Clinical trials: Intestinal Dysfunction
Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradiation (TBI) in those diagnosed with Common Variable Immunodeficiency…
- Conditions
- Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder, Immune Dysregulation, DiGeorge Syndrome
- Trial name
- CVID/PIRD (NCT07284641)
- Testing
- Hematopoietic stem cell transplant (HSCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paul Szabolcs
Inflammatory Bowel Diseases, Mild Cognitive Impairment
Cognitive Impairment and Affective Mood Disorders in Patients With IBD
The aim is to evaluate the presence of mild cognitive impairment (MCI) in patients with inflammatory bowel disease (IBD). This will be done by cognitive tests.
- Conditions
- Inflammatory Bowel Diseases, Mild Cognitive Impairment, Depression, Anxiety
- Trial name
- COGN-IBD-1 (NCT05760729)
- Testing
- Cognitive testing
- Where
- 3 sites in Romania
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Lymphoma, Small Intestine Cancer
S0355 Ixabepilone in Treating Patients With Advanced Solid Tumors or Lymphomas and Liver Dysfunction
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase I trial is studying the side effects and best dose of ixabepilone in treating…
- Conditions
- Lymphoma, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00049400
- Testing
- BMS-247550
- Where
- 23 sites in United States
- Volunteers
- 78 people
- Sponsor
- SWOG Cancer Research Network
Bladder and Bowel Dysfunction, SCI - Spinal Cord Injury
SCS Therapy for Patients With Bladder and Bowel Dysfunction After SCI
This clinical trial aims to evaluate the safety and efficacy of spinal cord stimulation (SCS) in treating patients with urinary and bowel dysfunction after spinal cord injury (SCI).
- Trial name
- SCSBBD (NCT07511244)
- Testing
- Spinal Cord Stimulation and Evaluation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Rectal Cancer, Quality of Life
The OPERa Study: Evaluating QoL After Rectal Cancer Surgery
Advances in rectal cancer management have significantly reduced morbidity and mortality. The most commonly performed operation for rectal cancer is restorative proctectomy (RP), leaving up to 70% with long-term bowel dysfunction…
- Conditions
- Rectal Cancer, Quality of Life, Bowel Dysfunction, Sexual Dysfunction
- Trial name
- NCT04893876
- Volunteers
- 1,200 people
- Sponsor
- Jewish General Hospital
Opioid-induced Bowel Dysfunction
Opioid-induced Bowel Dysfunction (OBD) Pivotal Assessment of Lubiprostone (OPAL)
The primary purpose of the study is to evaluate the efficacy and safety of lubiprostone administration in subjects with Opioid-induced Bowel Dysfunction.
- Trial name
- NCT01298219
- Testing
- Lubiprostone
- Where
- 142 sites in United States, Belgium and 5 more
- Volunteers
- 439 people
- Sponsor
- Sucampo Pharma Americas, LLC
Rectal Prolapse, Pelvic Organ Prolapse
Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction
The purpose of this randomized double blind controlled study is to assess the value of robotics for the treatment of complex pelvic floor dysfunction.
- Trial name
- NCT01346436
- Testing
- Minimally invasive rectopexy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Nicolas C. Buchs
IBD and Renal Involement, Chronic Kidney Disease
Renal Dysfunction in Patients With Inflammatory Bowel Disease and the General Population (NEPHRO-IBD)
The NEPHRO-IBD study is a multicenter prospective observational study designed to evaluate the prevalence of renal dysfunction and renal complications in adult patients with inflammatory bowel disease (IBD) compared with…
- Conditions
- IBD and Renal Involement, Chronic Kidney Disease, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
- Trial name
- NEPHRO-IBD (NCT07593352)
- Testing
- Prospective assessment of the prevalence of kidney disease and/or renal complications in patients with IBD/the general population based on routine laboratory test and abdominal ultrasound.
- Where
- Poland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji
Intestinal Inflammation
Prospective Study Evaluating the Prevalence of Intestinal Dysfunction
The intestinal tract has multiple functions within the body beyond its primary function of nutrient absorption. It acts as a true barrier protecting the body from living microorganisms and antigens in the intestinal lumen.
- Trial name
- DIR-H (NCT07022548)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
Bowel Dysfunction, Bladder Dysfunction
Incidence of The Bowel, Bladder, and Sexual Dysfunction Following Surgery for Colorectal Malignancy
Colorectal cancer is the second most common cancer by the site in Europe and the third most common cancer in the USA with high morbidity and mortality.
- Conditions
- Bowel Dysfunction, Bladder Dysfunction, Sexual Dysfunction, Colorectal Surgery
- Trial name
- NCT04134104
- Testing
- Surgery for Colorectal malignant diseases either LAR or APR
- Volunteers
- 38 people
- Sponsor
- National Academy of Medical Sciences, Nepal
Chronic Granulomatous Disease, Crohn'S-like IBD
Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease
This study will determine if the drug infliximab is safe for treating inflammatory bowel disease (IBD) in patients with chronic granulomatous disease (CGD).
- Conditions
- Chronic Granulomatous Disease, Crohn'S-like IBD, Inflammatory Bowel Disease (IBD)
- Trial name
- NCT00325078
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bowel Dysfunction, Helicobacter Pylori Infection
The Clinical Evaluation of Probiotics Product in Patients With Various Functional Bowel Disorders and Helicobacter Pylori Infection
People nowadays tend to have irregular diet and routine due to the stress at work. This condition may cause intestinal microflora imbalance, and in the long term may lead to constipation, diarrhea, gastroenteritis, gastric ulcer…
- Trial name
- NCT04319991
- Testing
- Probiotics product
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fooyin University
Low Anterior Resection Syndrome
Translation of the International Consensus Definition of LARS Into a Bowl Dysfunction Severity Scoring Tool (New LARS Score)
The purpose of this study is to develop a new severity scoring tool for Low Anterior Resection Syndrome (LARS) drawing on the international consensus criteria for LARS as well as opinions of patients with lived-experience of LARS.
- Trial name
- NCT05605600
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Cardiff and Vale University Health Board
Endothelial Dysfunction, Mood Disorders
Relative Energy Deficiency in Rowers
This study aims to learn about relative energy deficiency in male and female rowers at the end of the direct sport preparation phase of the annual training cycle.
- Conditions
- Endothelial Dysfunction, Mood Disorders, Malnutrition, Calorie
- Trial name
- NCT06452758
- Testing
- 2000 meter ergometer test
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Poznan University of Physical Education
Bladder-Bowel Dysfunction, Obesity & Overweight
Target Physiotherapy Versus Exercise Support Intervention for Bladder-bowel Dysfunction in Adolescents With Obesity
Bladder and bowel dysfunction (BBD) is a common condition that includes problems such as urinary urgency, daytime urinary incontinence, bedwetting, constipation, or difficulties emptying the bladder or bowel.
- Trial name
- OBE-BBD (NCT07724158)
- Testing
- Target physiotherapy, Exercise support intervention, Usual obesity care
- Where
- Portugal
- Volunteers
- 237 people
- Sponsor
- University of Lisbon
Cholestasis, Short Bowel Syndrome
Compassionate Use of Omegaven for Pediatric Patients With Parenteral Nutrition Associated Liver Disease
A compassionate use protocol to provide Omegaven to pediatric patients with parenteral nutrition (PN) dependence and parenteral nutrition associated liver disease (PNALD).
- Trial name
- Omegaven (NCT01297933)
- Testing
- Omegaven
- Where
- United States
- Sponsor
- Children's Hospital of Philadelphia
Rectal Cancer, Ileostomy; Functional Disturbance
Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer (GRECCAR17)
GRECCAR 17 will be the first prospective and randomized trial to assess a tailored policy in the use of defunctioning stoma after TME according to the personalized risk of anastomotic leakage.
- Trial name
- GRECCAR17 (NCT05233787)
- Testing
- Tailored use of defunctioning stoma after TME, Systematic use of defunctioning stoma
- Where
- 28 sites in France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Bordeaux
Acute Pancreatitis, Intestinal Bacteria Flora Disturbance
Fecal Microbiota Transplantation for Pancreatitis
The intestinal microbiota plays a pivotal role in the maintenance of intestinal homeostasis and protecting the gut against pathogens by competing for nutrients, creating the intestinal biological barrier and modulating the host…
- Conditions
- Acute Pancreatitis, Intestinal Bacteria Flora Disturbance, Intestinal Dysfunction, Fecal Microbiota Transplantation
- Trial name
- FMTP (NCT02318134)
- Testing
- Fecal Microbiota Transplantation, normal saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Opioid-Induced Bowel Dysfunction
Opioid-induced Bowel Dysfunction Pivotal Assessment of Lubiprostone
The primary purpose of this study is to evaluate the efficacy and safety of lubiprostone administration in patients with opioid-induced bowel dysfunction (OBD).
- Trial name
- OPAL (NCT00597428)
- Testing
- Lubiprostone
- Where
- 114 sites in United States, Canada
- Volunteers
- 437 people
- Sponsor
- Sucampo Pharma Americas, LLC
Multiple Sclerosis, Constipation
Symptoms and Treatment Assessment of Ano-Rectal Disorders in Multiple Sclerosis Patients : STAR-Q
Multiple sclerosis (MS) is known to cause urinary disorders, sexual and bowel dysfunction. Urinary symptoms due to MS are well known and profit of multiple questionnaire or tool developed in MS patients.
- Conditions
- Multiple Sclerosis, Constipation, Fecal Incontinence
- Trial name
- STAR-Q (NCT04996186)
- Testing
- Clinical interviews
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Pierre and Marie Curie University