Clinical trials: Intestinal Motility
Colorectal Neoplasms, Ileus Postoperative
The ACURE Trial: Acupuncture for Colorectal Recovery
Purpose: The goal of this clinical trial is to evaluate whether electroacupuncture (EA) can accelerate the recovery of bowel function in patients undergoing minimally invasive surgery for colorectal cancer.
- Conditions
- Colorectal Neoplasms, Ileus Postoperative, Postoperative Complication, Gastrointestinal Motility
- Trial name
- ACURE (NCT07496528)
- Testing
- Electroacupuncture (EA), Enhanced Recovery After Surgery (ERAS) Protocol
- Volunteers
- 240 people
- Sponsor
- Chang Gung Memorial Hospital
Functional Gastrointestinal Disorders
GLP-1 Inhibits Prandial Antro-duodeno-jejunal Motility in Humans
The inhibitory effect of low dose GLP-1 is investigated on prandial motility of the stomach, duodenum and jejunum in vivo in humans.
- Trial name
- GLPMOT (NCT02731664)
- Testing
- GLP-1, Intravenous saline
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Gastrointestinal Dysfunction, Critical Illness
Ear-Vagus Nerve Stimulation and Body Acupuncture for Gut Motility in Elderly ICU Patients
This study aims to investigate whether acupuncture, specifically a combination of body acupuncture and ear vagus nerve stimulation (taVNS), can improve gastrointestinal function in critically ill elderly patients in the Intensive…
- Trial name
- NCT07861503
- Testing
- Standard Care, Body Acupuncture, Transcutaneous Auricular Vagus Nerve Stimulation
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Constipation
Probiotics for Alleviating Chronic Constipation in Adults
To investigate the clinical effects of probiotics in relieving intestinal motility and chronic constipation through regulating gut microbiota.
- Trial name
- NCT07152795
- Testing
- Probiotic
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Obesity, Endoscopic Sleeve Gastroplasty
Endoscopic Sleeve Gastroplasty for Obesity and Microbiota Randomized Trial
This is an interventional, open-label, randomized (2:1), standard medical therapy-controlled trial. Subjects in the standard therapy group will be given the opportunity to undergo the active endoscopic treatment after 6 months of…
- Conditions
- Obesity, Endoscopic Sleeve Gastroplasty, Gastric Motility, Gastric Hormones
- Trial name
- ESGORT (NCT04200144)
- Testing
- Endoscopic sleeve gastroplasty
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Post Abdominal Surgery, Gastrointestinal Motility Disorder
Association Between Preoperative Mediterranean Diet Adherence and Postoperative Bowel Motility
Postoperative bowel motility is an important indicator of recovery after abdominal surgery and may be influenced by preoperative nutritional status.
- Conditions
- Post Abdominal Surgery, Gastrointestinal Motility Disorder, Postoperative Ileus
- Trial name
- NCT07808281
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Bahçeşehir University
Gastroparesis
A Study to Evaluate the Effect of Camicinal on Gastroparesis Symptoms in Type 1 and 2 Diabetic Subjects With Gastroparesis
This study is a randomized, double-blind, placebo controlled trial designed to confirm the symptomatic effects of camicinal treatment vs. placebo, on gastroparesis symptoms in type 1 and 2 diabetic subjects with gastroparesis.
- Trial name
- NCT02210000
- Testing
- Camicinal
- Where
- 34 sites in United States
- Volunteers
- 114 people
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome
Efficacy of a Low FODMAP Diet According to Colonic pH in Irritable Bowel Syndrome Patients
Treatments efficacy in irritable bowel syndrome (IBS) patients is inconstant and predictive factors of their efficacy are needed. The role of dysbiosis in IBS is well-known.
- Trial name
- FOSIIL (NCT05326646)
- Testing
- Low FODMAP diet
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Rouen
Postoperative Ileus
Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery
Postoperative bowel dysmotility is a frequent condition after colorectal surgery. The influence of colon stimulating laxatives have not been studied.
- Trial name
- NCT00509327
- Testing
- bisacodyl, glucosemonohydricum
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Gastroesophageal Reflux
Verification Study on Lafutidine in Mild Reflux Oesophagitis - Double Blind Controlled Study With Famotidine -
The purpose of the study is to verify superiority of the lafutidine group over the placebo group and non-inferiority to the famotidine group in terms of endoscopic healing rate of the patients with mild reflux oesophagitis.
- Trial name
- NCT00229424
- Testing
- Lafutidine, Famotidine
- Where
- Japan
- Volunteers
- 325 people
- Sponsor
- Taiho Pharmaceutical Co., Ltd.
