Clinical trials: Intestinal Transplantation
Carbapenem-Resistant Enterobacteriaceae, Vancomycin (Glycopeptide) Resistant Enterococcus (VRE)
Efficacy and Safety of FMT for the Decolonization of MDROs in the Intestinal Tract
The goal of this unblinded randomized controlled trial is to evaluate the efficacy and safety of fecal microbiota transplantation for the decolonization of carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CP-CRE)…
- Trial name
- NCT06001333
- Testing
- fecal microbiota transplantation
- Where
- 2 sites in South Korea
- Volunteers
- 240 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Irritable Bowel Syndrome, Fecal Microbiota Transplantation
FMT for Patients With IBS With Fecal and Mucosal Microbiota Assessment
Irritable bowel syndrome (IBS) is a common functional bowel disorder of the gastrointestinal tract affecting up to 20 percent of the adolescent and adult populations.
- Trial name
- NCT03125564
- Testing
- Fecal Microbiota Transplantation, Fecal and Mucosal Microbiota Assessment
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- Chinese University of Hong Kong
Clostridioides Difficile Infection
Long-Term Outcomes After CDI: FMT Versus Antibiotic-Only Treatment
The goal of this observational study is to learn about the long-term effects of fecal microbiota transplantation (FMT) compared with antibiotic-only treatment in adults who were treated for Clostridioides difficile infection…
- Trial name
- LTO-CDI (NCT07569380)
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Umeå University
Ulcerative Colitis (UC), Inflammatory Bowel Disease
Fecal Microbiota Transplantation for Ulcerative Colitis Using Dai and Han Donors
This study is a randomized clinical trial evaluating fecal microbiota transplantation (FMT) for ulcerative colitis (UC) using healthy donors from two ethnic groups in Yunnan, China.
- Trial name
- NCT07814456
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Pitt Hopkins Syndrome
MTT for Children With Both Pitt Hopkins Syndrome and Gastrointestinal Disorders
The investigators propose to investigate Microbiota Transfer Therapy (MTT) for treating patients with Pitt Hopkins Syndrome (PTHS) and gastrointestinal problems similar to Irritable Bowel Syndrome (IBS).
- Trial name
- NCT04132427
- Testing
- vancomycin, magnesium citrate, microbiota
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Arizona State University
Ulcerative Colitis, FMT
Refined Fecal Microbiota Transplantation (FMT) for Ulcerative Colitis (UC)
The researchers intend to prospectively study the safety, clinical efficacy and microbial outcomes in patients with recently diagnosed UC with FMT capsule therapy derived from pre-defined donors.
- Conditions
- Ulcerative Colitis, FMT, Fecal Microbiota Transplant
- Trial name
- REFOCUS (NCT04968951)
- Testing
- Metronidazole, Vancomycin, Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ari M Grinspan
Ulcerative Colitis
Capsulized Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis Patients
Fecal Microbiota Transplantation(FMT) - reconstitution of normal flora by a stool transplant from a healthy individual, is increasingly being recognized as a therapeutic modality for diseases that are associated with gut…
- Trial name
- FMT UC (NCT03582969)
- Testing
- Fecal transplantation
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Anxiety Disorder, Cancer Survivor
Quality of Life in Younger Leukemia and Lymphoma Survivors
RATIONALE: Collecting information about the effect of hematologic cancer and its treatment on quality of life may help doctors learn more about the disease and plan the best treatment.
- Conditions
- Anxiety Disorder, Cancer Survivor, Fatigue, Leukemia
- Trial name
- NCT00956475
- Testing
- telephone-based intervention, questionnaire administration, assessment of therapy complications
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Case Comprehensive Cancer Center
Aging, Frailty
Effect of Gut Microbiome Intervention on Aging Via Oral FMT
A severe public health issue facing global population is aging. Increasing preclinical and clinical data indicate the contribution of gut microbiome on aging and aging-related diseases such as cardiovascular disease, Alzheimer…
- Trial name
- STEP-aging (NCT05598112)
- Testing
- FMT capsules
- Where
- 6 sites in China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Ulcerative Colitis
Fecal Microbiota Transplantation in Ulcerative Colitis
Fecal Microbiota Transplantation(FMT) - reconstitution of normal flora by a stool transplant from a healthy individual, is increasingly being recognized as a therapeutic modality for diseases that are associated with gut…
- Trial name
- NCT03273465
- Testing
- Fecal transplantation
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Ulcerative Colitis
Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis (UC)
This study included two topics: one was to test the efficacy and safety of fecal microbiota transplants plus partial enteral nutrition (PEN) in refractory pediatric UC where conventional therapy has failed, and the other was to…
- Trial name
- FMT (NCT05679622)
- Testing
- Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biao Zou
Irritable Bowel Syndrome
Effect of Antibiotic Pretreatment on the Efficacy of WMT in the Treatment of Irritable Bowel Syndrome
This is a randomized controlled trial to explore the efficacy of antibiotic pretreatment on the efficacy of WMT in the treatment of Irritable bowel syndrome in adults: a multi-center, randomized, placebo-controlled clinical study
- Trial name
- NCT06437041
- Testing
- Ornidazole
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Faming Zhang
Physical Activity, Exercise Training
Home-based Exercise and Physical Activity Intervention After Kidney Transplantation: Impact of Exercise Intensity
This multicentre two-phased RCT aims to evaluate implementation potential, cost-effectiveness, effectiveness, and the role of exercise intensity of a home-based exercise and physical activity intervention to improve de novo…
- Conditions
- Physical Activity, Exercise Training, Kidney Transplantation, Physical Fitness
- Trial name
- PHOENIX-Kidney (NCT06260579)
- Testing
- Exercise/physical activity
- Where
- 2 sites in Belgium
- Volunteers
- 147 people
- Sponsor
- KU Leuven
Multidrug Resistant Organisms, Faecal Microbiota Transplantation
The Effect of Faecal Microbiota Transplantation (FMT) on Eradication of Multidrug Resistant Organisms (MRO) in Intestinal Carriers
The aim of this study is to investigate the effect of faecal microbiota transplantation (FMT) on eradication of multidrug resistant organisms (MRO) in the intestine.
- Trial name
- FEMRO (NCT05742074)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 83 people
- Sponsor
- Hvidovre University Hospital
Irritable Bowel Syndrome
Transplantation of Anaerobic Cultured Human Intestinal Microbiota in Irritable Bowel Syndrome
Patients with irritable bowel syndrome (IBS) are treated with microbiota from a human intestinal anaerobic sample cultured for decades. Patients are recruited consecutively with symptoms of IBS and serve as their own controls.
- Trial name
- ACHIM2 (NCT02857257)
- Testing
- ACHIM
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Acute Myeloid Leukemia With FLT3/ITD Mutation, Allogeneic Hematopoietic Stem Cell Transplantation
The Gut Microbiome in FLT3-ITD+ AML Undergoing Allo-HSCT With Or Without Sorafenib Maintenance After Allo-HSCT
This prospective trial investigates the effect of sorafenib maintenance therapy in FLT3-ITD AML patients after allo-HSCT in terms of gut microbiome.
- Trial name
- NCT05596981
- Testing
- Sorafenib
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Liver Metastasis Colon Cancer, Colorectal Cancer
Liver Transplantation for Non-Resectable Colorectal Liver Metastasis
The study aims to evaluate the efficacy of liver transplantation in the context of non-resectable colorectal liver metastasis. The primary endpoint is the overall survival in this group of patients while the secondary endpoint is…
- Trial name
- NCT05185245
- Testing
- Liver Transplantation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Crohns Disease
A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Crohn Disease on Advanced Therapies
Advanced therapies including biologics and small molecules target specific inflammatory pathways. IBD's multifactorial etiology means that blocking a single pathway may not be sufficient for all patients.
- Trial name
- BOOST-CD (NCT06890637)
- Testing
- Fecal Microbial Transplantation, Crohns Disease Exclusion Diet, Advanced therapy
- Where
- 6 sites in India
- Volunteers
- 168 people
- Sponsor
- All India Institute of Medical Sciences
Ulcerative Colitis
Fecal Transplantation in Ulcerative Colitis
Adult individuals with ulcerative colitis in remission are given a single fecal microbiota transplantation (FMT) in colonoscopy.
- Trial name
- FMT-CU (NCT03561532)
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- 2 sites in Finland
- Volunteers
- 48 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Ulcerative Colitis, Fecal Microbiota Transplantation
Long-term Efficacy and Safety of Fecal Microbiota Transplantation in Patients With Ulcerative Colitis
This study aims to perform fecal microbiota transplantation (FMT) and analyze its effects in selected patients aged between 10 and 80 years who have been diagnosed with ulcerative colitis and have been receiving treatment for…
- Trial name
- NCT07154784
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital