Clinical trials: Intestinal Transplantation
IBD (Inflammatory Bowel Disease), Crohns Disease
OPTImization of Inflammatory Bowel Disease Treatment Through Understanding of Gut VIRome Heterogeneity
Title: The Role of Good Viruses in Inflammatory Bowel Disease Background An imbalance in the bacteria in the gut - called gut dysbiosis - is linked to chronic bowel diseases such as Crohn's disease and ulcerative colitis (IBD).
- Conditions
- IBD (Inflammatory Bowel Disease), Crohns Disease, Colitis Ulcerative
- Trial name
- OPTIVIR (NCT07240181)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Andreas Munk Petersen
Irritable Bowel Syndrome, Diarrhea
Fecal Microbiota Transplantation for IBS
The purpose of this study is to learn the efficacy and safety of fecal microbiota transplantation (FMT) using stool from a donor with low proteolytic activity and containing the bacteria Alistipes putredinis in patients with…
- Trial name
- NCT05776914
- Testing
- Donor Fecal Microbiota Transplantation, Autologous Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Madhusudan (Madhu) Grover, MBBS
Melanoma Stage Iv, Unresectable Stage III Melanoma
Fecal Microbiota Transplantation (FMT) in Metastatic Melanoma Patients Who Failed Immunotherapy
Altering the Gut Microbiota of Melanoma Patients Who Failed Immunotherapy Using Fecal Microbiota Transplantation (FMT) From Responding Patients. FMT includes both colonoscopy and stool capsules.
- Trial name
- NCT03353402
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Lymphoma, Small Intestine Cancer
High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma
RATIONALE: Giving chemotherapy before a peripheral blood stem cell transplant stops the growth of cancer cells by stopping them from dividing or by killing them.
- Trial name
- NCT00669812
- Testing
- carmustine, cyclophosphamide, cytarabine
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cancer Research UK
Hematopoietic Stem Cell Transplant (HSCT)
Developing Self-Management Interventions After HCT
This is a prospective, longitudinal, observational trial to evaluate quality of life in hematopoietic stem cell transplant survivors.
- Trial name
- NCT03710031
- Testing
- PNS Tracking
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Florida
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHD
The primary goals of this phase 2 clinical trial are to determine the feasibility, safety, and tolerability of oral Fecal Microbiota Transplantation (FMT) in adolescents (aged 13-17) with Attention-Deficit/Hyperactivity Disorder…
- Conditions
- ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD - Combined Type
- Trial name
- FMT-ADHD-2026 (NCT07756255)
- Testing
- Fecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
NAFLD, Fecal Microbiota
Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study
There are several studies performed to reveal the linkage between diet, fecal microbiota, and obesity. Human fecal microbiota transplantations in this asset are still scarce.
- Conditions
- NAFLD, Fecal Microbiota, Gut Microbiota, Obesity
- Trial name
- DIFTOB (NCT05607745)
- Where
- 3 sites in Finland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Peanut Allergy
Evaluating the Safety and Efficacy of Oral Encapsulated Fecal Microbiota Transplant in Peanut Allergic Patients
This is a Phase I trial to evaluate the safety and efficacy of oral encapsulated fecal microbiota transplantation (FMT) in the treatment of peanut allergy.
- Trial name
- NCT02960074
- Testing
- Fecal Microbiota Capsule
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rima Rachid
Ulcerative Colitis, Fecal Microbiota Transplantation
The Study of Efficacy and Mechanism in Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis
The aim of our study is to investigate the efficacy and mechanism in fecal microbiota transplantation in the treatment of ulcerative colitis.
- Trial name
- NCT02435160
- Testing
- Fecal Microbiota Transplantation
- Volunteers
- 20 people
- Sponsor
- Jun Liu
Crohn Disease
Treatment of Crohn's Complex Perianal Fistulas With Tissue Transplantation by Local Injection of Micro-fragmented Autologous Adipose Tissue.
multicentre randomized controlled prospective study aimed at evaluating the efficacy of the infiltration of microfractured adipose tissue in the healing of perianal fistulas not-responding to treatment with biologics, in order to…
- Trial name
- ATTIC (NCT05594862)
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Lipogems International spa
Ulcerative Colitis
The Effect of Therapeutic Fecal Transplant on the Gut Microbiome in Children With Ulcerative Colitis
Ninety Six patients with mild to moderate ulcerative colitis will be randomized to double blind, placebo controlled study. The safety and efficacy of the intervention will be closely monitored.
