Clinical trials: Intestinal Permeability, open to volunteers
Healthy Adult Participants
Multilevel Exercise Response in Rowers
This observational study aims to evaluate multilevel physiological, molecular, metabolic, intestinal, immunological, and psychophysiological responses to rowing-specific exercise in elite rowers.
- Trial name
- NCT07613619
- Testing
- 2000-m rowing ergometer test, 6000-m rowing ergometer test
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Preleukemia, Myelodysplastic Neoplasm
Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS
This is a single-arm pilot study of the feasibility and safety of metformin in patients with clonal cytopenia of undetermined significance (CCUS) or lower-risk myelodysplastic neoplasms (LR-MDS).
- Conditions
- Preleukemia, Myelodysplastic Neoplasm, Cytopenia, Preleukemic Anemia
- Trial name
- NCT04741945
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kirsten Grønbæk
Gut Health, LBP
The Effects of Mango on Gut Health Markers
This is an ancillary study of NCT06159543, which was a clinical trial that examined the effect of a 12-week 1.5 cups daily mango crossover intervention on cardiometabolic outcomes in individuals with prediabetes, male and female…
- Conditions
- Gut Health, LBP, Short Chain Fatty Acids, sCD14
- Trial name
- NCT07559604
- Testing
- Mango
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Loma Linda University
Obesity & Overweight
Changes in Intestinal Permeability and Systemic Inflammation Following Fast Food Overfeeding.
The purpose of this study is to investigate whether lifestyle factors can alter gut barrier integrity and whether disruptions of the gut barrier can trigger systemic and tissue-specific inflammation.
- Trial name
- ChIPS (NCT07893743)
- Testing
- Fast-food overfeeding
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Irritable Bowel Syndrome (IBS)
IBS-Oriented CDED Versus Low FODMAP Diet for Irritable Bowel Syndrome
Background: Irritable Bowel Syndrome (IBS) affects approximately 4.1% of the global population and imposes a significant personal and healthcare burden.
- Trial name
- IBS-CDED (NCT07707635)
- Testing
- Modified Crohn's Disease Exclusion Diet (CDED), Low FODMAP Diet
- Volunteers
- 150 people
- Sponsor
- Ariel University
IBD
Role of Altered Intestinal Permeability and Lipopolysaccharide in Thrombotic Risk and Vascular Injury in IBD Patients
Chronic inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic immune-mediated inflammation primarily affecting the gastrointestinal tract.
- Trial name
- PERVASC-IBD (NCT06772350)
- Testing
- examinations
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Prematurity Complications
Gut Permeability and Microbiome in Preterm Infants
NEC, a life-threatening, GI emergency characterized by increased IP, affects approximately 7 to 10% of preterm neonates, and typically occurs within 7 to 14 days of birth with mortality as high as 30-50%.
- Trial name
- NCT07667049
- Testing
- measurement of intestinal permeability
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Maryland, Baltimore
Celiac Disease in Children, Non-Alcoholic Fatty Liver Disease
Liver Steatosis in Pediatric CD Patients
Celiac disease (CD) is an autoimmune enteropathy triggered by the intake of gluten, characterized by a genetic predisposition. Although, CD is often associated with malabsorption symptoms, a growing number of affected subjects…
- Trial name
- NCT06206616
- Testing
- Gluten-free diet
- Where
- 2 sites in Italy
- Volunteers
- 91 people
- Sponsor
- University of Palermo
Healthy Participants
Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.
Systemic inflammation and intestinal hyperpermeability (disruption of the gut barrier which allows nutrient molecules and bacteria to enter the bloodstream) are triggered by consumption of high-sugar meals and are linked to…
- Trial name
- NCT07650058
- Testing
- High-Glycemic Breakfast Containing Cereal and Fresh Mango, High-Glycemic Breakfast Containing Cereal and Table Sugar
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ball State University
Mental Disorder
Meals, Microbiota & Mental Health of Children & Adolescents
Recent studies indicate that the interplay between diet, intestinal microbiota composition, and intestinal permeability might impact mental health.
- Trial name
- MMM (NCT04330703)
- Volunteers
- 30 people
- Sponsor
- University of Iceland
Irritable Bowel Syndrome
Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome
This study aimed to evaluate the effects of a Low-FODMAP diet on intestinal permeability, symptom severity, and quality of life in patients with Irritable Bowel Syndrome (IBS).
- Trial name
- NCT07467278
- Testing
- low fodmap diet, dietary intervention
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Aging, Diet, Healthy
Western Diet on Cardiometabolic and Immune Function
This study will implement a Western Diet (WD) to understand cardiometabolic and immune function in middle-aged adults (50- 64 years old).
- Trial name
- WD (NCT06528977)
- Testing
- Western Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Intestinal Permability
CP: Intestinal Permeability
The goal of this clinical trial is to evaluate the effects of 45 days daily administration of three different doses (2.5g, 5g, and 10g) of collagen peptide in healthy adults as compared to a Placebo on intestinal permeability…
- Trial name
- NCT07586930
- Testing
- AP GUT collagen peptides
- Where
- Ireland
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Inflammatory Bowel Diseases
Impact of a Human Origin Heat Inactivated Probiotic-Lactobacillus Paracasei D3.5 (LpD3.5) as Dietary Supplement on Gut Mucin and Intestinal Permeability in Adults With IBD
This study aims to study a biological phenomenon of reduced mucin barriers that are linked with increased intestinal permeabil-ity in the gut of individuals with IBD and determine whether and how a human originated, and heat…
- Trial name
- LIBD (NCT07017959)
- Testing
- LpD3.5 supplementation.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of South Florida
Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers
Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents
Mangos contain a number of nutrients that may improve gut and metabolic health. The purpose of this research is to see how eating mangos every day for 4 weeks instead of snacks high in calories and low in nutrients such as…
- Conditions
- Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers, Inflammation
- Trial name
- NCT07125001
- Testing
- Ataulfo mango
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Intolerance to "Conventional" Bread
Tolerance to an Artisanal Bread in a Population Intolerant of the Conventional Bread and Study of Associated Markers
The objective of this study is to evaluate the effect of consuming an "artisanal" bread for 15 days on gastrointestinal symptoms in individuals intolerant to "conventional" bread.
- Trial name
- TOLERBREAD (NCT07568223)
- Testing
- Artisanal Bread
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Autism Spectrum Disorders
Intestinal Permeability in Children With Autism Spectrum Disorder
In recent years, increasing attention has been directed toward the role of the gut-brain axis in the pathogenesis of neurodevelopmental disorders, particularly Autism Spectrum Disorder (ASD).
- Trial name
- IP-ASD (NCT07032857)
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- University of Bari
Gut Permeability, Gut Health
Effects of Effera Human Lactoferrin at One Dose Compared to Placebo on Gut Permeability
The purpose of this study is to evaluate the impact of 28-day supplementation with effera human lactoferrin, compared to a placebo control product on indicators of gut barrier health in males and females
- Trial name
- NCT07035964
- Testing
- human lactoferrin
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Helaina Inc.
Symbiotic, Uremic Toxins
Modulation of Gut Microbiota Composition and Gut Permeability Profiles by Multispecies Synbiotic Supplementation in Hemodialysis Patients
Chronic kidney disease (CKD) patients undergoing maintenance hemodialysis experience profound alterations in their gut microbiota, leading to dysbiosis and increased gut permeability.
- Conditions
- Symbiotic, Uremic Toxins, Gut -Microbiota, Gut Permeability
- Trial name
- NCT07461233
- Testing
- Multispecies Synbiotic Supplementation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital