Clinical trials: Intestinal Dysfunction
Non-Alcoholic Fatty Liver Disease, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Effects of Probiotics (P. Pentosaceus, L. Lactis or L. Helveticus) in NASH
A study for evaluating the improvement effect on Metabolic dysfunction-associated steatotic liver disease (MASLD) of probiotics Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with dysbiosis of the…
- Trial name
- NCT04555434
- Testing
- Probiotics
- Where
- South Korea
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Environmental Enteric Dysfunction
OCT Guided Trans Nasal Imaging of the Small Intestine in Adults
The investigators are seeking healthy adult participants 18-60 years and healthy pregnant women in their 2nd trimester of pregnancy for a research study to assess a new imaging device.
- Trial name
- NCT04984447
- Testing
- TNIB Catheter
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Spinal Cord Injuries
Osteopathic Manipulative Treatments and Neurogenic Bowel Dysfunction in Patients With Spinal Cord Injuries.
Studies based on the relationship between Osteopathic Manipulative Treatment (OMT) and the gastrointestinal system have been conducted in patients with constipation with Irritable Bowel Syndrome (IBS), and in children with…
- Trial name
- NCT04367571
- Testing
- Osteopathic Manipulative treatment (OMT)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Acidosis, Oxidative Stress
Effects of Zeolite + Dolomite on Performance and Acidosis
Purpose: This study investigates the effects of dietary zeolite + dolomite on performance, exercise-induced acidosis, oxidative stress, inflammation and intestinal barrier dysfunction in trained people.
- Conditions
- Acidosis, Oxidative Stress, Inflammation
- Trial name
- NCT01831492
- Testing
- zeolite + dolomite, cellulose
- Where
- Austria
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Green Beat
Sacral Neuromodulation
Preliminary Outcomes of Sacral Neuromodulation Applications; Tertiary-Center Experience in Turkey
to report our patients' outcomes of SNM in tertiary health centres in Turkey
- Trial name
- NCT06098963
- Testing
- sacral neuromodulation
- Volunteers
- 16 people
- Sponsor
- Cigli Regional Training Hospital
Colorectal Cancer
Late Organ Specific Adverse Effects hiPec or pElvic eXenteration
The purpose of this study is to describe type and extent of organ specific late adverse effects in patients undergoing surgery for colorectal cancer with peritoneal metastases and after surgery for colorectal cancer with…
- Trial name
- LOSAPEX (NCT04970316)
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 225 people
- Sponsor
- University of Aarhus
Inflammatory Bowel Diseases
Assessing Cardiovascular Dysfunction Pre- & Post-treatment in Inflammatory Bowel Diseases
The aim of this study is to compare medical and surgery treatment in IBD patients and healthy controls, by assessing the endothelial and cardiac function and the inflammation status.
- Trial name
- NCT03615287
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Athens
Liver Cirrhoses
Alterations in Intestinal Mucosal Barrier Visualized by Confocal Laser Endomicroscopy in Liver Cirrhosis: a Pilot Trial (AMBIC)
Clinical trial with medical devices. A diagnostic trial conducted to find a better (less invasive) procedure for predicting the onset of spontaneous bacterial peritonitis(SBP), which is a complication of liver cirrhosis with…
- Trial name
- AMBIC (NCT03878563)
- Testing
- Cellvisio 100 Series (fibered confocal microscopic system)
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people
- Sponsor
- Dr.med. Monica Rusticeanu
Colorectal Cancer, Sexual Dysfunction
An Internet Delivered Intervention for Re-Adjustment to Sexual Intimacy With an Ostomy After Cancer
This study investigates the feasibility and efficacy of an Internet-delivered intervention for the sexual and intimate re-adjustment of couples in which one partner is living with a temporary or permanent ostomy (e.g., colostomy…
- Trial name
- NCT03526952
- Testing
- Internet-Delivered Intervention for Sexual Re-Adjustment, Written Educational Material
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Low Anterior Resection Syndrome, Radiotherapy
Development and Validation of The Post-RT LARS Prediction Model (PORTLARS)
Bowel dysfunction is common after a restorative rectal cancer resection. Neoadjuvant radiotherapy is an influential factor that impairs bowel function and quality of life.
- Conditions
- Low Anterior Resection Syndrome, Radiotherapy, Rectal Cancer
- Trial name
- PORTLARS (NCT05129215)
- Testing
- Questionnaire
- Where
- China
- Volunteers
- 901 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Empty Pelvis Syndrome, Pelvic Exenteration
PelvEx - Beating the Empty Pelvis Syndrome
The empty pelvis syndrome is an unsolved and poorly defined problem severely affecting patients that have pelvic exenteration surgery, and also the teams looking after them.
- Conditions
- Empty Pelvis Syndrome, Pelvic Exenteration, Pelvic Neoplasm, Pelvic Cancer
- Trial name
- NCT05683795
- Testing
- Consensus study
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Aging
Age-associated Arterial Dysfunction, Western Diet, and Aerobic Exercise: Role of the Gut Microbiome
The risk of developing cardiovascular diseases increases with aging largely due to age-related declines in the function of arteries (arterial dysfunction), which are influenced by common lifestyle factors such as consumption of a…
- Trial name
- NCT03334201
- Testing
- Western Diet, Non-Western Diet
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Electric Stimulation Therapy, Bowel Dysfunction
The Effect of NMES on Bowel Management in People With Chronic SCI
It has been reported that 62% of all people with Spinal Cord Injury (SCI) have experienced faecal incontinence and that neurogenic bowel dysfunction (NBD) is a major sequela.
- Conditions
- Electric Stimulation Therapy, Bowel Dysfunction, Spinal Cord Injuries, Defecation Disorder
- Trial name
- FES_Bowel (NCT04914975)
- Testing
- Neuromuscular electrical stimulation
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Fecal Incontinence
Indirect Non-invasive Evaluation of Pudendal Neuropathy
Purpose: Pelvic floor is a complex anatomical entity and its neuromuscular assessment is evaluated through electromyography, evoked potentials and pudendal nerve terminal motor latency.
- Trial name
- NCT03933683
- Testing
- Pudendal nerve terminal motor latency assessment
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Bladder and Bowel Dysfunction, Femoral Anteversion, Bladder and Bowel Dysfunction, Hip Strength Ratios
Relationship Between Pelvic Angle, Femoral Anteversion, and Hip Muscle Strength Ratios in Bladder-bowel Dysfunction
Bladder and bowel dysfunction is a combination of lower urinary tract and bowel dysfunction seen in children over 5 years of age without identifiable or discernible neurological abnormalities.
- Conditions
- Bladder and Bowel Dysfunction, Femoral Anteversion, Bladder and Bowel Dysfunction, Hip Strength Ratios, Bladder and Bowel Dysfunction, Pelvic Angle
- Trial name
- NCT05182671
- Testing
- Scales and measurements for bladder and bowel dysfunction, pelvic angle, proximal hip strength, femoral hip anteversion
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Halil Tugtepe
Rectal Cancer, Low Anterior Resection Syndrome
The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal Cancer
This randomized controlled trial aims to evaluate the effects of combining Kegel exercise with a single biofeedback session on bowel function, emotional distress, and quality of life in patients who have undergone low anterior…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, LARS - Low Anterior Resection Syndrome
- Trial name
- BFT in LARS (NCT07253298)
- Testing
- Kegel Exercise with Biofeedback, Kegel Exercise Only
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- National Taiwan University Hospital
Gastrointestinal Diseases
Gastrointestinal Myoelectric Activity Protocol, the G-Tech EEnG Protocol
A feasibility study for monitoring and recording gastrointestinal (GI) myoelectric activity in subjects with suspected or diagnosed irritable bowel syndrome (IBS) and reports of GI pain and asymptomatic subjects without IBS and…
- Trial name
- NCT01697397
- Testing
- Recording of Myoelectric Signals
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- G-Tech Corporation
Central Nervous System Injury, Neurogenic Bowel Dysfunction
Effects of Osteopathic Manipulative Treatment in People With Neurogenic Bowel Dysfunction
People affected central nervous system (CNS) diseases often suffer from neurogenic bowel dysfunction (NBD) that causes a reduction in the quality of life and participation in social life.
- Trial name
- NCT04127617
- Testing
- Osteopathic Manipulative Treatment, Nursing Educational Care
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Turin, Italy
Endothelial Dysfunction, Aging
Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults
Aging is the primary risk factor for cardiovascular disease (CVD) largely due to vascular endothelial dysfunction, a major initial step in the development of atherosclerosis.
- Trial name
- NCT03824041
- Testing
- Aronia full spectrum - half dose, Aronia full spectrum - full dose
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Ulcerative Colitis
Predicting Clinical Response to Golimumab With Mucosal Barrier Dysfunction
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease (IBD). UC is an ongoing disease of the colon or large intestine. Studies have shown that leakiness of the gut plays a major role in the development of UC.
- Trial name
- NCT02729233
- Testing
- patients receiving biopsies
- Sponsor
- University of Arkansas