Clinical trials: Intestine
Inflammatory Bowel Disease (IBD), Clostridioides Difficile Infection
Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients With Inflammatory Bowel Disease
This 3+3 dose escalation pilot trial will assess the safety and efficacy of xylitol as an oral therapeutic for decolonization of C. difficile in the Inflammatory Bowel Disease (IBD) patient population.
- Trial name
- NCT06799039
- Testing
- Xylitol
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Brigham and Women's Hospital
Colon Cancer, Breast Cancer
Genomic Services Research Program
Background: Genes are the instructions a person s body uses to function. Genome sequencing reads through all of a person s genes. Everyone has many gene variants, and most do not cause disease.
- Trial name
- NCT02595957
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Body Image Disorder
Prevention of Body Image Disorder by Nurse Intervention on the Patient and Family Prior to Breast and Colon Surgery
This is a non-blinded, randomized, controlled clinical trial consisting of 64 participants, which aims to assess the effectiveness of a nursing intervention for family members and patients prior to surgery to prevent body image…
- Trial name
- NCT03726801
- Testing
- HEALTH EDUCATION
- Where
- Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Healthy
Methionine Intake Microbiota
Pro-inflammatory immune cells play a pivotal role in multiple sclerosis, and the gut microbiota is increasingly recognized as a key factor shaping the immune system.
- Trial name
- NCT07283328
- Testing
- Methionine-restricted diet
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Ovarian Neoplasms, Prostatic Neoplasms
A Study of DM002 in Patients With Advanced Solid Tumors
The goal of study： The study has two parts: Part 1 Dose Escalation and Part 2 Dose Expansion. In Part 1, a few participants will receive the lowest dose of study drug.
- Conditions
- Ovarian Neoplasms, Prostatic Neoplasms, Endometrial Neoplasms, Colorectal Neoplasms
- Trial name
- NCT06751329
- Testing
- DM002
- Where
- 7 sites in United States, Australia
- Volunteers
- 280 people
- Sponsor
- Xadcera Biopharmaceutical (Suzhou) Co., Ltd.
Crohn Disease (CD)
Qualitative Exploration of Key Symptoms of Stricturing Crohn's Disease: Toward the Development of a Clinical Assessment Score.
The goal of this qualitative study is to identify and better understand the symptoms of stricturing Crohn's disease in order to inform the development of more appropriate clinical evaluation scores.
- Trial name
- SYMCROHNS (NCT07441629)
- Testing
- Semi-structured interview
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Inflammatory Bowel Diseases, Anorectal Malformations
StoMakker Mobile Application
The goal of this clinical trial is to investigate if access to the StoMakker application will significantly improve health-related quality of life in children receiving surgery resulting in an ileostomy, colostomy or continent…
- Conditions
- Inflammatory Bowel Diseases, Anorectal Malformations, Spina Bifida, Ostomy
- Trial name
- StoMakker (NCT06065995)
- Testing
- StoMakker
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Small Intestine Length
Small Intestine Length Measurement Using 3D CT Volumetry and in Vivo Measurement Using Pre-marked Graspers in Revisional Bariatric Surgeries. A Comparative Study
Measuring bowel length during hypo-absorptive surgeries like Roux-en-Y gastric bypass (RYGB) and Single Anastomosis Duodeno-ileal Sleeve (SADI-s) is controversial and usually abandoned due to the high risk of intestinal injury.
- Trial name
- NCT06696677
- Testing
- CT, Measuring the small instestine length using pre-marked laparoscopic graspers
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Anastomotic Leaks
Observational Analysis of the Cause of Leaks When Bowel is Cut and Reconnected
The purpose of this study is to identify the cause of leaks that sometimes occur after a section of the bowel is removed and reconnected.
- Trial name
- NCT02178228
- Where
- United States
- Volunteers
- 1,077 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ulcerative Colitis, Mesenchymal Stem Cells
Umbilical Cord Mesenchymal Stem Cells Infusion for Ulcerative Colitis
The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for ulcerative colitis is safe and effective.
- Conditions
- Ulcerative Colitis, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01221428
- Testing
- Umbilical Cord Mesenchymal Stem Cells
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Rectal Cancer, Quality of Life
Prospective Observational Trial to Evaluate Quality of Life After Neoadjuvant Radiation or Chemoradiation Followed by Surgery in Patients With Rectal Cancer
Observational study to evaluate longitudinal quality of life according to standardized EORTC questionaires as well as functional Outcome, oncological outcome and toxicity in patients treated with neoadjuvant short term radiation…
- Conditions
- Rectal Cancer, Quality of Life, Radiation Therapy, Chemoradiation
- Trial name
- NEOCARE (NCT03731130)
- Testing
- EORTC QLQ C30, EORTC QLQ CR29
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Chronic Liver Disease, Inflammatory Bowel Diseases
Impact of Counselling and Visual Aid on Anxiety in Endoscopic Patients
A single blind randomized controlled trial was conducted to compare the effect of counselling and visual aid on the anxiety levels in patients undergoing endoscopy and to investigate the superiority of visual aid over…
- Trial name
- NCT05241158
- Testing
- Counselling with visual aid, Counselling
- Where
- Pakistan
- Volunteers
- 240 people
- Sponsor
- King Edward Medical University
Colorectal Cancer
Personalized Medicine in Early Stage Colorectal Cancer: Organ Preservation and Immune Benefit
The overall aim of this study is to determine whether the Immunoscore associated with histopathological features of endoscopically resected stage T1 colorectal tumors is predictive of locoregional lymph node invasion, in order to…
- Trial name
- COLOSAVE (NCT06251726)
- Testing
- Immunoscore Colon Test
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mixed Fiber Supplementation for Healthy Adults
Assessing the Short-Term Effects of Multi-Fiber Supplementation on Gut Health
This is a randomized, parallel-group interventional study evaluating the short-term gastrointestinal effects of a standardized multi-fiber supplement in healthy adults.
- Trial name
- NCT07787026
- Testing
- Prebiotic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brown University
Hyperbilirubinemia, Neonatal
The Efficacy of Oral Probiotics on Neonatal Hyperbilirubinemia
This trial will be carried out in two stages in the sick baby room of the Children's Hospital of China Medical University (CMUH).
- Trial name
- NCT03876678
- Testing
- Lactobacillus salivarius AP-32, Bifidobacterium animalis subspecies lactis CP-9
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- China Medical University Hospital
Serum Cholesterol, Gut Microbiome
Evaluation of Dietary Milk Polar Lipids on Serum Cholesterol and Gut Microbiota in Healthy Adults
The purpose of this study is to examine whether the daily consumption of 5 g of milk polar lipids influences serum lipids and gut microbiota composition in healthy adults.
- Trial name
- NCT04208815
- Testing
- Milk Polar Lipids, Milk Fat
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Endothelial Dysfunction, High Blood Pressure
Inulin and Nitrate's Effects on Vascular Health and Gut Microbiome
Previous research has revealed that adults with pre-hypertensive and hypertensive blood pressure levels typically exhibit impaired vasodilation, which is a crucial aspect of blood vessel function, due to decreased nitric oxide…
- Conditions
- Endothelial Dysfunction, High Blood Pressure, Gut Microbiota Dysbiosis and Nutrition
- Trial name
- NCT06502535
- Testing
- Inulin, Potassium nitrate and inulin
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Exeter
Rectal Cancer, Surgery
Assessment of Functional Digestive and Genitourinary Outcomes in Patients With Rectal Cancer.
Total mesorectal excision and neoadjuvant radio-chemotherapy have revolutionized the management of rectal cancer allowing an increase in survival (between 55 and 68% at 5 years) and allowing a decrease of local recurrence (under…
- Trial name
- Rectqol (NCT03459235)
- Testing
- quality of life
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Caen
Colorectal Cancer, Quality of Life
Quality of Life in Colorectal (ex-)Cancer Patients, Based on the Belgian Cancer Registry.
This study is collecting data on quality of life, (care)needs and socio-economic factors in colorectal (ex-)cancer patients via a written questionnaire completed by the patient him/herself.
- Trial name
- QOLColorect (NCT02545725)
- Testing
- Questionnaire on Quality of Life
- Where
- Belgium
- Volunteers
- 1,220 people
- Sponsor
- Elizabeth Van Eycken
Rectal Neoplasm
Radiotherapy & Total Neoadjuvant Therapy for Recurrent Rectal Cancer in Previously Irradiated Patients, an Italian Association for Radiotherapy and Clinical Oncology (AIRO)-GI Platform: a Multi-centre Prospective Observational Study
The introduction of neoadjuvant chemoradiation therapy (CRT) and the use of advanced surgical techniques have led to a reduction in mortality and recurrence rates for rectal cancer, the rate of which currently stands at 4-8%.
- Trial name
- RETRY (NCT05984576)
- Testing
- Reirradiation
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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