ulcer (DU), Anastomotic Ulcer (AU), Non-erosive Reflux Esophagitis Disease (NERD)
- Trial name
- NCT02153398
- Testing
- D961H sachet 10 mg, D961H capsule 10mg, D961H capsule 20 mg
- Where
- 15 sites in Japan
- Volunteers
- 55 people
- Sponsor
- AstraZeneca