Clinical trials: Intra-operative Anesthesia
Breast Cancer
Selective Intraoperative Administration of Local Anesthesia in Breast Reconstruction
Subjects are being asked to participate in this study because they will be undergoing unilateral (one) or bilateral (two) mastectomy surgery with immediate reconstruction involving insertion of a tissue expander.
- Trial name
- NCT02525718
- Testing
- Saline, 0.25 % bupivacaine (2.5 mg/ml) w/ 1:100,000 epinephrine & 4 mg dexamethasone
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Northwestern University
Prostate Hypertrophy, Renal Disease
Effect of Deep BLock on Intraoperative Surgical Conditions
Rationale: A deep neuromuscular block is often associated with improved surgical conditions especially in laparoscopic surgery. However, a deep block comes at the expense of a variety of items that may conflict with the use of a…
- Trial name
- BLISS (NCT01631149)
- Testing
- Surgical block (rocuronium; atracurium/mivacurium)
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Leiden University Medical Center
Neuromuscular Blockade, Rocuronium
Impact of Deep Versus Standard Muscle Relaxation on Intra-operative Safety
Muscle relaxants are routinely applied during anesthesia to facilitate endotracheal intubation and to improve surgical working conditions.
- Conditions
- Neuromuscular Blockade, Rocuronium, Anesthetics, Anesthesia Complication
- Trial name
- EURORELAX (NCT04124757)
- Testing
- Deep neuromuscular block
- Where
- 8 sites in France, Italy and 2 more
- Volunteers
- 731 people
- Sponsor
- Leiden University Medical Center
Hypothermia Following Anesthesia, Hypothermia
Intraoperative Warming During Major Surgical Procedures Using the Esophageal Temperature Management System
The aim of this study is to assess the effectiveness of EnsoETM as a supplemental warming device compared to the standard of care warming practice in patients having major surgery.
- Conditions
- Hypothermia Following Anesthesia, Hypothermia, Surgery
- Trial name
- NCT03790683
- Testing
- EnsoETM, Surface Warming
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Advanced Cooling Therapy, Inc., d/b/a Attune Medical
Postoperative Pain, Objective Assessment of Sedation
Infrared Pupillometry During General Anesthesia to Predict Pain
The study comprises of a series of pupillary measurements using infrared pupillometry in patients undergoing arthroscopic knee surgery of any type.
- Trial name
- NCT02058511
- Testing
- Anesthesia Premedication, Induction and Maintenance, Pupillometry after administration of anesthetic drugs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Postoperative Pain
Dexamethasone for Post Cesarean Delivery Analgesia
The purpose of this study is to assess the effectiveness intravenous (IV) dexamethasone when used as part of a multimodal regimen to manage post cesarean delivery pain.
- Trial name
- NCT01868633
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Iowa
Anesthesia; Adverse Effect
Postoperative Consequences of Intraoperative NOL Titration
To demonstrate that intraoperative NOL-guided titration of fentanyl improves initial recovery characteristics.
- Trial name
- NCT04679818
- Testing
- Routine opioid management, PMD-200 Nol-guided opioid administration
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- The Cleveland Clinic
Pain, Procedural
The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort
The purpose of this study is to compare patient responses during and after surgery when local anesthetic is used for dental treatment under general anesthesia (GA) and when it is not used.
- Trial name
- NCT04500158
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Virginia Commonwealth University
Nausea, Vomiting
Acupuncture Point P6 Stimulation for Reduction of Nausea and Vomiting During Cesarean
The purpose of this study is to compare the effectiveness of acupressure point P6 stimulation versus intravenous ondansetron plus metoclopramide versus no antiemetic prophylaxis during elective cesarean section under regional…
- Conditions
- Nausea, Vomiting, Satisfaction
- Trial name
- NCT02959840
- Testing
- Acupressure Point P6 stimulator, Metoclopramide, Ondansetron
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Perioperative Care, Surgery--Complications
Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
We propose to test the hypothesis that aggressive warming reduces the incidence of major cardiovascular complications, compared to routine care.
- Conditions
- Perioperative Care, Surgery--Complications, Hypothermia; Anesthesia, Myocardial Injury
- Trial name
- PROTECT (NCT03111875)
- Testing
- aggressive warming, routine thermal management
- Where
- 11 sites in United States, China
- Volunteers
- 5,056 people
- Sponsor
- The Cleveland Clinic
Idiopathic Scoliosis
Anesthesia and Motor Evoked Potential (MEP) Recruitment
Test the hypothesis to recruit larger motor responses to transcranial stimulation.