Gastrointestinal Motility
Effect of Coffee Consumption on Intestinal Motility
Randomized controlled trial in Obstetrics and Gynecology department (MULTI-CENTRIC).To measure the effect of coffee consumption on intestinal motility after caesarean section for the patient who fulfills the criteria.
- Trial name
- NCT03191877
- Testing
- coffee
- Where
- Saudi Arabia
- Volunteers
- 600 people
- Sponsor
- Armed Forces Hospitals, Southern Region, Saudi Arabia
Dyspepsia, Peptic Ulcer Disease
Minimally Invasive Evaluation of Dyspepsia by Combined Magnetically Controlled Capsule Endoscopy and Urea Breath Test: a Pilot Prospective Cohort Study
The combined diagnostic accuracy of MCCE and UBT in Hong Kong patients with uninvestigated dyspepsia between age 35 to 60 years for structural pathology and HP infection is comparable to that of conventional UGI endoscopy with…
- Conditions
- Dyspepsia, Peptic Ulcer Disease, Gastroesophageal Reflux, Ugi Malignancies
- Trial name
- MCUDYSPEPSIA (NCT04918472)
- Testing
- MCCE
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Healthy
The Effect of Obeticholic Acid in Healthy Volunteers
This study investigates whether obeticholic acid affects gut microbiota, gastric motility, accommodation, and gastrointestinal peptide in healthy subjects. This study is a single-blind, placebo-controlled, randomized study.
- Trial name
- OCARINA (NCT05740631)
- Testing
- Ocaliva
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postoperative Ileus, Delayed Gastrointestinal Motility
Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery Patients
Postoperative ileus (POI) is a frequent complication after abdominal surgery, leading to delayed gastrointestinal motility, prolonged hospital stay, and increased patient discomfort.
- Conditions
- Postoperative Ileus, Delayed Gastrointestinal Motility, Postoperative Gut Dysfunction
- Trial name
- NCT07425249
- Testing
- Chewing Gum
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Khyber Medical University Peshawar
Gastric Ulcer, Duodenal Ulcer, Anastomotic Ulcer, Reflux Oesophagitis,"Non-erosive Reflux Disease, Zollinger-Ellison Syndrome
Nexium Capsules Clinical Experience Investigation
The purpose of this study is to confirm the safety profile / factors which impact safety and efficacy of Nexium capsules in daily clinical usage for the patients who have been prescribed Nexium for "gastric ulcer", "duodenal…
- Trial name
- NCT01434485
- Where
- 47 sites in Japan
- Volunteers
- 3,691 people
- Sponsor
- AstraZeneca
GERD, Reflux Esophagitis
A Novel Endoloop Pre-test to Treat Gastroesophageal Reflux
The purpose of this study was to evaluate the safety and efficacy of endoscopic endoloop pre-test for gastroesophageal reflux before anti-reflux surgery or endoscopic treatment.
- Trial name
- NCT05192538
- Testing
- Endoscopic endoloop pre-test treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Effects of 2 Mu-opiates on Gastrointestinal Transit
Comparison of the Effects of Tapentadol and Oxycodone on Gastrointestinal and Colonic Transit in Humans
Tapentadol is FDA approved for the treatment of moderate to severe acute pain. Due to the dual mechanism of action as an opioid agonist and norepinephrine reuptake inhibitor, there is potential for off label use in chronic pain.
- Trial name
- tap-oxy (NCT01500317)
- Testing
- Tapentadol, Oxycodone
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastrointestinal Disease, Gastrointestinal Disorders
Telehealth-Delivered Gut-Directed Hypnotherapy for Managing GI Health
This study aims to evaluate the specific and non-specific effects of hypnotherapy and to evaluate the efficacy of group-format gut-directed hypnotherapy (GDH) delivered via telehealth for managing gastrointestinal health.
- Conditions
- Gastrointestinal Disease, Gastrointestinal Disorders, Nervous System
- Trial name
- NCT06890663
- Testing
- Nonspecific Hypnotherapy for Relaxation, Gut-Directed Hypnotherapy (GDH), 3-month Follow-Up
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Central Florida
Irritable Bowel Syndrome
Comparing of the Gastrointestinal Motility in Irritable Bowel Syndrome (IBS) Patients With Healthy Volunteers
The hypothesis of the study is that the motility of the small intestine and the colon will alter according to the subtype of the irritable bowel syndrome (IBS) patient.
- Trial name
- NCT00957398
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Gastroschisis
Metoclopramide Pilot Trial
Infants with gastroschisis typically have poor intestinal motility for the first weeks to months after birth. Prokinetic agents are often used in these infants to improve intestinal motility in an attempt to quicken the…
- Trial name
- NCT02098915
- Testing
- intravenous metoclopramide
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children