Clinical trials: Intestinal Polyps, open to volunteers
Familial Adenomatous Polyposis (FAP)
Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients.
This study aimed to investigate the efficacy of vitamin B1 in patients with familial adenomatous polyposis, and to determine the inhibitory effect of vitamin B1 on the size and number of colorectal adenomas by administering oral…
- Trial name
- VitB1; FAP (NCT06649825)
- Testing
- Vitamin B1
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Zhongshan Hospital
Colorectal Cancer, Adenoma Colon
Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection
This is an multicenter study that will test the diagnostic accuracy of a blood test (i.e., a liquid biopsy) for the diagnosis of colorectal cancer (CRC), advanced adenomas (AAs), as well as Lynch-syndrome associated cancers.
- Conditions
- Colorectal Cancer, Adenoma Colon, Adenoma Colon Polyp, Colon Adenoma
- Trial name
- BEACON (NCT07450612)
- Testing
- BEACON
- Where
- 4 sites in Italy
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- San Raffaele University
Familial Adenomatous Polyposis
Colorectal Adenoma Canceration in FAP
The current internationally accepted treatment method for familial adenomatous polyposis is prophylactic total colorectal resection combined with endoscopic follow-up.
- Trial name
- NCT04531930
- Testing
- surgery, enhanced colonoscopy, self choosed methods
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Changhai Hospital
Hypoxia, Gastric Polyp
The Efficacy and Safety of the COMBO Endoscopy Oropharyngeal Airway in Gastrointestinal Endoscopy Procedure
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing gastrointestinal endoscopy with propofol.
- Conditions
- Hypoxia, Gastric Polyp, Colon Cancer, Esophageal Cancer
- Trial name
- NCT06081647
- Testing
- the COMBO Endoscopy Oropharyngeal Airway, Regular Nasal Cannula
- Where
- 10 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Colorectal Cancer, Colorectal Neoplasms
Clinical Performance of the Mainz Biomed Colorectal Cancer Screening Test for Colorectal Cancer and Advanced Adenoma
This study is to determine how the Mainz Biomed Colorectal Cancer Screening Test works when used in people aged ≥45 years of age and at an average risk of developing colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenoma
- Trial name
- reconAAsense (NCT05636085)
- Testing
- Mainz Biomed Colorectal Cancer Screening Test
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Mainz Biomed
Colonic Polyp, Colon Adenoma
Training Physicians to Differentiate the Paris Classification Using Artificial Colon Polyp Images
Training in endoscopy is essential for the early detection of precursors of colorectal cancer. Up to now, this training has been carried out with image collections of findings and in practice when working on patients.
- Trial name
- LUTETIA2 (NCT06550908)
- Testing
- Lutetia Training Plattform - real images, Lutetia Training Plattform - artifical images
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Bowel Cancer, Polyp Rectal
Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal
1.1 Polyps or tumours in the lower part of the bowel (rectum) can be removed using instruments inserted through the bottom which avoids major surgery and the possibility of a stoma bag (colostomy).
- Conditions
- Bowel Cancer, Polyp Rectal, Rectal Cancer, Rectal Adenocarcinoma
- Trial name
- R-ALERT (NCT07341126)
- Testing
- LumenEye X1 digital rectoscope
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Polyps, Adenoma Colon
Early DiAgnosis Real-Time Healthcare System for CANcer Trial
The purpose of the study is to assess whether the AI characterisation system of the CADDIE device improves the endoscopists accuracy in the optical diagnosis of diminutive colorectal polyps in the bowel during colonoscopy.
- Conditions
- Polyps, Adenoma Colon, Colorectal Polyp, Colon Polyp
- Trial name
- EARTHSCAN (NCT05064124)
- Testing
- CADDIE - Computer Aided Detection and Diagnosis for Intelligent Endoscopy
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University College, London
Familial Adenomatous Polyposis
Microbial and Environmental Factors Associated With Polyps Development in Familial Adenomatous Polyposis (MicrobEnvironment in FAP)
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder linked to a mutation in the APC gene, associated with the development of multiple colonic and duodenal adenomas, which in 100% of cases progress to…
- Trial name
- NCT06614738
- Testing
- Sampling of feces and duodenal fluids
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Shared Decision Making, Colonic Polyp
The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp
Management of unexpected malignant colorectal polyps removed endoscopically can be challenging due to the risk of residual tumor and lymphatic spread.
- Conditions
- Shared Decision Making, Colonic Polyp, Decision Aids, Rectal Polyp
- Trial name
- NCT05776381
- Testing
- Shared Decision Making using a Patient Decision Aid.
- Volunteers
- 110 people
- Sponsor
- Vejle Hospital
Colonic Polyps, Colorectal Neoplasms
Right Colon Enema to Improve Bowel Preparation Quality During Colonoscopy
Colonoscopy is a test that lets doctors look inside the large bowel to find and remove growths called polyps, which can develop into bowel cancer. Before the test, people take a bowel preparation to empty the bowel.
- Conditions
- Colonic Polyps, Colorectal Neoplasms, Colonoscopy, Bowel Preparation Quality
- Trial name
- RIGHT-CLEAN (NCT07813013)
- Testing
- Sodium phosphate enema, Water instillation
- Where
- 2 sites in Australia
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Westmead Hospital
Colorectal Polyp
CBM588 Reduces Colorectal Polyp Recurrence
The goal of this randomized crossover clinical trial is to evaluate the efficacy of Clostridium butyricum MIYAIRI 588 (CBM588) in reducing colorectal adenomatous polyp recurrence in adult patients with a history of colorectal…
- Trial name
- NCT06855355
- Testing
- Clostridium butyricum MIYAIRI 588
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Kaohsiung Medical University
Colonic Polyps, CRC (Colorectal Cancer)
A Prospective Study to Evaluate the Performance of a Real-time System in the Estimation of Colorectal Polyp Size
Colorectal polyp size is related to the risk of exhibiting advanced histological features. Moreover, polyps larger than 10 mm are associated with an elevated risk of metachronous advanced neoplasia and colorectal cancer (CRC).
- Conditions
- Colonic Polyps, CRC (Colorectal Cancer), Artificial Intelligence (AI)
- Trial name
- EndoAIM (NCT06957015)
- Testing
- EndoAIM
- Where
- Hong Kong
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colonic Polyp
Review of the Impact of a Computer-aided Real-time Polyp Detection System on Adult Colonoscopy
Background: Removal of adenomatous polyps during colonoscopy is associated with long-term prevention of colorectal cancer-related deaths.
- Trial name
- COPILOT (NCT05822895)
- Testing
- CADe enabled programme (GI Genius)
- Where
- Singapore
- Volunteers
- 764 people
- Sponsor
- Sengkang General Hospital
Colonoscopy, Colorectal Neoplasms
Efficacy of CAD in Screening Colonoscopy to Reduce the Risk of Advanced Adenoma at 3 Years.
The occurrence of interval cancers after colonoscopy raises the possibility of missed lesions. High- performance computer aided diagnosis (CAD) systems have been specially designed for the detection of colorectal lesions (CAD for…
- Conditions
- Colonoscopy, Colorectal Neoplasms, Intestinal Polyps
- Trial name
- IA-COLO 2 (NCT07299071)
- Testing
- Standard colonoscopy, Colonoscopy CADe
- Where
- 15 sites in France
- Volunteers
- 592 people
- Sponsor
- University Hospital, Bordeaux
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Colorectal Carcinoma, Polyp
New bioMarkers tO straTIfy cOlorectal caNcer Referrals
The goal of this observational study is to evaluate if a blood test for circulating progastrin (hPG80) and transposable elements (TEs) can accurately predict colorectal cancer (CRC) or polyps in adult patients referred to the…
- Conditions
- Colorectal Carcinoma, Polyp, Colorectal Adenoma
- Trial name
- MOTION (NCT07035691)
- Where
- United Kingdom
- Volunteers
- 582 people
- Sponsor
- Queen Mary University of London
Colonic Polyp, Artificial Intelligence
Autonomous Artificial Intelligence Versus AI Assisted Human Optical Diagnosis
Computer-aided image-enhanced endoscopy can predict the nature of colorectal polyps with over 90% accuracy. This technology uses artificial intelligence (AI) to analyze video recordings of polyps, learning to make diagnoses in…
- Trial name
- CADx-Prosp (NCT06543862)
- Testing
- CADx (AI) system
- Where
- Canada
- Volunteers
- 540 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Polyp of Colon, Crohn Disease
Lesion Size Measurement During Gastrointestinal Endoscopies
The goal of this prospective observational study is to assess the accuracy and reliability of laser readings obtained through AccuMeasure, in comparison to other measurements performed by gastroenterologists.
- Trial name
- AccuMeasure (NCT07770425)
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cancer Diagnosis, Liver Cancer, Adult
Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis
The goal of this observational study is to explore whether a Raman-based, deep learning-assisted approach can be used to develop an effective method for early pan-cancer screening.
- Conditions
- Cancer Diagnosis, Liver Cancer, Adult, Cancer Screening, Colorectal Cancer (CRC)
- Trial name
- NCT06822413
- Testing
- No Interventions
- Where
- 4 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine