Clinical trials: Intestinal Pseudo-Obstruction
Complication, Postoperative
Early Initiation of Oral Feeding Versus Traditional Feeding Post Caesarean Section
Early initiation of oral feeding, within 6-12 hours post-caesarean section, has been noticed to be well tolerated by patients and helps them recover fast.
- Trial name
- NCT06539117
- Testing
- Early feeding post caesarean section
- Where
- Nigeria
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
PIPO
Role of ACTG2 Variants in Smooth Muscle Determination and Function in Pediatric Intestinal Pseudo-obstruction.
The primary objective of this study is to describe the transcriptional impact of R178, R257, R40 or A136 variants of the ACTG2 gene on iPS differentiation mechanisms up to organoids derived from PIPO patient samples versus those…
- Trial name
- SMOOTH-PIPO (NCT06687564)
- Testing
- Biopsy
- Where
- 3 sites in France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Grenoble
Paralytic Ileus, Critically Ill
Efficacy of PRUcalopride in Critically Ill Patients With Paralytic ILeus
Paralytic ileus is a common intestinal dysfunction in critically ill patients. There are still no established the effective medications except correcting the primary causes and prokinetics trial which limited in efficacy and…
- Trial name
- EPRUCIL (NCT04190173)
- Testing
- Prucalopride
- Where
- Thailand
- Volunteers
- 62 people
- Sponsor
- Prince of Songkla University
Intestinal Pseudo-Obstruction, Short Bowel Syndrome
Improved Quality of Life in Children With Intestinal Failure
Children with intestinal failure have a lack of tolerance for food in the intestine. The children are dependent on intravenous nutrition over a long period of time period to ensure growth and development.
- Conditions
- Intestinal Pseudo-Obstruction, Short Bowel Syndrome, Malabsorption Syndrome Autoimmune Enteropathy, Bacterial Overgrowth
- Trial name
- NCT04981262
- Testing
- Stimulance
- Where
- Norway
- Volunteers
- 56 people
- Sponsor
- Oslo University Hospital
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Paralytic Ileus
Effect of Preoperative Intrathecal Dexamethasone Versus Dexmedetomidine on Paralytic Ileus After Major Abdominal Surgery
Postoperative Ileus (POI) is considered as intolerance of oral intake due to disruption of the normal coordinated propulsive motor activity of the gastrointestinal (GI) tract following abdominal or non-abdominal surgery.
- Trial name
- NCT06752317
- Testing
- Dexamethasone, Dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Assiut University
Chronic Intestinal Pseudo-obstruction
Safety and Efficacy of Endoscopic Full Thickness Biopsy in Patients With Chronic Intestinal Pseudo-obstruction
To evaluate the safety and efficacy of endoscopic full thickness biopsy for the diagnostic purpose of chronic intestinal pseudo-obstruction.
- Trial name
- EFTB-CIPO (NCT06943417)
- Testing
- Over the scope clip
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- International University of Health and Welfare
Large Bowel Obstruction
Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or Surgery
The purpose of this study is to assess quality of life and bowel symptoms after treatment.The main objective is to compare the effect on quality of life of minimally invasive bowel surgery and endoscopic stent placement in the…
- Trial name
- NCT00140868
- Testing
- Luminal stents, Minimally Invasive Surgical Bowel Diversion
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Small Bowel Obstruction, Intestinal Pseudo-Obstruction
Predicting NOM Failure in Bowel Obstruction
"This study aims to collect data on patients with small bowel obstruction (SBO) admitted to hospitals in France and Italy from May 2022 to October 2024 to develop a deep convolutional neural network (DCNN) model.
- Trial name
- NCT06711107
- Where
- France
- Volunteers
- 370 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Intestinal Obstruction
Intestinal Microbiota and Visceral Pain in Chronic Intestinal Pseudo-Obstruction Syndrome (CIPO)
Chronic Intestinal Pseudo-Obstruction Syndrome (CIPO) is a rare gastrointestinal motility disorder. CIPO evolves through iterative flare-ups that can be triggered by viral or bacterial infections, psychological stress, or…
- Trial name
- METADOLOMIC (NCT06610929)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Intestinal Pseudo-obstruction
Velusetrag for the Treatment of Chronic Intestinal Pseudo-Obstruction (CIPO).
This is a phase II, multicenter, double-blind, placebo-controlled trial to evaluate the efficacy and safety of velusetrag once a day, compared to placebo, in subjects with CIPO.
- Trial name
- NCT05724069
- Testing
- Velusetrag 15 mg once daily for 4 weeks.
- Where
- 4 sites in Belgium, Italy and 1 more
- Volunteers
- 17 people
- Sponsor
- Alfasigma S.p.A.
Intestinal Pseudo-Obstruction, Fecal Microbiota Transplantation
Investigation of Fecal Microbiota Transplant in Chronic Intestinal Pseudo-obstruction Patients
Chronic Intestinal Pseudo-Obstruction (CIPO) is a rare gastrointestinal disorder that primarily affects the movement of the intestines, leading to symptoms that resemble a true bowel obstruction but without a physical blockage.
- Trial name
- FMT-CIP (NCT06020365)
- Testing
- sequential fecal microbiota transplant combined with small intestinal fluid transplant
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai 10th People's Hospital
Ogilvie Syndrome
Neostigmine Route for Acute Colonic Pseudo Obstruction
Neostigmine is commonly used for medical treatment of acute colonic pseudo obstruction, however, the ideal route of administration has not been determined.
- Trial name
- NCT04951726
- Testing
- Neostigmine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Southern California
Pseudo Obstruction
ACTG2/FLNA Testing Yield in Adult Idiopathic Chronic Intestinal Pseudo-Obstruction (CIPO) With Reduced/Absent Distal Esophageal Contractility
To assess the diagnostic yield of Sanger sequencing for ACTG2 and FLNA genes evaluation on blood or saliva sample in patients with idiopathic CIPO in which high-resolution esophageal manometry (HRM) shows reduced (DCI <450…
- Trial name
- CIPO_GEN (NCT07448753)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Marina Coletta
Paralytic Ileus
Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer
Following extensive abdominal surgery for the treatment of endometrial or ovarian cancer, paralytic ileus frequently develops. Gum chewing can promotes the return of bowel function through the cephalic-vagal reflex and increased…
- Trial name
- NCT01389986
- Testing
- Gum chewing
- Where
- Thailand
- Sponsor
- Chiang Mai University