- Trial name
- NCT02199314
- Testing
- Desflurane
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Blood Loss
Intraoperative Bleeding During Endoscopic Sinus Surgery
The purpose of this study is to compare the blood loss during sinus surgery looking at two different types of anesthesia: either intravenous anesthesia with propofol or inhalational anesthesia with sevoflurane.
- Trial name
- NCT01014728
- Testing
- propofol, sevoflurane
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Major Surgery Under General Anesthesia
The Effects of Ambient Temperature and Forced-air Warming on Intraoperative Core Temperature
The purpose of this study is to determine: 1. the effect of ambient temperature on the rate of core temperature change from 1 to 3 hours after induction of anesthesia (linear phase of the hypothermia curve) in major operations…
- Trial name
- NCT02715076
- Testing
- Ambient Temperature 19°C, Ambient Temperature 21°C, Ambient Temperature 23°C
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Peking Union Medical College Hospital
Pain, Pain, Acute
Intraoperative Sublingual Sufentanil for Acute Pain in the Ambulatory Surgery Center
The purpose of this study is to determine if a single dose of sublingual sufentanil given 15-30 minutes prior to wake up is efficacious at reducing recovery room time.
- Conditions
- Pain, Pain, Acute, Anesthesia
- Trial name
- NCT04387136
- Testing
- Sublingual Sufentanil
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Minnesota
Intraoperative Complication, Malignant Female Reproductive System Neoplasm
Epidural Anesthesia Within an Enhanced Recovery Pathway in Reducing Pain in Patients Undergoing Gynecologic Surgery
This randomized clinical trial studies epidural anesthesia within an enhanced recovery pathway (ERP) in reducing pain in patients undergoing gynecologic surgery.
- Conditions
- Intraoperative Complication, Malignant Female Reproductive System Neoplasm, Pain
- Trial name
- NCT02423876
- Testing
- Epidural analgesia, Intraoperative Complication Management and Prevention, Pain Therapy
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Wisconsin, Madison
Pain, Postoperative, Crohn Disease
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Traditionally, opioids are heavily utilized in treating postoperative pain but they are associated with numerous side effects. The use of the transversus abdominis plane (TAP) blocks have become standard practice to extend the…
- Conditions
- Pain, Postoperative, Crohn Disease, Inflammatory Bowel Diseases, Colorectal Cancer
- Trial name
- TINGLE (NCT03723447)
- Testing
- Liposomal bupivacaine, Bupivacaine/epinephrine/dexamethasone
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Cedars-Sinai Medical Center
Peripheral Arterial Disease
A Study of Loco-Regional Liposomal Bupivacaine Injection
The purpose of this research is to find out if using liposomal bupivacaine solution (bupivacaine liposome) injections during lower extremity revascularization surgery will lower the amount of narcotic drugs used during and…
- Trial name
- NCT05992896
- Testing
- Bupivacaine liposome
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Pediatric Cardiac Surgery, Intraoperative Awareness
Closed Loop Propofol Administration in Pediatric Cardiac Surgery
The purpose of the study is to evaluate and compare the feasibility, efficacy and safety of IAADS (Improved Anaesthetic Agent Delivery System) for propofol anaesthesia against manual control using bispectral index in paediatric…
- Conditions
- Pediatric Cardiac Surgery, Intraoperative Awareness, Automated Drug Delivery
- Trial name
- NCT01600287
- Testing
- IAADS, Manual propofol administration
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hypothermia, Anesthesia
Electric Warming Mattress to Prevent IPH During LSCS
This study will demonstrate whether an electric warming mattress can reduce the number of patients who get cold and shiver after elective cesarean section.
- Conditions
- Hypothermia, Anesthesia, Obstetric Anesthesia Problems
- Trial name
- ObsIPH (NCT01054209)
- Testing
- Warming with warming mattress
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Cancer Pain
Intraoperative Aromatherapy Versus Placebo for Port-a-Cath Placement Under Monitored Anesthesia Care. A Randomized Controlled Trial
This is a prospective, controlled, randomized trial. Primary objective is to compare the time to readiness for discharge (minutes) from Post-Anesthesia Care Unit (PACU) after Port-a-Cath placement surgery between patients who are…
- Trial name
- NCT05328973
- Testing
- ELEQUIL
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center