Clinical trials: Intestinal Functional Disorder
Functional Gastrointestinal Disorders, Lactose Intolerance
Fructose and Lactose Intolerance and Malabsorption in Functional Gastrointestinal Disorders
Background: The association of fructose and lactose intolerance and malabsorption with the symptoms of different functional gastrointestinal disorders (FGID) is unclear.
- Conditions
- Functional Gastrointestinal Disorders, Lactose Intolerance, Fructose Intolerance
- Trial name
- NCT02085889
- Testing
- no intervention: observational study
- Where
- Switzerland
- Volunteers
- 3,000 people
- Sponsor
- Brain-Gut Research Group
Diarrhea-predominant Irritable Bowel Syndrome
Study to Evaluate the Efficacy, Safety, and Tolerability of BOS-589 in the Treatment of Patients With Diarrhea-predominant Irritable Bowel Syndrome (IBS-D)
This study is being conducted to evaluate in participants with diarrhea-predominant Irritable Bowel Syndrome (IBS-D) the abdominal pain response to BOS-589 after 4 weeks of treatment and to evaluate the overall safety and…
- Trial name
- NCT03977155
- Testing
- BOS-589
- Where
- 58 sites in United States
- Volunteers
- 133 people
- Sponsor
- Boston Pharmaceuticals
Crohn's Disease
Impact of Diet and Lifestyle Modification on the Intestinal Barrier Integrity in Crohn's Disease
The goal of this prospective interventional study is to evaluate whether the targeted avoidance of a particular food that was diagnosed to be disruptive for the intestinal barrier during confocal laser endomicroscopy (CLE)…
- Trial name
- LeakyDiet (NCT06719778)
- Testing
- Two-stage nutritional therapy concept
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universität Duisburg-Essen
Irritable Bowel Syndrome
Nurse-administered, Gut-directed Hypnotherapy for Patients With Irritable Bowel Syndrome (IBS).
Adult IBS patients with symptoms refractory to standard medical treatment received nurse-administered, gut-directed hypnotherapy. The primary outcome measure was change in gastro-intestinal symptom severity.
- Trial name
- NCT06167018
- Testing
- Gut-directed hypnotherapy
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Sahlgrenska University Hospital
Irritable Bowel Syndrome
Phase I Clinical Trial of DA-6886 in Healthy Male Subjects
DA-6886_IBS_I is a phase I, dose block-randomized, double-blind, placebo-controlled, single/multiple dosing, dose escalation clinical trial with open-labelled food effect study of single dose to investigate the safety…
- Trial name
- NCT01633723
- Testing
- DA-6886
- Where
- South Korea
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Irritable Bowel Syndrome
Effect of Curcumin on Gut Microbiota in IBS
To evaluate the effect of curcumin food supplement on gut microbiota of children with irritable bowel syndrome (IBS) and to review any correlation between the changes in the microbiota with symptoms.
- Trial name
- NCT03568513
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical College of Wisconsin
Fecal Incontinence
Functional Outcomes in Ulcerative Colitis Patients With Ileal Pouch Anal Anastomosis Treated With High Intensity Focused Electromagnetic Stimulation
The purpose of this research is to evaluate functional outcomes in patients with Ulcerative Colitis and IBDU who have received an ileal pouch anal anastomosis (IPAA), commonly referred to as a J pouch, after treatment with the…
- Trial name
- NCT07034443
- Testing
- High Intensity Focused Electromagnetic Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Irritable Bowel Syndrome, Wheat Sensitivity
Effects of Wheat Breads on Symptoms of IBS, a Pilot Study
This is randomized pilot study comparing tolerability of yeast-baked wheat bread and sourdough wheat bread in irritable bowel syndrome.
- Trial name
- Wheat-IBS (NCT02572908)
- Testing
- Sourdough wheat bread, Regular yeast baked toast bread, Gluten-free diet
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Oy Karl Fazer Ab
Type 1 Diabetes
Intervention for Children With Type 1 Diabetes Targeting Gut Microbes
The goal of this clinical study is to evaluate the effect of nutritional intervention program based on dietary products in the clinical treatment of newly diagnosed children with type 1 diabetes.
- Trial name
- TRIM1 (NCT06198725)
- Testing
- Trimtab
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Children's Hospital of Fudan University
Irritable Bowel Syndrome
Digestive Enzyme Formulation Intervention in IBS Patients Who Previously Clinically Responded to Mediterranean LFD
Irritable bowel syndrome (IBS) is a highly prevalent chronic functional gastrointestinal disorder. The cardinal symptoms include abdominal pain, flatulence, bloating, and changes in bowel habits related to stool frequency and…
- Trial name
- NCT06749613
- Testing
- digestive enzymes
- Where
- 2 sites in Greece
- Volunteers
- 40 people
- Sponsor
- Attikon Hospital
Irritable Bowel Syndrome
Effects of Pectin Supplementation in Diarrhea-predominant Irritable Bowel Syndrome
The purpose of this study is to investigate the effect of pectin, a kind of soluble dietary fiber, on clinical symptoms, gut microbiota and the immune status in patients with diarrhea-predominant irritable bowel syndrome
- Trial name
- NCT02270268
- Testing
- Pectin, maltodextrin
- Volunteers
- 114 people
- Sponsor
- Nanjing PLA General Hospital
Ileus
Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/ Postoperative Ileus
Patients undergoing major abdominal surgery are at highest risk for developing postoperative ileus (POI), occurring in nearly all cases.
- Trial name
- NCT00388479
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 666 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Irritable Bowel Syndrome (IBS)
Probiotics and Biomarkers in Irritable Bowel Syndrome
The goal of this double-blind parallel-arm randomized controlled trial is to learn if a probiotic supplement (containing a new strain derived from L.
- Trial name
- BIO-IBS (NCT07584278)
- Testing
- Probiotic Supplementation (Lactobacillus Reuteri)
- Where
- Sweden
- Volunteers
- 252 people
- Sponsor
- Sahlgrenska University Hospital
Colorectal Cancer
Radiation Therapy on Pelvic Floor Disorders in Women
Investigators propose a retrospective cohort study to examine the impact of radiation therapy on the global pelvic floor function of women who have completed the immediate surveillance period for colorectal cancer
- Trial name
- RadPFD (NCT04623515)
- Testing
- REDCap Questionnaires
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Osteo Arthritis Knee, Obesity
Effect of Prebiotics on Function and Pain in Patients with Osteoarthritis and Obesity
The purpose of the present study is to determine if prebiotic supplementation can, through changes in the intestinal gut microbiota, lead to improvements in knee function and physical performance and reduce knee pain in adults…
- Trial name
- NCT04172688
- Testing
- Prebiotic oligofructose-enriched inulin
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University of Calgary
Irritable Bowel Syndrome
Ethosuximide to Treat IBS
Abdominal pain remains the most deleterious symptom for patients with irritable bowel syndrome (IBS) and is causing a significant alteration of their quality of life.
- Trial name
- IBSET (NCT02973542)
- Testing
- Ethosuximide
- Where
- France
- Volunteers
- 162 people
- Sponsor
- University Hospital, Clermont-Ferrand
Irritable Bowel Syndrome
Efficacy, Safety and Tolerability of DNK333 (25 and 100 mg Bid) in Women With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
This study will evaluate the tolerability, safety and efficacy of DNK333 against diarrhea caused by Irritable Bowel Syndrome in women.
- Trial name
- CDNK333B2201 (NCT00699166)
- Testing
- DNK333
- Where
- 29 sites in United States
- Volunteers
- 135 people
- Sponsor
- Novartis
Environmental Enteric Dysfunction
Maternal Probiotic Intervention to Improve Gut Health - Trial II - Bangladesh
Burden: Environmental Enteric Dysfunction (EED) is an enteropathic condition characterised by altered gut permeability, infiltration of immune cells and changes in villous architecture and cell differentiation.
- Trial name
- MPIGH-II (NCT06817031)
- Testing
- VE818, Oral Vancomycin
- Where
- Bangladesh
- Volunteers
- 144 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Overweight Adults
Effects of a Sugar-Based Synbiotic Product on Cardiometabolic and Intestinal Health (SUGAR-SYN BC3O)
This randomized, double-blind, controlled, crossover study investigates the effects of a sugar-based synbiotic product containing inulin and Bacillus coagulans BC30™ spores in healthy overweight individuals.
- Trial name
- SUGAR-SYN BC3O (NCT07806383)
- Testing
- Sugar-Based Synbiotic Product, Inulin-Containing Sugar Product
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Irritable Bowel Syndrome
Asimadoline for the Treatment of Subjects With Irritable Bowel Syndrome
The purpose of this study is to evaluate the safety and efficacy of different doses of asimadoline in the treatment of patients with irritable bowel syndrome.
- Trial name
- NCT00454688
- Testing
- Asimadoline
- Where
- 112 sites in United States
- Volunteers
- 596 people
- Sponsor
- Tioga Pharmaceuticals