- Trial name
- FMT_UC (NCT02291523)
- Testing
- Fecal Microbial Transplant
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Bacteria, Microbiota
Standardized Fecal Microbiota Transplantation for Ulcerative Colitis
The gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism.
- Conditions
- Bacteria, Microbiota, Fecal Microbiota Transplantation, Inflammatory Bowel Disease
- Trial name
- NCT01790061
- Testing
- Standardized FMT, Traditional treatments
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Allografted With Myeloablative Conditioning
Complement and Graft-versus-host Disease
Allogeneic haematopoietic stem cell transplantation (HSCT) often remains the only curative treatment for haematological malignancies.
- Trial name
- NCT01520623
- Testing
- Serum concentration /Serum inflammatory
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
Fecal Microbiota Transplantation (FMT) in the Management of Active Crohn's Disease
Manipulation of the intestinal microbiota through FMT is a potential therapeutic target for CD patients. Studies are now required to determine if repeated FMT can overcome the apparent immune response to FMT thereby maintaining…
- Trial name
- NCT02199561
- Testing
- Fecal Microbiota Transplant
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Irritable Bowel Syndrome
Effect of Fecal Microbiota Transplantation in Irritable Bowel Syndrome
The purpose of this study is to investigate if fecal microbiota transplantation (FMT) will result in improvement in clinical outcome in patients with irritable bowel syndrome (IBS).
- Trial name
- NCT02788071
- Testing
- FMT capsules
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- Aleris-Hamlet Hospitaler København
Transplantation
Prospective Study of Drug Resistant Pathogens Among Liver, Intestinal and Multivisceral Transplant Recipients
Infections caused by multidrug resistant bacteria have become more prevalent at many tertiary care and academic centers. These infections are associated with increased morbidity and mortality.
- Trial name
- NCT00235664
- Testing
- Collection of stool and endotracheal aspirate samples
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Lymphoma, Lymphoproliferative Disorder
KX2-391 in Treating Patients With Advanced Solid Tumors or Lymphoma That Did Not Respond to Treatment
RATIONALE: KX2-391 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying the side effects and best dose of KX2-391 in treating patients with advanced…
- Conditions
- Lymphoma, Lymphoproliferative Disorder, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00646139
- Testing
- Src kinase inhibitor KX2-391, immunoenzyme technique, pharmacological study
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Roswell Park Cancer Institute
Gastrointestinal Lesions, Signs and Symptoms, Digestive
Small Bowel Capsule Endoscopy Findings in Patients Receiving Cellcept®
The purpose of this study is to learn more about symptoms and gastrointestinal lesions associated with taking myfortic® by switching patients to a delayed release formulation that is developed to alleviate GI symptoms.
- Trial name
- NCT00652834
- Testing
- Small bowel capsule endoscopy (SBCE), myfortic
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, Los Angeles
Clostridium Difficile Infection
Harnessing the Healthy Gut Microbiota to Cure Patients With Recurrent C. Difficile Infection
CDI (Clostridium difficile infection) causes diarrheal illness and can cause colitis which may be fatal. A patient being treated for CDI has a 10-25% chance of developing relapse. Recurrent CDI is on the rise.
- Trial name
- NCT01372943
- Testing
- "synthetic stool" or pure cultures of probiotic intestinal bacteria
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Queen's University
Organ Transplantation, Intestine
Leuven Tolerogenic Protocol for Intestinal Transplantation
An immunomodulatory protocol, experimentally-proven to promote T-regulatory dependent graft protective mechanisms was applied in a clinical cohort of 13 intestinal transplant recipients to activate - in a protolerogenic…
- Trial name
- LP (NCT02314949)
- Testing
- intestinal transplantation
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven